JP5059786B2 - 単針生体内エレクトロポレーションのための装置および方法 - Google Patents

単針生体内エレクトロポレーションのための装置および方法 Download PDF

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Publication number
JP5059786B2
JP5059786B2 JP2008554405A JP2008554405A JP5059786B2 JP 5059786 B2 JP5059786 B2 JP 5059786B2 JP 2008554405 A JP2008554405 A JP 2008554405A JP 2008554405 A JP2008554405 A JP 2008554405A JP 5059786 B2 JP5059786 B2 JP 5059786B2
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needle
electrode
tissue
gauge
electroporation
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Japanese (ja)
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JP2009525829A5 (enExample
JP2009525829A (ja
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クイェケン，ルネ
マティエセン，イアコブ
エリザベート ティエーレ，トルン
マッキュー，ジョージ
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ジェネトロニクス，インコーポレイティド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biophysics (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)
  • Electrotherapy Devices (AREA)
  • Finger-Pressure Massage (AREA)
JP2008554405A 2006-02-11 2007-02-09 単針生体内エレクトロポレーションのための装置および方法 Active JP5059786B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77225506P 2006-02-11 2006-02-11
US60/772,255 2006-02-11
PCT/US2007/003615 WO2007095140A2 (en) 2006-02-11 2007-02-09 Device and method for single-needle in vivo electroporation

Publications (3)

Publication Number Publication Date
JP2009525829A JP2009525829A (ja) 2009-07-16
JP2009525829A5 JP2009525829A5 (enExample) 2010-03-18
JP5059786B2 true JP5059786B2 (ja) 2012-10-31

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JP2008554405A Active JP5059786B2 (ja) 2006-02-11 2007-02-09 単針生体内エレクトロポレーションのための装置および方法

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US (3) US10369359B2 (enExample)
EP (1) EP1981581B1 (enExample)
JP (1) JP5059786B2 (enExample)
KR (1) KR101385865B1 (enExample)
CN (1) CN101370553B (enExample)
AU (1) AU2007215263B2 (enExample)
CA (2) CA3063263C (enExample)
EA (1) EA200870252A1 (enExample)
NO (1) NO340500B1 (enExample)
WO (1) WO2007095140A2 (enExample)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007117651A2 (en) * 2006-04-07 2007-10-18 University Of South Florida Passive electric field focus system for in vivo and in vitro applications
EP2091558B1 (en) 2006-11-17 2018-04-04 Genetronics, Inc. Methods of enhancing immune response using electroporation-assisted vaccination and boosting
US10702326B2 (en) 2011-07-15 2020-07-07 Virginia Tech Intellectual Properties, Inc. Device and method for electroporation based treatment of stenosis of a tubular body part
US9198733B2 (en) 2008-04-29 2015-12-01 Virginia Tech Intellectual Properties, Inc. Treatment planning for electroporation-based therapies
US11272979B2 (en) 2008-04-29 2022-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US11254926B2 (en) 2008-04-29 2022-02-22 Virginia Tech Intellectual Properties, Inc. Devices and methods for high frequency electroporation
US10272178B2 (en) 2008-04-29 2019-04-30 Virginia Tech Intellectual Properties Inc. Methods for blood-brain barrier disruption using electrical energy
US10448989B2 (en) 2009-04-09 2019-10-22 Virginia Tech Intellectual Properties, Inc. High-frequency electroporation for cancer therapy
AU2009243079A1 (en) 2008-04-29 2009-11-05 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation to create tissue scaffolds
US10117707B2 (en) 2008-04-29 2018-11-06 Virginia Tech Intellectual Properties, Inc. System and method for estimating tissue heating of a target ablation zone for electrical-energy based therapies
US10245098B2 (en) 2008-04-29 2019-04-02 Virginia Tech Intellectual Properties, Inc. Acute blood-brain barrier disruption using electrical energy based therapy
US8992517B2 (en) * 2008-04-29 2015-03-31 Virginia Tech Intellectual Properties Inc. Irreversible electroporation to treat aberrant cell masses
US8926606B2 (en) 2009-04-09 2015-01-06 Virginia Tech Intellectual Properties, Inc. Integration of very short electric pulses for minimally to noninvasive electroporation
US10238447B2 (en) 2008-04-29 2019-03-26 Virginia Tech Intellectual Properties, Inc. System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress
US9283051B2 (en) 2008-04-29 2016-03-15 Virginia Tech Intellectual Properties, Inc. System and method for estimating a treatment volume for administering electrical-energy based therapies
US9867652B2 (en) 2008-04-29 2018-01-16 Virginia Tech Intellectual Properties, Inc. Irreversible electroporation using tissue vasculature to treat aberrant cell masses or create tissue scaffolds
EP2251452B1 (en) 2009-05-13 2018-07-18 SiO2 Medical Products, Inc. Pecvd apparatus for vessel coating
US8632534B2 (en) 2009-04-03 2014-01-21 Angiodynamics, Inc. Irreversible electroporation (IRE) for congestive obstructive pulmonary disease (COPD)
US11638603B2 (en) 2009-04-09 2023-05-02 Virginia Tech Intellectual Properties, Inc. Selective modulation of intracellular effects of cells using pulsed electric fields
US11382681B2 (en) 2009-04-09 2022-07-12 Virginia Tech Intellectual Properties, Inc. Device and methods for delivery of high frequency electrical pulses for non-thermal ablation
US8903488B2 (en) 2009-05-28 2014-12-02 Angiodynamics, Inc. System and method for synchronizing energy delivery to the cardiac rhythm
US9895189B2 (en) 2009-06-19 2018-02-20 Angiodynamics, Inc. Methods of sterilization and treating infection using irreversible electroporation
WO2010148440A1 (en) 2009-06-24 2010-12-29 International Scientific Pty Ltd An apparatus and method of treatment utilizing a varying electromagnetic energisation profile
US9458536B2 (en) 2009-07-02 2016-10-04 Sio2 Medical Products, Inc. PECVD coating methods for capped syringes, cartridges and other articles
US20110202052A1 (en) * 2010-02-12 2011-08-18 Daniel Gelbart System for treating benign prostatic hyperplasia
WO2011109406A1 (en) 2010-03-01 2011-09-09 Inovio Pharmaceuticals, Inc. A tolerable and minimally invasive skin electroporation device
US11624115B2 (en) 2010-05-12 2023-04-11 Sio2 Medical Products, Inc. Syringe with PECVD lubrication
EP2627274B1 (en) 2010-10-13 2022-12-14 AngioDynamics, Inc. System for electrically ablating tissue of a patient
US9878101B2 (en) 2010-11-12 2018-01-30 Sio2 Medical Products, Inc. Cyclic olefin polymer vessels and vessel coating methods
US9272095B2 (en) 2011-04-01 2016-03-01 Sio2 Medical Products, Inc. Vessels, contact surfaces, and coating and inspection apparatus and methods
EP2720740A1 (en) 2011-06-15 2014-04-23 ChronTech Pharma AB Injection needle and device
US9913978B2 (en) * 2011-06-28 2018-03-13 Kate Broderick Miniminally invasive dermal electroporation device
US9078665B2 (en) 2011-09-28 2015-07-14 Angiodynamics, Inc. Multiple treatment zone ablation probe
US9554968B2 (en) 2013-03-11 2017-01-31 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging
US11116695B2 (en) 2011-11-11 2021-09-14 Sio2 Medical Products, Inc. Blood sample collection tube
EP2776603B1 (en) 2011-11-11 2019-03-06 SiO2 Medical Products, Inc. PASSIVATION, pH PROTECTIVE OR LUBRICITY COATING FOR PHARMACEUTICAL PACKAGE, COATING PROCESS AND APPARATUS
US9414881B2 (en) 2012-02-08 2016-08-16 Angiodynamics, Inc. System and method for increasing a target zone for electrical ablation
CA2887352A1 (en) 2012-05-09 2013-11-14 Sio2 Medical Products, Inc. Saccharide protective coating for pharmaceutical package
US20150297800A1 (en) 2012-07-03 2015-10-22 Sio2 Medical Products, Inc. SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS
WO2014071061A1 (en) 2012-11-01 2014-05-08 Sio2 Medical Products, Inc. Coating inspection method
WO2014078666A1 (en) 2012-11-16 2014-05-22 Sio2 Medical Products, Inc. Method and apparatus for detecting rapid barrier coating integrity characteristics
US9764093B2 (en) 2012-11-30 2017-09-19 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition
US10201660B2 (en) 2012-11-30 2019-02-12 Sio2 Medical Products, Inc. Controlling the uniformity of PECVD deposition on medical syringes, cartridges, and the like
US9662450B2 (en) 2013-03-01 2017-05-30 Sio2 Medical Products, Inc. Plasma or CVD pre-treatment for lubricated pharmaceutical package, coating process and apparatus
US9937099B2 (en) 2013-03-11 2018-04-10 Sio2 Medical Products, Inc. Trilayer coated pharmaceutical packaging with low oxygen transmission rate
US20160017490A1 (en) 2013-03-15 2016-01-21 Sio2 Medical Products, Inc. Coating method
EP3122917B1 (en) 2014-03-28 2020-05-06 SiO2 Medical Products, Inc. Antistatic coatings for plastic vessels
CN106715682A (zh) 2014-05-12 2017-05-24 弗吉尼亚暨州立大学知识产权公司 使用脉冲电场选择性调节细胞的胞内影响
US12114911B2 (en) 2014-08-28 2024-10-15 Angiodynamics, Inc. System and method for ablating a tissue site by electroporation with real-time pulse monitoring
US10694972B2 (en) 2014-12-15 2020-06-30 Virginia Tech Intellectual Properties, Inc. Devices, systems, and methods for real-time monitoring of electrophysical effects during tissue treatment
CA2981474A1 (en) * 2015-03-31 2016-10-06 Oncosec Medical Incorporated Systems and methods for improved tissue-sensing based electroporation
EP3081198A1 (en) * 2015-04-14 2016-10-19 Eyevensys Elektroporation device for the eye with a support and with a needle electrode
CN111579769B (zh) * 2015-04-30 2023-10-27 李小卫 一种对组织样本进行免疫标记的方法
AU2016282210B2 (en) * 2015-06-25 2021-05-06 Newsouth Innovations Pty Limited Electroporation system for controlled localized therapeutics delivery
CN116982977A (zh) 2015-08-18 2023-11-03 Sio2医药产品公司 具有低氧气传输速率的药物和其他包装
KR101788301B1 (ko) * 2015-09-17 2017-10-20 주식회사 엘림텍 전기천공장치 및 그 제어방법
CN106388933B (zh) * 2016-09-14 2017-10-10 上海睿刀医疗科技有限公司 用于不可逆电穿孔设备的电极
US10905492B2 (en) 2016-11-17 2021-02-02 Angiodynamics, Inc. Techniques for irreversible electroporation using a single-pole tine-style internal device communicating with an external surface electrode
JP6884037B2 (ja) * 2017-05-29 2021-06-09 株式会社ジェイメック パルス電圧治療装置
US11607537B2 (en) 2017-12-05 2023-03-21 Virginia Tech Intellectual Properties, Inc. Method for treating neurological disorders, including tumors, with electroporation
US11925405B2 (en) 2018-03-13 2024-03-12 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11311329B2 (en) 2018-03-13 2022-04-26 Virginia Tech Intellectual Properties, Inc. Treatment planning for immunotherapy based treatments using non-thermal ablation techniques
US12390262B2 (en) 2018-03-13 2025-08-19 Virginia Tech Intellectual Properties, Inc. Treatment planning system for immunotherapy enhancement via non-thermal ablation
US11071860B2 (en) 2019-02-06 2021-07-27 Oncosec Medical Incorporated Systems and methods for detecting fault conditions in electroporation therapy
US11950835B2 (en) 2019-06-28 2024-04-09 Virginia Tech Intellectual Properties, Inc. Cycled pulsing to mitigate thermal damage for multi-electrode irreversible electroporation therapy
US12214189B2 (en) 2019-07-24 2025-02-04 Virginia Tech Intellectual Properties, Inc. Fourier analysis spectroscopy for monitoring tissue impedance changes and treatment outcome during electroporation-based-therapies
WO2021072507A1 (en) * 2019-10-18 2021-04-22 Newsouth Innovations Pty Limited Electrotransfer therapeutic delivery device, system and method
KR102290081B1 (ko) * 2019-11-29 2021-08-13 부산대학교 산학협력단 전기천공장치
US20230256236A1 (en) * 2020-06-24 2023-08-17 Oncosec Medical Incorporated Transformable needle for electroporation
JP2023544816A (ja) * 2020-10-08 2023-10-25 ベクトン・ディキンソン・アンド・カンパニー 送達装置およびコーティングされた針またはカニューレ
US12485279B2 (en) 2020-11-25 2025-12-02 Virginia Tech Intellectual Properties, Inc. Methods for modulating temporal infrastructure of pulsed electric fields
KR102576604B1 (ko) * 2021-02-16 2023-09-08 주식회사 밀알 의료용 정밀 약물주입 및 전기천공 융합 전극
WO2023034771A1 (en) * 2021-08-30 2023-03-09 Nanovis, LLC Devices and methods for treating infected tissue
KR102576111B1 (ko) * 2021-10-18 2023-09-08 주식회사 밀알 미들커넥터를 포함하는 가역적 전기천공시스템
US20250360295A1 (en) * 2024-05-21 2025-11-27 Wisconsin Alumni Research Foundation Adaptive, Multi-Injection Port, Double Balloon Catheter for Organ-Based Local Delivery of Gene Therapy

Family Cites Families (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2525398A (en) * 1948-02-02 1950-10-10 Arthur L Collins Hypodermic syringe holder and guide
US3313293A (en) * 1964-01-13 1967-04-11 Hewlett Packard Co Multi-electrode needle
GB8618253D0 (en) * 1986-07-25 1986-09-03 Wallace Ltd H G Intermittent administration of therapeutic substance
US4733661A (en) * 1987-04-27 1988-03-29 Palestrant Aubrey M Guidance device for C.T. guided drainage and biopsy procedures
US5389069A (en) * 1988-01-21 1995-02-14 Massachusetts Institute Of Technology Method and apparatus for in vivo electroporation of remote cells and tissue
JP2798459B2 (ja) * 1988-01-21 1998-09-17 マサチユセツツ・インスチチユート・オブ・テクノロジー エレクトロポレーションを利用した診断装置及び分子の組織内移動装置
JPH04158870A (ja) * 1990-10-23 1992-06-01 Olympus Optical Co Ltd 治療器具
CA2114950A1 (en) * 1991-08-10 1993-02-11 Michael J. Embleton Treatment of cell populations
US5328451A (en) * 1991-08-15 1994-07-12 Board Of Regents, The University Of Texas System Iontophoretic device and method for killing bacteria and other microbes
US5273525A (en) * 1992-08-13 1993-12-28 Btx Inc. Injection and electroporation apparatus for drug and gene delivery
US5702359A (en) * 1995-06-06 1997-12-30 Genetronics, Inc. Needle electrodes for mediated delivery of drugs and genes
US5993434A (en) * 1993-04-01 1999-11-30 Genetronics, Inc. Method of treatment using electroporation mediated delivery of drugs and genes
AU6260896A (en) * 1995-06-06 1996-12-24 Board Of Regents, The University Of Texas System Electrode system in iontophoretic treatment devices
US5873849A (en) * 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
US6055453A (en) * 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
DE19740825A1 (de) * 1997-09-17 1999-03-18 Laser & Med Tech Gmbh Vorrichtung zur Erzeugung röhrenförmiger Nekrosen- und von Druckamplituden in Muskelgewebe
US6356783B1 (en) * 1997-11-20 2002-03-12 David R. Hubbard, Jr. Multi-electrode and needle injection device for diagnosis and treatment of muscle injury and pain
US6778853B1 (en) * 1997-12-17 2004-08-17 University Of South Florida Electroporation device
US6135990A (en) * 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6302903B1 (en) * 1998-07-07 2001-10-16 Medtronic, Inc. Straight needle apparatus for creating a virtual electrode used for the ablation of tissue
EP2428249B1 (en) * 1998-07-13 2015-10-07 Inovio Pharmaceuticals, Inc. Skin and muscle-targeted gene therapy by pulsed electrical field
US6192270B1 (en) * 1998-08-14 2001-02-20 Genetronics, Inc. Apparatus and method for the delivery of drugs and genes into tissue
ATE256484T1 (de) * 1999-01-28 2004-01-15 Cyto Pulse Sciences Inc Einbringen von makromolekülen in zellen
JP4566496B2 (ja) 1999-12-15 2010-10-20 ユニヴァーシティ オブ サウス フロリダ 電気穿孔素子及び電気穿孔方法
US6591133B1 (en) * 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
AU2002239929A1 (en) * 2001-01-16 2002-07-30 Novacept Apparatus and method for treating venous reflux
US7127284B2 (en) * 2001-06-11 2006-10-24 Mercator Medsystems, Inc. Electroporation microneedle and methods for its use
US6994706B2 (en) * 2001-08-13 2006-02-07 Minnesota Medical Physics, Llc Apparatus and method for treatment of benign prostatic hyperplasia
AU2002326717A1 (en) * 2001-08-22 2003-03-10 Maxcyte, Inc. Apparatus and method for electroporation of biological samples
CA2477872A1 (en) 2002-03-07 2003-09-18 Merck & Co., Inc. Clinical syringe with electrical stimulation aspects
US8209006B2 (en) * 2002-03-07 2012-06-26 Vgx Pharmaceuticals, Inc. Constant current electroporation device and methods of use
CA2482183A1 (en) * 2002-04-16 2003-10-30 Cyto Pulse Sciences, Inc. Method of treating biological materials with translating electrical fields and electrode polarity reversal
SE0201977D0 (sv) 2002-06-24 2002-06-24 Astrazeneca Ab Novel compounds
US20050070841A1 (en) * 2002-07-04 2005-03-31 Inovio As Electroporation device and injection apparatus
US7328064B2 (en) * 2002-07-04 2008-02-05 Inovio As Electroporation device and injection apparatus
JP4225743B2 (ja) 2002-07-04 2009-02-18 株式会社東芝 無線端末及び通信制御方法
RU2334506C2 (ru) 2003-01-29 2008-09-27 И-Пилл Фарма Лтд. Активная доставка лекарственного средства в желудочно-кишечном тракте
CN1897920A (zh) * 2003-10-31 2007-01-17 阿尔扎公司 用于经皮疫苗递送的系统和方法
US20050209548A1 (en) * 2004-03-19 2005-09-22 Dev Sukhendu B Electroporation-mediated intravascular delivery
US20070083239A1 (en) * 2005-09-23 2007-04-12 Denise Demarais Methods and apparatus for inducing, monitoring and controlling renal neuromodulation
US7776373B2 (en) * 2004-11-19 2010-08-17 Eteka Llc Apparatus and method for the enhancement of food properties and food prepared therefrom
US20060293725A1 (en) * 2005-06-24 2006-12-28 Boris Rubinsky Methods and systems for treating fatty tissue sites using electroporation
US8262885B2 (en) * 2005-11-18 2012-09-11 President And Fellows Of Harvard College Dielectrophoretic tweezers apparatus and methods
US20080045880A1 (en) 2006-02-11 2008-02-21 Rune Kjeken Device and method for single-needle in vivo electroporation

Also Published As

Publication number Publication date
CA3063263C (en) 2024-01-16
CN101370553B (zh) 2013-04-10
AU2007215263B2 (en) 2011-07-07
EP1981581A4 (en) 2011-05-25
CA2635437C (en) 2020-01-28
NO20083811L (no) 2008-09-05
EA200870252A1 (ru) 2009-02-27
US11331479B2 (en) 2022-05-17
AU2007215263A1 (en) 2007-08-23
US20070287950A1 (en) 2007-12-13
US20200001076A1 (en) 2020-01-02
US10369359B2 (en) 2019-08-06
EP1981581A2 (en) 2008-10-22
WO2007095140A2 (en) 2007-08-23
WO2007095140A3 (en) 2008-01-10
KR101385865B1 (ko) 2014-04-17
CN101370553A (zh) 2009-02-18
US20230001190A1 (en) 2023-01-05
CA3063263A1 (en) 2007-08-23
CA2635437A1 (en) 2007-08-23
KR20080110988A (ko) 2008-12-22
NO340500B1 (no) 2017-05-02
JP2009525829A (ja) 2009-07-16
EP1981581B1 (en) 2016-04-13

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