JP5111729B2 - 肝成長及び肝保護のための組成物と方法 - Google Patents

肝成長及び肝保護のための組成物と方法 Download PDF

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JP5111729B2
JP5111729B2 JP2004510702A JP2004510702A JP5111729B2 JP 5111729 B2 JP5111729 B2 JP 5111729B2 JP 2004510702 A JP2004510702 A JP 2004510702A JP 2004510702 A JP2004510702 A JP 2004510702A JP 5111729 B2 JP5111729 B2 JP 5111729B2
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liver
vegf
flt
agent
kdr
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JP2005534648A (ja
JP2005534648A5 (https=
Inventor
ナポレオン フェララ，
ケニス， ジェイ． ヒラン，
クーテー， ジェニファー ル
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ジェネンテック， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2004510702A 2002-06-05 2003-06-05 肝成長及び肝保護のための組成物と方法 Expired - Fee Related JP5111729B2 (ja)

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US38663702P 2002-06-05 2002-06-05
US60/386,637 2002-06-05
PCT/US2003/017591 WO2003103581A2 (en) 2002-06-05 2003-06-05 Compositions and methods for liver growth and liver protection

Related Child Applications (1)

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JP2010038622A Division JP2010159266A (ja) 2002-06-05 2010-02-24 肝成長及び肝保護のための組成物と方法

Publications (3)

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JP2005534648A JP2005534648A (ja) 2005-11-17
JP2005534648A5 JP2005534648A5 (https=) 2006-07-20
JP5111729B2 true JP5111729B2 (ja) 2013-01-09

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JP2004510702A Expired - Fee Related JP5111729B2 (ja) 2002-06-05 2003-06-05 肝成長及び肝保護のための組成物と方法
JP2010038622A Withdrawn JP2010159266A (ja) 2002-06-05 2010-02-24 肝成長及び肝保護のための組成物と方法

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US (2) US7700571B2 (https=)
EP (2) EP1531676B1 (https=)
JP (2) JP5111729B2 (https=)
AU (1) AU2003251397B2 (https=)
CA (1) CA2486270C (https=)
IL (2) IL165392A0 (https=)
WO (1) WO2003103581A2 (https=)

Cited By (1)

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WO2025047927A1 (ja) 2023-08-31 2025-03-06 ペプチドリーム株式会社 Ｖｅｇｆｒ－２アゴニスト活性を有するペプチド複合体

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US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
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US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
KR102461927B1 (ko) * 2016-02-17 2022-10-31 차의과학대학교 산학협력단 이식용 줄기세포 및 이를 포함하는 혈관신생의 유도 또는 촉진을 위한 이식용 약학 조성물
CN114224893B (zh) * 2022-01-25 2023-06-06 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 喹唑啉衍生物在制备防治砷致肝损伤药物中的用途
CN116869986B (zh) * 2023-07-13 2025-12-02 南方医科大学 β-羟基丁酸在制备促进肝细胞增殖和肝脏再生产品方面的应用

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US7709455B2 (en) 2010-05-04
US20070122394A1 (en) 2007-05-31
CA2486270C (en) 2015-07-28
IL165392A0 (en) 2006-01-15
HK1076227A1 (en) 2006-01-13
EP1531676A4 (en) 2009-06-17
IL165392A (en) 2015-11-30
AU2003251397B2 (en) 2009-10-01
JP2010159266A (ja) 2010-07-22
AU2003251397A1 (en) 2003-12-22
US7700571B2 (en) 2010-04-20
US20040170613A1 (en) 2004-09-02
WO2003103581A3 (en) 2004-04-15
CA2486270A1 (en) 2003-12-18
EP1531676A2 (en) 2005-05-25
EP1531676B1 (en) 2015-07-22
JP2005534648A (ja) 2005-11-17
EP2430923A1 (en) 2012-03-21
WO2003103581A2 (en) 2003-12-18

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