JP4991307B2 - 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法 - Google Patents

抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法 Download PDF

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JP4991307B2
JP4991307B2 JP2006541588A JP2006541588A JP4991307B2 JP 4991307 B2 JP4991307 B2 JP 4991307B2 JP 2006541588 A JP2006541588 A JP 2006541588A JP 2006541588 A JP2006541588 A JP 2006541588A JP 4991307 B2 JP4991307 B2 JP 4991307B2
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seq
amino acid
acid residues
antibody
polypeptide
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JP2007535490A (ja
JP2007535490A5 (enExample
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ウェンフェン スー
ウェイン アール． キンズボゲル
チー チェン
スティーブン ディー． ヒューズ
ヤスミン エー． チャンドラセカー
ステイシー アール． ディロン
ジョイス エム． レーナー
アンソニー ダブリュー． シアダク
パラブール ブイ． シバクラマー
マーガレット ディー． ムーア
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ザイモジェネティクス， インコーポレイテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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    • A61P39/00—General protective or antinoxious agents
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    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
    • C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto

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  • Biochemistry (AREA)
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  • Cell Biology (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2006541588A 2003-11-21 2004-11-19 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法 Expired - Fee Related JP4991307B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US52413103P 2003-11-21 2003-11-21
US60/524,131 2003-11-21
US55585704P 2004-03-24 2004-03-24
US60/555,857 2004-03-24
PCT/US2004/039071 WO2005052000A2 (en) 2003-11-21 2004-11-19 Anti-il-20 antibodies and binding partners and methods of using in inflammation

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JP2011212399A Division JP2012036204A (ja) 2003-11-21 2011-09-28 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法

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JP2007535490A JP2007535490A (ja) 2007-12-06
JP2007535490A5 JP2007535490A5 (enExample) 2011-03-03
JP4991307B2 true JP4991307B2 (ja) 2012-08-01

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JP2006541588A Expired - Fee Related JP4991307B2 (ja) 2003-11-21 2004-11-19 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法
JP2006541597A Pending JP2007537993A (ja) 2003-11-21 2004-11-19 抗ｉｌ−２０受容体抗体および結合パートナーならびに炎症において用いる方法
JP2011212399A Pending JP2012036204A (ja) 2003-11-21 2011-09-28 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法

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JP2006541597A Pending JP2007537993A (ja) 2003-11-21 2004-11-19 抗ｉｌ−２０受容体抗体および結合パートナーならびに炎症において用いる方法
JP2011212399A Pending JP2012036204A (ja) 2003-11-21 2011-09-28 抗ｉｌ−２０抗体および結合パートナーならびに炎症において用いる方法

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US (3) US20050170468A1 (enExample)
EP (3) EP1697418A2 (enExample)
JP (3) JP4991307B2 (enExample)
AT (1) ATE447587T1 (enExample)
CA (2) CA2545867A1 (enExample)
DE (1) DE602004023965D1 (enExample)
ES (1) ES2334140T3 (enExample)
WO (2) WO2005052000A2 (enExample)

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CN107743586B (zh) 2015-06-03 2021-07-02 百时美施贵宝公司 用于癌症诊断的抗gitr抗体
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US7393684B2 (en) 2008-07-01
US8907068B2 (en) 2014-12-09
CA2542546A1 (en) 2005-06-09
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US20080247945A1 (en) 2008-10-09
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CA2545867A1 (en) 2005-06-09
JP2012036204A (ja) 2012-02-23
WO2005052000A2 (en) 2005-06-09
US20050170468A1 (en) 2005-08-04
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US20050136004A1 (en) 2005-06-23
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