JP5138372B2 - 凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法 - Google Patents

凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法 Download PDF

Info

Publication number
JP5138372B2
JP5138372B2 JP2007525791A JP2007525791A JP5138372B2 JP 5138372 B2 JP5138372 B2 JP 5138372B2 JP 2007525791 A JP2007525791 A JP 2007525791A JP 2007525791 A JP2007525791 A JP 2007525791A JP 5138372 B2 JP5138372 B2 JP 5138372B2
Authority
JP
Japan
Prior art keywords
platelets
composition
platelet
blood
lyophilized
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2007525791A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008509924A (ja
JP2008509924A5 (enExample
Inventor
ディヴィッド ホー
シンディー エス オーサー
アレン エス ルドルフ
キース エイ モスコウィッツ
ジョシュア ディー
Original Assignee
セルフィアー インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/152,774 external-priority patent/US20060035383A1/en
Priority claimed from US11/197,310 external-priority patent/US20060051731A1/en
Application filed by セルフィアー インコーポレイテッド filed Critical セルフィアー インコーポレイテッド
Publication of JP2008509924A publication Critical patent/JP2008509924A/ja
Publication of JP2008509924A5 publication Critical patent/JP2008509924A5/ja
Application granted granted Critical
Publication of JP5138372B2 publication Critical patent/JP5138372B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007525791A 2004-08-12 2005-08-12 凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法 Expired - Lifetime JP5138372B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US60083804P 2004-08-12 2004-08-12
US60/600,838 2004-08-12
US61993004P 2004-10-20 2004-10-20
US60/619,930 2004-10-20
US11/152,774 2005-06-15
US11/152,774 US20060035383A1 (en) 2004-08-12 2005-06-15 Dry platelet preparations for use in diagnostics
US11/197,310 US20060051731A1 (en) 2004-08-12 2005-08-05 Processes for preparing lyophilized platelets
US11/197,310 2005-08-05
PCT/US2005/028559 WO2006020773A2 (en) 2004-08-12 2005-08-12 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use

Publications (3)

Publication Number Publication Date
JP2008509924A JP2008509924A (ja) 2008-04-03
JP2008509924A5 JP2008509924A5 (enExample) 2008-10-02
JP5138372B2 true JP5138372B2 (ja) 2013-02-06

Family

ID=35908143

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007525791A Expired - Lifetime JP5138372B2 (ja) 2004-08-12 2005-08-12 凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法

Country Status (10)

Country Link
US (1) US8486617B2 (enExample)
EP (1) EP1784639B1 (enExample)
JP (1) JP5138372B2 (enExample)
CN (1) CN101072506B (enExample)
AT (1) ATE455463T1 (enExample)
AU (1) AU2005272821B2 (enExample)
CA (1) CA2577068C (enExample)
DE (1) DE602005019064D1 (enExample)
NZ (1) NZ553389A (enExample)
WO (1) WO2006020773A2 (enExample)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2668551T3 (es) 2005-09-26 2018-05-18 Lifecell Corporation Composición seca de plaquetas
US8058064B2 (en) * 2006-10-04 2011-11-15 The University Of Tokyo Sac-like structure enclosing hematopoietic progenitor cells produced from ES cells and method for preparing blood cells
US8372343B2 (en) * 2007-12-07 2013-02-12 Sheldon Goldstein Multiple coagulation test cartridge and method of using same
WO2010022202A1 (en) * 2008-08-20 2010-02-25 Bio/Data Corporation Kinetic biologic activity assays and kinetic von willebrand assay
US20100049542A1 (en) * 2008-08-22 2010-02-25 Fenwal, Inc. Systems, articles of manufacture, and methods for managing blood processing procedures
EP2555613A1 (en) * 2010-04-08 2013-02-13 INSERM - Institut National de la Santé et de la Recherche Médicale Zeodration method for the preservation of blood platelets
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
CN101957364A (zh) * 2010-09-19 2011-01-26 李勇 冻干型血小板抗原谱细胞的制备方法
WO2012098358A1 (en) * 2011-01-20 2012-07-26 Biopharma Technology Ltd Freeze drying method
GB201101002D0 (en) * 2011-01-20 2011-03-09 Biopharma Technology Ltd Freeze drying method
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
CN102327288B (zh) * 2011-10-17 2012-11-14 济南环肽医药科技有限公司 一种注射用血小板冻干粉制剂及其制备方法
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
AU2013204728B2 (en) 2013-03-15 2016-09-15 Baxalta GmbH Methods for treating bleeding disorders using a platelet subpopulation
WO2014144370A1 (en) 2013-03-15 2014-09-18 Cook Biotech Incorporated Ecm implant compositions and methods
TW201446253A (zh) * 2013-06-07 2014-12-16 Chang Gung Medical Foundation Lin Kou Chang Gung Memorial Hospital 非凝集預活變形血小板之應用及其藥劑
EP3942931A1 (en) * 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
CN106796219B (zh) 2014-08-07 2022-05-27 通用医疗公司 全血样品的稳定化
KR20170102319A (ko) * 2014-12-31 2017-09-08 안트로제네시스 코포레이션 혈소판을 분리하는 방법
EP3265116B1 (en) * 2015-03-04 2021-06-02 University of Rochester Systemic and topical application of platelet microparticles to treat bleeding in trauma patients
BR112017026660A2 (pt) * 2015-06-10 2018-08-14 Cellphire Inc composição e kit para tratamento de perda de fluidos que provocam hipotensão e/ou hipovolemia
EP3364954A4 (en) * 2015-08-28 2019-08-07 Cellphire Inc. PRODUCTS AND METHODS OF USING A PLATELET DERIVATIVE HEMOSTATIC AGENT FOR REGULATING BLEEDING AND ENHANCING HEALING
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
JP7062954B2 (ja) * 2016-02-10 2022-05-09 ソニーグループ株式会社 血液凝固解析装置及び血液凝固解析方法
AU2016431615A1 (en) * 2016-12-08 2019-06-20 Cellphire, Inc. Compositions and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia
WO2018112780A1 (en) * 2016-12-21 2018-06-28 Chung Chin Sun Novel method for blood plasma protein activity preservation
US20190076478A1 (en) * 2017-09-13 2019-03-14 Cellphire, Inc. Canine blood platelet preparations
CN107998375B (zh) * 2017-12-14 2021-11-05 广东医科大学 一种多肽在预防或治疗血栓性疾病或脑缺血再灌注损伤相关疾病中的应用
WO2020113090A1 (en) * 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3937631A4 (en) * 2019-03-13 2023-01-04 Cellphire Inc. DOG PLALETLET PREPARATIONS
US10429377B1 (en) 2019-03-15 2019-10-01 Coagulation Sciences Llc Coagulation test device, system, and method of use
CA3138529C (en) 2019-05-03 2025-10-07 Cellphire Inc Materials and methods for producing blood products
CA3147618A1 (en) * 2019-07-17 2021-01-21 Cellphire, Inc. Use of platelets in treating infections
WO2022178177A1 (en) 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating antiplatelet-induced coagulopathy
WO2021034719A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
WO2023081804A1 (en) 2021-11-04 2023-05-11 Cellphire, Inc. Platelet derivative compositions, and methods of making and using such compositions
WO2023220739A1 (en) 2022-05-12 2023-11-16 Cellphire, Inc. Platelet derivative compositions for use in subjects afflicted with hermansky pudlak syndrome or bernard soulier syndrome
AU2020333666A1 (en) * 2019-08-16 2022-03-31 Cellphire, Inc. Thrombosomes as an anticoagulant reversal agent
CN110585240B (zh) * 2019-10-10 2021-10-29 石开生物科技(广州)有限公司 一种含再生因子的冻干制剂及其制备方法和应用
WO2021108538A1 (en) * 2019-11-27 2021-06-03 Cellphire, Inc. PLATELETS LOADED WITH mRNA
CA3170134A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Treatment of von willebrand disease
WO2021232015A1 (en) * 2020-05-15 2021-11-18 Cellphire, Inc. Platelet derived extracellular vesicles
CN113156144A (zh) * 2021-01-29 2021-07-23 郑州普湾医疗技术有限公司 一种血小板聚集功能花生四烯酸杯检测试剂及其制备方法
US20220273724A1 (en) * 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy
WO2022178191A1 (en) 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating anticoagulant-induced coagulopathy
EP4086634A1 (en) * 2021-05-06 2022-11-09 Eberhard Karls Universität Tübingen Medizinische Fakultät Method for diagnosing a predisposition of a living being to develop thrombocytopenia
WO2023220694A1 (en) 2022-05-12 2023-11-16 Cellphire, Inc. Mri-agent loaded platelet compositions and methods of preparing and using the same
WO2024192173A1 (en) 2023-03-14 2024-09-19 Cellphire, Inc. Hla-characterized platelet derivative compositions, and methods of making, selecting and using such compositions
WO2024229305A1 (en) 2023-05-03 2024-11-07 Cellphire, Inc. Platelet derivative compositions for use in controlling bleeding in a subject
WO2024233577A1 (en) 2023-05-11 2024-11-14 Vetstem, Inc. Platelet-rich plasma compositions, preparation, and uses thereof
CN117018265A (zh) * 2023-08-16 2023-11-10 浙江大学 一种含冻干血小板的止血敷料及其制备方法
CN117180441B (zh) * 2023-10-11 2024-10-15 北京朴汇细胞生物科技有限公司 一种血小板脱水干燥保护剂、血小板脱水干燥制剂及其制备方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5213814A (en) 1989-04-10 1993-05-25 Cryopharm Corporation Lyophilized and reconstituted blood platelet compositions
DE69332756T2 (de) 1992-05-29 2004-02-19 University Of North Carolina At Chapel Hill Im immobilisierten zustand getrocknete pharmazeutische verträgliche menschliche blutplättchen
DE69534151T2 (de) 1994-02-22 2006-01-12 Nippon Telegraph And Telephone Corp. Gefriergetrocknete Blutzellen, Stammzellen und Plättchen und Verfahren zu deren Herstellung
JP3788522B2 (ja) * 1994-02-22 2006-06-21 日本電信電話株式会社 血球、幹細胞、および血小板の凍結乾燥生成物の製造方法
JPH09109136A (ja) 1995-10-16 1997-04-28 Mitsubishi Materials Corp モルタル又はコンクリートの製造装置
US5736313A (en) * 1995-10-20 1998-04-07 The United States Of America As Represented By The Secretary Of The Navy Method of lyophilizing platelets by incubation with high carbohydrate concentrations and supercooling prior to freezing
WO1997045009A2 (en) 1996-05-29 1997-12-04 Universal Preservation Technologies, Inc. Long-term shelf preservation by vitrification
ATE230923T1 (de) * 1997-02-07 2003-02-15 Elan Drug Delivery Ltd Verfahren und zusammensetzungen zur herstellung getrockneter, lagerungsstabiler blutplättchen
US6211575B1 (en) * 1999-08-18 2001-04-03 Sigmatel Inc. Method and apparatus for identifying customized integrated circuits
AU2001234978A1 (en) * 2000-02-10 2001-08-20 The Regents Of The University Of California Therapeutic platelets and methods
US20020076445A1 (en) 2000-02-10 2002-06-20 Crowe John H. Eukaryotic cells and method for preserving cells
US6653062B1 (en) 2000-07-26 2003-11-25 Wisconsin Alumni Research Foundation Preservation and storage medium for biological materials
CA2426584C (en) 2000-10-19 2010-08-10 Bracco Research Usa Radiopharmaceutical formulations
AU2003302323A1 (en) 2002-11-29 2004-06-23 The Regents Of The University Of California A method and therapeutic platelets

Also Published As

Publication number Publication date
CA2577068A1 (en) 2006-02-23
ATE455463T1 (de) 2010-02-15
WO2006020773A3 (en) 2007-07-12
CN101072506A (zh) 2007-11-14
NZ553389A (en) 2009-10-30
US8486617B2 (en) 2013-07-16
DE602005019064D1 (de) 2010-03-11
JP2008509924A (ja) 2008-04-03
AU2005272821A1 (en) 2006-02-23
CA2577068C (en) 2016-05-17
EP1784639B1 (en) 2010-01-20
EP1784639A4 (en) 2008-05-07
AU2005272821B2 (en) 2010-09-09
WO2006020773A2 (en) 2006-02-23
US20070243178A1 (en) 2007-10-18
EP1784639A2 (en) 2007-05-16
CN101072506B (zh) 2010-05-12

Similar Documents

Publication Publication Date Title
JP5138372B2 (ja) 凍結乾燥血小板の調製法、凍結乾燥血小板を含む組成物、および使用法
US7811558B2 (en) Use of stabilized platelets as hemostatic agent
US8097403B2 (en) Freeze-dried platelets, method of making and method of use as a diagnostic agent
US7285266B2 (en) Cell-polymer fiber compositions and uses thereof
EP1338648B1 (en) Pharmaceutically acceptable fixed-dried human blood platelets
Kim et al. Microparticles from aged packed red blood cell units stimulate pulmonary microthrombus formation via P-selectin
US20060035383A1 (en) Dry platelet preparations for use in diagnostics
Calciolari et al. Differences between first‐and second‐generation autologous platelet concentrates
US20110183311A1 (en) Dry platelet preparations for use in diagnostics
US20060051731A1 (en) Processes for preparing lyophilized platelets
US20230112136A1 (en) Canine blood platelet preparations
Abonnenc et al. In vitro evaluation of pathogen-inactivated buffy coat-derived platelet concentrates during storage: psoralen-based photochemical treatment step-by-step
WO2017177104A1 (en) Reconstitution solution for spray-dried plasma
US20200291356A1 (en) Canine blood platelet preparations
Smith et al. Procoagulant phospholipid concentration in canine erythrocyte concentrates stored with or without prestorage leukoreduction
Orser et al. Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use
US20190255114A1 (en) Storage of platelets
Ilvonen et al. Extracellular vesicles in ageing cold‐stored whole blood may not compensate for the decreasing haemostatic function in vitro
RU2850504C2 (ru) Материалы и способы получения продуктов на основе крови
WO2024233577A1 (en) Platelet-rich plasma compositions, preparation, and uses thereof
JP7538600B2 (ja) Ｒｍｐ組成物および使用方法
Tissot In vitro evaluation of pathogen-inactivated buffy coat-derived platelet concentrates during storage: psoralen-based photochemical treatment step-by-step
Koksch et al. Flow Cytometric Analysis of Platelet Function in Micro-and Macroangiopathy.
HK1058376B (en) Pharmaceutically acceptable fixed-dried human blood platelets

Legal Events

Date Code Title Description
A711 Notification of change in applicant

Free format text: JAPANESE INTERMEDIATE CODE: A711

Effective date: 20080616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20080616

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20080808

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20080808

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110823

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111116

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111124

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20111220

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20111228

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20120118

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20120125

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120223

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20121023

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20121114

R150 Certificate of patent or registration of utility model

Ref document number: 5138372

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20151122

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term