JP4981442B2 - 抗疲労組成物 - Google Patents
抗疲労組成物 Download PDFInfo
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- JP4981442B2 JP4981442B2 JP2006513012A JP2006513012A JP4981442B2 JP 4981442 B2 JP4981442 B2 JP 4981442B2 JP 2006513012 A JP2006513012 A JP 2006513012A JP 2006513012 A JP2006513012 A JP 2006513012A JP 4981442 B2 JP4981442 B2 JP 4981442B2
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- coenzyme
- carnitine
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- CMWTZPSULFXXJA-VIFPVBQESA-N naproxen Chemical compound C1=C([C@H](C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-N 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 239000013110 organic ligand Substances 0.000 description 1
- 235000006408 oxalic acid Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 229960000649 oxyphenbutazone Drugs 0.000 description 1
- HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000006072 paste Substances 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 229960002895 phenylbutazone Drugs 0.000 description 1
- VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 1
- 235000021110 pickles Nutrition 0.000 description 1
- 235000015108 pies Nutrition 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229960003101 pranoprofen Drugs 0.000 description 1
- 229960002800 prednisolone acetate Drugs 0.000 description 1
- DGYSDXLCLKPUBR-SLPNHVECSA-N prednisolone valerate acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(C)=O)(OC(=O)CCCC)[C@@]1(C)C[C@@H]2O DGYSDXLCLKPUBR-SLPNHVECSA-N 0.000 description 1
- 229950008480 prednisolone valerate acetate Drugs 0.000 description 1
- 235000013324 preserved food Nutrition 0.000 description 1
- FYPMFJGVHOHGLL-UHFFFAOYSA-N probucol Chemical compound C=1C(C(C)(C)C)=C(O)C(C(C)(C)C)=CC=1SC(C)(C)SC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 FYPMFJGVHOHGLL-UHFFFAOYSA-N 0.000 description 1
- 229960003912 probucol Drugs 0.000 description 1
- 235000020991 processed meat Nutrition 0.000 description 1
- 235000019260 propionic acid Nutrition 0.000 description 1
- 150000005599 propionic acid derivatives Chemical class 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 229940058287 salicylic acid derivative anticestodals Drugs 0.000 description 1
- 150000003872 salicylic acid derivatives Chemical class 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000004208 shellac Substances 0.000 description 1
- 235000013874 shellac Nutrition 0.000 description 1
- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 1
- 229940113147 shellac Drugs 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 235000011888 snacks Nutrition 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229940001607 sodium bisulfite Drugs 0.000 description 1
- 239000012279 sodium borohydride Substances 0.000 description 1
- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical class O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000001384 succinic acid Substances 0.000 description 1
- 229960000894 sulindac Drugs 0.000 description 1
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 229960002871 tenoxicam Drugs 0.000 description 1
- WZWYJBNHTWCXIM-UHFFFAOYSA-N tenoxicam Chemical compound O=C1C=2SC=CC=2S(=O)(=O)N(C)C1=C(O)NC1=CC=CC=N1 WZWYJBNHTWCXIM-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960002905 tolfenamic acid Drugs 0.000 description 1
- YEZNLOUZAIOMLT-UHFFFAOYSA-N tolfenamic acid Chemical compound CC1=C(Cl)C=CC=C1NC1=CC=CC=C1C(O)=O YEZNLOUZAIOMLT-UHFFFAOYSA-N 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- SOECUQMRSRVZQQ-UHFFFAOYSA-N ubiquinone-1 Chemical compound COC1=C(OC)C(=O)C(CC=C(C)C)=C(C)C1=O SOECUQMRSRVZQQ-UHFFFAOYSA-N 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 229920003169 water-soluble polymer Polymers 0.000 description 1
- 239000008256 whipped cream Substances 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/075—Ethers or acetals
- A61K31/085—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon
- A61K31/09—Ethers or acetals having an ether linkage to aromatic ring nuclear carbon having two or more such linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Description
[1] (a)下記式(1);
(b)カルニチンまたはその誘導体、
を含む、哺乳動物の抗疲労組成物。
[2] 補酵素Qが補酵素Q10である、[1]の哺乳動物の抗疲労組成物。
[3] [1]の抗疲労組成物、および医薬または食品として許容される担体を含む、医薬または食品用の組成物。
[4] さらに抗酸化剤を含む[3]の組成物。
[5] 抗酸化剤が、ビタミンC、ビタミンC誘導体、リコペン、ビタミンA、カロテノイド類、ビタミンB、ビタミンB誘導体、フラボノイド類、ポリフェノール類、グルタチオン、セレン、チオ硫酸ナトリウム、ビタミンE、ビタミンE誘導体、ピクノジェノール、プラバンジェノール、ピロロキノリンキノン、ピロロキノリンキノン誘導体、スーパーオキサイドディスムターゼ(SOD)、グルタチオンペルオキシダーゼ、グルタチオン−S−トランスフェラーゼ、グルタチオン還元酵素、カタラーゼ、およびアスコルビン酸ペルオキシダーゼからなる群より選択される、[4]の組成物。
[6] 哺乳動物対象の疲労を予防または処置する方法であって、[1]ないし[5]いずれか抗疲労組成物の有効量を、該哺乳動物対象に投与することを含む方法。
[7] 抗疲労組成物の製造方法であって、
(a)下記式(1);
(b)カルニチンまたはその誘導体、
を混合すること、を含む方法。
[8] (a)下記式(1);
(b)カルニチンまたはその誘導体、
を混合して製造され得る、哺乳動物の抗疲労組成物。
1000gのエタノール中に、100gの酸化型補酵素Q10(純度99.4%)、60gのL−アスコルビン酸を加え、78℃にて攪拌し、還元反応を行った。30時間後、50℃まで冷却し、同温を保持しながらエタノール330gと水70g添加した。このエタノール溶液(還元型補酵素Q10を100gを含む)を攪拌しながら、10℃/時間の冷却速度で2℃まで冷却し、白色のスラリーを得た。得られたスラリーを減圧濾過し、湿結晶を冷エタノール、冷水、冷エタノールで順に洗浄(洗浄に用いた冷溶媒の温度は2℃)して、さらに湿結晶を減圧乾燥(20〜40℃、1〜30mmHg)することにより、白色の乾燥結晶97gを得た。減圧乾燥を除く全ての操作は窒素雰囲気下で実施した。
100gの酸化型補酵素Q10を25℃で1000gのヘプタン溶液に溶解させた。攪拌しながら、還元剤として次亜硫酸ナトリウム(純度75%以上)100gに1000mlの水を加えて溶解させた水溶液を徐々に添加し、25℃、pH4〜6で還元反応を行った。2時間後、反応液から水相を除去し、脱気した飽和食塩水1000gでヘプタン相を6回水洗した。以上、すべての操作は窒素雰囲気下で実施した。このヘプタン相を減圧下にて溶媒置換し、50℃の還元型補酵素Q10の7%(w/w)エタノール溶液を調製した(還元型補酵素Q10を100g含む)。このエタノール溶液に水50gを添加し、攪拌しながら、10℃/時間の冷却速度で2℃まで冷却して結晶を析出させた。全ての操作は窒素雰囲気下で実施した。得られたスラリーを減圧濾過し、湿結晶を冷エタノール、冷水、冷エタノールで順に洗浄(洗浄に用いた冷溶媒の温度は2℃)して、さらに、湿結晶を減圧乾燥(20〜40℃、1〜30mmHg)することにより、白色の乾燥結晶97gを得た。
SD系雄性ラット(7〜10週齢、n=20)を用いて還元型補酵素Q10(約2%の酸化型補酵素Q10を含有する)単独、カルニチン単独および還元型補酵素Q10とカルニチンの併用による抗疲労効果をトレッドミルにより評価した。即ち、トレッドミル装置(型式NK−73−4、夏目製作所)を用いて、ラットを10m/minの速度で走行させ、3分毎に5m/minずつ段階的に速度を上げていき、ラットが走行不能となるまでの時間(最大走行時間)を測定した。
被験物質として、還元型補酵素Q10(但し、約2%の酸化型補酵素Q10を含む)またはカルニチンの0.5%カルボキシメチルセルロースナトリウム(CMC−Na)水溶液(還元型補酵素Q10またはカルニチン/CMC−Na=10mg/ml)を作製し、100mg/kgの投与量で、ラットに経口投与した。ラットは4群に分け、溶媒投与群、還元型補酵素Q10単独投与群、カルニチン単独投与群、および還元型補酵素Q10とカルニチンの併用群とした。最大走行時間は、投与前および投与3時間後に測定し、最大走行時間の延長時間を算出した。対照群には、0.5%CMC−Na水溶液を投与した。
SD系雄性ラット(7〜10週齢、n=15)を用いて酸化型補酵素Q10とカルニチンの併用および還元型補酵素Q10とカルニチンの併用による抗疲労効果を、実施例1と同様に評価した。
オリーブオイルを60℃に加温し、同様に60℃で溶融した補酵素Q10(還元型補酵素Q10:酸化型補酵素Q10=85:15)及びL−カルニチンを加えた。これにビタミンEを少しずつ加えて均質とし、常法によりソフトカプセル化した。1カプセル中に補酵素Q10として20mg、L−カルニチンとして20mgを含有するソフトカプセル製剤を得た。
L−カルニチン 20重量部
ビタミンE 15重量部
オリーブ油 350重量部
補酵素Q10(還元型補酵素Q10:酸化型補酵素Q10=85:15)及びL−カルニチンをアセトンに加え、次いでこれを結晶セルロース(微粉末)に吸着させた後、乾燥した。これをコーンスターチと混合し、常法により散剤とした。
L−カルニチン 10重量部
結晶セルロース 40重量部
コーンスターチ 55重量部
補酵素Q10(還元型補酵素Q10:酸化型補酵素Q10=85:15)及びL−カルニチンをアセトンに加え、次いでこれを結晶セルロース(微粉末)に吸着させた後、乾燥した。これにコーンスターチ、乳糖、カルボキシメチルセルロース、ステアリン酸マグネシウムを混合し、次いでポリビニルピロリドンの水溶液を結合剤として加えて常法により顆粒化した。これに滑沢剤としてタルクを加えて混合した後、1錠に補酵素Q10を20mg、L−カルニチンを20mg含有する錠剤に打錠した。
L−カルニチン 20重量部
コーンスターチ 25重量部
乳糖 15重量部
カルボキシメチルセルロースカルシウム 10重量部
結晶セルロース 40重量部
ポリビニルピロリドン 5重量部
ステアリン酸マグネシウム 3重量部
タルク 10重量部
下記成分を常法により顆粒化した後、ゼラチン硬カプセルに充填した。1カプセル中に補酵素Q10を20mg、L−カルニチンを20mg含有するカプセル剤を得た。
(還元型補酵素Q10:酸化型補酵素Q10=85:15)
L−カルニチン 20重量部
結晶セルロース 40重量部
コーンスターチ 20重量部
乳糖 62重量部
ステアリン酸マグネシウム 2重量部
ポリビニルピロリドン 3重量部
Claims (5)
- 補酵素Qが補酵素Q10である、請求項1の組成物。
- さらに抗酸化剤を含む請求項1または2の組成物。
- 抗酸化剤が、ビタミンC、リコペン、ビタミンA、カロテノイド類、ビタミンB、フラボノイド類、ポリフェノール類、グルタチオン、セレン、チオ硫酸ナトリウム、ビタミンE、ピクノジェノール、プラバンジェノール、ピロロキノリンキノン、スーパーオキサイドディスムターゼ(SOD)、グルタチオンペルオキシダーゼ、グルタチオン−S−トランスフェラーゼ、グルタチオン還元酵素、カタラーゼ、およびアスコルビン酸ペルオキシダーゼからなる群より選択される、請求項3の組成物。
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JP2004263225 | 2004-09-10 | ||
PCT/JP2005/008422 WO2005107737A1 (ja) | 2004-05-11 | 2005-05-09 | 抗疲労組成物 |
JP2006513012A JP4981442B2 (ja) | 2004-05-11 | 2005-05-09 | 抗疲労組成物 |
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US (1) | US20070293572A1 (ja) |
EP (1) | EP1747778B1 (ja) |
JP (1) | JP4981442B2 (ja) |
KR (1) | KR20070024582A (ja) |
AT (1) | ATE485038T1 (ja) |
AU (1) | AU2005239931A1 (ja) |
CA (1) | CA2566083A1 (ja) |
DE (1) | DE602005024255D1 (ja) |
TW (1) | TW200603786A (ja) |
WO (1) | WO2005107737A1 (ja) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2006117626A (ja) * | 2004-09-24 | 2006-05-11 | Nisshin Pharma Inc | コエンザイムq10配合組成物の製造方法 |
WO2012020767A1 (ja) * | 2010-08-09 | 2012-02-16 | 三菱瓦斯化学株式会社 | ピロロキノリンキノンのゲル |
EP2694051B1 (en) * | 2011-04-05 | 2022-10-26 | Lonza Ltd | Use of l-carnitine and salts thereof for reducing or preventing fatigue and improving cognitive function |
EP2508179A1 (en) * | 2011-04-05 | 2012-10-10 | Lonza Ltd. | Use of L-Carnitine, salts and derivatives thereof for reducing or preventing fatigue and improving cognitive function |
KR101669362B1 (ko) * | 2015-01-21 | 2016-10-26 | 주식회사 엘지생활건강 | 발효 태반 조성물을 유효성분으로 하는 면역 증강 또는 항피로 조성물과 그의 용도 |
CN108514114A (zh) * | 2018-03-27 | 2018-09-11 | 西安交通大学 | 基于线粒体营养素理论的缓解体力疲劳的组合物及用途 |
CN114468196A (zh) * | 2022-03-02 | 2022-05-13 | 中国人民解放军北部战区总医院 | 一种复方多维辅酶q10泡腾片及其制备方法 |
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JPS5942649B2 (ja) | 1976-02-14 | 1984-10-16 | エーザイ株式会社 | 重症筋無力症治療剤 |
JPS5938204B2 (ja) | 1976-02-14 | 1984-09-14 | エーザイ株式会社 | 再生不良性貧血治療剤 |
CH666184A5 (it) | 1985-08-06 | 1988-07-15 | Seuref Ag | Composizione farmaceutica orale a base di ubichinoni. |
JPH07330584A (ja) | 1994-06-08 | 1995-12-19 | Taisho Pharmaceut Co Ltd | 疲労改善剤 |
JPH07330593A (ja) | 1994-06-09 | 1995-12-19 | Taisho Pharmaceut Co Ltd | 疲労改善剤 |
JP3889481B2 (ja) * | 1996-08-16 | 2007-03-07 | 株式会社カネカ | 医薬組成物 |
NZ338026A (en) * | 1997-03-27 | 2001-09-28 | Michael J Sole | Nutritional composition comprising L-carnitine, ubiquione and taurine and use for treating organ systems |
US6232346B1 (en) * | 1997-03-27 | 2001-05-15 | Michael J. Sole | Composition for improvement of cellular nutrition and mitochondrial energetics |
JPH10287560A (ja) | 1997-04-11 | 1998-10-27 | Taisho Pharmaceut Co Ltd | 医薬組成物 |
US8753675B1 (en) * | 2000-01-20 | 2014-06-17 | Raj K. Chopra | Reduced form of Coenzyme Q in high bioavailability stable dosage forms and related applications |
US6664287B2 (en) * | 2000-03-15 | 2003-12-16 | Bethesda Pharmaceuticals, Inc. | Antioxidants |
JP2003119127A (ja) * | 2001-10-10 | 2003-04-23 | Kanegafuchi Chem Ind Co Ltd | 安定な還元型補酵素q製剤 |
TW200302055A (en) * | 2002-01-18 | 2003-08-01 | Kaneka Corp | Ubiquinol-enriched fat-containing foods |
TWI322008B (en) * | 2003-01-31 | 2010-03-21 | Kaneka Corp | Fatigue improving agent including reduced coenzyme q10 |
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- 2005-05-09 JP JP2006513012A patent/JP4981442B2/ja active Active
- 2005-05-09 DE DE602005024255T patent/DE602005024255D1/de active Active
- 2005-05-09 EP EP05737195A patent/EP1747778B1/en active Active
- 2005-05-09 WO PCT/JP2005/008422 patent/WO2005107737A1/ja active Application Filing
- 2005-05-09 AU AU2005239931A patent/AU2005239931A1/en not_active Abandoned
- 2005-05-09 US US11/596,059 patent/US20070293572A1/en not_active Abandoned
- 2005-05-09 KR KR1020067025977A patent/KR20070024582A/ko not_active Application Discontinuation
- 2005-05-09 CA CA002566083A patent/CA2566083A1/en not_active Abandoned
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Also Published As
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JPWO2005107737A1 (ja) | 2008-03-21 |
EP1747778A4 (en) | 2007-10-31 |
EP1747778A1 (en) | 2007-01-31 |
AU2005239931A1 (en) | 2005-11-17 |
WO2005107737A1 (ja) | 2005-11-17 |
EP1747778B1 (en) | 2010-10-20 |
US20070293572A1 (en) | 2007-12-20 |
CA2566083A1 (en) | 2005-11-17 |
KR20070024582A (ko) | 2007-03-02 |
TW200603786A (en) | 2006-02-01 |
DE602005024255D1 (de) | 2010-12-02 |
ATE485038T1 (de) | 2010-11-15 |
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