JP4980346B2 - 自律神経平衡を制御する神経刺激システム - Google Patents

自律神経平衡を制御する神経刺激システム Download PDF

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Publication number
JP4980346B2
JP4980346B2 JP2008511286A JP2008511286A JP4980346B2 JP 4980346 B2 JP4980346 B2 JP 4980346B2 JP 2008511286 A JP2008511286 A JP 2008511286A JP 2008511286 A JP2008511286 A JP 2008511286A JP 4980346 B2 JP4980346 B2 JP 4980346B2
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stimulation
nerve
sympathetic
parasympathetic
circuit
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Japanese (ja)
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JP2008539961A (ja
JP2008539961A5 (enExample
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リバス,イマッド
クラマー,アンドリュー・ピイ
スピネリ,ジュリオ・シイ
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カーディアック ペースメイカーズ, インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
    • A61N1/36114—Cardiac control, e.g. by vagal stimulation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36135—Control systems using physiological parameters
    • A61N1/36139—Control systems using physiological parameters with automatic adjustment
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
    • A61N1/36585—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by two or more physical parameters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3621—Heart stimulators for treating or preventing abnormally high heart rate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Biophysics (AREA)
  • Physiology (AREA)
  • Electrotherapy Devices (AREA)
  • Measuring Pulse, Heart Rate, Blood Pressure Or Blood Flow (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
JP2008511286A 2005-05-09 2006-05-09 自律神経平衡を制御する神経刺激システム Expired - Fee Related JP4980346B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US11/124,791 US7561923B2 (en) 2005-05-09 2005-05-09 Method and apparatus for controlling autonomic balance using neural stimulation
US11/124,791 2005-05-09
PCT/US2006/017971 WO2006122148A2 (en) 2005-05-09 2006-05-09 Neural stimulation system controlling autonomic balance

Publications (3)

Publication Number Publication Date
JP2008539961A JP2008539961A (ja) 2008-11-20
JP2008539961A5 JP2008539961A5 (enExample) 2009-06-25
JP4980346B2 true JP4980346B2 (ja) 2012-07-18

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JP2008511286A Expired - Fee Related JP4980346B2 (ja) 2005-05-09 2006-05-09 自律神経平衡を制御する神経刺激システム

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US (5) US7561923B2 (enExample)
EP (1) EP1919556B1 (enExample)
JP (1) JP4980346B2 (enExample)
WO (1) WO2006122148A2 (enExample)

Families Citing this family (195)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7444183B2 (en) 2003-02-03 2008-10-28 Enteromedics, Inc. Intraluminal electrode apparatus and method
US20040172084A1 (en) 2003-02-03 2004-09-02 Knudson Mark B. Method and apparatus for treatment of gastro-esophageal reflux disease (GERD)
US7844338B2 (en) 2003-02-03 2010-11-30 Enteromedics Inc. High frequency obesity treatment
US9050469B1 (en) 2003-11-26 2015-06-09 Flint Hills Scientific, Llc Method and system for logging quantitative seizure information and assessing efficacy of therapy using cardiac signals
US7783353B2 (en) 2003-12-24 2010-08-24 Cardiac Pacemakers, Inc. Automatic neural stimulation modulation based on activity and circadian rhythm
US20050149133A1 (en) * 2003-12-24 2005-07-07 Imad Libbus Sensing with compensation for neural stimulator
US7706884B2 (en) 2003-12-24 2010-04-27 Cardiac Pacemakers, Inc. Baroreflex stimulation synchronized to circadian rhythm
US7869881B2 (en) 2003-12-24 2011-01-11 Cardiac Pacemakers, Inc. Baroreflex stimulator with integrated pressure sensor
US8200331B2 (en) * 2004-11-04 2012-06-12 Cardiac Pacemakers, Inc. System and method for filtering neural stimulation
US7509166B2 (en) 2003-12-24 2009-03-24 Cardiac Pacemakers, Inc. Automatic baroreflex modulation responsive to adverse event
US8126560B2 (en) 2003-12-24 2012-02-28 Cardiac Pacemakers, Inc. Stimulation lead for stimulating the baroreceptors in the pulmonary artery
US7486991B2 (en) 2003-12-24 2009-02-03 Cardiac Pacemakers, Inc. Baroreflex modulation to gradually decrease blood pressure
US20050149132A1 (en) 2003-12-24 2005-07-07 Imad Libbus Automatic baroreflex modulation based on cardiac activity
US9020595B2 (en) * 2003-12-24 2015-04-28 Cardiac Pacemakers, Inc. Baroreflex activation therapy with conditional shut off
US8024050B2 (en) 2003-12-24 2011-09-20 Cardiac Pacemakers, Inc. Lead for stimulating the baroreceptors in the pulmonary artery
US7460906B2 (en) 2003-12-24 2008-12-02 Cardiac Pacemakers, Inc. Baroreflex stimulation to treat acute myocardial infarction
US9089691B2 (en) 2004-12-07 2015-07-28 Cardiac Pacemakers, Inc. Stimulator for auricular branch of vagus nerve
US8260426B2 (en) 2008-01-25 2012-09-04 Cyberonics, Inc. Method, apparatus and system for bipolar charge utilization during stimulation by an implantable medical device
US8565867B2 (en) 2005-01-28 2013-10-22 Cyberonics, Inc. Changeable electrode polarity stimulation by an implantable medical device
US9314633B2 (en) 2008-01-25 2016-04-19 Cyberonics, Inc. Contingent cardio-protection for epilepsy patients
US7660628B2 (en) 2005-03-23 2010-02-09 Cardiac Pacemakers, Inc. System to provide myocardial and neural stimulation
US7499748B2 (en) 2005-04-11 2009-03-03 Cardiac Pacemakers, Inc. Transvascular neural stimulation device
US7561923B2 (en) 2005-05-09 2009-07-14 Cardiac Pacemakers, Inc. Method and apparatus for controlling autonomic balance using neural stimulation
US7734348B2 (en) 2005-05-10 2010-06-08 Cardiac Pacemakers, Inc. System with left/right pulmonary artery electrodes
US7958131B2 (en) * 2005-08-19 2011-06-07 International Business Machines Corporation Method for data management and data rendering for disparate data types
US7616990B2 (en) 2005-10-24 2009-11-10 Cardiac Pacemakers, Inc. Implantable and rechargeable neural stimulator
US7996079B2 (en) 2006-01-24 2011-08-09 Cyberonics, Inc. Input response override for an implantable medical device
US7657310B2 (en) 2006-01-26 2010-02-02 Cyberonics, Inc. Treatment of reproductive endocrine disorders by vagus nerve stimulation
WO2007092330A1 (en) 2006-02-03 2007-08-16 Synecor, Llc Intravascular device for neuromodulation
EP2004283B1 (en) 2006-03-29 2016-03-16 Dignity Health Synchronization of vagus nerve stimulation with the cardiac cycle of a patient
US7962220B2 (en) 2006-04-28 2011-06-14 Cyberonics, Inc. Compensation reduction in tissue stimulation therapy
US7869885B2 (en) 2006-04-28 2011-01-11 Cyberonics, Inc Threshold optimization for tissue stimulation therapy
US7647101B2 (en) * 2006-06-09 2010-01-12 Cardiac Pacemakers, Inc. Physical conditioning system, device and method
US8457734B2 (en) 2006-08-29 2013-06-04 Cardiac Pacemakers, Inc. System and method for neural stimulation
US7869867B2 (en) 2006-10-27 2011-01-11 Cyberonics, Inc. Implantable neurostimulator with refractory stimulation
WO2008070189A2 (en) 2006-12-06 2008-06-12 The Cleveland Clinic Foundation Method and system for treating acute heart failure by neuromodulation
US8706212B2 (en) * 2006-12-13 2014-04-22 Cardiac Pacemakers, Inc. Neural stimulation systems, devices and methods
ES2430613T3 (es) 2007-01-29 2013-11-21 Simon Fraser University Aparato de neuroestimulación transvascular
US8442639B2 (en) * 2007-02-13 2013-05-14 Cardiac Pacemakers, Inc. Systems and methods for electrical stimulation of blood vessels
US8068918B2 (en) 2007-03-09 2011-11-29 Enteromedics Inc. Remote monitoring and control of implantable devices
US7962214B2 (en) 2007-04-26 2011-06-14 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7904175B2 (en) 2007-04-26 2011-03-08 Cyberonics, Inc. Trans-esophageal vagus nerve stimulation
US7869884B2 (en) 2007-04-26 2011-01-11 Cyberonics, Inc. Non-surgical device and methods for trans-esophageal vagus nerve stimulation
US7974701B2 (en) 2007-04-27 2011-07-05 Cyberonics, Inc. Dosing limitation for an implantable medical device
US20080281365A1 (en) * 2007-05-09 2008-11-13 Tweden Katherine S Neural signal duty cycle
US8755892B2 (en) 2007-05-16 2014-06-17 Cardiac Pacemakers, Inc. Systems for stimulating neural targets
US8532787B2 (en) 2007-05-31 2013-09-10 Enteromedics Inc. Implantable therapy system having multiple operating modes
CN101939048B (zh) * 2007-12-12 2015-06-17 心脏起搏器股份公司 用于从肺动脉递送神经刺激的系统
US7848816B1 (en) 2007-12-27 2010-12-07 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US7949398B1 (en) * 2007-12-27 2011-05-24 Pacesetter, Inc. Acquiring nerve activity from carotid body and/or sinus
US8337404B2 (en) 2010-10-01 2012-12-25 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
US8571643B2 (en) 2010-09-16 2013-10-29 Flint Hills Scientific, Llc Detecting or validating a detection of a state change from a template of heart rate derivative shape or heart beat wave complex
US8382667B2 (en) 2010-10-01 2013-02-26 Flint Hills Scientific, Llc Detecting, quantifying, and/or classifying seizures using multimodal data
AU2009214632B2 (en) * 2008-02-14 2015-02-19 Reshape Lifesciences, Inc. Treatment of excess weight by neural downregulation in combination with compositions
US7925352B2 (en) 2008-03-27 2011-04-12 Synecor Llc System and method for transvascularly stimulating contents of the carotid sheath
US9549704B1 (en) 2008-03-28 2017-01-24 Sandia Corporation Neural interface methods and apparatus to provide artificial sensory capabilities to a subject
CN105031811B (zh) 2008-04-04 2017-09-08 安特罗麦迪克斯公司 用于葡萄糖调节的方法和系统
US8204603B2 (en) 2008-04-25 2012-06-19 Cyberonics, Inc. Blocking exogenous action potentials by an implantable medical device
US8228706B2 (en) * 2008-07-07 2012-07-24 International Business Machines Corporation Magnetic shift register memory device
US8768469B2 (en) 2008-08-08 2014-07-01 Enteromedics Inc. Systems for regulation of blood pressure and heart rate
WO2010019481A1 (en) 2008-08-11 2010-02-18 Conceptx Medical, Inc. Systems and methods for treating dyspnea, including via electrical afferent signal blocking
US20100057158A1 (en) * 2008-08-26 2010-03-04 Pacesetter, Inc. Neurostimulation Based On Glycemic Condition
US8718761B2 (en) * 2008-09-16 2014-05-06 Cardiac Pacemakers, Inc. Cardiac function management integrating cardiac contractility modulation
US8457747B2 (en) 2008-10-20 2013-06-04 Cyberonics, Inc. Neurostimulation with signal duration determined by a cardiac cycle
US8417344B2 (en) 2008-10-24 2013-04-09 Cyberonics, Inc. Dynamic cranial nerve stimulation based on brain state determination from cardiac data
US8548593B2 (en) * 2008-11-10 2013-10-01 Cardiac Pacemakers, Inc. Distal end converter for a medical device lead
US20100191304A1 (en) 2009-01-23 2010-07-29 Scott Timothy L Implantable Medical Device for Providing Chronic Condition Therapy and Acute Condition Therapy Using Vagus Nerve Stimulation
WO2010088533A1 (en) * 2009-01-30 2010-08-05 Medtronic, Inc. Closed-loop neurostimulation to treat pulmonary edema
WO2010104700A1 (en) * 2009-03-09 2010-09-16 Cardiac Pacemakers, Inc. Systems for autonomic nerve modulation comprising electrodes implantable in a lymphatic vessel
US8239028B2 (en) 2009-04-24 2012-08-07 Cyberonics, Inc. Use of cardiac parameters in methods and systems for treating a chronic medical condition
US8827912B2 (en) 2009-04-24 2014-09-09 Cyberonics, Inc. Methods and systems for detecting epileptic events using NNXX, optionally with nonlinear analysis parameters
WO2010138228A1 (en) * 2009-05-26 2010-12-02 Cardiac Pacemakers, Inc. Helically formed coil for a neural cuff electrode
JP5816408B2 (ja) * 2009-11-13 2015-11-18 オリンパス株式会社 神経刺激装置
AU2011239668B2 (en) 2010-04-15 2014-04-17 Cardiac Pacemakers, Inc. Autonomic modulation using transient response with intermittent neural stimulation
US8649871B2 (en) 2010-04-29 2014-02-11 Cyberonics, Inc. Validity test adaptive constraint modification for cardiac data used for detection of state changes
US8639327B2 (en) 2010-04-29 2014-01-28 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8831732B2 (en) 2010-04-29 2014-09-09 Cyberonics, Inc. Method, apparatus and system for validating and quantifying cardiac beat data quality
US8620425B2 (en) 2010-04-29 2013-12-31 Medtronic, Inc. Nerve signal differentiation in cardiac therapy
US8888699B2 (en) 2010-04-29 2014-11-18 Medtronic, Inc. Therapy using perturbation and effect of physiological systems
US8562536B2 (en) 2010-04-29 2013-10-22 Flint Hills Scientific, Llc Algorithm for detecting a seizure from cardiac data
US8825164B2 (en) 2010-06-11 2014-09-02 Enteromedics Inc. Neural modulation devices and methods
US8679009B2 (en) 2010-06-15 2014-03-25 Flint Hills Scientific, Llc Systems approach to comorbidity assessment
US8641646B2 (en) 2010-07-30 2014-02-04 Cyberonics, Inc. Seizure detection using coordinate data
EP3002037B1 (en) 2010-09-15 2018-06-06 Cardiac Pacemakers, Inc. Automatic selection of lead configuration for a neural stimulation lead
US8684921B2 (en) 2010-10-01 2014-04-01 Flint Hills Scientific Llc Detecting, assessing and managing epilepsy using a multi-variate, metric-based classification analysis
US12383190B2 (en) 2011-03-04 2025-08-12 Flint Hills Scientific, Llc Detecting, assessing and managing extreme seizure events
US20120172680A1 (en) * 2010-12-28 2012-07-05 G & L Consulting, Llc Method for sympathetic rebalancing of patient
US8706223B2 (en) 2011-01-19 2014-04-22 Medtronic, Inc. Preventative vagal stimulation
US8725259B2 (en) 2011-01-19 2014-05-13 Medtronic, Inc. Vagal stimulation
US8781582B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US8718763B2 (en) 2011-01-19 2014-05-06 Medtronic, Inc. Vagal stimulation
US8781583B2 (en) 2011-01-19 2014-07-15 Medtronic, Inc. Vagal stimulation
US8983601B2 (en) * 2011-02-25 2015-03-17 The Cleveland Clinic Foundation Extravascular neuromodulation to treat heart failure
US9504390B2 (en) 2011-03-04 2016-11-29 Globalfoundries Inc. Detecting, assessing and managing a risk of death in epilepsy
US8725239B2 (en) 2011-04-25 2014-05-13 Cyberonics, Inc. Identifying seizures using heart rate decrease
EP2701795B1 (en) 2011-04-28 2020-12-09 Interventional Autonomics Corporation Neuromodulation systems for treating acute heart failure syndromes
US9402550B2 (en) 2011-04-29 2016-08-02 Cybertronics, Inc. Dynamic heart rate threshold for neurological event detection
US8996114B2 (en) 2011-06-28 2015-03-31 Cardiac Pacemakers, Inc. Strain relief feature for an implantable medical device lead
JP2014521400A (ja) 2011-07-07 2014-08-28 カーディアック ペースメイカーズ, インコーポレイテッド 植え込み型医療装置リード用の絶縁および安定機構
US20130072995A1 (en) 2011-07-11 2013-03-21 Terrance Ransbury Catheter system for acute neuromodulation
US9446240B2 (en) 2011-07-11 2016-09-20 Interventional Autonomics Corporation System and method for neuromodulation
EP2731671B1 (en) * 2011-07-11 2019-04-03 Interventional Autonomics Corporation Catheter system for acute neuromodulation
WO2013030743A1 (en) * 2011-08-26 2013-03-07 Symap Medical Limited System and method for locating and identifying functional nerves innervating wall of arteries and catheters for same
US9820811B2 (en) 2011-08-26 2017-11-21 Symap Medical (Suzhou), Ltd System and method for mapping the functional nerves innervating the wall of arteries, 3-D mapping and catheters for same
US8702619B2 (en) 2011-08-26 2014-04-22 Symap Holding Limited Mapping sympathetic nerve distribution for renal ablation and catheters for same
US8600505B2 (en) 2011-12-07 2013-12-03 Cyberonics, Inc. Implantable device for facilitating control of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction
US8577458B1 (en) 2011-12-07 2013-11-05 Cyberonics, Inc. Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring
US8918190B2 (en) * 2011-12-07 2014-12-23 Cyberonics, Inc. Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction
US8918191B2 (en) 2011-12-07 2014-12-23 Cyberonics, Inc. Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration
US8630709B2 (en) 2011-12-07 2014-01-14 Cyberonics, Inc. Computer-implemented system and method for selecting therapy profiles of electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction
US10188856B1 (en) 2011-12-07 2019-01-29 Cyberonics, Inc. Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction
US8571654B2 (en) 2012-01-17 2013-10-29 Cyberonics, Inc. Vagus nerve neurostimulator with multiple patient-selectable modes for treating chronic cardiac dysfunction
US8700150B2 (en) 2012-01-17 2014-04-15 Cyberonics, Inc. Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration
AU2013230648B2 (en) 2012-03-05 2017-06-15 Lungpacer Medical Inc. Transvascular nerve stimulation apparatus and methods
AU2013230776B2 (en) 2012-03-08 2015-12-03 Medtronic Af Luxembourg S.A.R.L. Immune system neuromodulation and associated systems and methods
WO2013134763A2 (en) 2012-03-09 2013-09-12 Enteromedics Inc. Safety features for use in medical devices
EP2827944B1 (en) 2012-03-21 2016-05-18 Cardiac Pacemakers, Inc. Systems and methods for stimulation of vagus nerve
US10448839B2 (en) 2012-04-23 2019-10-22 Livanova Usa, Inc. Methods, systems and apparatuses for detecting increased risk of sudden death
EP2840993A4 (en) 2012-04-24 2016-03-30 Cibiem Inc ENDOVASCULAR CATHETERS AND METHOD FOR CAROTID BODY ABLATION
US9398930B2 (en) 2012-06-01 2016-07-26 Cibiem, Inc. Percutaneous methods and devices for carotid body ablation
WO2013181660A1 (en) 2012-06-01 2013-12-05 Cibiem, Inc. Methods and devices for cryogenic carotid body ablation
EP4233953A3 (en) 2012-06-21 2023-11-01 Lungpacer Medical Inc. Transvascular diaphragm pacing systems
US9283033B2 (en) 2012-06-30 2016-03-15 Cibiem, Inc. Carotid body ablation via directed energy
US8688212B2 (en) 2012-07-20 2014-04-01 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation
US12377269B2 (en) * 2012-08-31 2025-08-05 Flint Hills Scientific, Llc Contingent cardio-protection for epilepsy patients
EP2903686B1 (en) 2012-10-02 2018-10-24 Cardiac Pacemakers, Inc. Pinch to open cuff electrode
EP2903685B1 (en) 2012-10-02 2019-08-07 Cardiac Pacemakers, Inc. Pinch to open cuff electrode
US9452290B2 (en) 2012-11-09 2016-09-27 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing tachyarrhythmia through vagus nerve stimulation
US9643008B2 (en) 2012-11-09 2017-05-09 Cyberonics, Inc. Implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation
US8923964B2 (en) 2012-11-09 2014-12-30 Cyberonics, Inc. Implantable neurostimulator-implemented method for enhancing heart failure patient awakening through vagus nerve stimulation
US12082868B2 (en) 2012-11-13 2024-09-10 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9827036B2 (en) 2012-11-13 2017-11-28 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
JP6026674B2 (ja) 2012-12-28 2016-11-16 カーディアック ペースメイカーズ, インコーポレイテッド 刺激カフ及び埋め込み器具
CN114768089A (zh) 2013-01-21 2022-07-22 卡拉健康公司 用于控制震颤的设备和方法
US12453853B2 (en) 2013-01-21 2025-10-28 Cala Health, Inc. Multi-modal stimulation for treating tremor
US10220211B2 (en) 2013-01-22 2019-03-05 Livanova Usa, Inc. Methods and systems to diagnose depression
JP6069523B2 (ja) 2013-02-13 2017-02-01 カーディアック ペースメイカーズ, インコーポレイテッド 一体型つる状体を備えたカフ電極
US9522271B2 (en) 2013-03-07 2016-12-20 Cardiac Pacemakers, Inc. Method and apparatus for controlling blood pressure using respiration-mediated heart rate variation
US9643011B2 (en) 2013-03-14 2017-05-09 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation
US9242097B2 (en) 2013-06-18 2016-01-26 Cardiac Pacemakers, Inc. System and method for mapping baroreceptors
US9999773B2 (en) 2013-10-30 2018-06-19 Cyberonics, Inc. Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters
EP3071285B1 (en) 2013-11-22 2020-06-03 Lungpacer Medical Inc. Apparatus for assisted breathing by transvascular nerve stimulation
US9511228B2 (en) 2014-01-14 2016-12-06 Cyberonics, Inc. Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation
US10413731B2 (en) 2014-01-17 2019-09-17 Cardiac Pacemakers, Inc. Selective nerve stimulation using presynaptic terminal depletion block
EP3096835B1 (en) 2014-01-21 2019-08-07 Lungpacer Medical Inc. Systems for optimization of multi-electrode nerve pacing
WO2015138795A1 (en) 2014-03-12 2015-09-17 Cibiem, Inc. Carotid body ablation with a transvenous ultrasound imaging and ablation catheter
US9272143B2 (en) 2014-05-07 2016-03-01 Cyberonics, Inc. Responsive neurostimulation for the treatment of chronic cardiac dysfunction
US9415224B2 (en) 2014-04-25 2016-08-16 Cyberonics, Inc. Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction
US9409024B2 (en) 2014-03-25 2016-08-09 Cyberonics, Inc. Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction
US9950169B2 (en) 2014-04-25 2018-04-24 Cyberonics, Inc. Dynamic stimulation adjustment for identification of a neural fulcrum
US9713719B2 (en) 2014-04-17 2017-07-25 Cyberonics, Inc. Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction
US9999463B2 (en) * 2014-04-14 2018-06-19 NeuroMedic, Inc. Monitoring nerve activity
CN106456975B (zh) 2014-05-22 2020-09-04 卡迪诺米克公司 用于电神经调制的导管和导管系统
BR112016025203B1 (pt) 2014-06-02 2022-09-06 Cala Health, Inc Sistema transcutâneo para tratar um paciente que sofre de tremor
US9737716B2 (en) 2014-08-12 2017-08-22 Cyberonics, Inc. Vagus nerve and carotid baroreceptor stimulation system
US9770599B2 (en) 2014-08-12 2017-09-26 Cyberonics, Inc. Vagus nerve stimulation and subcutaneous defibrillation system
US9533153B2 (en) 2014-08-12 2017-01-03 Cyberonics, Inc. Neurostimulation titration process
WO2016040038A1 (en) 2014-09-08 2016-03-17 CARDIONOMIC, Inc. Methods for electrical neuromodulation of the heart
CA2957791A1 (en) 2014-09-08 2016-03-17 CARDIONOMIC, Inc. Catheter and electrode systems for electrical neuromodulation
US9504832B2 (en) 2014-11-12 2016-11-29 Cyberonics, Inc. Neurostimulation titration process via adaptive parametric modification
AU2015358385B2 (en) 2014-12-03 2020-09-03 Medtronic Ireland Manufacturing Unlimited Company Systems and methods for modulating nerves or other tissue
WO2016100195A1 (en) * 2014-12-15 2016-06-23 University Of Florida Research Foundation, Inc. Vagal nerve stimulation
CN109568786A (zh) 2015-01-05 2019-04-05 卡迪诺米克公司 心脏调节促进方法及系统
CA2988586A1 (en) 2015-06-10 2016-12-15 Cala Health, Inc. Neuromodulation system for peripheral nerve stimulation with detachable therapy unit
US20200093400A1 (en) 2015-07-31 2020-03-26 Cala Health, Inc. Systems, devices, and method for the treatment of osteoarthritis
WO2017040218A1 (en) * 2015-08-28 2017-03-09 Sunshine Heart Company Pty Ltd. Restoring autonomic balance
WO2017053847A1 (en) 2015-09-23 2017-03-30 Cala Health, Inc. Systems and methods for peripheral nerve stimulation in the finger or hand to treat hand tremors
US11344722B2 (en) 2016-01-21 2022-05-31 Cala Health, Inc. Systems, methods and devices for peripheral neuromodulation for treating diseases related to overactive bladder
AU2017229496B2 (en) 2016-03-09 2022-03-31 CARDIONOMIC, Inc. Cardiac contractility neurostimulation systems and methods
US10524859B2 (en) 2016-06-07 2020-01-07 Metavention, Inc. Therapeutic tissue modulation devices and methods
CA3033662A1 (en) 2016-08-25 2018-03-01 Cala Health, Inc. Systems and methods for treating cardiac dysfunction through peripheral nerve stimulation
US10029068B2 (en) 2016-11-01 2018-07-24 Polyvagal Science LLC Methods and systems for reducing sound sensitivities and improving auditory processing, behavioral state regulation and social engagement behaviors
EP3606604A4 (en) 2017-04-03 2020-12-16 Cala Health, Inc. PERIPHERAL NEUROMODULATION SYSTEMS, METHODS AND DEVICES FOR THE TREATMENT OF DISEASES ASSOCIATED WITH BLADDER HYPERACTIVITY
WO2018217577A1 (en) * 2017-05-22 2018-11-29 Thync Global, Inc. Systems and methods for applying electrical energy to treat medical disorders
US10293164B2 (en) 2017-05-26 2019-05-21 Lungpacer Medical Inc. Apparatus and methods for assisted breathing by transvascular nerve stimulation
CN111163834A (zh) 2017-06-30 2020-05-15 隆佩瑟尔医疗公司 用于预防、减轻和/或治疗认知损伤的装置
US10195429B1 (en) 2017-08-02 2019-02-05 Lungpacer Medical Inc. Systems and methods for intravascular catheter positioning and/or nerve stimulation
US10940308B2 (en) 2017-08-04 2021-03-09 Lungpacer Medical Inc. Systems and methods for trans-esophageal sympathetic ganglion recruitment
WO2019055434A1 (en) 2017-09-13 2019-03-21 CARDIONOMIC, Inc. NEUROSTIMULATION SYSTEMS AND METHODS FOR AFFECTING CARDIAC CONTRACTILITY
US20190175908A1 (en) 2017-12-11 2019-06-13 Lungpacer Medical Inc. Systems and methods for strengthening a respiratory muscle
WO2019143790A1 (en) 2018-01-17 2019-07-25 Cala Health, Inc. Systems and methods for treating inflammatory bowel disease through peripheral nerve stimulation
CA3091209C (en) 2018-03-01 2021-08-31 Polyvagal Science LLC Systems and methods for modulating physiological state
US12569745B2 (en) 2018-03-08 2026-03-10 Citizen Watch Co., Ltd. Heart rate control device
AU2019320750A1 (en) 2018-08-13 2021-04-08 CARDIONOMIC, Inc. Systems and methods for affecting cardiac contractility and/or relaxation
WO2020097331A1 (en) 2018-11-08 2020-05-14 Lungpacer Medical Inc. Stimulation systems and related user interfaces
JP2022531658A (ja) 2019-05-06 2022-07-08 カーディオノミック,インク. 電気神経調節中に生理学的信号をノイズ除去するためのシステムおよび方法
WO2020232333A1 (en) 2019-05-16 2020-11-19 Lungpacer Medical Inc. Systems and methods for sensing and stimulation
US11771900B2 (en) 2019-06-12 2023-10-03 Lungpacer Medical Inc. Circuitry for medical stimulation systems
US12251560B1 (en) 2019-08-13 2025-03-18 Cala Health, Inc. Connection quality determination for wearable neurostimulation systems
US12611115B2 (en) 2019-09-27 2026-04-28 Medtronic, Inc. Determining likelihood of an adverse health event based on various physiological diagnostic states
US11890468B1 (en) 2019-10-03 2024-02-06 Cala Health, Inc. Neurostimulation systems with event pattern detection and classification
AU2021293019A1 (en) 2020-06-16 2023-02-23 CARDIONOMIC, Inc. Chronically implantable systems and methods for affecting cardiac contractility and/or relaxation
CN116173410B (zh) * 2023-02-28 2023-07-28 浙江迈达佩思医疗科技有限公司 基于心脏迷走神经传出活性的闭环经皮穴位电刺激系统
WO2025014855A2 (en) * 2023-07-07 2025-01-16 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Simultaneous direct modulation of sympathetic and parasympathetic nervous systems to improve cardiac function and mitigate cardiac arrhythmias
US12678627B1 (en) * 2025-04-28 2026-07-14 Cvrx, Inc. Systems and methods for closed-loop or partially closed-loop baroreflex activation therapy

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5203326A (en) * 1991-12-18 1993-04-20 Telectronics Pacing Systems, Inc. Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy
EP0688577A1 (en) 1994-06-24 1995-12-27 Pacesetter AB Device for treating atrial tachyarrhythmia
US5752976A (en) * 1995-06-23 1998-05-19 Medtronic, Inc. World wide patient location and data telemetry system for implantable medical devices
US5700282A (en) * 1995-10-13 1997-12-23 Zabara; Jacob Heart rhythm stabilization using a neurocybernetic prosthesis
US6006134A (en) * 1998-04-30 1999-12-21 Medtronic, Inc. Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers
US6366814B1 (en) * 1998-10-26 2002-04-02 Birinder R. Boveja External stimulator for adjunct (add-on) treatment for neurological, neuropsychiatric, and urological disorders
US6210344B1 (en) * 1999-03-24 2001-04-03 Umm Electronics, Inc. Method and apparatus for passive heart rate detection
US6678547B2 (en) * 2001-03-08 2004-01-13 Cardiac Pacemakers, Inc. Cardiac rhythm management system using time-domain heart rate variability indicia
US7069070B2 (en) * 2003-05-12 2006-06-27 Cardiac Pacemakers, Inc. Statistical method for assessing autonomic balance
US6600954B2 (en) * 2001-01-25 2003-07-29 Biocontrol Medical Bcm Ltd. Method and apparatus for selective control of nerve fibers
US6748272B2 (en) * 2001-03-08 2004-06-08 Cardiac Pacemakers, Inc. Atrial interval based heart rate variability diagnostic for cardiac rhythm management system
US6684105B2 (en) * 2001-08-31 2004-01-27 Biocontrol Medical, Ltd. Treatment of disorders by unidirectional nerve stimulation
US6907295B2 (en) * 2001-08-31 2005-06-14 Biocontrol Medical Ltd. Electrode assembly for nerve control
US6622041B2 (en) * 2001-08-21 2003-09-16 Cyberonics, Inc. Treatment of congestive heart failure and autonomic cardiovascular drive disorders
US7778703B2 (en) * 2001-08-31 2010-08-17 Bio Control Medical (B.C.M.) Ltd. Selective nerve fiber stimulation for treating heart conditions
US7734355B2 (en) * 2001-08-31 2010-06-08 Bio Control Medical (B.C.M.) Ltd. Treatment of disorders by unidirectional nerve stimulation
US7123959B2 (en) * 2002-03-25 2006-10-17 Cardiac Pacemakers, Inc. Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation
US7277761B2 (en) * 2002-06-12 2007-10-02 Pacesetter, Inc. Vagal stimulation for improving cardiac function in heart failure or CHF patients
US7572226B2 (en) * 2003-10-28 2009-08-11 Cardiac Pacemakers, Inc. System and method for monitoring autonomic balance and physical activity
US8396560B2 (en) * 2004-11-18 2013-03-12 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US7769450B2 (en) * 2004-11-18 2010-08-03 Cardiac Pacemakers, Inc. Cardiac rhythm management device with neural sensor
US7260431B2 (en) * 2004-05-20 2007-08-21 Cardiac Pacemakers, Inc. Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device
US8332047B2 (en) * 2004-11-18 2012-12-11 Cardiac Pacemakers, Inc. System and method for closed-loop neural stimulation
US7672724B2 (en) * 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for optimizing electrical stimulation parameters using heart rate variability
US7672725B2 (en) * 2005-01-18 2010-03-02 Cardiac Pacemakers, Inc. Method and apparatus for using heart rate variability as a safety check in electrical therapies
US7587238B2 (en) * 2005-03-11 2009-09-08 Cardiac Pacemakers, Inc. Combined neural stimulation and cardiac resynchronization therapy
US7561923B2 (en) 2005-05-09 2009-07-14 Cardiac Pacemakers, Inc. Method and apparatus for controlling autonomic balance using neural stimulation

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US9216289B2 (en) 2015-12-22

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