CA2577068C - Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use - Google Patents

Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use Download PDF

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Publication number
CA2577068C
CA2577068C CA2577068A CA2577068A CA2577068C CA 2577068 C CA2577068 C CA 2577068C CA 2577068 A CA2577068 A CA 2577068A CA 2577068 A CA2577068 A CA 2577068A CA 2577068 C CA2577068 C CA 2577068C
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CA
Canada
Prior art keywords
platelets
freeze
dried
blood
platelet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CA2577068A
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English (en)
French (fr)
Other versions
CA2577068A1 (en
Inventor
David Ho
Cindy S. Orser
Alan S. Rudolph
Keith A. Moskowitz
Joshua Dee
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cellphire Inc
Original Assignee
Cellphire Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US11/152,774 external-priority patent/US20060035383A1/en
Priority claimed from US11/197,310 external-priority patent/US20060051731A1/en
Application filed by Cellphire Inc filed Critical Cellphire Inc
Publication of CA2577068A1 publication Critical patent/CA2577068A1/en
Application granted granted Critical
Publication of CA2577068C publication Critical patent/CA2577068C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/16—Physical preservation processes
    • A01N1/162—Temperature processes, e.g. following predefined temperature changes over time
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/19—Platelets; Megacaryocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Dentistry (AREA)
  • Molecular Biology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • Diabetes (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2577068A 2004-08-12 2005-08-12 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use Expired - Lifetime CA2577068C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US60083804P 2004-08-12 2004-08-12
US60/600,838 2004-08-12
US61993004P 2004-10-20 2004-10-20
US60/619,930 2004-10-20
US11/152,774 2005-06-15
US11/152,774 US20060035383A1 (en) 2004-08-12 2005-06-15 Dry platelet preparations for use in diagnostics
US11/197,310 US20060051731A1 (en) 2004-08-12 2005-08-05 Processes for preparing lyophilized platelets
US11/197,310 2005-08-05
PCT/US2005/028559 WO2006020773A2 (en) 2004-08-12 2005-08-12 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use

Publications (2)

Publication Number Publication Date
CA2577068A1 CA2577068A1 (en) 2006-02-23
CA2577068C true CA2577068C (en) 2016-05-17

Family

ID=35908143

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2577068A Expired - Lifetime CA2577068C (en) 2004-08-12 2005-08-12 Methods for preparing freeze-dried platelets, compositions comprising freeze-dried platelets, and methods of use

Country Status (10)

Country Link
US (1) US8486617B2 (enExample)
EP (1) EP1784639B1 (enExample)
JP (1) JP5138372B2 (enExample)
CN (1) CN101072506B (enExample)
AT (1) ATE455463T1 (enExample)
AU (1) AU2005272821B2 (enExample)
CA (1) CA2577068C (enExample)
DE (1) DE602005019064D1 (enExample)
NZ (1) NZ553389A (enExample)
WO (1) WO2006020773A2 (enExample)

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US8372343B2 (en) * 2007-12-07 2013-02-12 Sheldon Goldstein Multiple coagulation test cartridge and method of using same
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US20100049542A1 (en) * 2008-08-22 2010-02-25 Fenwal, Inc. Systems, articles of manufacture, and methods for managing blood processing procedures
EP2555613A1 (en) * 2010-04-08 2013-02-13 INSERM - Institut National de la Santé et de la Recherche Médicale Zeodration method for the preservation of blood platelets
US10575515B2 (en) 2010-05-04 2020-03-03 The General Hospital Corporation Methods and compositions for preserving tissues and organs
EP2598661B1 (en) 2010-07-26 2017-09-27 Biomatrica, INC. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
WO2012018638A2 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in blood and other biological samples during shipping and storage at ambient temperatures
CN101957364A (zh) * 2010-09-19 2011-01-26 李勇 冻干型血小板抗原谱细胞的制备方法
WO2012098358A1 (en) * 2011-01-20 2012-07-26 Biopharma Technology Ltd Freeze drying method
GB201101002D0 (en) * 2011-01-20 2011-03-09 Biopharma Technology Ltd Freeze drying method
EP2508892A1 (de) * 2011-04-04 2012-10-10 Siemens Healthcare Diagnostics Products GmbH Kontrollen und Kit für Thrombozytenaktivitätsteste
CN102327288B (zh) * 2011-10-17 2012-11-14 济南环肽医药科技有限公司 一种注射用血小板冻干粉制剂及其制备方法
EP3249054A1 (en) 2012-12-20 2017-11-29 Biomatrica, INC. Formulations and methods for stabilizing pcr reagents
AU2013204728B2 (en) 2013-03-15 2016-09-15 Baxalta GmbH Methods for treating bleeding disorders using a platelet subpopulation
WO2014144370A1 (en) 2013-03-15 2014-09-18 Cook Biotech Incorporated Ecm implant compositions and methods
TW201446253A (zh) * 2013-06-07 2014-12-16 Chang Gung Medical Foundation Lin Kou Chang Gung Memorial Hospital 非凝集預活變形血小板之應用及其藥劑
EP3942931A1 (en) * 2014-06-10 2022-01-26 Biomatrica, INC. Stabilization of thrombocytes at ambient temperatures
CN106796219B (zh) 2014-08-07 2022-05-27 通用医疗公司 全血样品的稳定化
KR20170102319A (ko) * 2014-12-31 2017-09-08 안트로제네시스 코포레이션 혈소판을 분리하는 방법
EP3265116B1 (en) * 2015-03-04 2021-06-02 University of Rochester Systemic and topical application of platelet microparticles to treat bleeding in trauma patients
BR112017026660A2 (pt) * 2015-06-10 2018-08-14 Cellphire Inc composição e kit para tratamento de perda de fluidos que provocam hipotensão e/ou hipovolemia
EP3364954A4 (en) * 2015-08-28 2019-08-07 Cellphire Inc. PRODUCTS AND METHODS OF USING A PLATELET DERIVATIVE HEMOSTATIC AGENT FOR REGULATING BLEEDING AND ENHANCING HEALING
KR20250047404A (ko) 2015-12-08 2025-04-03 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
JP7062954B2 (ja) * 2016-02-10 2022-05-09 ソニーグループ株式会社 血液凝固解析装置及び血液凝固解析方法
AU2016431615A1 (en) * 2016-12-08 2019-06-20 Cellphire, Inc. Compositions and methods for treatment of loss of fluids leading to hypotension and/or hypovolemia
WO2018112780A1 (en) * 2016-12-21 2018-06-28 Chung Chin Sun Novel method for blood plasma protein activity preservation
US20190076478A1 (en) * 2017-09-13 2019-03-14 Cellphire, Inc. Canine blood platelet preparations
CN107998375B (zh) * 2017-12-14 2021-11-05 广东医科大学 一种多肽在预防或治疗血栓性疾病或脑缺血再灌注损伤相关疾病中的应用
WO2020113090A1 (en) * 2018-11-30 2020-06-04 Cellphire, Inc. Platelets as delivery agents
US11767511B2 (en) 2018-11-30 2023-09-26 Cellphire, Inc. Platelets as delivery agents
EP3937631A4 (en) * 2019-03-13 2023-01-04 Cellphire Inc. DOG PLALETLET PREPARATIONS
US10429377B1 (en) 2019-03-15 2019-10-01 Coagulation Sciences Llc Coagulation test device, system, and method of use
CA3138529C (en) 2019-05-03 2025-10-07 Cellphire Inc Materials and methods for producing blood products
CA3147618A1 (en) * 2019-07-17 2021-01-21 Cellphire, Inc. Use of platelets in treating infections
WO2022178177A1 (en) 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating antiplatelet-induced coagulopathy
WO2021034719A1 (en) 2019-08-16 2021-02-25 Cellphire, Inc. Thrombosomes as an antiplatelet agent reversal agent
WO2023081804A1 (en) 2021-11-04 2023-05-11 Cellphire, Inc. Platelet derivative compositions, and methods of making and using such compositions
WO2023220739A1 (en) 2022-05-12 2023-11-16 Cellphire, Inc. Platelet derivative compositions for use in subjects afflicted with hermansky pudlak syndrome or bernard soulier syndrome
AU2020333666A1 (en) * 2019-08-16 2022-03-31 Cellphire, Inc. Thrombosomes as an anticoagulant reversal agent
CN110585240B (zh) * 2019-10-10 2021-10-29 石开生物科技(广州)有限公司 一种含再生因子的冻干制剂及其制备方法和应用
WO2021108538A1 (en) * 2019-11-27 2021-06-03 Cellphire, Inc. PLATELETS LOADED WITH mRNA
CA3170134A1 (en) 2020-02-04 2021-08-12 Cellphire, Inc. Treatment of von willebrand disease
WO2021232015A1 (en) * 2020-05-15 2021-11-18 Cellphire, Inc. Platelet derived extracellular vesicles
CN113156144A (zh) * 2021-01-29 2021-07-23 郑州普湾医疗技术有限公司 一种血小板聚集功能花生四烯酸杯检测试剂及其制备方法
US20220273724A1 (en) * 2021-02-17 2022-09-01 Cellphire Inc. Freeze-dried platelet derivative compositions for treating antiplatelet induced coagulopathy
WO2022178191A1 (en) 2021-02-17 2022-08-25 Cellphire, Inc. Freeze-dried platelet derivative compositions for treating anticoagulant-induced coagulopathy
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Also Published As

Publication number Publication date
CA2577068A1 (en) 2006-02-23
ATE455463T1 (de) 2010-02-15
WO2006020773A3 (en) 2007-07-12
CN101072506A (zh) 2007-11-14
NZ553389A (en) 2009-10-30
US8486617B2 (en) 2013-07-16
DE602005019064D1 (de) 2010-03-11
JP2008509924A (ja) 2008-04-03
JP5138372B2 (ja) 2013-02-06
AU2005272821A1 (en) 2006-02-23
EP1784639B1 (en) 2010-01-20
EP1784639A4 (en) 2008-05-07
AU2005272821B2 (en) 2010-09-09
WO2006020773A2 (en) 2006-02-23
US20070243178A1 (en) 2007-10-18
EP1784639A2 (en) 2007-05-16
CN101072506B (zh) 2010-05-12

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