JP4977252B2 - 自動注射器 - Google Patents
自動注射器 Download PDFInfo
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- JP4977252B2 JP4977252B2 JP2010545447A JP2010545447A JP4977252B2 JP 4977252 B2 JP4977252 B2 JP 4977252B2 JP 2010545447 A JP2010545447 A JP 2010545447A JP 2010545447 A JP2010545447 A JP 2010545447A JP 4977252 B2 JP4977252 B2 JP 4977252B2
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- plunger rod
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- 238000002347 injection Methods 0.000 claims description 29
- 239000007924 injection Substances 0.000 claims description 29
- 239000003814 drug Substances 0.000 claims description 20
- 229940079593 drug Drugs 0.000 claims description 20
- 238000004146 energy storage Methods 0.000 claims description 16
- 230000002093 peripheral effect Effects 0.000 claims 1
- 229940090047 auto-injector Drugs 0.000 description 2
- 238000005452 bending Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000037452 priming Effects 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2403—Ampoule inserted into the ampoule holder
- A61M2005/2407—Ampoule inserted into the ampoule holder from the rear
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/24—Ampoule syringes, i.e. syringes with needle for use in combination with replaceable ampoules or carpules, e.g. automatic
- A61M2005/2485—Ampoule holder connected to rest of syringe
- A61M2005/2488—Ampoule holder connected to rest of syringe via rotation, e.g. threads or bayonet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3146—Priming, e.g. purging, reducing backlash or clearance
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31553—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe without axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Description
さまざまな種類の自動機能を備えた注射器が長年に亘って開発されている。こういった機能には、少し述べるだけでも穿刺、注射、投与量設定、混合、プライミング、針シールドなどが含まれ得る。
この発明は、最先端の技術の欠点を是正することを目的とする。この目的は、独立特許請求項に記載される特徴によって達成される。この発明の好ましい実施例は、従属請求項の主題である。
この出願において、用語「後部/後端部」が用いられるとき、これは、注射装置の、注射装置の使用時に患者の薬物注射部位から最も遠くに位置している部分/端部またはその部材の部分/端部を指す。対応して、用語「前部/前端部」が用いられるとき、これは、注射装置の、注射装置の使用時に患者の薬物注射部位の最も近く位置する部分/端部またはその部材の部分/端部を指す。
Claims (11)
- 前端部と後端部とを有する自動注射装置であって、
−取外可能に互いに接続された後部ハウジングおよび容器ハウジング(10)と、
−容器ハウジング内に配置された薬物容器(12)であって薬物を通過させて送達するための送達部材の付いたまたはのための前開口部と少なくとも1つの可動止め具とを有する薬物容器と、
−1回投与分の薬物を設定および再設定することができる投与量設定機構と、
−取外可能に投与量設定機構に接続された駆動ナット(18)とを備えるように配置されており、前記装置は、
−回転可能に前記駆動ナットに接続されており、その前端部が前記止め具と接触するように配置された中空プランジャーロッド(14)と、
−エネルギ蓄積部材(46)とをさらに備え、前記エネルギ蓄積部材は、前記投与量設定機構が操作されて投与量を設定するとき、少なくとも1つの予め定められたステップでエネルギを蓄積するように、投与量設定機構に接続された第1の端部と後部ハウジングの固定点に接続された第2の端部とを有し、
−作動機構(24)をさらに備え、前記作動機構は、エネルギ蓄積部材に蓄積され投与量設定機構を通して伝達されるエネルギによる前記駆動ナットの回転によって前記中空プランジャーロッドが装置の前端部に向かって線形に変位されるように、取外可能に前記駆動ナットに接続されており、投与量が設定される際は前記駆動ナットを回転しないようにロックし、前記作動機構が手動で作動されるときは前記駆動ナットを解放することができ、
−動作可能に前記中空プランジャーロッドに接続されており、前記中空プランジャーロッドを回転によって弾性的にかつ軸方向に変位されないようにロックすることができる位置決め機構をさらに備え、前記位置決め機構は、第1のロックナット(28)と、弾性部材(52)とを含み、前記第1のロックナットは、回転方向にロックされているが前記中空プランジャーロッドを取囲んで軸方向に摺動可能であり、前記後部ハウジングに配置され前記第1のロックナットを回転しないようにロックするための可撓性ロック手段(38)と協働するように配置されており、前記弾性部材は、前記中空プランジャーロッドの内側に配置され、前記第1のロックナットがロック解除されているとき前記中空プランジャーロッドを弾性的にかつ軸方向に変位させることができることを特徴とする、自動注射装置。 - 弾性部材(52)は、中空プランジャーロッドの前端部にある内壁に寄りかかっている前端部と、前記後部ハウジングの遠位端にある内壁上の固定点に寄りかかっている後端部とを有する、請求項1に記載の自動注射装置。
- 中空プランジャーロッドは、その外側表面に、第1のロックナットの内側円周面にある対応する突起(32)と噛み合う細長い溝(30)を含み、これによって中空プランジャーロッドは、前記第1のロックナットに回転方向にロックされているが、前記第1のロックナットを通って軸方向に摺動可能である、請求項1または2に記載の自動注射装置。
- 前記可撓性ロック手段(38)は、第1の径方向に内方に突出する手段を含み、前記第1の径方向に内方に突出する手段は、前記第1のロックナットの外側円周面にある対応する第1の組の溝と、前記第1の径方向に内方に突出する手段が前記対応する前記第1の組の溝と接触しているとき前記第1のロックナットが回転方向にロックされるように噛み合う、請求項1から3のいずれかに記載の自動注射装置。
- 前記駆動ナットは、その内側円周面に、中空プランジャーロッドの外側円周面にある対応する一組のねじ山と噛み合う一組のねじ山を含む、請求項1から4のいずれかに記載の自動注射装置。
- 前記駆動ナットは、前記駆動ナットの外側円周面にある窪みを通って延在する可撓性係合手段(26)をさらに含み、前記可撓性係合手段は、第2の径方向に内方に突出する手段を含む、請求項1から5のいずれかに記載の自動注射装置。
- 前記投与量設定機構は、投与量つまみ(50)と、動作可能に前記投与量つまみに接続された駆動シャフト(42)と、前記駆動シャフト(42)の前端部に取付けられた第2のロックナット(44)とを含み、前記第2のロックナットは、その外側円周面に、前記第2の径方向に内方に突出する手段と噛み合う第2の組の溝を含み、前記第2の組の溝と前記第2の径方向に内方に突出する手段とは、投与量が設定されるとき駆動シャフトが一方向にのみ回転されるような幾何学的配置を構成する、請求項6に記載の自動注射装置。
- 前記エネルギ蓄積部材(46)の第1の端部は、駆動シャフト(42)に接続されている、請求項7に記載の自動注射装置。
- 前記駆動ナットは、その外側円周面に第1の組の係合手段(20)をさらに含み、前記第1の組の係合手段は、前記作動機構の内側円周面にある対応する第2の組の係合手段(22)と、前記エネルギ蓄積部材がエネルギを蓄積するために駆動シャフトを介して張力を受けるとき前記駆動ナットを回転方向にロックされた位置にロックするために前記各組の係合部(20、22)が互いに接触しているように配置されるように噛み合う、請求項8に記載の自動注射装置。
- 前記作動機構は、手動作動つまみ(40)を含み、前記手動作動つまみは、前記手動作動つまみが作動されると前記第2の組の係合手段(22)が第1の組の係合手段(20)から解放され、これによってエネルギ蓄積部材に蓄積されたエネルギが駆動ナットを回転させるために駆動シャフトおよび第2のロックナットを介して駆動ナットまで伝達されることによって、中空プランジャーロッドを装置の前端部に向かって軸方向に駆動させるように作動される、請求項9に記載の自動注射装置。
- 投与量つまみおよび駆動シャフトは、投与量を再設定するために前記第2ロックナットの第2の組の溝と前記可撓性係合手段26の前記第2の径方向に内方に突出する手段との噛合せが押されて係合が外れるように、軸方向に変位されるように配置されている、請求項10に記載の自動注射装置。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE0800313-9 | 2008-02-12 | ||
SE0800313 | 2008-02-12 | ||
PCT/EP2009/051202 WO2009101005A1 (en) | 2008-02-12 | 2009-02-03 | Auto-injector |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2011511659A JP2011511659A (ja) | 2011-04-14 |
JP4977252B2 true JP4977252B2 (ja) | 2012-07-18 |
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Application Number | Title | Priority Date | Filing Date |
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JP2010545447A Active JP4977252B2 (ja) | 2008-02-12 | 2009-02-03 | 自動注射器 |
Country Status (9)
Country | Link |
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US (1) | US8632507B2 (ja) |
EP (1) | EP2254624B1 (ja) |
JP (1) | JP4977252B2 (ja) |
CN (1) | CN101951979B (ja) |
AU (1) | AU2009214255B2 (ja) |
DK (1) | DK2254624T3 (ja) |
ES (1) | ES2507518T3 (ja) |
PL (1) | PL2254624T3 (ja) |
WO (1) | WO2009101005A1 (ja) |
Cited By (13)
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US9144648B2 (en) | 2006-05-03 | 2015-09-29 | Antares Pharma, Inc. | Injector with adjustable dosing |
US9180259B2 (en) | 2005-01-24 | 2015-11-10 | Antares Pharma, Inc. | Prefilled syringe jet injector |
US9220660B2 (en) | 2011-07-15 | 2015-12-29 | Antares Pharma, Inc. | Liquid-transfer adapter beveled spike |
US9333309B2 (en) | 2002-02-11 | 2016-05-10 | Antares Pharma, Inc. | Intradermal injector |
US9364610B2 (en) | 2012-05-07 | 2016-06-14 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9446195B2 (en) | 2011-07-15 | 2016-09-20 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
US9486583B2 (en) | 2012-03-06 | 2016-11-08 | Antares Pharma, Inc. | Prefilled syringe with breakaway force feature |
US9561333B2 (en) | 2008-08-05 | 2017-02-07 | Antares Pharma, Inc. | Multiple dosage injector |
US9707354B2 (en) | 2013-03-11 | 2017-07-18 | Antares Pharma, Inc. | Multiple dosage injector with rack and pinion dosage system |
US9744302B2 (en) | 2013-02-11 | 2017-08-29 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9808582B2 (en) | 2006-05-03 | 2017-11-07 | Antares Pharma, Inc. | Two-stage reconstituting injector |
US9867949B2 (en) | 2008-03-10 | 2018-01-16 | Antares Pharma, Inc. | Injector safety device |
US9950125B2 (en) | 2012-04-06 | 2018-04-24 | Antares Pharma, Inc. | Needle assisted jet injection administration of testosterone compositions |
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US9358341B2 (en) | 2009-09-30 | 2016-06-07 | Sanofi-Aventis Deutschland Gmbh | Resettable drug delivery device |
TW201127434A (en) * | 2009-09-30 | 2011-08-16 | Sanofi Aventis Deutschland | Drug delivery device |
DK2493529T3 (en) * | 2009-10-26 | 2016-05-17 | Shl Group Ab | Drug delivery device |
ES2574057T3 (es) * | 2009-12-15 | 2016-06-14 | Shl Group Ab | Dispositivo de administración de medicamento |
US10322244B2 (en) | 2009-12-15 | 2019-06-18 | Shl Group Ab | Medicament delivery device |
US10322243B2 (en) | 2009-12-15 | 2019-06-18 | Shl Group Ab | Medicament delivery device |
TW201138882A (en) | 2010-01-25 | 2011-11-16 | Sanofi Aventis Deutschland | Drive assembly for a drug delivery device and drug delivery device |
DK2536452T3 (da) | 2010-02-18 | 2019-01-02 | Sanofi Aventis Deutschland | Autoinjektor |
EP2399635A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2468330A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2468333A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
USRE48593E1 (en) | 2010-12-21 | 2021-06-15 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
JP5791780B2 (ja) * | 2011-03-24 | 2015-10-07 | エス・ホー・エル・グループ・アクチボラゲットShl Group Ab | 薬剤送達装置 |
TWI576129B (zh) * | 2011-05-06 | 2017-04-01 | 賽諾菲阿凡提斯德意志有限公司 | 用於藥物輸送裝置之驅動組件及對應之藥物輸送裝置 |
AU2012348406B2 (en) * | 2011-12-06 | 2015-05-07 | Shl Medical Ag | Medicament delivery device |
PL220720B1 (pl) * | 2012-02-08 | 2015-12-31 | Copernicus Spółka Z Ograniczoną Odpowiedzialnością | Urządzenie wstrzykujące z mechanizmem resetu dawki |
CN104394909B (zh) * | 2012-05-25 | 2017-03-29 | 阿普塔尔法国简易股份公司 | 自动注射器 |
JP6363083B2 (ja) * | 2012-10-15 | 2018-07-25 | ノボ・ノルデイスク・エー/エス | ばね駆動式注射デバイス |
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- 2009-02-03 WO PCT/EP2009/051202 patent/WO2009101005A1/en active Application Filing
- 2009-02-03 CN CN2009801049027A patent/CN101951979B/zh active Active
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Also Published As
Publication number | Publication date |
---|---|
DK2254624T3 (da) | 2014-10-06 |
WO2009101005A1 (en) | 2009-08-20 |
CN101951979A (zh) | 2011-01-19 |
CN101951979B (zh) | 2013-03-20 |
US8632507B2 (en) | 2014-01-21 |
JP2011511659A (ja) | 2011-04-14 |
EP2254624A1 (en) | 2010-12-01 |
ES2507518T3 (es) | 2014-10-15 |
EP2254624B1 (en) | 2014-07-02 |
AU2009214255A1 (en) | 2009-08-20 |
PL2254624T3 (pl) | 2015-01-30 |
US20110034881A1 (en) | 2011-02-10 |
AU2009214255B2 (en) | 2011-09-29 |
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