CA2486270C - Vegfr modulating agents and methods for liver growth and liver protection - Google Patents

Vegfr modulating agents and methods for liver growth and liver protection Download PDF

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Publication number
CA2486270C
CA2486270C CA2486270A CA2486270A CA2486270C CA 2486270 C CA2486270 C CA 2486270C CA 2486270 A CA2486270 A CA 2486270A CA 2486270 A CA2486270 A CA 2486270A CA 2486270 C CA2486270 C CA 2486270C
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CA
Canada
Prior art keywords
flt
agonist
vegf
liver
amino acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA2486270A
Other languages
English (en)
French (fr)
Other versions
CA2486270A1 (en
Inventor
Napoleone Ferrara
Kenneth J. Hillan
Jennifer Le Couter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genentech Inc
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of CA2486270A1 publication Critical patent/CA2486270A1/en
Application granted granted Critical
Publication of CA2486270C publication Critical patent/CA2486270C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1858—Platelet-derived growth factor [PDGF]
    • A61K38/1866—Vascular endothelial growth factor [VEGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
    • C12N2799/022—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from an adenovirus

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Vascular Medicine (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CA2486270A 2002-06-05 2003-06-05 Vegfr modulating agents and methods for liver growth and liver protection Expired - Fee Related CA2486270C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US38663702P 2002-06-05 2002-06-05
US60/386,637 2002-06-05
PCT/US2003/017591 WO2003103581A2 (en) 2002-06-05 2003-06-05 Compositions and methods for liver growth and liver protection

Publications (2)

Publication Number Publication Date
CA2486270A1 CA2486270A1 (en) 2003-12-18
CA2486270C true CA2486270C (en) 2015-07-28

Family

ID=29736189

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2486270A Expired - Fee Related CA2486270C (en) 2002-06-05 2003-06-05 Vegfr modulating agents and methods for liver growth and liver protection

Country Status (7)

Country Link
US (2) US7700571B2 (https=)
EP (2) EP1531676B1 (https=)
JP (2) JP5111729B2 (https=)
AU (1) AU2003251397B2 (https=)
CA (1) CA2486270C (https=)
IL (2) IL165392A0 (https=)
WO (1) WO2003103581A2 (https=)

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US8263739B2 (en) 2000-06-02 2012-09-11 Bracco Suisse Sa Compounds for targeting endothelial cells, compositions containing the same and methods for their use
US20050123925A1 (en) 2002-11-15 2005-06-09 Genentech, Inc. Compositions and methods for the diagnosis and treatment of tumor
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
AU2003278807A1 (en) 2002-03-01 2004-08-13 Bracco International B.V. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
IL165392A0 (en) * 2002-06-05 2006-01-15 Genentech Inc Compositions and methods for liver growth and liver protection
CA2553303C (en) * 2004-01-14 2014-06-10 Novahep Ab Human hepatic progenitor cells and methods of use thereof
US8070703B2 (en) * 2004-03-10 2011-12-06 Vision Quest Industries Incorporated Electrically stimulating orthotic device and segmented liner
LT1781698T (lt) 2004-07-20 2016-09-26 Genentech, Inc. Į angiopoetiną panašaus baltymo 4 kompozicijos ir panaudojimo būdai
MX2007011735A (es) 2005-03-24 2008-03-14 Thrombogenics Nv Anticuerpo anti-plgf novedoso.
JP2008537551A (ja) 2005-03-31 2008-09-18 カランド ファーマシューティカルズ， インコーポレイテッド リボヌクレオチドレダクターゼサブユニット２の阻害剤およびその使用
EP1904095B1 (en) 2005-06-30 2013-05-29 VIB, vzw Treatment of liver cirrhosis and its complications
BRPI0621124A2 (pt) 2005-12-22 2011-11-29 Genentech Inc métodos para recuperação de uma proteìna de ligação à heparina
BRPI0709411A2 (pt) * 2006-03-27 2011-07-12 Genentech Inc método para tratamento de uma doença renal
US8685730B2 (en) * 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
CN101250498B (zh) * 2008-04-07 2010-06-09 南通大学附属医院 用载肝细胞生长因子聚乳酸-o-羧甲基壳聚糖纳米粒子的肝细胞培养方法
CN102239178B (zh) 2008-10-02 2017-06-23 Vib研究所 抑制PlGF以治疗费城染色体阳性白血病
CA2816593C (en) * 2010-11-09 2021-05-25 Shahin Rafii Methods for organ regeneration
PL2508207T3 (pl) * 2011-03-31 2013-09-30 Bioalliance Pharma Nanocząsteczki zawierające chemioterapeutyczny lek przeciwnowotworowy
WO2013033513A1 (en) 2011-08-31 2013-03-07 University Of Georgia Research Foundation, Inc. Apoptosis-targeting nanoparticles
AU2012321082B2 (en) 2011-12-01 2015-03-12 Oxurion NV Improving trabeculectomy outcome
JP6356614B2 (ja) 2012-02-17 2018-07-11 ユニバーシティ・オブ・ジョージア・リサーチ・ファウンデイション・インコーポレイテッド 薬剤のミトコンドリア輸送のためのナノ粒子
US10398663B2 (en) 2014-03-14 2019-09-03 University Of Georgia Research Foundation, Inc. Mitochondrial delivery of 3-bromopyruvate
KR102461927B1 (ko) * 2016-02-17 2022-10-31 차의과학대학교 산학협력단 이식용 줄기세포 및 이를 포함하는 혈관신생의 유도 또는 촉진을 위한 이식용 약학 조성물
CN114224893B (zh) * 2022-01-25 2023-06-06 贵州省中国科学院天然产物化学重点实验室(贵州医科大学天然产物化学重点实验室) 喹唑啉衍生物在制备防治砷致肝损伤药物中的用途
CN116869986B (zh) * 2023-07-13 2025-12-02 南方医科大学 β-羟基丁酸在制备促进肝细胞增殖和肝脏再生产品方面的应用
TWI909652B (zh) 2023-08-31 2025-12-21 日商肽夢想股份有限公司 具有ｖｅｇｆｒ－２促效劑活性的肽複合物

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ATE420177T1 (de) 1999-04-16 2009-01-15 Genentech Inc Vaskuläre endothelzellen wachstumsfaktor (vegf) varianten und dessen verwendungen
AU5023300A (en) 1999-05-20 2000-12-12 Scios Inc. Vascular endothelial growth factor variants
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Also Published As

Publication number Publication date
US7709455B2 (en) 2010-05-04
US20070122394A1 (en) 2007-05-31
IL165392A0 (en) 2006-01-15
HK1076227A1 (en) 2006-01-13
EP1531676A4 (en) 2009-06-17
JP5111729B2 (ja) 2013-01-09
IL165392A (en) 2015-11-30
AU2003251397B2 (en) 2009-10-01
JP2010159266A (ja) 2010-07-22
AU2003251397A1 (en) 2003-12-22
US7700571B2 (en) 2010-04-20
US20040170613A1 (en) 2004-09-02
WO2003103581A3 (en) 2004-04-15
CA2486270A1 (en) 2003-12-18
EP1531676A2 (en) 2005-05-25
EP1531676B1 (en) 2015-07-22
JP2005534648A (ja) 2005-11-17
EP2430923A1 (en) 2012-03-21
WO2003103581A2 (en) 2003-12-18

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Effective date: 20200831