JP5016925B2 - デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 - Google Patents
デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 Download PDFInfo
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- JP5016925B2 JP5016925B2 JP2006537909A JP2006537909A JP5016925B2 JP 5016925 B2 JP5016925 B2 JP 5016925B2 JP 2006537909 A JP2006537909 A JP 2006537909A JP 2006537909 A JP2006537909 A JP 2006537909A JP 5016925 B2 JP5016925 B2 JP 5016925B2
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- Prior art keywords
- deoxynojirimycin
- disease
- glucosylceramide
- adamantan
- glycosphingolipid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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| Application Number | Priority Date | Filing Date | Title |
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| EP03078395A EP1528056A1 (en) | 2003-10-29 | 2003-10-29 | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| EP03078395.5 | 2003-10-29 | ||
| PCT/NL2004/000761 WO2005040118A1 (en) | 2003-10-29 | 2004-10-29 | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
Related Child Applications (1)
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| JP2012091984A Division JP5730808B2 (ja) | 2003-10-29 | 2012-04-13 | デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 |
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| JP2012091984A Expired - Lifetime JP5730808B2 (ja) | 2003-10-29 | 2012-04-13 | デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012180353A (ja) * | 2003-10-29 | 2012-09-20 | Genzyme Corp | デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 |
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| AU2004283631A1 (en) * | 2003-10-29 | 2005-05-06 | Genzyme Corporation | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| WO2005092334A2 (en) * | 2004-03-25 | 2005-10-06 | David Priestman | Use of n-substituted imino sugars for appetite suppression |
| BRPI0517701A8 (pt) | 2004-11-10 | 2018-01-23 | Genzyme Corp | métodos de tratamento de diabetes mellitus |
| FR2887549B1 (fr) * | 2005-06-23 | 2009-07-10 | Centre Nat Rech Scient | Nouveaux composes de la famille des iminosucres, leurs utilisations, notamment pour le traitement de maladies lysosomales, ainsi que leur procede de preparation |
| FR2894482A1 (fr) * | 2005-12-14 | 2007-06-15 | Galderma Sa | Utilisation d'une composition comprenant une association d'hydroquinone,d'acetonide de fluocinolone et de tretinoine, dans le traitement d'l'hyperpigmentation de la peau suite au psoriasis ou a l'eczema |
| CA2650311A1 (en) * | 2006-04-24 | 2007-11-01 | Academisch Medisch Centrum | Improved treatment of cystic fibrosis |
| ES2546181T3 (es) | 2006-05-09 | 2015-09-21 | Genzyme Corporation | Métodos de tratar la enfermedad del hígado graso mediante inhibición de la síntesis de glucoesfingolípidos |
| GB0614947D0 (en) * | 2006-07-27 | 2006-09-06 | Isis Innovation | Epitope reduction therapy |
| EP2594563B1 (en) | 2007-05-31 | 2018-07-18 | Genzyme Corporation | 2-acylaminopropanol-type glucosylceramide synthase inhibitors |
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| WO2015147639A1 (en) | 2014-03-27 | 2015-10-01 | Academisch Medisch Centrum | N-(5-((aryl or heteroaryl)methyloxy)pentyl)-substituted iminosugars as inhibitors of glucosylceramide synthase |
| CA2955074A1 (en) | 2014-08-08 | 2016-02-11 | Dana-Farber Cancer Institute, Inc. | Diazepane derivatives and uses thereof |
| JP2017525759A (ja) | 2014-08-08 | 2017-09-07 | ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド | ジヒドロプテリジノン誘導体およびその使用 |
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| AU2016276963C1 (en) | 2015-06-12 | 2021-08-05 | Dana-Farber Cancer Institute, Inc. | Combination therapy of transcription inhibitors and kinase inhibitors |
| BR112018004618A2 (pt) | 2015-09-11 | 2018-09-25 | Dana-Farber Cancer Institute, Inc. | ciano tienotriazoldiazepinas e usos das mesmas |
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| EP3318277A1 (en) | 2016-11-04 | 2018-05-09 | Institut du Cerveau et de la Moelle Epiniere-ICM | Inhibitors of glucosylceramide synthase for the treatment of motor neuron diseases |
| US20220257604A1 (en) * | 2019-03-08 | 2022-08-18 | University Of Virginia Patent Foundation | Compositions and methods for modulating viral infections by regulating glucosylceramides |
| PH12022552955A1 (en) * | 2020-05-07 | 2024-02-26 | Alectos Therapeutics Inc | Non-lysosomal glucosylceramidase inhibitors and uses thereof |
| WO2022227287A1 (zh) * | 2021-04-25 | 2022-11-03 | 中南大学 | Dnj及其衍生物在制备预防和/或治疗肺动脉高压药物中的应用 |
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| JP2504000B2 (ja) | 1986-09-02 | 1996-06-05 | 日本新薬株式会社 | グルコシルモラノリン誘導体 |
| JP4564108B2 (ja) * | 1996-07-15 | 2010-10-20 | ジェンザイム コーポレーション | デオキシノジリマイシン誘導体及び該誘導体のグルコシルセラミダーゼ阻害剤としての用途 |
| BR9902585A (pt) | 1999-02-11 | 2000-09-26 | Claudio Cerqueira Lopes | Um novo processo de sìntese de aza-açúcares com atividade biológica |
| GB0100889D0 (en) * | 2001-01-12 | 2001-02-21 | Oxford Glycosciences Uk Ltd | Compounds |
| US6235737B1 (en) | 2000-01-25 | 2001-05-22 | Peter Styczynski | Reduction of hair growth |
| US20040204379A1 (en) | 2000-06-19 | 2004-10-14 | Cheng Seng H. | Combination enzyme replacement, gene therapy and small molecule therapy for lysosomal storage diseases |
| JP4575156B2 (ja) * | 2002-07-17 | 2010-11-04 | アクテリオン ファーマシューティカルズ リミテッド | グルコシルセラミドシンターゼの阻害剤としてのピペリジントリオール誘導体 |
| ES2393919T3 (es) * | 2002-07-17 | 2013-01-02 | Actelion Pharmaceuticals Ltd. | Derivados de PIPERIDINETRIOL como inhibidores de GLUCOSILCERAMIDA SINTASA |
| GB0229476D0 (en) | 2002-12-17 | 2003-01-22 | Oxford Glycosciences Uk Ltd | Novel process |
| EP1528056A1 (en) | 2003-10-29 | 2005-05-04 | Academisch Ziekenhuis bij de Universiteit van Amsterdam | Deoxynojirimycin analogues and their uses as glucosylceramidase inhibitors |
| AU2004283631A1 (en) * | 2003-10-29 | 2005-05-06 | Genzyme Corporation | Use of a deoxynojirimycin derivative or a pharmaceutically salt thereof |
| WO2005063706A1 (en) | 2003-12-23 | 2005-07-14 | Macrozyme Dnm B.V. | Synthesis of nojirimycins |
| EP2932982B1 (en) | 2005-05-17 | 2018-10-03 | Amicus Therapeutics, Inc. | A method for the treatment of pompe disease using 1-deoxynojirimycin and derivatives |
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- 2004-10-29 WO PCT/NL2004/000761 patent/WO2005040118A1/en not_active Ceased
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2012180353A (ja) * | 2003-10-29 | 2012-09-20 | Genzyme Corp | デオキシノジリマイシン類似体、及びグルコシルセラミダーゼ阻害剤としてのその使用 |
Also Published As
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| WO2005040118A1 (en) | 2005-05-06 |
| CA2551060C (en) | 2012-08-28 |
| EP1528056A1 (en) | 2005-05-04 |
| AU2004284012A1 (en) | 2005-05-06 |
| EP1680403A1 (en) | 2006-07-19 |
| AU2004284012B2 (en) | 2010-06-17 |
| CY1118191T1 (el) | 2017-06-28 |
| US20070066581A1 (en) | 2007-03-22 |
| PL1680403T3 (pl) | 2017-08-31 |
| PT1680403T (pt) | 2016-09-07 |
| CA2551060A1 (en) | 2005-05-06 |
| SI1680403T1 (sl) | 2017-01-31 |
| JP2012180353A (ja) | 2012-09-20 |
| ES2594356T3 (es) | 2016-12-19 |
| US7528153B2 (en) | 2009-05-05 |
| HUE029637T2 (en) | 2017-03-28 |
| JP5730808B2 (ja) | 2015-06-10 |
| IL175260A0 (en) | 2006-09-05 |
| JP2007509926A (ja) | 2007-04-19 |
| DK1680403T3 (en) | 2016-09-26 |
| EP1680403B1 (en) | 2016-06-29 |
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