JP4974201B2 - 医薬組成物の製造方法及び医薬品混合装置 - Google Patents
医薬組成物の製造方法及び医薬品混合装置 Download PDFInfo
- Publication number
- JP4974201B2 JP4974201B2 JP2000566009A JP2000566009A JP4974201B2 JP 4974201 B2 JP4974201 B2 JP 4974201B2 JP 2000566009 A JP2000566009 A JP 2000566009A JP 2000566009 A JP2000566009 A JP 2000566009A JP 4974201 B2 JP4974201 B2 JP 4974201B2
- Authority
- JP
- Japan
- Prior art keywords
- mixing
- water
- mixing device
- pharmaceutical
- porous
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002156 mixing Methods 0.000 title claims description 82
- 238000004519 manufacturing process Methods 0.000 title claims description 15
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 7
- 239000000463 material Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 27
- 230000001954 sterilising effect Effects 0.000 claims description 27
- 238000004659 sterilization and disinfection Methods 0.000 claims description 26
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 claims description 16
- 239000010931 gold Substances 0.000 claims description 16
- 229910052737 gold Inorganic materials 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 16
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 16
- 229910001220 stainless steel Inorganic materials 0.000 claims description 13
- 239000010935 stainless steel Substances 0.000 claims description 13
- 239000012528 membrane Substances 0.000 claims description 9
- 239000002872 contrast media Substances 0.000 claims description 5
- 150000002632 lipids Chemical class 0.000 claims description 5
- 239000000919 ceramic Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 238000002604 ultrasonography Methods 0.000 claims description 2
- 239000007789 gas Substances 0.000 description 16
- 239000002502 liposome Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 11
- 239000006185 dispersion Substances 0.000 description 9
- 239000007921 spray Substances 0.000 description 8
- 239000000725 suspension Substances 0.000 description 8
- 238000001125 extrusion Methods 0.000 description 7
- 230000005660 hydrophilic surface Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 5
- 239000000825 pharmaceutical preparation Substances 0.000 description 4
- 229940127557 pharmaceutical product Drugs 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 229910000831 Steel Inorganic materials 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 239000000839 emulsion Substances 0.000 description 3
- -1 for example Substances 0.000 description 3
- 230000002209 hydrophobic effect Effects 0.000 description 3
- 239000011148 porous material Substances 0.000 description 3
- 239000002243 precursor Substances 0.000 description 3
- 239000010959 steel Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000000084 colloidal system Substances 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 238000001816 cooling Methods 0.000 description 2
- 239000002961 echo contrast media Substances 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 239000000693 micelle Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 150000003904 phospholipids Chemical class 0.000 description 2
- 238000007747 plating Methods 0.000 description 2
- 229920000098 polyolefin Polymers 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000003068 static effect Effects 0.000 description 2
- TXEYQDLBPFQVAA-UHFFFAOYSA-N tetrafluoromethane Chemical compound FC(F)(F)F TXEYQDLBPFQVAA-UHFFFAOYSA-N 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 229910018503 SF6 Inorganic materials 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003570 air Substances 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000005422 blasting Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000000306 component Substances 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 239000002826 coolant Substances 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 229940127089 cytotoxic agent Drugs 0.000 description 1
- 239000002254 cytotoxic agent Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000002059 diagnostic imaging Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- MPOKJOWFCMDRKP-UHFFFAOYSA-N gold;hydrate Chemical compound O.[Au] MPOKJOWFCMDRKP-UHFFFAOYSA-N 0.000 description 1
- 238000000265 homogenisation Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 229920001600 hydrophobic polymer Polymers 0.000 description 1
- 230000005661 hydrophobic surface Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 239000005414 inactive ingredient Substances 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000003475 lamination Methods 0.000 description 1
- 239000010410 layer Substances 0.000 description 1
- 239000004973 liquid crystal related substance Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- KAVGMUDTWQVPDF-UHFFFAOYSA-N perflubutane Chemical compound FC(F)(F)C(F)(F)C(F)(F)C(F)(F)F KAVGMUDTWQVPDF-UHFFFAOYSA-N 0.000 description 1
- 229950003332 perflubutane Drugs 0.000 description 1
- 239000002304 perfume Substances 0.000 description 1
- 238000009832 plasma treatment Methods 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- SFZCNBIFKDRMGX-UHFFFAOYSA-N sulfur hexafluoride Chemical compound FS(F)(F)(F)(F)F SFZCNBIFKDRMGX-UHFFFAOYSA-N 0.000 description 1
- 229960000909 sulfur hexafluoride Drugs 0.000 description 1
- 239000002344 surface layer Substances 0.000 description 1
- 230000003746 surface roughness Effects 0.000 description 1
- 239000000375 suspending agent Substances 0.000 description 1
- 238000007740 vapor deposition Methods 0.000 description 1
- 239000007762 w/o emulsion Substances 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
- B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
- B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
- B01F33/811—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles in two or more consecutive, i.e. successive, mixing receptacles or being consecutively arranged
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/834—Mixing in several steps, e.g. successive steps
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F2025/91—Direction of flow or arrangement of feed and discharge openings
- B01F2025/912—Radial flow
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/051—Stirrers characterised by their elements, materials or mechanical properties
- B01F27/053—Stirrers characterised by their elements, materials or mechanical properties characterised by their materials
- B01F27/0531—Stirrers characterised by their elements, materials or mechanical properties characterised by their materials with particular surface characteristics, e.g. coated or rough
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
- B01F27/05—Stirrers
- B01F27/11—Stirrers characterised by the configuration of the stirrers
- B01F27/19—Stirrers with two or more mixing elements mounted in sequence on the same axis
- B01F27/191—Stirrers with two or more mixing elements mounted in sequence on the same axis with similar elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/80—Mixing plants; Combinations of mixers
- B01F33/81—Combinations of similar mixers, e.g. with rotary stirring devices in two or more receptacles
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Apparatus For Disinfection Or Sterilisation (AREA)
- Medicinal Preparation (AREA)
- Accessories For Mixers (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9818021.9 | 1998-08-18 | ||
| GBGB9818021.9A GB9818021D0 (en) | 1998-08-18 | 1998-08-18 | Apparatus |
| PCT/GB1999/002741 WO2000010697A1 (en) | 1998-08-18 | 1999-08-18 | Apparatus having partially gold-plated surface |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2002523209A JP2002523209A (ja) | 2002-07-30 |
| JP2002523209A5 JP2002523209A5 (enExample) | 2010-04-15 |
| JP4974201B2 true JP4974201B2 (ja) | 2012-07-11 |
Family
ID=10837468
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000566009A Expired - Lifetime JP4974201B2 (ja) | 1998-08-18 | 1999-08-18 | 医薬組成物の製造方法及び医薬品混合装置 |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1105209A1 (enExample) |
| JP (1) | JP4974201B2 (enExample) |
| AU (1) | AU5435999A (enExample) |
| GB (1) | GB9818021D0 (enExample) |
| NO (1) | NO20010781L (enExample) |
| WO (1) | WO2000010697A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO20015534D0 (no) * | 2001-11-12 | 2001-11-12 | Amersham Health As | Farmasöytisk blandeapparat |
| JP2006088060A (ja) * | 2004-09-24 | 2006-04-06 | Susumu Takayama | 撹拌装置 |
| MX383456B (es) * | 2009-11-02 | 2025-03-14 | Mannkind Corp | Reactor para producir particulas farmaceuticas en un procedimiento de precipitacion. |
| JP2020168598A (ja) * | 2019-04-02 | 2020-10-15 | Kyb株式会社 | 気泡含有液体製造装置及び気泡含有液体製造システム |
| EP4570366A1 (en) * | 2023-12-15 | 2025-06-18 | Licitar, Antonijo | Apparatuses and methods for producing nanoparticles from material in working liquid |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2592876A (en) * | 1946-07-22 | 1952-04-15 | Clarence E Earle | Rotor and stator for fluid handling machines having surfaces coated with gold |
| US3854083A (en) * | 1973-10-11 | 1974-12-10 | Gen Dynamics Corp | Millimeter wave mixer |
| JPS6047913B2 (ja) * | 1981-11-18 | 1985-10-24 | 正己 小林 | ステンレス鋼に直接金メツキを施す方法 |
| DE3207422A1 (de) * | 1982-03-02 | 1983-09-08 | Licentia Patent-Verwaltungs-Gmbh, 6000 Frankfurt | Koaxiales tiefpassfilter oder kontaktloser kurzschlussschieber |
| JPH0631469B2 (ja) * | 1987-02-06 | 1994-04-27 | 株式会社関西プラント工業 | 金めっき容器類の製造方法 |
| JPH08141378A (ja) * | 1994-11-25 | 1996-06-04 | Nittetsu Mining Co Ltd | 乳化分散装置 |
| JPH10137577A (ja) * | 1996-09-13 | 1998-05-26 | Oji Paper Co Ltd | マイクロカプセルの製造方法 |
| GB9717476D0 (en) * | 1997-08-18 | 1997-10-22 | Nycomed Imaging As | Process |
-
1998
- 1998-08-18 GB GBGB9818021.9A patent/GB9818021D0/en not_active Ceased
-
1999
- 1999-08-18 AU AU54359/99A patent/AU5435999A/en not_active Abandoned
- 1999-08-18 JP JP2000566009A patent/JP4974201B2/ja not_active Expired - Lifetime
- 1999-08-18 EP EP99940366A patent/EP1105209A1/en not_active Withdrawn
- 1999-08-18 WO PCT/GB1999/002741 patent/WO2000010697A1/en not_active Ceased
-
2001
- 2001-02-16 NO NO20010781A patent/NO20010781L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000010697A1 (en) | 2000-03-02 |
| AU5435999A (en) | 2000-03-14 |
| EP1105209A1 (en) | 2001-06-13 |
| NO20010781L (no) | 2001-04-17 |
| GB9818021D0 (en) | 1998-10-14 |
| JP2002523209A (ja) | 2002-07-30 |
| NO20010781D0 (no) | 2001-02-16 |
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