JP4980597B2 - Solids containing processed kuzuhana - Google Patents

Description

  The present invention relates to a kuzuka solid comprising a kuzuka processed product and at least one sugar selected from the group consisting of sugar alcohol and two or more sugars (hereinafter sometimes referred to as “specific sugar”). About. Furthermore, the present invention relates to a method for preventing deliquescence of solids containing processed kuzu flowers.

  Kuzu is a large vine plant of the legume family, and katsu starch collected from its roots has long been used as a raw material for Japanese confectionery. The roots and flowers are referred to as kudzu and kuzuka, respectively, and are used as raw materials for traditional Chinese medicines such as antipyretic drugs, analgesics, antispasmodics, and drugs for symptoms such as sweating. In particular, unlike other legumes, Kuzuka has been shown to have various effects such as an action for improving liver damage, an action for preventing hangover, and an action for improving urinary nitrogen metabolism (Patent Documents 1 to 3). .

As described above, Katsuhana uses the dried product itself or the dried powder of the extract as a raw material for Chinese medicine. However, the dried powder of Kuzuka dried product and Kuzuka extract have deliquescence. Therefore, it is difficult to use these dried Kuzuka products as solids (powder, granules, etc.), even though they contain various components that may be useful. The form is limited to liquids such as beverages.
Japanese Patent No. 3454718 Japanese Patent Publication No. 8-32632 JP-A 64-68318

  The object of the present invention is to prevent the processed kuzu flower (especially, dried kuzu flower and dried katsu flower extract) from deliquescent, and thus a solid material containing the kuzu flower processed product, for example, a granulated product. There is in getting.

  The present inventor examined the measures for preventing the deliquescent of the kuzu flower treatment product, and by using the kuzu flower treatment product and a specific saccharide in combination, the deliquesce of the kuzu flower treatment product is prevented and excellent in storage stability. It was found that a solid was obtained.

  The present invention provides a kuzuka solid, comprising a kuzuka processed product and at least one sugar selected from the group consisting of sugar alcohols and disaccharides or more.

  Furthermore, the present invention provides a method for preventing deliquescence of a solid containing a kuzu flower treatment product, and the method comprises at least one selected from the group consisting of sugar alcohols and sugars of two or more sugars. The step of adding the sugar.

  According to the present invention, it is possible to prevent deliquescence of a solid material containing the processed kuzu flower. As a result, since it has excellent storage stability, a solid (eg, a granulated product such as a powder, a tablet, or a granule) containing a processed kuzu flower product that can be easily used can be obtained.

(Katsuhana treatment product)
Kuzuka, the flower part of Kuzu, contains flavonoids, saponins, and tryptophan glycosides. In the present specification, “Kuzuhana” refers to a flower collected at the stage from the bud to the fully opened flower. In the present invention, it is particularly preferable to use soot.

  In the present specification, the “Kuzuhana processed product” refers to a product obtained by subjecting Kuzuka to at least one of a drying process, a pulverizing process, and an extracting process.

  In the present specification, particularly when it is described as “dried kuzuka”, it means a product obtained by drying kuzuka, a dry powder obtained by crushing kuzuka after drying, and the following kuzuka Contains no extract.

  In the present specification, when particularly described as “Kuzuhana extract”, the extract of Kuzuka, the extract extracted from Kuzuka, the concentrate or the concentrate obtained by concentrating the extract, these juice Or the dry powder (extract powder) etc. which are obtained by drying an extract.

  Hereinafter, a method for preparing a kuzu flower dried product, kuzu flower powder (dry powder and extract powder), and a kuzu flower extract, which are processed kuzu flowers, will be described.

  The dried kuzu flower is obtained by drying kuzu flowers, preferably kuzu flowers in the cocoon stage, by sun drying, hot air drying or the like. Preferably, it is dried until the water content is 10% by mass or less.

  Kuzuka powder (dry powder) is obtained by pulverizing the dried Kuzuka product. The powderization is performed by a method commonly used by those skilled in the art, for example, a ball mill, a hammer mill, a roller mill or the like.

  Alternatively, the Kuzuka powder (dried powder) is obtained by crushing the collected Kuzuka using a mass colloider, a slicer, a Komitrol, etc. to obtain a Kuzuka crushed product, and drying the Kuzuka crushed product. .

  The kuzu flower extract is prepared by adding a solvent to a kuzu flower dried product such as kuzu flower, kuzu flower crushed product, kuzu flower dried product, or kuzu flower powder (dried powder), preferably kuzu flower dried powder, for example. Accordingly, the extraction is performed by heating, and the extract is collected by centrifugation or filtration.

  Examples of the solvent that can be used to obtain the Kuzuhana extract include water, organic solvents, and hydrous organic solvents. Examples of the organic solvent include methanol, ethanol, n-propanol, n-butanol, acetone, hexane, cyclohexane, propylene glycol, ethyl methyl ketone, glycerin, methyl acetate, ethyl acetate, diethyl ether, dichloromethane, edible oils and fats, 1, Examples include 1,1,2-tetrafluoroethane, 1,1,2-trichloroethene and the like. Among these, a polar organic solvent is preferable, ethanol, n-butanol, methanol, acetone, propylene glycol, and ethyl acetate are more preferable, and ethanol is most preferable.

  Examples of the extraction method include a warm extraction method such as heating reflux, a supercritical extraction method, and the like. In these extraction methods, heating may be performed by applying pressure as necessary. When heating, it is necessary to prevent the solvent added to Kuzuka from volatilizing. When heating, the extraction temperature is preferably 50 ° C. or higher, more preferably 70 ° C. or higher, preferably 130 ° C. or lower, more preferably 100 ° C. or lower.

  The extraction time may be a time for sufficiently extracting soluble components from the extraction raw material, and may be set as appropriate according to the extraction temperature and the like. Preferably, it is 30 minutes to 48 hours. For example, when the extraction temperature is less than 50 ° C, it is preferably 6 hours to 48 hours, and when it is 50 ° C or more, it is preferably 30 minutes to 24 hours.

  The obtained extract may be concentrated or dried by a method such as concentration under reduced pressure or freeze-drying, if necessary, to form a liquid, a paste, or a powder (extract powder).

(Sugar alcohol and disaccharide or higher sugar (specific sugar))
In the present specification, “sugar alcohol” widely refers to a polyhydric alcohol obtained by reducing a carbonyl group of a sugar molecule. Examples of the sugar alcohol used in the present invention include erythritol, pentitol, hexitol, xylitol, sorbitol, reduced palatinose, maltitol (reduced maltose), lactitol, mannitol and the like.

  Examples of the saccharides higher than the disaccharide used in the present invention include disaccharides, oligosaccharides, and polysaccharides. Examples of disaccharides include trehalose type disaccharides such as trehalose and sucrose (disaccharides in which carbon atoms having reducing groups of both constituent monosaccharides are ether-linked) and maltose type disaccharides such as maltose, cellobiose, gentiobiose, and lactose. (A disaccharide having an ether bond between a carbon atom having a reducing group of the first monosaccharide and a carbon atom having no reducing group of the second monosaccharide). Examples of the oligosaccharide include isomaltooligosaccharide, fructooligosaccharide, galactooligosaccharide, palatinose, maltooligosaccharide, dairy oligosaccharide, and xylo-oligosaccharide. Examples of polysaccharides include homopolysaccharides composed of one kind of constituent sugar, heteropolysaccharides composed of two or more kinds of constituent sugars, neutral polysaccharides, acidic polysaccharides, glycosaminoglycans, dextrins, starches, amylose, amylopectin, and cellulose. Can be mentioned.

  These specific saccharides have a chain structure (such as maltose, amylose, cellulose), a branched structure (such as amylopectin), and a cyclic structure (such as cyclodextrin). In the present invention, the structure of the specific saccharide is not limited, and a specific saccharide having a chain structure and a branched structure is particularly preferable. Furthermore, in the present invention, it is preferable to use a specific water-soluble saccharide.

(Other additives)
The kuzuhana solids of the present invention may contain additives such as excipients, extenders, binders, thickeners, emulsifiers, colorants, fragrances, other food ingredients, seasonings, and pharmaceutical ingredients as necessary. You may contain. Examples of additives include royal jelly, propolis, vitamins (A, B ₁ , B ₂ , B ₆ , B ₁₂ , niacin, C, D, E, K, folic acid, pantothenic acid, biotin, derivatives thereof, etc.) , Minerals (iron, magnesium, calcium, zinc, selenium, etc.), chitin / chitosan, lecithin, polyphenols (flavonoids, derivatives thereof, etc.), carotenoids (lycopene, astaxanthin, zeaxanthin, lutein, etc.), xanthine derivatives (caffeine, etc.) ), Fatty acids, proteins (collagen, elastin, etc.), mucopolysaccharides (hyaluronic acid, chondroitin, dermatan, heparan, heparin, ketalan, salts thereof, etc.), amino sugars (glucosamine, acetylglucosamine, galactosamine, acetylgalactosamine) , Neuraminic acid, acetylneuraminic acid, hexosamine, and salts thereof), phospholipids and derivatives thereof (phosphatidylcholine, sphingomyelin, ceramide, etc.), sulfur-containing compounds (eg, alliin, sepaene, taurine, glutathione, methylsulfonylmethane), Examples include lignans (such as sesamin), animal and plant extracts containing these, and root vegetables (such as turmeric and ginger).

(Katsuhana solids)
The Kuzuka solid of the present invention contains the Kuzuka processed product and the specific saccharide, and if necessary, contains additives and the like.

  In the Kuzuka solid material of the present invention, the Kuzuka treatment product is contained in a proportion of preferably 5 to 80 mass%, more preferably 10 to 70 mass% in terms of dry mass.

  The specific saccharide used in the present invention is preferably 0.3 to 4 parts by mass, more preferably 1 part by mass with respect to 1 part by mass of the Kuzuka process product, from the viewpoint of the effect of preventing or suppressing the deliquescence of the Kuzuka process product. It is good to set it as 0.4-3 mass parts.

  When the Kuzuka solid of the present invention is a granulated product, a generally used granulation method may be used as the granulation method of the granulated product. Examples of such granulation methods include, for example, rolling granulation method, mixed stirring granulation method, extrusion granulation method, fluidized bed granulation method, emulsion granulation method, granulation method using fluidized granulation spray dryer , Coating granulation method, compression granulation method, crushing granulation method and the like. The Kuzuka solids of the present invention include powders, tablets and the like in addition to the granules obtained by these methods.

  The kuzu flower solids of the present invention are superior in storage stability because deliquescence is prevented compared to kuzu flower solids not containing specific sugars. Therefore, the kuzuka solid of the present invention can be easily ingested as a food or the like, and the components contained in kuzuka can be efficiently ingested. By ingesting the Kuzuka solids of the present invention, effects such as improvement of liver damage, beautiful skin, improvement of alcohol metabolism, prevention of hangover can be expected.

(Method to prevent deliquescence)
The method for preventing deliquescence of the present invention is a method for preventing deliquescence of a kuzu flower treatment product by adding the specific sugar to a solid containing the kuzu flower treatment product.

  If the specific sugar is added to the solid material containing the processed kuzu flower product, the deliquescent of the processed kuzu flower product is prevented, so that the storage stability of the solid material is improved.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to this range.

(Example 1: Production of granulated product)
A kneaded product was obtained by kneading 75 parts by weight of Kuzuhana extract (extract powder: manufactured by Ota Gakusan), 15 parts by weight of water, 5 parts by weight of ethanol, and 5 parts by weight of reduced maltose. Subsequently, the obtained kneaded material was extruded using an extrusion granulator (screw type extrusion granulator: manufactured by Fuji Powder Co., Ltd.). The hole diameter of the extrusion granulator was 7 mm, and the extruded molded product was cut with a cutter so as to have a length of about 10 mm. Subsequently, the cut molding was dried at 65 degreeC for 15 hours using the shelf-type dryer, and the granulated material was prepared. The moisture content of the granulated product was 3% by mass or less.

(Example 2: Production of granulated product)
A granulated product was prepared in the same procedure as in Example 1 except that 5 parts by mass of trehalose was used instead of reduced maltose.

(Comparative Example 1)
A granulated product was prepared in the same procedure as in Example 1 except that reduced maltose was not used.

(Example 3: Verification of deliquescence)
In order to verify the deliquescence of the granules prepared in Examples 1 and 2 and Comparative Example 1, each granulated product was stored in a thermo-hygrostat (40 ° C., relative humidity 75%) for 24 hours.

  The granulated products of Examples 1 and 2 were in a relatively good state, although some moisture was absorbed. On the other hand, the granulated product of Comparative Example 1 was not only deliquescent but also discolored dramatically. Therefore, it was found that the granulated materials of Examples 1 and 2 were prevented from deliquescent.

(Example 4: Verification of granule production and storage stability)
A mixed powder was prepared with the blending amounts shown in Table 1 using kuzuhana extract (extract powder: manufactured by Ota Gasakusan), crystalline cellulose, reduced maltose, trehalose, isomaltoligosaccharide, and fructose. Next, fluidized bed granulation was performed using the obtained powders to prepare granules 1 to 4.

  Next, each of granules 1 to 4 was packaged in aluminum pouches in an amount of 3 g, and 6 capsules were prepared. Three of the six packages were stored at 50 ° C. and 75% humidity for 2 weeks (condition 1). The remaining 3 packets were stored in a cool dark room at 4 ° C. for 2 weeks (referred to as condition 2). Two weeks later, the state of the granules packaged in each aluminum pouch was observed and judged according to the following criteria. The results are shown in Table 1. The score in Table 1 is the total score for each granule capsule of Condition 1. In condition 2, water absorption and discoloration were not observed in any of the granules.

<Criteria>
Comparison between condition 2 and condition 1 shows no change: 2 points Condition 1 shows only water absorption compared to condition 2 (no discoloration): 1 point Discoloration is seen: 0 points

  As shown in Table 1, the granules 1 to 3 containing the kuzuka processed product and the specific sugar are stored in each of the conditions 1 and 2 as compared with the granule 4 containing the kuzuka processed product and the monosaccharide. When the states after the comparison were compared, the storage stability was excellent because of little change. That is, it was found that by combining a kuzu flower processed product and a specific sugar, a kuzu flower solid (granule) excellent in storage stability can be obtained.

(Example 5: Production of tablets and verification of storage stability)
Tablets 1-5 with the compounding amounts shown in Table 2 using the kuzu flower extract, crystalline cellulose, sucrose ester, maltose, erythritol, palatinose, fructooligosaccharide, and a mixture of fructose and glucose used in Example 1. Was prepared.

  Next, tablets 1 to 5 were each packaged in 3 aluminum pouches, and 6 tablets were prepared. Next, in the same manner as in Example 4, three of the six packages were stored at 50 ° C. and 75% humidity for 2 weeks (condition 1). The remaining 3 packets were stored in a cool dark room at 4 ° C. for 2 weeks (condition 2). Two weeks later, each tablet was determined based on the same criteria as in Example 4, one tablet at a time. The results are shown in Table 2. The score in Table 2 is the total score for each tablet of Condition 1. In condition 2, water absorption and discoloration were not observed in any tablet.

  As shown in Table 2, also in tablets, tablets 1 to 4 containing a kuzu flower processed product and a specific saccharide used a kuzu flower processed product and a mixture of monosaccharides (a mixture of fructose and glucose). The storage stability was superior to that of tablet 5. That is, it was found that by combining a processed kuzuka product and a specific sugar, a kuzuka solid (tablet) excellent in storage stability can be obtained.

  According to the present invention, a solid katsuka containing a kuzu flower processed product and a specific sugar is not deliquescent and has excellent storage stability, and thus can be easily used for foods and the like. Furthermore, the Kuzuka solid material of the present invention is useful in the food field because it can be expected to have effects such as improvement of liver damage, beautiful skin, improvement of alcohol metabolism, prevention of hangover.

Claims (1)

A method for preventing deliquescence of solid matter containing processed kuzuhana,
Selected from the group consisting of reduced maltose, trehalose, isomaltoligosaccharide, maltose, erythritol, palatinose and fructo- oligosaccharide to 1 part by weight of kuzuka processed product selected from dried kuzuka, katsuka dry powder and kuzuka extract powder The method comprising the step of adding 0.4 to 3 parts by mass of at least one selected from the group consisting of