JP4981681B2 - 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 - Google Patents

哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 Download PDF

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JP4981681B2
JP4981681B2 JP2007545671A JP2007545671A JP4981681B2 JP 4981681 B2 JP4981681 B2 JP 4981681B2 JP 2007545671 A JP2007545671 A JP 2007545671A JP 2007545671 A JP2007545671 A JP 2007545671A JP 4981681 B2 JP4981681 B2 JP 4981681B2
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sequence
seq
oligonucleotide
pharmaceutical composition
agent
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JP2008523094A (ja
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ハルトマン、グンター
ホルヌング、ファイト
エンドレス、シュテファン
フォージロールズ、アントニン デ
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Alnylam Pharmaceuticals Inc
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    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
    • C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA

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JP2007545671A 2004-12-09 2005-12-09 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法 Expired - Lifetime JP4981681B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US63484904P 2004-12-09 2004-12-09
US60/634,849 2004-12-09
PCT/US2005/044662 WO2006063252A2 (en) 2004-12-09 2005-12-09 Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas

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JP2011221109A Division JP2012031191A (ja) 2004-12-09 2011-10-05 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法

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JP2008523094A JP2008523094A (ja) 2008-07-03
JP2008523094A5 JP2008523094A5 (https=) 2011-11-24
JP4981681B2 true JP4981681B2 (ja) 2012-07-25

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JP2007545671A Expired - Lifetime JP4981681B2 (ja) 2004-12-09 2005-12-09 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法
JP2011221109A Pending JP2012031191A (ja) 2004-12-09 2011-10-05 哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉ｒｎａなどのオリゴヌクレオチド剤に対する免疫応答の回避方法

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US (2) US8003619B2 (https=)
EP (1) EP1819365B1 (https=)
JP (2) JP4981681B2 (https=)
AU (1) AU2005313883B2 (https=)
CA (1) CA2589406A1 (https=)
WO (1) WO2006063252A2 (https=)

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US20060217330A1 (en) 2006-09-28
CA2589406A1 (en) 2006-06-15
US8003619B2 (en) 2011-08-23
WO2006063252A3 (en) 2009-04-30
EP1819365A4 (en) 2010-08-25
AU2005313883B2 (en) 2011-03-31
WO2006063252A2 (en) 2006-06-15
JP2008523094A (ja) 2008-07-03
US20120045461A1 (en) 2012-02-23
AU2005313883A1 (en) 2006-06-15
EP1819365B1 (en) 2014-07-02
EP1819365A2 (en) 2007-08-22

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