JP4988354B2 - マイクロ流体装置における試料混合 - Google Patents

マイクロ流体装置における試料混合 Download PDF

Info

Publication number
JP4988354B2
JP4988354B2 JP2006543806A JP2006543806A JP4988354B2 JP 4988354 B2 JP4988354 B2 JP 4988354B2 JP 2006543806 A JP2006543806 A JP 2006543806A JP 2006543806 A JP2006543806 A JP 2006543806A JP 4988354 B2 JP4988354 B2 JP 4988354B2
Authority
JP
Japan
Prior art keywords
process chamber
mixing
chamber
sample
sample processing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
JP2006543806A
Other languages
English (en)
Japanese (ja)
Other versions
JP2007513757A5 (enExample
JP2007513757A (ja
Inventor
ベッディンガム，ウィリアム
ダブリュ． ロボレ，バリー
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
3M Innovative Properties Co
Original Assignee
3M Innovative Properties Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 3M Innovative Properties Co filed Critical 3M Innovative Properties Co
Publication of JP2007513757A publication Critical patent/JP2007513757A/ja
Publication of JP2007513757A5 publication Critical patent/JP2007513757A5/ja
Application granted granted Critical
Publication of JP4988354B2 publication Critical patent/JP4988354B2/ja
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/712—Feed mechanisms for feeding fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
    • B01F35/71—Feed mechanisms
    • B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
    • B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0803—Disc shape
    • B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/06—Valves, specific forms thereof
    • B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Sampling And Sample Adjustment (AREA)
JP2006543806A 2003-12-12 2004-10-20 マイクロ流体装置における試料混合 Expired - Lifetime JP4988354B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/734,682 US7837947B2 (en) 2003-12-12 2003-12-12 Sample mixing on a microfluidic device
US10/734,682 2003-12-12
PCT/US2004/034749 WO2005061084A1 (en) 2003-12-12 2004-10-20 Sample mixing on a microfluidic device

Publications (3)

Publication Number Publication Date
JP2007513757A JP2007513757A (ja) 2007-05-31
JP2007513757A5 JP2007513757A5 (enExample) 2007-12-06
JP4988354B2 true JP4988354B2 (ja) 2012-08-01

Family

ID=34653418

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2006543806A Expired - Lifetime JP4988354B2 (ja) 2003-12-12 2004-10-20 マイクロ流体装置における試料混合

Country Status (9)

Country Link
US (2) US7837947B2 (enExample)
EP (1) EP1699548B1 (enExample)
JP (1) JP4988354B2 (enExample)
CN (1) CN1890018A (enExample)
AT (1) ATE399054T1 (enExample)
AU (1) AU2004305486B2 (enExample)
CA (1) CA2548414A1 (enExample)
DE (1) DE602004014641D1 (enExample)
WO (1) WO2005061084A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7837947B2 (en) * 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
WO2007106013A1 (en) * 2006-03-13 2007-09-20 Gyros Patent Ab Enhanced magnetic particle steering
JP4593517B2 (ja) * 2006-05-15 2010-12-08 株式会社日立ハイテクノロジーズ 化学分析装置
JP4597091B2 (ja) * 2006-05-24 2010-12-15 株式会社日立ハイテクノロジーズ 生化学分析装置及びそれに用いる検査カートリッジ
US20080121591A1 (en) * 2006-11-29 2008-05-29 Canon U.S. Life Sciences, Inc. Device for nucleic acid preparation
CN101568384B (zh) * 2006-12-22 2013-05-01 3M创新有限公司 改进的样品处理装置、系统和方法
US8128893B2 (en) 2006-12-22 2012-03-06 3M Innovative Properties Company Thermal transfer methods and structures for microfluidic systems
WO2008106782A1 (en) * 2007-03-02 2008-09-12 Universite Laval Serial siphon valves for fluidic or microfluidic devices
CA2683990A1 (en) * 2007-04-25 2008-11-06 3M Innovative Properties Company Chemical component and processing device assembly
CN101668590A (zh) 2007-04-25 2010-03-10 3M创新有限公司 化学组分和处理装置组件
EP2215211A1 (en) * 2007-11-06 2010-08-11 3M Innovative Properties Company Processing device tablet
EP2133149A1 (en) * 2008-06-13 2009-12-16 F.Hoffmann-La Roche Ag Lab-on-disc device
JP5521454B2 (ja) * 2009-09-15 2014-06-11 凸版印刷株式会社 試料分析チップ、これを用いた試料分析装置及び試料分析方法
KR101951055B1 (ko) * 2010-12-16 2019-02-21 인제네론 인코포레이티드 조직 검체로부터 세포 및 세포가 풍부한 기질의 강화된 회수를 위한 방법 및 기구
KR20120091631A (ko) * 2011-02-09 2012-08-20 삼성전자주식회사 미세유동장치
USD672467S1 (en) 2011-05-18 2012-12-11 3M Innovative Properties Company Rotatable sample processing disk
KR101963721B1 (ko) 2011-05-18 2019-03-29 디아소린 에스.피.에이. 샘플 처리 장치 상의 밸빙을 위한 시스템 및 방법
AU2012255151B2 (en) 2011-05-18 2015-09-03 Diasorin Italia S.P.A. Systems and methods for detecting the presence of a selected volume of material in a sample processing device
MX336625B (es) 2011-05-18 2016-01-26 3M Innovative Properties Co Sistemas y metodos para medicion volumetrica en dispositivo de procesamiento de muestra.
KR101257700B1 (ko) * 2011-12-05 2013-04-24 삼성전자주식회사 미세유동장치 및 이를 포함하는 미세유동시스템
DE102013220257B3 (de) 2013-10-08 2015-02-19 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Vorrichtung und verfahren zur durchmischung zumindest einer flüssigkeit
CN107305210B (zh) 2016-04-20 2019-09-17 光宝电子(广州)有限公司 生物检测卡匣及其检测流体的流动方法
DE102023202639A1 (de) 2023-03-23 2024-09-26 Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. Fluidikmodul, Fluidhandhabungsvorrichtung und Verfahren mit vorübergehendem Druckausgleich in einer Pneumatikkammer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3873217A (en) * 1973-07-24 1975-03-25 Atomic Energy Commission Simplified rotor for fast analyzer of rotary cuvette type
AU4047493A (en) * 1992-04-02 1993-11-08 Abaxis, Inc. Analytical rotor with dye mixing chamber
US5627041A (en) * 1994-09-02 1997-05-06 Biometric Imaging, Inc. Disposable cartridge for an assay of a biological sample
US6143247A (en) 1996-12-20 2000-11-07 Gamera Bioscience Inc. Affinity binding-based system for detecting particulates in a fluid
US6143248A (en) 1996-08-12 2000-11-07 Gamera Bioscience Corp. Capillary microvalve
US6632399B1 (en) 1998-05-22 2003-10-14 Tecan Trading Ag Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays
EP0983504A2 (en) 1997-05-23 2000-03-08 Gamera Bioscience Corporation Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system
DE60012562D1 (de) 1999-06-18 2004-09-02 Gamera Bioscience Corp Vorrichtungen und verfahren zur durchführung miniaturisierter homogener tests
US6884395B2 (en) 2000-05-12 2005-04-26 Gyros Ab Integrated microfluidic disc
ATE329691T1 (de) * 1999-12-23 2006-07-15 Gyros Patent Ab Verfahren zur behandlung einer matrixnukleinsäure unter verwendung einer integrierten mikrofluidischen platte
JP2003533681A (ja) 2000-05-15 2003-11-11 テカン・トレーディング・アクチェンゲゼルシャフト ミクロ流体装置および細胞ベースの分析を実行する方法
US6734401B2 (en) 2000-06-28 2004-05-11 3M Innovative Properties Company Enhanced sample processing devices, systems and methods
US6627159B1 (en) 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US6919058B2 (en) 2001-08-28 2005-07-19 Gyros Ab Retaining microfluidic microcavity and other microfluidic structures
ATE477054T1 (de) 2001-09-17 2010-08-15 Gyros Patent Ab Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit
US7192560B2 (en) 2001-12-20 2007-03-20 3M Innovative Properties Company Methods and devices for removal of organic molecules from biological mixtures using anion exchange
US7837947B2 (en) 2003-12-12 2010-11-23 3M Innovative Properties Company Sample mixing on a microfluidic device
US7322254B2 (en) 2003-12-12 2008-01-29 3M Innovative Properties Company Variable valve apparatus and methods

Also Published As

Publication number Publication date
US8057757B2 (en) 2011-11-15
EP1699548B1 (en) 2008-06-25
US20050129583A1 (en) 2005-06-16
US20110027904A1 (en) 2011-02-03
AU2004305486A1 (en) 2005-07-07
WO2005061084A1 (en) 2005-07-07
DE602004014641D1 (de) 2008-08-07
CN1890018A (zh) 2007-01-03
EP1699548A1 (en) 2006-09-13
US7837947B2 (en) 2010-11-23
ATE399054T1 (de) 2008-07-15
AU2004305486B2 (en) 2010-07-15
CA2548414A1 (en) 2005-07-07
JP2007513757A (ja) 2007-05-31

Similar Documents

Publication Publication Date Title
JP4988354B2 (ja) マイクロ流体装置における試料混合
EP1284818B1 (en) Bidirectional flow centrifugal microfluidic devices
US10625258B2 (en) Microfluidic size-exclusion devices, systems, and methods
JP4225972B2 (ja) 過剰な希釈剤を有する精製カラムを備える微小流体デバイスおよび方法
US8911684B2 (en) Microfluidic element for analyzing a liquid sample
JP3699721B1 (ja) 検体試料の遠心分注方法及び遠心分注装置
US20120230887A1 (en) Devices and methods for interfacing microfluidic devices with macrofluidic devices
WO2005016532A2 (en) Automated reaction chamber system for biological assays
CA2599657A1 (en) Microfluidic valve for liquids
JP4181046B2 (ja) サンプル処理装置
JP2003533361A (ja) ミクロ流体構造での蒸着相似コーティングの使用
US20190321820A1 (en) A fluidic device for aliquoting and combinatorial mixing of liquids
US7935318B2 (en) Microfluidic centrifugation systems
CN101248356A (zh) 能减少气泡的微流测试系统
JP2013509578A (ja) 異種アッセイの洗浄方法及び装置としてのサイフォン吸引
CA2599338A1 (en) Flow switching on a multi-structured microfluidic cd (compact disc) using coriolis force
CN113773951B (zh) 一种核酸检测芯片

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20071019

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20071019

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20101214

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20110314

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20110322

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110614

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20111122

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20120221

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20120327

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20120426

R150 Certificate of patent or registration of utility model

Ref document number: 4988354

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20150511

Year of fee payment: 3

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

S111 Request for change of ownership or part of ownership

Free format text: JAPANESE INTERMEDIATE CODE: R313113

R350 Written notification of registration of transfer

Free format text: JAPANESE INTERMEDIATE CODE: R350

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

EXPY Cancellation because of completion of term