CA2366216C - Polycationic carbohydrates as immunostimulants in vaccines - Google Patents
Polycationic carbohydrates as immunostimulants in vaccines Download PDFInfo
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- CA2366216C CA2366216C CA2366216A CA2366216A CA2366216C CA 2366216 C CA2366216 C CA 2366216C CA 2366216 A CA2366216 A CA 2366216A CA 2366216 A CA2366216 A CA 2366216A CA 2366216 C CA2366216 C CA 2366216C
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000001737 promoting effect Effects 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 238000005956 quaternization reaction Methods 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 210000001533 respiratory mucosa Anatomy 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000000527 sonication Methods 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
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- 239000007929 subcutaneous injection Substances 0.000 description 1
- 238000010254 subcutaneous injection Methods 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
- 238000012385 systemic delivery Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229960000814 tetanus toxoid Drugs 0.000 description 1
- 229960002766 tetanus vaccines Drugs 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 229940021747 therapeutic vaccine Drugs 0.000 description 1
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- 238000004448 titration Methods 0.000 description 1
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- 229940031572 toxoid vaccine Drugs 0.000 description 1
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- 239000003981 vehicle Substances 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55583—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Virology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9906694.6A GB9906694D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| GB9906696.1 | 1999-03-24 | ||
| GB9906694.6 | 1999-03-24 | ||
| GBGB9906696.1A GB9906696D0 (en) | 1999-03-24 | 1999-03-24 | Vaccine composition |
| PCT/GB2000/001118 WO2000056362A2 (en) | 1999-03-24 | 2000-03-23 | Polycationic carbohydrates as immunostimulants in vaccines |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2366216A1 CA2366216A1 (en) | 2000-09-28 |
| CA2366216C true CA2366216C (en) | 2012-10-23 |
Family
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2366216A Expired - Fee Related CA2366216C (en) | 1999-03-24 | 2000-03-23 | Polycationic carbohydrates as immunostimulants in vaccines |
| CA002366908A Abandoned CA2366908A1 (en) | 1999-03-24 | 2000-03-23 | Vaccine composition |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002366908A Abandoned CA2366908A1 (en) | 1999-03-24 | 2000-03-23 | Vaccine composition |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20080057083A1 (enExample) |
| EP (2) | EP1163001A2 (enExample) |
| JP (3) | JP5124066B2 (enExample) |
| AT (1) | ATE403436T1 (enExample) |
| AU (2) | AU762078B2 (enExample) |
| CA (2) | CA2366216C (enExample) |
| DE (1) | DE60039754D1 (enExample) |
| DK (1) | DK1163002T3 (enExample) |
| ES (1) | ES2311451T3 (enExample) |
| NZ (1) | NZ514323A (enExample) |
| WO (2) | WO2000056361A2 (enExample) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU780182B2 (en) * | 2000-03-22 | 2005-03-03 | Secretary Of State For Defence, The | Pharmaceutical composition for administration to mucosal surfaces |
| WO2001098206A1 (en) | 2000-06-22 | 2001-12-27 | Rxkinetix, Inc. | Delivery vehicle composition and methods for delivering antigens and other drugs |
| WO2002000173A2 (en) | 2000-06-26 | 2002-01-03 | Rxkinetix, Inc. | Methods for use of delivery composition for expanding, activating, committing or mobilizing one or more pluripotent, self-renewing and committed stem cells |
| AU2002354644C1 (en) * | 2001-07-10 | 2009-04-30 | Corixa Corporation | Compositions and methods for delivery of proteins and adjuvants encapsulated in microspheres |
| JP2005501845A (ja) | 2001-08-16 | 2005-01-20 | メディカル リサーチ カウンシル | キチン微小粒子およびそれらの医学的用途 |
| CA2383259A1 (en) | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| ATE345775T1 (de) * | 2001-10-03 | 2006-12-15 | Celator Pharmaceuticals Inc | Zusammensetzungen zur verabreichung von arzneimittelkombinationen |
| US7850990B2 (en) | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| GB0302218D0 (en) * | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
| ATE426412T1 (de) * | 2003-01-30 | 2009-04-15 | Novartis Vaccines & Diagnostic | Adjuvante influenza-vakzine |
| JP2006516609A (ja) * | 2003-01-30 | 2006-07-06 | カイロン ソチエタ ア レスポンサビリタ リミタータ | 粘膜髄膜炎菌性ワクチン |
| CA2528007C (en) | 2003-06-02 | 2012-03-27 | Chiron Corporation | Immunogenic compositions based on microparticles comprising adsorbed toxoid and a polysaccharide-containing antigen |
| JP4669665B2 (ja) * | 2004-04-12 | 2011-04-13 | 正彦 阿部 | 細胞毒性のないポリカチオン修飾リポソームおよびその製造方法 |
| GB0519871D0 (en) | 2005-09-30 | 2005-11-09 | Secr Defence | Immunogenic agents |
| CA2643322C (en) * | 2006-02-24 | 2015-07-21 | Novartis Ag | Microparticles containing biodegradable polymer and cationic polysaccharide for use in immunogenic compositions |
| JPWO2008041703A1 (ja) * | 2006-10-02 | 2010-02-04 | 国立大学法人大阪大学 | インフルエンザワクチン用アジュバントおよびインフルエンザワクチン |
| JP5297009B2 (ja) * | 2007-07-24 | 2013-09-25 | 大日精化工業株式会社 | 免疫アジュバント水溶液 |
| MY148321A (en) * | 2007-10-02 | 2013-03-29 | Malaysian Palm Oil Board Mpob | Vitamin e supplementation to tetanus toxoid |
| GB0721937D0 (en) | 2007-11-08 | 2007-12-19 | Secr Defence | Rodenticide |
| US20110280949A1 (en) * | 2008-08-06 | 2011-11-17 | Padma Malyala | Microparticles for use in immunogenic compositions |
| GB0900455D0 (en) | 2009-01-13 | 2009-02-11 | Secr Defence | Vaccine |
| KR101670340B1 (ko) * | 2011-05-18 | 2016-10-28 | 매트리백스 인코포레이티드 | 폴리양이온을 포함하는 단백질 매트릭스 백신 조성물 |
| US10500283B2 (en) | 2011-05-30 | 2019-12-10 | National Institute Of Immunology | Vaccine composition capable of inducing memory antibody response from single point immunization |
| CN107200788B (zh) * | 2017-05-11 | 2020-04-14 | 暨南大学 | 一种季鏻化壳聚糖及其作为疫苗免疫佐剂的应用 |
| CN107899021A (zh) * | 2017-11-06 | 2018-04-13 | 扬州大学 | 一种表面修饰s‑层蛋白的壳聚糖微球、制备及应用 |
| KR102384808B1 (ko) * | 2018-12-20 | 2022-04-08 | 주식회사 스킨메드 | 키토산으로 코팅된 나노 캡슐 및 이의 용도 |
| EP3960203A1 (en) | 2020-08-25 | 2022-03-02 | Université de Liège | Complexes for the delivery of proteinaceous agents |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3740421A (en) * | 1966-09-19 | 1973-06-19 | Basf Wyandotte Corp | Polyoxyethylene-polyoxypropylene aqueous gels |
| GB1290141A (enExample) * | 1968-05-31 | 1972-09-20 | ||
| FR2306684A1 (fr) * | 1975-04-11 | 1976-11-05 | Crinex Lab | Nouvelle composition a action immunostimulante |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| US6024983A (en) * | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| ES2052685T3 (es) * | 1987-03-17 | 1994-07-16 | Akzo Nv | Metodo para producir un adyuvante libre. |
| DE69015222T2 (de) * | 1989-02-04 | 1995-05-04 | Akzo Nv | Tocole als Impfstoffadjuvans. |
| US5562910A (en) * | 1989-09-25 | 1996-10-08 | University Of Utah Research Foundation | Vaccine compositions and method for enhancing an immune response |
| US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
| DE4004430A1 (de) * | 1990-02-09 | 1991-08-14 | Schering Ag | Aus polyaldehyden aufgebaute kontrastmittel |
| US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
| US5292513A (en) * | 1992-05-18 | 1994-03-08 | Anthony G. Gristina | Method for nonspecific cellular immune stimulation |
| CN1120310A (zh) * | 1993-03-11 | 1996-04-10 | 塞科雷泰克公司 | 在粘膜表面转运免疫原的聚合粘膜粘合剂 |
| US6913767B1 (en) * | 1993-10-25 | 2005-07-05 | Genentech, Inc. | Compositions for microencapsulation of antigens for use as vaccines |
| US5643605A (en) * | 1993-10-25 | 1997-07-01 | Genentech, Inc. | Methods and compositions for microencapsulation of adjuvants |
| US5902565A (en) * | 1993-12-24 | 1999-05-11 | Csl Limited | Spray dried vaccine preparation comprising aluminium adsorbed immunogens |
| GB9419979D0 (en) * | 1994-10-04 | 1994-11-16 | Medeva Holdings Bv | Vaccine compositions |
| EP0805678B1 (en) * | 1995-01-05 | 2003-10-29 | THE BOARD OF REGENTS acting for and on behalf of THE UNIVERSITY OF MICHIGAN | Surface-modified nanoparticles and method of making and using same |
| CA2215203C (en) * | 1995-03-13 | 2008-12-09 | The Secretary Of State For Defence In Her Britannic Majesty's Government Of The United Kingdom Of Great Britain And Northern Ireland | Vaccines for plague |
| US6428771B1 (en) * | 1995-05-15 | 2002-08-06 | Pharmaceutical Discovery Corporation | Method for drug delivery to the pulmonary system |
| GB9525083D0 (en) * | 1995-12-07 | 1996-02-07 | Danbiosyst Uk | Vaccine compositions |
| DE19603649A1 (de) * | 1996-02-01 | 1997-08-07 | Werner Lubitz | Rekombinante Expression von S-Layer-Proteinen |
| US6309623B1 (en) * | 1997-09-29 | 2001-10-30 | Inhale Therapeutic Systems, Inc. | Stabilized preparations for use in metered dose inhalers |
| GB9810126D0 (enExample) * | 1998-05-13 | 1998-07-08 | Glaxo Group Ltd | |
| HU230454B1 (hu) * | 1998-11-02 | 2016-07-28 | Alkermes Pharma Ireland Limited | Metilfenidátot tartalmazó módosított felszabadulású sokszemcsés készítmény |
| US20030171258A1 (en) * | 1999-03-24 | 2003-09-11 | Alpar Hazire Oya | Particle based vaccine composition |
| US20020103165A1 (en) * | 2000-02-29 | 2002-08-01 | Alliance Pharmaceutical Corp., | Engineered spray-dried lipid-based microparticles for cellular targeting |
| AU780182B2 (en) * | 2000-03-22 | 2005-03-03 | Secretary Of State For Defence, The | Pharmaceutical composition for administration to mucosal surfaces |
| GB0300885D0 (en) * | 2003-01-15 | 2003-02-12 | Secr Defence | Pharmaceutical composition |
-
2000
- 2000-03-23 EP EP00912777A patent/EP1163001A2/en not_active Withdrawn
- 2000-03-23 AU AU34424/00A patent/AU762078B2/en not_active Ceased
- 2000-03-23 CA CA2366216A patent/CA2366216C/en not_active Expired - Fee Related
- 2000-03-23 DE DE60039754T patent/DE60039754D1/de not_active Expired - Lifetime
- 2000-03-23 WO PCT/GB2000/001104 patent/WO2000056361A2/en not_active Ceased
- 2000-03-23 ES ES00912788T patent/ES2311451T3/es not_active Expired - Lifetime
- 2000-03-23 AT AT00912788T patent/ATE403436T1/de active
- 2000-03-23 AU AU34435/00A patent/AU755502C/en not_active Ceased
- 2000-03-23 WO PCT/GB2000/001118 patent/WO2000056362A2/en not_active Ceased
- 2000-03-23 EP EP00912788A patent/EP1163002B1/en not_active Expired - Lifetime
- 2000-03-23 NZ NZ514323A patent/NZ514323A/xx unknown
- 2000-03-23 JP JP2000606266A patent/JP5124066B2/ja not_active Expired - Fee Related
- 2000-03-23 JP JP2000606265A patent/JP2002540076A/ja not_active Withdrawn
- 2000-03-23 CA CA002366908A patent/CA2366908A1/en not_active Abandoned
- 2000-03-23 DK DK00912788T patent/DK1163002T3/da active
-
2007
- 2007-10-29 US US11/926,468 patent/US20080057083A1/en not_active Abandoned
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2011
- 2011-09-20 JP JP2011204971A patent/JP2012031186A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU755502B2 (en) | 2002-12-12 |
| ATE403436T1 (de) | 2008-08-15 |
| AU762078B2 (en) | 2003-06-19 |
| JP2012031186A (ja) | 2012-02-16 |
| CA2366216A1 (en) | 2000-09-28 |
| JP5124066B2 (ja) | 2013-01-23 |
| WO2000056361A2 (en) | 2000-09-28 |
| WO2000056361A3 (en) | 2001-03-01 |
| EP1163001A2 (en) | 2001-12-19 |
| WO2000056362A2 (en) | 2000-09-28 |
| DK1163002T3 (da) | 2009-01-19 |
| AU755502C (en) | 2003-08-14 |
| EP1163002B1 (en) | 2008-08-06 |
| NZ514323A (en) | 2003-03-28 |
| WO2000056362A3 (en) | 2001-02-01 |
| JP2002540076A (ja) | 2002-11-26 |
| EP1163002A2 (en) | 2001-12-19 |
| US20080057083A1 (en) | 2008-03-06 |
| DE60039754D1 (de) | 2008-09-18 |
| ES2311451T3 (es) | 2009-02-16 |
| CA2366908A1 (en) | 2000-09-28 |
| AU3443500A (en) | 2000-10-09 |
| AU3442400A (en) | 2000-10-09 |
| JP2002540077A (ja) | 2002-11-26 |
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