JP5080453B2 - 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 - Google Patents

非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 Download PDF

Info

Publication number
JP5080453B2
JP5080453B2 JP2008512759A JP2008512759A JP5080453B2 JP 5080453 B2 JP5080453 B2 JP 5080453B2 JP 2008512759 A JP2008512759 A JP 2008512759A JP 2008512759 A JP2008512759 A JP 2008512759A JP 5080453 B2 JP5080453 B2 JP 5080453B2
Authority
JP
Japan
Prior art keywords
core
polymer
bas
release
microcapsules
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008512759A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008542220A5 (https=
JP2008542220A (ja
Inventor
グスタフション，ニルス・オーベ
ヨンション，モニカ
ラークソ，ティモ
Original Assignee
ストラトスフィア・ファーマ・アクチボラグ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ストラトスフィア・ファーマ・アクチボラグ filed Critical ストラトスフィア・ファーマ・アクチボラグ
Publication of JP2008542220A publication Critical patent/JP2008542220A/ja
Publication of JP2008542220A5 publication Critical patent/JP2008542220A5/ja
Application granted granted Critical
Publication of JP5080453B2 publication Critical patent/JP5080453B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1658—Proteins, e.g. albumin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2008512759A 2005-05-27 2006-05-24 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法 Expired - Fee Related JP5080453B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP05011516.1 2005-05-27
EP05011516 2005-05-27
EP05028165A EP1726299A3 (en) 2005-05-27 2005-12-22 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
EP05028165.8 2005-12-22
PCT/EP2006/004940 WO2006125620A2 (en) 2005-05-27 2006-05-24 Cores and microcapsules suitable for parenteral administration as well as process for their manufacture

Publications (3)

Publication Number Publication Date
JP2008542220A JP2008542220A (ja) 2008-11-27
JP2008542220A5 JP2008542220A5 (https=) 2009-07-02
JP5080453B2 true JP5080453B2 (ja) 2012-11-21

Family

ID=36935013

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008512759A Expired - Fee Related JP5080453B2 (ja) 2005-05-27 2006-05-24 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法

Country Status (7)

Country Link
EP (2) EP1726299A3 (https=)
JP (1) JP5080453B2 (https=)
AT (1) ATE424190T1 (https=)
CA (1) CA2609891A1 (https=)
DE (1) DE602006005491D1 (https=)
DK (1) DK1906928T3 (https=)
WO (1) WO2006125620A2 (https=)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2861734B1 (fr) 2003-04-10 2006-04-14 Corneal Ind Reticulation de polysaccharides de faible et forte masse moleculaire; preparation d'hydrogels monophasiques injectables; polysaccharides et hydrogels obtenus
GB0707612D0 (en) 2007-04-19 2007-05-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
CA2687983A1 (en) 2007-05-23 2008-12-04 Allergan, Inc. Coated hyaluronic acid particles
WO2008147867A2 (en) 2007-05-23 2008-12-04 Allergan, Inc. Cross-linked collagen and uses thereof
US8318695B2 (en) 2007-07-30 2012-11-27 Allergan, Inc. Tunably crosslinked polysaccharide compositions
US8697044B2 (en) 2007-10-09 2014-04-15 Allergan, Inc. Crossed-linked hyaluronic acid and collagen and uses thereof
US8114898B2 (en) 2007-11-16 2012-02-14 Allergan, Inc. Compositions and methods for treating purpura
US8394784B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having multi-stage bioactive agent delivery
US8394782B2 (en) 2007-11-30 2013-03-12 Allergan, Inc. Polysaccharide gel formulation having increased longevity
US8357795B2 (en) 2008-08-04 2013-01-22 Allergan, Inc. Hyaluronic acid-based gels including lidocaine
AU2009288118B2 (en) 2008-09-02 2014-12-11 Allergan, Inc. Threads of hyaluronic acid and/or derivatives thereof, methods of making thereof and uses thereof
US9114188B2 (en) 2010-01-13 2015-08-25 Allergan, Industrie, S.A.S. Stable hydrogel compositions including additives
US20110172180A1 (en) 2010-01-13 2011-07-14 Allergan Industrie. Sas Heat stable hyaluronic acid compositions for dermatological use
CN102905677A (zh) 2010-03-12 2013-01-30 阿勒根工业有限公司 用于改善皮肤状况的包含透明质烷聚合物和甘露糖醇的流体组合物
ES2585388T5 (es) 2010-03-22 2019-08-08 Allergan Inc Hidrogeles reticulados de polisacárido y proteína-polisacárido para aumento de tejido blando
US8697057B2 (en) 2010-08-19 2014-04-15 Allergan, Inc. Compositions and soft tissue replacement methods
US8889123B2 (en) 2010-08-19 2014-11-18 Allergan, Inc. Compositions and soft tissue replacement methods
US9005605B2 (en) 2010-08-19 2015-04-14 Allergan, Inc. Compositions and soft tissue replacement methods
US8883139B2 (en) 2010-08-19 2014-11-11 Allergan Inc. Compositions and soft tissue replacement methods
US9393263B2 (en) 2011-06-03 2016-07-19 Allergan, Inc. Dermal filler compositions including antioxidants
US9408797B2 (en) 2011-06-03 2016-08-09 Allergan, Inc. Dermal filler compositions for fine line treatment
KR102312056B1 (ko) 2011-06-03 2021-10-12 알러간 인더스트리 에스에이에스 항산화제를 포함하는 피부 충전제 조성물
US20130096081A1 (en) 2011-06-03 2013-04-18 Allergan, Inc. Dermal filler compositions
US9662422B2 (en) 2011-09-06 2017-05-30 Allergan, Inc. Crosslinked hyaluronic acid-collagen gels for improving tissue graft viability and soft tissue augmentation
US20130244943A1 (en) 2011-09-06 2013-09-19 Allergan, Inc. Hyaluronic acid-collagen matrices for dermal filling and volumizing applications
WO2016051219A1 (en) 2014-09-30 2016-04-07 Allergan Industrie, Sas Stable hydrogel compositions including additives
WO2016128783A1 (en) 2015-02-09 2016-08-18 Allergan Industrie Sas Compositions and methods for improving skin appearance
PL3256179T3 (pl) 2015-02-13 2020-05-18 Allergan Industrie, Sas Implanty do kształtowania, uwydatniania lub korygowania cech twarzy takich jak broda
WO2025137151A2 (en) 2023-12-18 2025-06-26 The Johns Hopkins University Dendrimer compositions for the treatment of atherosclerosis, obesity, and metabolic syndromes
CN118146569B (zh) * 2024-01-24 2024-11-22 中国海洋大学 透明质酸-青蒿琥酯-聚精氨酸纳米粒、制备方法及应用
WO2025265116A1 (en) 2024-06-21 2025-12-26 Georgia State University Research Foundation, Inc. Nanobodies to henipavirus and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60100516A (ja) * 1983-11-04 1985-06-04 Takeda Chem Ind Ltd 徐放型マイクロカプセルの製造法
EP0576675A4 (en) * 1991-03-25 1994-06-01 Fujisawa Pharmaceutical Co Long-acting pharmaceutical preparation
DE4201179A1 (de) * 1992-01-17 1993-07-22 Alfatec Pharma Gmbh Wirkstoff(e) enthaltendes granulat oder pellet mit einem geruest aus hydrophilen makromolekuelen und verfahren zu seiner herstellung
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
SE505146C2 (sv) 1995-10-19 1997-06-30 Biogram Ab Partiklar för fördröjd frisättning
CA2296620A1 (en) * 1997-07-18 1999-01-28 Kris P. Antonsen Methods of removing residual solvent from nasal drug delivery compositions
SE9903236D0 (sv) 1999-09-10 1999-09-10 Astra Ab Method to obtain microparticles
RU2002112751A (ru) * 1999-11-12 2004-02-27 Файброджен, Инк. (Us) Рекомбинантные желатины
AU9445801A (en) 2000-10-06 2002-04-15 Bioglan Ab Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
CA2424888A1 (en) 2000-10-06 2002-04-11 Jagotec Ag Pharmaceutically acceptable starch
CA2424896A1 (en) * 2000-10-06 2002-04-11 Jagotec Ag A controlled-release, parenterally administrable microparticle preparation

Also Published As

Publication number Publication date
DK1906928T3 (da) 2009-04-20
EP1906928A2 (en) 2008-04-09
DE602006005491D1 (de) 2009-04-16
EP1906928B1 (en) 2009-03-04
EP1726299A3 (en) 2007-04-18
WO2006125620A2 (en) 2006-11-30
EP1726299A2 (en) 2006-11-29
CA2609891A1 (en) 2006-11-30
ATE424190T1 (de) 2009-03-15
WO2006125620A3 (en) 2007-08-02
JP2008542220A (ja) 2008-11-27

Similar Documents

Publication Publication Date Title
JP5080453B2 (ja) 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法
US6706288B2 (en) Microparticles
AU2001294458B2 (en) Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
JP2000501380A (ja) 持続放出性粒子
CA2400186A1 (en) Microencapsulation and sustained release of biologically active agent
EP1187602A1 (en) Injectable sustained release pharmaceutical composition and processes for preparing the same
JP2004510730A (ja) 非経口的投与可能な制御放出微粒子調製物
AU2001294458A1 (en) Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
US7105181B2 (en) Microparticles
US6936278B2 (en) Microparticles
KR20140097541A (ko) 폴리머 약물-전달 물질, 이의 제조 방법 및 약물-전달 조성물을 전달하는 방법
US8017152B2 (en) Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
JP2010524900A (ja) 非経口投与に適したコアとマイクロカプセル並びにそれらの製造方法
SE518008C2 (sv) Parenteralt administrerbara mikropartiklar och förfarande för framställning av desamma
CA2429100A1 (en) Parenterally administrable microparticles
KR100908517B1 (ko) 호흡기계 약제 전달을 위한 서방형 다공성 미세입자 및 그제조 방법
HK1061981B (en) Biodegradable microparticles for controlled release administration, with purified amylopectin-based starch of reduced molecular weight
EP1333815A1 (en) Process for producing microparticles

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090518

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090518

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20110913

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20120322

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20120322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120622

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120801

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120830

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150907

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

LAPS Cancellation because of no payment of annual fees