JP5124066B2 - ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 - Google Patents

ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 Download PDF

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JP5124066B2
JP5124066B2 JP2000606266A JP2000606266A JP5124066B2 JP 5124066 B2 JP5124066 B2 JP 5124066B2 JP 2000606266 A JP2000606266 A JP 2000606266A JP 2000606266 A JP2000606266 A JP 2000606266A JP 5124066 B2 JP5124066 B2 JP 5124066B2
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chitosan
adjuvant
protective
water
animal
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JP2002540077A5 (enExample
JP2002540077A (ja
Inventor
ハザイア オヤ アルパー
ジェイムス エドワード アイレス
サトヤナラヤナ ソマヴァラプ
エセル ダイアン ウィリアムソン
レスリー ウィリアム ジェイムズ バイリー
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UK Secretary of State for Defence
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Priority claimed from GBGB9906694.6A external-priority patent/GB9906694D0/en
Priority claimed from GBGB9906696.1A external-priority patent/GB9906696D0/en
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Publication of JP2002540077A publication Critical patent/JP2002540077A/ja
Publication of JP2002540077A5 publication Critical patent/JP2002540077A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0043—Nose
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2000606266A 1999-03-24 2000-03-23 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用 Expired - Fee Related JP5124066B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB9906694.6A GB9906694D0 (en) 1999-03-24 1999-03-24 Vaccine composition
GB9906696.1 1999-03-24
GB9906694.6 1999-03-24
GBGB9906696.1A GB9906696D0 (en) 1999-03-24 1999-03-24 Vaccine composition
PCT/GB2000/001118 WO2000056362A2 (en) 1999-03-24 2000-03-23 Polycationic carbohydrates as immunostimulants in vaccines

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011204971A Division JP2012031186A (ja) 1999-03-24 2011-09-20 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用

Publications (3)

Publication Number Publication Date
JP2002540077A JP2002540077A (ja) 2002-11-26
JP2002540077A5 JP2002540077A5 (enExample) 2007-05-24
JP5124066B2 true JP5124066B2 (ja) 2013-01-23

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Application Number Title Priority Date Filing Date
JP2000606266A Expired - Fee Related JP5124066B2 (ja) 1999-03-24 2000-03-23 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用
JP2000606265A Withdrawn JP2002540076A (ja) 1999-03-24 2000-03-23 ワクチン組成物
JP2011204971A Pending JP2012031186A (ja) 1999-03-24 2011-09-20 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用

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JP2000606265A Withdrawn JP2002540076A (ja) 1999-03-24 2000-03-23 ワクチン組成物
JP2011204971A Pending JP2012031186A (ja) 1999-03-24 2011-09-20 ポリカチオン性炭水化物のワクチンにおける免疫賦活剤としての使用

Country Status (11)

Country Link
US (1) US20080057083A1 (enExample)
EP (2) EP1163001A2 (enExample)
JP (3) JP5124066B2 (enExample)
AT (1) ATE403436T1 (enExample)
AU (2) AU762078B2 (enExample)
CA (2) CA2366216C (enExample)
DE (1) DE60039754D1 (enExample)
DK (1) DK1163002T3 (enExample)
ES (1) ES2311451T3 (enExample)
NZ (1) NZ514323A (enExample)
WO (2) WO2000056361A2 (enExample)

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WO2002000173A2 (en) 2000-06-26 2002-01-03 Rxkinetix, Inc. Methods for use of delivery composition for expanding, activating, committing or mobilizing one or more pluripotent, self-renewing and committed stem cells
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JP2005501845A (ja) 2001-08-16 2005-01-20 メディカル リサーチ カウンシル キチン微小粒子およびそれらの医学的用途
CA2383259A1 (en) 2002-04-23 2003-10-23 Celator Technologies Inc. Synergistic compositions
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US7850990B2 (en) 2001-10-03 2010-12-14 Celator Pharmaceuticals, Inc. Compositions for delivery of drug combinations
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GB0300885D0 (en) * 2003-01-15 2003-02-12 Secr Defence Pharmaceutical composition
ATE426412T1 (de) * 2003-01-30 2009-04-15 Novartis Vaccines & Diagnostic Adjuvante influenza-vakzine
JP2006516609A (ja) * 2003-01-30 2006-07-06 カイロン ソチエタ ア レスポンサビリタ リミタータ 粘膜髄膜炎菌性ワクチン
CA2528007C (en) 2003-06-02 2012-03-27 Chiron Corporation Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen
JP4669665B2 (ja) * 2004-04-12 2011-04-13 正彦 阿部 細胞毒性のないポリカチオン修飾リポソームおよびその製造方法
GB0519871D0 (en) 2005-09-30 2005-11-09 Secr Defence Immunogenic agents
CA2643322C (en) * 2006-02-24 2015-07-21 Novartis Ag Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions
JPWO2008041703A1 (ja) * 2006-10-02 2010-02-04 国立大学法人大阪大学 インフルエンザワクチン用アジュバントおよびインフルエンザワクチン
JP5297009B2 (ja) * 2007-07-24 2013-09-25 大日精化工業株式会社 免疫アジュバント水溶液
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GB0900455D0 (en) 2009-01-13 2009-02-11 Secr Defence Vaccine
KR101670340B1 (ko) * 2011-05-18 2016-10-28 매트리백스 인코포레이티드 폴리양이온을 포함하는 단백질 매트릭스 백신 조성물
US10500283B2 (en) 2011-05-30 2019-12-10 National Institute Of Immunology Vaccine composition capable of inducing memory antibody response from single point immunization
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CN107899021A (zh) * 2017-11-06 2018-04-13 扬州大学 一种表面修饰s‑层蛋白的壳聚糖微球、制备及应用
KR102384808B1 (ko) * 2018-12-20 2022-04-08 주식회사 스킨메드 키토산으로 코팅된 나노 캡슐 및 이의 용도
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Also Published As

Publication number Publication date
AU755502B2 (en) 2002-12-12
ATE403436T1 (de) 2008-08-15
AU762078B2 (en) 2003-06-19
JP2012031186A (ja) 2012-02-16
CA2366216A1 (en) 2000-09-28
WO2000056361A2 (en) 2000-09-28
WO2000056361A3 (en) 2001-03-01
EP1163001A2 (en) 2001-12-19
WO2000056362A2 (en) 2000-09-28
DK1163002T3 (da) 2009-01-19
AU755502C (en) 2003-08-14
EP1163002B1 (en) 2008-08-06
NZ514323A (en) 2003-03-28
WO2000056362A3 (en) 2001-02-01
JP2002540076A (ja) 2002-11-26
CA2366216C (en) 2012-10-23
EP1163002A2 (en) 2001-12-19
US20080057083A1 (en) 2008-03-06
DE60039754D1 (de) 2008-09-18
ES2311451T3 (es) 2009-02-16
CA2366908A1 (en) 2000-09-28
AU3443500A (en) 2000-10-09
AU3442400A (en) 2000-10-09
JP2002540077A (ja) 2002-11-26

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