JP5007338B2 - 酵素を用いて生物化合物を測定する電気化学システム - Google Patents
酵素を用いて生物化合物を測定する電気化学システム Download PDFInfo
- Publication number
- JP5007338B2 JP5007338B2 JP2009521196A JP2009521196A JP5007338B2 JP 5007338 B2 JP5007338 B2 JP 5007338B2 JP 2009521196 A JP2009521196 A JP 2009521196A JP 2009521196 A JP2009521196 A JP 2009521196A JP 5007338 B2 JP5007338 B2 JP 5007338B2
- Authority
- JP
- Japan
- Prior art keywords
- measuring
- biological compound
- electrode
- sensor
- measurement
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 150000001875 compounds Chemical class 0.000 title claims description 37
- 108090000790 Enzymes Proteins 0.000 title claims description 21
- 102000004190 Enzymes Human genes 0.000 title claims description 21
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 46
- 239000008103 glucose Substances 0.000 claims description 46
- 238000005259 measurement Methods 0.000 claims description 38
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 32
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 32
- 238000010438 heat treatment Methods 0.000 claims description 31
- 239000000758 substrate Substances 0.000 claims description 25
- 238000000034 method Methods 0.000 claims description 12
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims description 10
- 239000000376 reactant Substances 0.000 claims description 10
- 238000002848 electrochemical method Methods 0.000 claims description 9
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 239000008280 blood Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 210000001124 body fluid Anatomy 0.000 claims description 6
- 239000010839 body fluid Substances 0.000 claims description 6
- 239000000919 ceramic Substances 0.000 claims description 6
- 238000004070 electrodeposition Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- KTWOOEGAPBSYNW-UHFFFAOYSA-N ferrocene Chemical class [Fe+2].C=1C=C[CH-]C=1.C=1C=C[CH-]C=1 KTWOOEGAPBSYNW-UHFFFAOYSA-N 0.000 claims description 4
- 229920001542 oligosaccharide Polymers 0.000 claims description 4
- 150000002482 oligosaccharides Chemical class 0.000 claims description 4
- MMXZSJMASHPLLR-UHFFFAOYSA-N pyrroloquinoline quinone Chemical compound C12=C(C(O)=O)C=C(C(O)=O)N=C2C(=O)C(=O)C2=C1NC(C(=O)O)=C2 MMXZSJMASHPLLR-UHFFFAOYSA-N 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 3
- 238000012545 processing Methods 0.000 claims description 3
- 230000027756 respiratory electron transport chain Effects 0.000 claims description 3
- 150000002772 monosaccharides Chemical class 0.000 claims description 2
- 150000002907 osmium Chemical class 0.000 claims description 2
- 150000001720 carbohydrates Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 description 11
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 9
- 230000004044 response Effects 0.000 description 9
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 8
- 108010015776 Glucose oxidase Proteins 0.000 description 7
- 239000004366 Glucose oxidase Substances 0.000 description 7
- 229940116332 glucose oxidase Drugs 0.000 description 7
- 235000019420 glucose oxidase Nutrition 0.000 description 7
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 7
- 229910052762 osmium Inorganic materials 0.000 description 5
- SYQBFIAQOQZEGI-UHFFFAOYSA-N osmium atom Chemical compound [Os] SYQBFIAQOQZEGI-UHFFFAOYSA-N 0.000 description 5
- 238000009792 diffusion process Methods 0.000 description 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 4
- 229910052760 oxygen Inorganic materials 0.000 description 4
- 239000001301 oxygen Substances 0.000 description 4
- 229910052697 platinum Inorganic materials 0.000 description 4
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 3
- 239000004020 conductor Substances 0.000 description 3
- 206010012601 diabetes mellitus Diseases 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- PHOQVHQSTUBQQK-SQOUGZDYSA-N D-glucono-1,5-lactone Chemical compound OC[C@H]1OC(=O)[C@H](O)[C@@H](O)[C@@H]1O PHOQVHQSTUBQQK-SQOUGZDYSA-N 0.000 description 2
- 102000004877 Insulin Human genes 0.000 description 2
- 108090001061 Insulin Proteins 0.000 description 2
- 241000186660 Lactobacillus Species 0.000 description 2
- 238000004082 amperometric method Methods 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 230000006957 competitive inhibition Effects 0.000 description 2
- 239000003792 electrolyte Substances 0.000 description 2
- 239000008151 electrolyte solution Substances 0.000 description 2
- 235000012209 glucono delta-lactone Nutrition 0.000 description 2
- 229960003681 gluconolactone Drugs 0.000 description 2
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 2
- 239000000017 hydrogel Substances 0.000 description 2
- 229940125396 insulin Drugs 0.000 description 2
- 229940039696 lactobacillus Drugs 0.000 description 2
- 230000002045 lasting effect Effects 0.000 description 2
- 125000003071 maltose group Chemical group 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- XDIYNQZUNSSENW-UUBOPVPUSA-N (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanal Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O XDIYNQZUNSSENW-UUBOPVPUSA-N 0.000 description 1
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- DBTMGCOVALSLOR-UHFFFAOYSA-N 32-alpha-galactosyl-3-alpha-galactosyl-galactose Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(OC2C(C(CO)OC(O)C2O)O)OC(CO)C1O DBTMGCOVALSLOR-UHFFFAOYSA-N 0.000 description 1
- ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 7h-pyrrolo[2,3-h]quinoline Chemical compound C1=CN=C2C(C=CN3)=C3C=CC2=C1 ZIUYHTQZEPDUCZ-UHFFFAOYSA-N 0.000 description 1
- RXVWSYJTUUKTEA-UHFFFAOYSA-N D-maltotriose Natural products OC1C(O)C(OC(C(O)CO)C(O)C(O)C=O)OC(CO)C1OC1C(O)C(O)C(O)C(CO)O1 RXVWSYJTUUKTEA-UHFFFAOYSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 108091000080 Phosphotransferase Proteins 0.000 description 1
- 102100030262 Regucalcin Human genes 0.000 description 1
- 108050007056 Regucalcin Proteins 0.000 description 1
- 229910021607 Silver chloride Inorganic materials 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 102000004139 alpha-Amylases Human genes 0.000 description 1
- 108090000637 alpha-Amylases Proteins 0.000 description 1
- 229940024171 alpha-amylase Drugs 0.000 description 1
- 230000006399 behavior Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 239000000872 buffer Substances 0.000 description 1
- 230000003197 catalytic effect Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 229910003460 diamond Inorganic materials 0.000 description 1
- 239000010432 diamond Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000003487 electrochemical reaction Methods 0.000 description 1
- 238000006056 electrooxidation reaction Methods 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 238000010030 laminating Methods 0.000 description 1
- 238000012417 linear regression Methods 0.000 description 1
- FYGDTMLNYKFZSV-UHFFFAOYSA-N mannotriose Natural products OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC2C(OC(O)C(O)C2O)CO)C(O)C1O FYGDTMLNYKFZSV-UHFFFAOYSA-N 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 150000002908 osmium compounds Chemical group 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 150000002926 oxygen Chemical class 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003304 ruthenium compounds Chemical class 0.000 description 1
- 238000007650 screen-printing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- FYGDTMLNYKFZSV-BYLHFPJWSA-N β-1,4-galactotrioside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@H](CO)O[C@@H](O[C@@H]2[C@@H](O[C@@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-BYLHFPJWSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/004—Enzyme electrodes mediator-assisted
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Emergency Medicine (AREA)
- Electrochemistry (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06117822A EP1882745A1 (fr) | 2006-07-25 | 2006-07-25 | Système électrochimique de dosage d'un composé biologique par une enzyme |
| EP06117822.4 | 2006-07-25 | ||
| PCT/EP2007/057012 WO2008012197A1 (fr) | 2006-07-25 | 2007-07-10 | Systeme electrochimique de dosage d'un compose biologique par une enzyme |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009544957A JP2009544957A (ja) | 2009-12-17 |
| JP2009544957A5 JP2009544957A5 (https=) | 2012-06-14 |
| JP5007338B2 true JP5007338B2 (ja) | 2012-08-22 |
Family
ID=37499624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009521196A Expired - Fee Related JP5007338B2 (ja) | 2006-07-25 | 2007-07-10 | 酵素を用いて生物化合物を測定する電気化学システム |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US8951404B2 (https=) |
| EP (2) | EP1882745A1 (https=) |
| JP (1) | JP5007338B2 (https=) |
| CN (1) | CN101517094A (https=) |
| AU (1) | AU2007278327B2 (https=) |
| CA (1) | CA2658906A1 (https=) |
| WO (1) | WO2008012197A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5366432B2 (ja) * | 2008-05-09 | 2013-12-11 | 株式会社船井電機新応用技術研究所 | ガス検出システム |
| US8101065B2 (en) * | 2009-12-30 | 2012-01-24 | Lifescan, Inc. | Systems, devices, and methods for improving accuracy of biosensors using fill time |
| US9435764B2 (en) * | 2013-06-27 | 2016-09-06 | Lifescan Scotland Limited | Transient signal error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| US9835578B2 (en) * | 2013-06-27 | 2017-12-05 | Lifescan Scotland Limited | Temperature compensation for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| US9435762B2 (en) * | 2013-06-27 | 2016-09-06 | Lifescan Scotland Limited | Fill error trap for an analyte measurement determined from a specified sampling time derived from a sensed physical characteristic of the sample containing the analyte |
| JP2020523565A (ja) * | 2017-06-07 | 2020-08-06 | サン・ケミカル・コーポレーション | 電気化学的バイオセンサー |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0814563B2 (ja) * | 1989-05-15 | 1996-02-14 | 株式会社エー・アンド・ディ | 酵素電極の製造方法及び酵素電極の製造装置 |
| FR2673183B1 (fr) * | 1991-02-21 | 1996-09-27 | Asulab Sa | Complexes mono, bis ou tris (2,2'-bipyridine substituee) d'un metal choisi parmi le fer, le ruthenium, l'osmium ou le vanadium et leurs procedes de preparation . |
| JPH05256812A (ja) * | 1992-03-10 | 1993-10-08 | Toto Ltd | バイオセンサ |
| JPH06174679A (ja) * | 1992-12-10 | 1994-06-24 | Sumitomo Metal Ind Ltd | バイオセンサ |
| AUPP238898A0 (en) * | 1998-03-12 | 1998-04-09 | Usf Filtration And Separations Group Inc. | Heated electrochemical cell |
| JP2000019146A (ja) * | 1998-07-06 | 2000-01-21 | Matsushita Electric Ind Co Ltd | 基質の定量法並びにそれに用いるバイオセンサおよび測定装置 |
| US6616819B1 (en) * | 1999-11-04 | 2003-09-09 | Therasense, Inc. | Small volume in vitro analyte sensor and methods |
| JP4038575B2 (ja) * | 2003-07-25 | 2008-01-30 | 独立行政法人産業技術総合研究所 | バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法 |
-
2006
- 2006-07-25 EP EP06117822A patent/EP1882745A1/fr not_active Withdrawn
-
2007
- 2007-07-10 EP EP07787288A patent/EP2054522A1/fr not_active Withdrawn
- 2007-07-10 CN CNA2007800353232A patent/CN101517094A/zh active Pending
- 2007-07-10 JP JP2009521196A patent/JP5007338B2/ja not_active Expired - Fee Related
- 2007-07-10 US US12/375,163 patent/US8951404B2/en not_active Expired - Fee Related
- 2007-07-10 WO PCT/EP2007/057012 patent/WO2008012197A1/fr not_active Ceased
- 2007-07-10 CA CA002658906A patent/CA2658906A1/en not_active Abandoned
- 2007-07-10 AU AU2007278327A patent/AU2007278327B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP1882745A1 (fr) | 2008-01-30 |
| CN101517094A (zh) | 2009-08-26 |
| WO2008012197A1 (fr) | 2008-01-31 |
| JP2009544957A (ja) | 2009-12-17 |
| AU2007278327A1 (en) | 2008-01-31 |
| US20100018866A1 (en) | 2010-01-28 |
| CA2658906A1 (en) | 2008-01-31 |
| EP2054522A1 (fr) | 2009-05-06 |
| US8951404B2 (en) | 2015-02-10 |
| AU2007278327B2 (en) | 2013-08-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP6150262B2 (ja) | 分析物バイオセンサシステム | |
| EP1678491B1 (en) | A meter for use in a method of reducing interferences in an electrochemical sensor using two different applied potentials | |
| JP5185044B2 (ja) | 生理学的サンプルから対照溶液を判別するシステム及び方法 | |
| JP4891821B2 (ja) | 生理学的サンプルから対照溶液を判別するシステム及び方法 | |
| CN102147388B (zh) | 检测填充是否足量的方法和系统 | |
| US8431011B2 (en) | Method for automatically and rapidly distinguishing between control and sample solutions in a biosensor strip | |
| CN101583721B (zh) | 过氧化氢浓度的测定 | |
| US9273337B2 (en) | Method for improving measurement accuracy and devices and systems related thereto | |
| US20140054171A1 (en) | Analyte Sensor Utilizing Oxygen as Oxidant | |
| JP5007338B2 (ja) | 酵素を用いて生物化合物を測定する電気化学システム | |
| JP2009544957A5 (https=) | ||
| CN115884713A (zh) | 分析物传感器及用于生产分析物传感器的方法 | |
| US20200200697A1 (en) | Electrochemical biosensors | |
| TW201719161A (zh) | 用於補償基於測試條的極化效應的樣本相關測量之系統及方法 | |
| TWI603083B (zh) | 用以測量樣品中之分析物及計算血容比鈍感血糖濃度之系統及方法 | |
| CN107003269A (zh) | 基于测量的温度、物理特性和估计的分析物值确定分析物测量时间的电化学测试条的准确分析物测量 | |
| HK40093318A (zh) | 分析物传感器及用於生产分析物传感器的方法 | |
| CN121867779A (zh) | 一种消除电活性干扰物的干扰的生物传感器 | |
| HK1135436A (en) | Electrochemical system for assaying a biological compound by an enzyme | |
| HK1091900B (en) | A meter for use in a method of reducing interferences in an electrochemical sensor using two different applied potentials | |
| HK1146302B (en) | Rapid-read gated amperometry |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100622 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100825 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20110401 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20111228 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120201 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120418 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20120418 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120517 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120528 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150601 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| LAPS | Cancellation because of no payment of annual fees |