JP4989648B2 - 抗癌剤として有用なイルジン類似体 - Google Patents

抗癌剤として有用なイルジン類似体 Download PDF

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JP4989648B2
JP4989648B2 JP2008525225A JP2008525225A JP4989648B2 JP 4989648 B2 JP4989648 B2 JP 4989648B2 JP 2008525225 A JP2008525225 A JP 2008525225A JP 2008525225 A JP2008525225 A JP 2008525225A JP 4989648 B2 JP4989648 B2 JP 4989648B2
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compound according
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cancer
hydrogen
compound
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JP2009503110A5 (https=
JP2009503110A (ja
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トレバー シー． マクモリス，
マイケル ジェイ． ケルナー，
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University of California
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/26—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of rings other than six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/93—Spiro compounds
    • C07C2603/95—Spiro compounds containing "not free" spiro atoms
    • C07C2603/96—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members
    • C07C2603/97—Spiro compounds containing "not free" spiro atoms containing at least one ring with less than six members containing five-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2008525225A 2005-08-03 2006-08-03 抗癌剤として有用なイルジン類似体 Active JP4989648B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US70501705P 2005-08-03 2005-08-03
US60/705,017 2005-08-03
PCT/US2006/030439 WO2007019308A2 (en) 2005-08-03 2006-08-03 Illudin analogs useful as anticancer agents

Publications (3)

Publication Number Publication Date
JP2009503110A JP2009503110A (ja) 2009-01-29
JP2009503110A5 JP2009503110A5 (https=) 2009-09-24
JP4989648B2 true JP4989648B2 (ja) 2012-08-01

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JP2008525225A Active JP4989648B2 (ja) 2005-08-03 2006-08-03 抗癌剤として有用なイルジン類似体

Country Status (5)

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US (1) US7655695B2 (https=)
EP (1) EP1909783B1 (https=)
JP (1) JP4989648B2 (https=)
AT (1) ATE527998T1 (https=)
WO (1) WO2007019308A2 (https=)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US10285955B2 (en) 2014-04-10 2019-05-14 Af Chemicals, Llc Affinity medicant conjugate
US11135182B2 (en) 2014-04-10 2021-10-05 Af Chemicals, Llc Affinity medicant conjugates
WO2015157578A2 (en) 2014-04-10 2015-10-15 Af Chemicals, Llc Affinity medicant conjugates
JP7489966B2 (ja) * 2018-09-04 2024-05-24 ランタン ファルマ インコーポレイテッド イルジン類似体、それらの使用、およびそれらを合成する方法
AU2019361781A1 (en) * 2018-10-14 2021-06-03 Lantern Pharma Inc. Methods for the treatment of solid tumor cancers using illudins and biomarkers
EP3667323B1 (en) 2018-12-11 2024-11-13 AF Chemical LLC Methods, compositions and devices for treating cancer with illudofulvenes
US11591295B2 (en) 2019-11-25 2023-02-28 Af Chemicals Llc Affinity illudofulvene conjugates
BR112022020595A2 (pt) * 2020-04-10 2023-01-17 Lantern Pharma Inc Métodos hidroxiureametil-acilfulveno para tratamento de câncer do cérebro ou câncer do snc.
EP4146181A4 (en) * 2020-05-08 2024-10-09 Lantern Pharma Inc. METHODS FOR TREATING PANCREATIC CANCER
WO2022147072A1 (en) * 2020-12-29 2022-07-07 Lantern Pharma Inc. Method for treating rhabdoid tumors
CN116847834A (zh) * 2021-01-08 2023-10-03 蓝腾制药公司 使用隐陡头菌素或羟基脲甲基酰基富烯治疗脑转移瘤和cns转移瘤
CA3215236A1 (en) * 2021-04-12 2022-10-20 Aditya Kulkarni Method for treating lung cancer and non-small cell lung cancer
CN117320704A (zh) * 2021-05-03 2023-12-29 蓝腾制药公司 血癌的治疗方法
JP2024528725A (ja) * 2021-07-29 2024-07-30 ランタン ファルマ インコーポレイテッド Ｐａｒｐ阻害剤及びアシルフルベンの併用によるがんの治療
KR20240073856A (ko) * 2021-07-29 2024-05-27 랜턴 파마 인코포레이티드 스피로노락톤 및 아실풀벤의 조합을 이용한 암의 치료
CN121218981A (zh) * 2023-05-30 2025-12-26 蓝腾制药公司 用抗cd20抗体和酰基富烯的组合治疗癌症

Family Cites Families (26)

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US459157A (en) * 1891-09-08 Running-gear for vehicles
US4559157A (en) 1983-04-21 1985-12-17 Creative Products Resource Associates, Ltd. Cosmetic applicator useful for skin moisturizing
LU84979A1 (fr) * 1983-08-30 1985-04-24 Oreal Composition cosmetique ou pharmaceutique sous forme aqueuse ou anhydre dont la phase grasse contient un polyether oligomere et polyethers oligomeres nouveaux
US4612302A (en) * 1983-11-14 1986-09-16 Brigham And Women's Hospital Clinical use of somatostatin analogues
US4684620A (en) * 1984-09-04 1987-08-04 Gibson-Stephens Neuropharmaceuticals, Inc. Cyclic polypeptides having mu-receptor specificity
JPS62234040A (ja) 1986-04-02 1987-10-14 Kyowa Hakko Kogyo Co Ltd Ｄｃ１０４３物質
US4853371A (en) * 1986-06-17 1989-08-01 The Administrators Of The Tulane Educational Fund Therapeutic somatostatin analogs
US4820508A (en) * 1987-06-23 1989-04-11 Neutrogena Corporation Skin protective composition
US4992478A (en) * 1988-04-04 1991-02-12 Warner-Lambert Company Antiinflammatory skin moisturizing composition and method of preparing same
US4938949A (en) * 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
JPH04502012A (ja) 1989-09-27 1992-04-09 モスコフスキ　ナウチノ―イススレドバテルスキ　インスティテュト　グラツィニフ　ボレツネイ　イメニ　ゲルムゴルツァ 進行性近視の治療用組成物
CA2067365C (en) * 1989-10-03 2006-01-31 Michael J. Kelner Illudin analogs as anti-tumor agents
US5439936A (en) * 1989-10-03 1995-08-08 The Regents Of The University Of California Method of treating certain tumors using illudin analogs
HU208115B (en) * 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives
EP0450761A1 (en) * 1990-03-02 1991-10-09 Merck & Co. Inc. Spirocyclic oxytocin antagonists
KR900016822A (ko) * 1990-04-20 1990-11-14 하라 레이노스께 슬라이드 프로젝터
GB9017024D0 (en) * 1990-08-03 1990-09-19 Erba Carlo Spa New linker for bioactive agents
EP0699069B9 (en) 1993-04-27 2003-10-22 Smithkline Beecham Corporation Endothelin receptor antagonists
US6303120B1 (en) 1994-03-15 2001-10-16 Memorial Sloan-Kettering Institute For Cancer Research Synthesis of glycoconjugates of the lewis y epitope and uses thereof
US5708163A (en) 1994-03-15 1998-01-13 Sloan-Kettering Institute Of Cancer Research Synthesis of the breast tumor-associated antigen defined by monoclonalantibody MBRL and uses thereof
JP3908798B2 (ja) * 1994-09-12 2007-04-25 武田薬品工業株式会社 ベンゾシクロアルケン類、その製造法および剤
AU3399895A (en) * 1994-09-12 1996-03-29 Takeda Chemical Industries Ltd. Benzocycloalkene compounds, their production and use
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) * 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6025328A (en) * 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents

Also Published As

Publication number Publication date
US20080306147A1 (en) 2008-12-11
WO2007019308A2 (en) 2007-02-15
US7655695B2 (en) 2010-02-02
ATE527998T1 (de) 2011-10-15
EP1909783A2 (en) 2008-04-16
WO2007019308A3 (en) 2007-07-12
EP1909783B1 (en) 2011-10-12
JP2009503110A (ja) 2009-01-29
EP1909783A4 (en) 2010-08-04

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