AU2004305486B2 - Sample mixing on a microfluidic device - Google Patents
Sample mixing on a microfluidic device Download PDFInfo
- Publication number
- AU2004305486B2 AU2004305486B2 AU2004305486A AU2004305486A AU2004305486B2 AU 2004305486 B2 AU2004305486 B2 AU 2004305486B2 AU 2004305486 A AU2004305486 A AU 2004305486A AU 2004305486 A AU2004305486 A AU 2004305486A AU 2004305486 B2 AU2004305486 B2 AU 2004305486B2
- Authority
- AU
- Australia
- Prior art keywords
- mixing
- process chamber
- chamber
- processing device
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 238000000034 method Methods 0.000 claims abstract description 211
- 239000000523 sample Substances 0.000 claims abstract description 176
- 238000012545 processing Methods 0.000 claims abstract description 108
- 239000012530 fluid Substances 0.000 claims abstract description 26
- 238000004891 communication Methods 0.000 claims abstract description 12
- 230000001133 acceleration Effects 0.000 claims description 7
- 239000010410 layer Substances 0.000 description 24
- 239000000463 material Substances 0.000 description 15
- 239000012792 core layer Substances 0.000 description 10
- 239000003153 chemical reaction reagent Substances 0.000 description 9
- 238000010276 construction Methods 0.000 description 7
- 238000003491 array Methods 0.000 description 5
- 230000000694 effects Effects 0.000 description 4
- -1 polypropylene Polymers 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 238000003466 welding Methods 0.000 description 3
- 239000004743 Polypropylene Substances 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000007834 ligase chain reaction Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229920001155 polypropylene Polymers 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 239000004831 Hot glue Substances 0.000 description 1
- 238000012408 PCR amplification Methods 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004820 Pressure-sensitive adhesive Substances 0.000 description 1
- 230000031018 biological processes and functions Effects 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 238000011847 diagnostic investigation Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000000670 ligand binding assay Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000002085 persistent effect Effects 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 239000010453 quartz Substances 0.000 description 1
- 230000010076 replication Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000012800 visualization Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/712—Feed mechanisms for feeding fluids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F35/00—Accessories for mixers; Auxiliary operations or auxiliary devices; Parts or details of general application
- B01F35/71—Feed mechanisms
- B01F35/717—Feed mechanisms characterised by the means for feeding the components to the mixer
- B01F35/71725—Feed mechanisms characterised by the means for feeding the components to the mixer using centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0803—Disc shape
- B01L2300/0806—Standardised forms, e.g. compact disc [CD] format
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/06—Valves, specific forms thereof
- B01L2400/0677—Valves, specific forms thereof phase change valves; Meltable, freezing, dissolvable plugs; Destructible barriers
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
- Y10T436/2575—Volumetric liquid transfer
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Clinical Laboratory Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Mixers With Rotating Receptacles And Mixers With Vibration Mechanisms (AREA)
- Mixers Of The Rotary Stirring Type (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Sampling And Sample Adjustment (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/734,682 | 2003-12-12 | ||
| US10/734,682 US7837947B2 (en) | 2003-12-12 | 2003-12-12 | Sample mixing on a microfluidic device |
| PCT/US2004/034749 WO2005061084A1 (en) | 2003-12-12 | 2004-10-20 | Sample mixing on a microfluidic device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2004305486A1 AU2004305486A1 (en) | 2005-07-07 |
| AU2004305486B2 true AU2004305486B2 (en) | 2010-07-15 |
Family
ID=34653418
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2004305486A Ceased AU2004305486B2 (en) | 2003-12-12 | 2004-10-20 | Sample mixing on a microfluidic device |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7837947B2 (enExample) |
| EP (1) | EP1699548B1 (enExample) |
| JP (1) | JP4988354B2 (enExample) |
| CN (1) | CN1890018A (enExample) |
| AT (1) | ATE399054T1 (enExample) |
| AU (1) | AU2004305486B2 (enExample) |
| CA (1) | CA2548414A1 (enExample) |
| DE (1) | DE602004014641D1 (enExample) |
| WO (1) | WO2005061084A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7837947B2 (en) * | 2003-12-12 | 2010-11-23 | 3M Innovative Properties Company | Sample mixing on a microfluidic device |
| JP2009530606A (ja) * | 2006-03-13 | 2009-08-27 | ギロス パテント アーべー | 増強型磁気粒子ステアリング |
| JP4593517B2 (ja) * | 2006-05-15 | 2010-12-08 | 株式会社日立ハイテクノロジーズ | 化学分析装置 |
| JP4597091B2 (ja) * | 2006-05-24 | 2010-12-15 | 株式会社日立ハイテクノロジーズ | 生化学分析装置及びそれに用いる検査カートリッジ |
| US20080121591A1 (en) * | 2006-11-29 | 2008-05-29 | Canon U.S. Life Sciences, Inc. | Device for nucleic acid preparation |
| CN101568385B (zh) | 2006-12-22 | 2012-08-15 | 3M创新有限公司 | 用于微流体系统的热转移方法和结构 |
| CN101568384B (zh) * | 2006-12-22 | 2013-05-01 | 3M创新有限公司 | 改进的样品处理装置、系统和方法 |
| EP2135069A4 (en) * | 2007-03-02 | 2011-03-09 | Univ Laval | SERIES SIPHON VALVES FOR FLUID OR MICRO-FLUIDIC DEVICES |
| CA2683990A1 (en) * | 2007-04-25 | 2008-11-06 | 3M Innovative Properties Company | Chemical component and processing device assembly |
| US8835157B2 (en) * | 2007-04-25 | 2014-09-16 | 3M Innovative Properties Company | Supported reagents, methods, and devices |
| EP2215211A1 (en) * | 2007-11-06 | 2010-08-11 | 3M Innovative Properties Company | Processing device tablet |
| EP2133149A1 (en) * | 2008-06-13 | 2009-12-16 | F.Hoffmann-La Roche Ag | Lab-on-disc device |
| JP5521454B2 (ja) * | 2009-09-15 | 2014-06-11 | 凸版印刷株式会社 | 試料分析チップ、これを用いた試料分析装置及び試料分析方法 |
| US8951513B2 (en) * | 2010-12-16 | 2015-02-10 | Ingeneron Incorporated | Methods and apparatus for enhanced recovery of cells and of cell-enriched matrix from tissue samples |
| KR20120091631A (ko) * | 2011-02-09 | 2012-08-20 | 삼성전자주식회사 | 미세유동장치 |
| KR20140022399A (ko) | 2011-05-18 | 2014-02-24 | 쓰리엠 이노베이티브 프로퍼티즈 컴파니 | 샘플 처리 장치 상의 체적 계량을 위한 시스템 및 방법 |
| USD672467S1 (en) | 2011-05-18 | 2012-12-11 | 3M Innovative Properties Company | Rotatable sample processing disk |
| EP2709760B1 (en) | 2011-05-18 | 2019-06-05 | DiaSorin S.p.A. | Systems and methods for valving on a sample processing device |
| AU2012255151B2 (en) | 2011-05-18 | 2015-09-03 | Diasorin Italia S.P.A. | Systems and methods for detecting the presence of a selected volume of material in a sample processing device |
| KR101257700B1 (ko) * | 2011-12-05 | 2013-04-24 | 삼성전자주식회사 | 미세유동장치 및 이를 포함하는 미세유동시스템 |
| DE102013220257B3 (de) | 2013-10-08 | 2015-02-19 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Vorrichtung und verfahren zur durchmischung zumindest einer flüssigkeit |
| CN107305210B (zh) | 2016-04-20 | 2019-09-17 | 光宝电子(广州)有限公司 | 生物检测卡匣及其检测流体的流动方法 |
| DE102023202639A1 (de) | 2023-03-23 | 2024-09-26 | Hahn-Schickard-Gesellschaft für angewandte Forschung e.V. | Fluidikmodul, Fluidhandhabungsvorrichtung und Verfahren mit vorübergehendem Druckausgleich in einer Pneumatikkammer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873217A (en) * | 1973-07-24 | 1975-03-25 | Atomic Energy Commission | Simplified rotor for fast analyzer of rotary cuvette type |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1993019827A1 (en) * | 1992-04-02 | 1993-10-14 | Abaxis, Inc. | Analytical rotor with dye mixing chamber |
| US5627041A (en) | 1994-09-02 | 1997-05-06 | Biometric Imaging, Inc. | Disposable cartridge for an assay of a biological sample |
| US6143247A (en) | 1996-12-20 | 2000-11-07 | Gamera Bioscience Inc. | Affinity binding-based system for detecting particulates in a fluid |
| US6143248A (en) | 1996-08-12 | 2000-11-07 | Gamera Bioscience Corp. | Capillary microvalve |
| US6063589A (en) | 1997-05-23 | 2000-05-16 | Gamera Bioscience Corporation | Devices and methods for using centripetal acceleration to drive fluid movement on a microfluidics system |
| US6632399B1 (en) | 1998-05-22 | 2003-10-14 | Tecan Trading Ag | Devices and methods for using centripetal acceleration to drive fluid movement in a microfluidics system for performing biological fluid assays |
| US6582662B1 (en) | 1999-06-18 | 2003-06-24 | Tecan Trading Ag | Devices and methods for the performance of miniaturized homogeneous assays |
| US6884395B2 (en) | 2000-05-12 | 2005-04-26 | Gyros Ab | Integrated microfluidic disc |
| ATE329691T1 (de) * | 1999-12-23 | 2006-07-15 | Gyros Patent Ab | Verfahren zur behandlung einer matrixnukleinsäure unter verwendung einer integrierten mikrofluidischen platte |
| EP1284817A2 (en) | 2000-05-15 | 2003-02-26 | Tecan Trading AG | Microfluidics devices and methods for performing cell based assays |
| US6734401B2 (en) | 2000-06-28 | 2004-05-11 | 3M Innovative Properties Company | Enhanced sample processing devices, systems and methods |
| US6627159B1 (en) | 2000-06-28 | 2003-09-30 | 3M Innovative Properties Company | Centrifugal filling of sample processing devices |
| US6919058B2 (en) | 2001-08-28 | 2005-07-19 | Gyros Ab | Retaining microfluidic microcavity and other microfluidic structures |
| DE60237289D1 (de) | 2001-09-17 | 2010-09-23 | Gyros Patent Ab | Einen kontrollierten strom in einer mikrofluidvorrichtung ermöglichende funktionseinheit |
| US7192560B2 (en) | 2001-12-20 | 2007-03-20 | 3M Innovative Properties Company | Methods and devices for removal of organic molecules from biological mixtures using anion exchange |
| US7837947B2 (en) | 2003-12-12 | 2010-11-23 | 3M Innovative Properties Company | Sample mixing on a microfluidic device |
| US7322254B2 (en) | 2003-12-12 | 2008-01-29 | 3M Innovative Properties Company | Variable valve apparatus and methods |
-
2003
- 2003-12-12 US US10/734,682 patent/US7837947B2/en active Active
-
2004
- 2004-10-20 AU AU2004305486A patent/AU2004305486B2/en not_active Ceased
- 2004-10-20 CN CNA2004800368592A patent/CN1890018A/zh active Pending
- 2004-10-20 AT AT04795855T patent/ATE399054T1/de not_active IP Right Cessation
- 2004-10-20 WO PCT/US2004/034749 patent/WO2005061084A1/en not_active Ceased
- 2004-10-20 DE DE602004014641T patent/DE602004014641D1/de not_active Expired - Lifetime
- 2004-10-20 CA CA002548414A patent/CA2548414A1/en not_active Abandoned
- 2004-10-20 JP JP2006543806A patent/JP4988354B2/ja not_active Expired - Lifetime
- 2004-10-20 EP EP04795855A patent/EP1699548B1/en not_active Expired - Lifetime
-
2010
- 2010-10-12 US US12/902,489 patent/US8057757B2/en not_active Expired - Lifetime
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3873217A (en) * | 1973-07-24 | 1975-03-25 | Atomic Energy Commission | Simplified rotor for fast analyzer of rotary cuvette type |
Also Published As
| Publication number | Publication date |
|---|---|
| EP1699548A1 (en) | 2006-09-13 |
| JP4988354B2 (ja) | 2012-08-01 |
| AU2004305486A1 (en) | 2005-07-07 |
| EP1699548B1 (en) | 2008-06-25 |
| DE602004014641D1 (de) | 2008-08-07 |
| CA2548414A1 (en) | 2005-07-07 |
| ATE399054T1 (de) | 2008-07-15 |
| WO2005061084A1 (en) | 2005-07-07 |
| US20050129583A1 (en) | 2005-06-16 |
| CN1890018A (zh) | 2007-01-03 |
| US20110027904A1 (en) | 2011-02-03 |
| US7837947B2 (en) | 2010-11-23 |
| US8057757B2 (en) | 2011-11-15 |
| JP2007513757A (ja) | 2007-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FGA | Letters patent sealed or granted (standard patent) | ||
| MK14 | Patent ceased section 143(a) (annual fees not paid) or expired |