JP5099571B2 - miRNA導入による新規hiPSC作製法 - Google Patents

miRNA導入による新規hiPSC作製法 Download PDF

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JP5099571B2
JP5099571B2 JP2011530189A JP2011530189A JP5099571B2 JP 5099571 B2 JP5099571 B2 JP 5099571B2 JP 2011530189 A JP2011530189 A JP 2011530189A JP 2011530189 A JP2011530189 A JP 2011530189A JP 5099571 B2 JP5099571 B2 JP 5099571B2
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pluripotent stem
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stem cell
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JPWO2012008302A1 (ja
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典正 三浦
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Tottori University NUC
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    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/65MicroRNA

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JP2011530189A 2010-07-12 2011-06-28 miRNA導入による新規hiPSC作製法 Expired - Fee Related JP5099571B2 (ja)

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JP2011530189A JP5099571B2 (ja) 2010-07-12 2011-06-28 miRNA導入による新規hiPSC作製法

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JP2010158192 2010-07-12
JP2010158193 2010-07-12
JP2010158193 2010-07-12
JP2010158194 2010-07-12
JP2010158194 2010-07-12
JP2010158192 2010-07-12
PCT/JP2011/064847 WO2012008302A1 (ja) 2010-07-12 2011-06-28 miRNA導入による新規hiPSC作製法
JP2011530189A JP5099571B2 (ja) 2010-07-12 2011-06-28 miRNA導入による新規hiPSC作製法

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JP2011530189A Expired - Fee Related JP5099571B2 (ja) 2010-07-12 2011-06-28 miRNA導入による新規hiPSC作製法
JP2011530188A Expired - Fee Related JP5099570B2 (ja) 2010-07-12 2011-06-28 siRNA導入による新規hiPSC作製法
JP2012202508A Pending JP2013046616A (ja) 2010-07-12 2012-09-14 siRNA導入による新規hiPSC作製法
JP2012202509A Pending JP2013034479A (ja) 2010-07-12 2012-09-14 miRNA導入による新規hiPSC作製法
JP2013264240A Expired - Fee Related JP5845493B2 (ja) 2010-07-12 2013-12-20 miRNA導入による新規hiPSC作製法

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JP2011530188A Expired - Fee Related JP5099570B2 (ja) 2010-07-12 2011-06-28 siRNA導入による新規hiPSC作製法
JP2012202508A Pending JP2013046616A (ja) 2010-07-12 2012-09-14 siRNA導入による新規hiPSC作製法
JP2012202509A Pending JP2013034479A (ja) 2010-07-12 2012-09-14 miRNA導入による新規hiPSC作製法
JP2013264240A Expired - Fee Related JP5845493B2 (ja) 2010-07-12 2013-12-20 miRNA導入による新規hiPSC作製法

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US (2) US9476041B2 (https=)
EP (2) EP2594643B1 (https=)
JP (5) JP5099571B2 (https=)
CN (2) CN103189511B (https=)
WO (2) WO2012008301A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017073689A1 (ja) * 2015-10-30 2017-05-04 国立大学法人鳥取大学 Dna損傷を修復するrna分子

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103189511B (zh) 2010-07-12 2016-10-12 国立大学法人鸟取大学 利用siRNA导入的新型hiPSC制作法
EP2686418A4 (en) 2011-03-17 2015-04-22 Minerva Biotechnologies Corp METHOD FOR THE PRODUCTION OF PLURIPOTENTAL STEM CELLS
EP2768945B1 (en) 2011-10-17 2022-01-05 Minerva Biotechnologies Corporation Media for stem cell proliferation and induction
EP2844744A2 (en) * 2012-02-22 2015-03-11 Brainstem Biotec Ltd. MicroRNAS FOR THE GENERATION OF ASTROCYTES
JP6748430B2 (ja) * 2012-07-13 2020-09-02 ミネルバ バイオテクノロジーズ コーポレーション より未分化状態への細胞の誘導方法
JPWO2015030149A1 (ja) * 2013-08-29 2017-03-02 国立大学法人鳥取大学 細胞のアンチエイジングに関連する生体分子群
TW201610152A (zh) * 2013-11-22 2016-03-16 國立臺灣大學 微rna146-a及其於診斷、治療及預防小核醣核酸病毒感染之用途及微rna146-a拮抗劑
CN104109670B (zh) * 2014-03-12 2018-01-05 首都医科大学附属北京安定医院 一种双链siRNA分子及其应用
AU2015278699B2 (en) 2014-06-27 2019-10-31 Rhizen Pharmaceuticals Sa Substituted chromene derivatives as selective dual inhibitors of PI3 delta and gamma protein kinases
US10806748B2 (en) 2015-04-24 2020-10-20 The Johns Hopkins University Compositions and methods related to characterizing proviral reservoirs
KR102011336B1 (ko) * 2015-12-31 2019-08-16 인터올리고 주식회사 약물 전달 및 안정화를 위한 복합체 및 그 제조방법
WO2018203553A1 (ja) * 2017-05-02 2018-11-08 株式会社ペジィー・ファーマ 分化細胞の品質改善方法
WO2023128862A1 (en) * 2021-12-29 2023-07-06 Livius Pte. Ltd. Method for repairing hair cycle-related genes and method for treating hair cycle-related diseases using mir-520d-5p
JP2023149907A (ja) * 2022-03-31 2023-10-16 株式会社島津製作所 微生物情報の提供方法および微生物検査システム

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006137514A1 (ja) * 2005-06-23 2006-12-28 Locomogene, Inc. シノビオリンの発現もしくは機能阻害物質を有効成分とする癌治療剤、および癌治療剤のスクリーニング方法
JP2008519606A (ja) * 2004-11-12 2008-06-12 アンビオン インコーポレーティッド miRNAおよびmiRNA阻害分子に関する方法および組成物
JP2008545406A (ja) * 2005-05-27 2008-12-18 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター
WO2009058907A2 (en) * 2007-10-29 2009-05-07 Isis Pharmaceuticals, Inc. Targeting micrornas for the treatment of liver cancer
WO2009058413A1 (en) * 2007-10-29 2009-05-07 Shi-Lung Lin Generation of human embryonic stem-like cells using intronic rna
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
WO2009091659A2 (en) * 2008-01-16 2009-07-23 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents
JP2009531019A (ja) * 2006-01-05 2009-09-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
WO2010058819A1 (ja) * 2008-11-19 2010-05-27 学校法人 慶應義塾 ヒト癌タンパク質MDM2とヒト癌抑制タンパク質p53との相互作用阻害ペプチド及びその使用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2467258A1 (en) * 2001-11-15 2003-05-22 Kyowa Hakko Kogyo Co., Ltd. Agent for inducing embryonic stem cell to ectodermal cell, method for obtaining the same and use of the same.
AU2003270734A1 (en) 2002-09-16 2004-04-30 University Of Southern California Rna-mediated gene modulation
JP2006519008A (ja) 2003-02-10 2006-08-24 独立行政法人産業技術総合研究所 哺乳動物細胞の調節
MX2007009417A (es) 2005-02-04 2007-08-17 Univ Auburn Sistema de suministro de farmaco de contacto.
WO2006112239A1 (ja) 2005-04-15 2006-10-26 National University Corporation Tottori University hTERT発現調節遺伝子
BRPI0619794B8 (pt) 2005-12-13 2022-06-14 Univ Kyoto Uso de um fator de reprogramação, agente para a preparação de uma célula-tronco pluripotente induzida a partir de uma célula somática e métodos para preparar uma célula- tronco pluripotente induzida método e para preparar uma célula somática e uso de células-tronco pluripotentes induzidas
CA2648132C (en) 2006-04-03 2019-05-28 Santaris Pharma A/S Pharmaceutical composition comprising anti-mirna antisense oligonucleotides
JP5558097B2 (ja) 2007-12-10 2014-07-23 国立大学法人京都大学 効率的な核初期化方法
WO2009082817A1 (en) * 2007-12-27 2009-07-09 Protiva Biotherapeutics, Inc. Silencing of polo-like kinase expression using interfering rna
CN101333524B (zh) * 2008-06-25 2010-06-02 中山大学 一个小分子非编码RNA基因hsa-miR-101及其抗肿瘤用途
CN101392251B (zh) * 2008-11-03 2015-07-22 清华大学深圳研究生院 能诱导干细胞向成骨细胞分化的微小rna及其应用
CN103189511B (zh) 2010-07-12 2016-10-12 国立大学法人鸟取大学 利用siRNA导入的新型hiPSC制作法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008519606A (ja) * 2004-11-12 2008-06-12 アンビオン インコーポレーティッド miRNAおよびmiRNA阻害分子に関する方法および組成物
JP2008545406A (ja) * 2005-05-27 2008-12-18 フォンダツィオーネ セントロ サン ラファエレ デル モンテ タボール 遺伝子ベクター
WO2006137514A1 (ja) * 2005-06-23 2006-12-28 Locomogene, Inc. シノビオリンの発現もしくは機能阻害物質を有効成分とする癌治療剤、および癌治療剤のスクリーニング方法
JP2009531019A (ja) * 2006-01-05 2009-09-03 ジ・オハイオ・ステイト・ユニバーシティ・リサーチ・ファウンデイション 固形癌の診断及び治療のためのマイクロrnaに基づく方法及び組成物
WO2009058907A2 (en) * 2007-10-29 2009-05-07 Isis Pharmaceuticals, Inc. Targeting micrornas for the treatment of liver cancer
WO2009058413A1 (en) * 2007-10-29 2009-05-07 Shi-Lung Lin Generation of human embryonic stem-like cells using intronic rna
WO2009057831A1 (ja) * 2007-10-31 2009-05-07 Kyoto University 核初期化方法
WO2009091659A2 (en) * 2008-01-16 2009-07-23 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents
WO2010058819A1 (ja) * 2008-11-19 2010-05-27 学校法人 慶應義塾 ヒト癌タンパク質MDM2とヒト癌抑制タンパク質p53との相互作用阻害ペプチド及びその使用

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN6011055351; 臨床薬理 Vol.40, No.Supplement, 20091118, p.S190 *
JPN6011055356; Cell Vol.131, No.5, 2007, p.861-872 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017073689A1 (ja) * 2015-10-30 2017-05-04 国立大学法人鳥取大学 Dna損傷を修復するrna分子

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EP2594643A1 (en) 2013-05-22
US9790491B2 (en) 2017-10-17
US20130190389A1 (en) 2013-07-25
JP2013046616A (ja) 2013-03-07
JPWO2012008301A1 (ja) 2013-09-09
EP2594643B1 (en) 2017-04-12
JPWO2012008302A1 (ja) 2013-09-09
EP2594644A1 (en) 2013-05-22
CN103097535A (zh) 2013-05-08
WO2012008301A1 (ja) 2012-01-19
CN103189511A (zh) 2013-07-03
JP2013034479A (ja) 2013-02-21
JP5099570B2 (ja) 2012-12-19
US20130184335A1 (en) 2013-07-18
CN103189511B (zh) 2016-10-12
EP2594644A4 (en) 2014-12-24
US9476041B2 (en) 2016-10-25
JP2014097059A (ja) 2014-05-29
JP5845493B2 (ja) 2016-01-20
EP2594643A4 (en) 2014-12-24
EP2594644B1 (en) 2016-08-10
WO2012008302A1 (ja) 2012-01-19

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