JP4968167B2 - Optical biometric apparatus and holder arrangement support system used therefor - Google Patents

Description

The present invention relates to an optical biometric apparatus that measures brain activity non-invasively and a holder arrangement support system used therefor. In particular, as an oxygen monitor or optical brain functional imaging device for diagnosing whether or not the tissue of a living body is normal by measuring changes in blood flow with time and changes in oxygen supply over time in each part of the brain The present invention relates to an optical biometric apparatus that can be used and a holder arrangement support system used therefor.

Hemoglobin plays a role in carrying oxygen in the blood. Since the hemoglobin concentration contained in the blood increases or decreases according to the expansion / contraction of the blood vessel, it is known to detect the expansion / contraction of the blood vessel by measuring the amount of change in the hemoglobin concentration.
In view of this, there has been known a biological measurement method that uses light to measure the inside of a living body simply and non-invasively by utilizing the fact that the amount of change in hemoglobin concentration corresponds to the oxygen metabolism function inside the living body. The amount of change in hemoglobin concentration is determined from the amount of change in light intensity (measurement data) obtained by irradiating a living body with light having a wavelength from visible light to the near-infrared region.

Furthermore, hemoglobin binds to oxygen to become oxyhemoglobin, while away from oxygen to deoxyhemoglobin. It is also known that in the brain, oxygen is supplied to a site activated by blood flow redistribution, and the concentration of oxyhemoglobin combined with oxygen increases. Therefore, it can be applied to the observation of brain activity by measuring the amount of change in oxyhemoglobin concentration. Since oxyhemoglobin and deoxyhemoglobin have different spectral absorption spectrum characteristics from visible light to near infrared region, oxyhemoglobin concentration using near infrared light of different wavelengths (for example, 780 nm, 805 nm, 830 nm). And the amount of deoxyhemoglobin concentration can be determined.

Therefore, in order to measure brain activity non-invasively, an optical biometric apparatus including a light transmitting probe and a light receiving probe has been developed. The optical biometric apparatus irradiates the brain with near-infrared light using a light-transmitting probe placed on the surface of the subject's scalp and emits near-infrared light emitted from the brain with a light-receiving probe placed on the surface of the scalp. The amount of change in light intensity (measurement data) is detected. Near-infrared light passes through scalp tissue and bone tissue and is absorbed by oxyhemoglobin or deoxyhemoglobin in blood. Therefore, by using near-infrared light of three different wavelengths in an optical biometric apparatus equipped with such a light-transmitting probe and a light-receiving probe, obtaining light reception amount information (measurement data) regarding the measurement site of the brain, The amount of change in oxyhemoglobin concentration, the amount of change in deoxyhemoglobin concentration at the measurement site of the brain, and the change over time in the amount of change in total hemoglobin concentration calculated from these are obtained.

Here, the relationship between the interval between the light transmitting probe and the light receiving probe (hereinafter referred to as “channel”) and the measurement site of the brain will be described. FIG. 13A is a cross-sectional view showing the relationship between the pair of light-transmitting probes 12 and the light-receiving probe 13 and the measurement site of the brain, and FIG. 13B is a plan view of FIG. .
The light transmitting probe 12 is pressed against the light transmitting point T on the scalp surface of the subject, and the light receiving probe 13 is pressed against the light receiving point R on the scalp surface of the subject. And while irradiating light from the light transmission probe 12, the light reception probe 13 is made to detect the light discharge | released from the scalp surface. At this time, among the light emitted from the light transmission point T on the scalp surface, the light passing through the banana shape (measurement region) reaches the light receiving point R on the scalp surface. Thereby, in the measurement region, in particular, from the midpoint M of the line L connecting the light transmitting point T and the light receiving point R along the scalp surface of the subject at the shortest distance, the light transmitting point T and the light receiving point R Is received light amount information (measurement data) at the site S of the subject having a depth L / 2 which is half the distance of the line connecting the shortest distance along the scalp surface of the subject.

Next, each part of the brain and the brain function will be described. FIG. 14 is a diagram showing an example of the cerebral cortex of the human brain. For convenience, the brain is divided into four parts: frontal lobe 71, parietal lobe 72, occipital lobe 73, and temporal lobe 74. A Sylvian groove 77 separates the temporal lobe 74 from other parts. A central groove 78 separates the frontal lobe 71 and the parietal lobe 72. Further, the parietal lobe 72 and the occipital lobe 73 are divided by a portion called angular turn (not shown).
A motor area 75 that transmits a command of movement to each part of the body is in front of the central groove 78 and occupies a part of the frontal lobe 71. A somatosensory area 76 that recognizes somatic sensations such as touch, pain, and pressure is behind the central groove 78 and occupies a part of the parietal lobe 72. The visual cortex 80 is in a part behind the occipital lobe 73. The auditory area 79 occupies a part of the temporal lobe 74. Furthermore, the motorized language center 81 occupies a part of the frontal lobe 71.

And, by measuring changes in oxyhemoglobin concentration changes over time at multiple measurement sites of the brain related to brain functions such as movement, sensation, and thinking, it can be applied to medical fields such as brain function diagnosis and cardiovascular system diagnosis Optical biometric devices have been developed. In such an optical biometric apparatus, for example, a near-infrared spectrometer (hereinafter abbreviated as “NIRS”) or the like is used (see, for example, Patent Document 1).
By the way, although a plurality of measurement sites are the brain, since the scalp exists outside the brain, it is impossible to determine the arrangement positions of the light transmitting probe and the light receiving probe while confirming the position of the brain. For this reason, the arrangement positions of the light transmitting probe and the light receiving probe are not determined based on the position of the brain, but are determined based on the reference point set on the scalp surface. As a reference point set on the scalp surface, for example, International 10-20 method has been published (for example, see Non-Patent Document 1).

The international 10-20 method will be described with reference to FIG. In the international 10-20 method, first, a sagittal center line connecting the nasal root (NASION) and the occipital pole (INION) is drawn, and the sagittal center line is divided into ten equal parts. Note that the midpoint of the sagittal center line is the vertex. In addition, draw the skull circumference from the nasal root through the left anterior pinna to the occipital pole, and draw the skull circumference from the nasal root through the right anterior pinna to the occipital pole. Divide into 10 equal parts. Subsequently, four concentric circles having a radius smaller by 1/10 of the sagittal center line with the head at the center are drawn. Furthermore, the coordinate which concerns on the international 10-20 method is created by drawing the line segment which connects each point which divided the skull circumference into 10 equal parts, and the top of the head.

Therefore, in NIRS, a fiber holder is used to bring a plurality of light-transmitting probes and a plurality of light-receiving probes into close contact with the scalp surface of the subject in a predetermined arrangement according to the coordinates according to the international 10-20 method. Is done. For example, such a fiber holder is molded into a scissors shape in accordance with the shape of the scalp surface. The fiber holder has a plurality of through holes, and the light transmitting probe and the light receiving probe are inserted into the through holes, so that the light transmitting probe and the light receiving probe are arranged at coordinates according to the international 10-20 method. Therefore, the amount of light received from the brain (measurement data) is obtained.
Such changes over time in the amount of change in the oxyhemoglobin concentration obtained from the received light amount information obtained by NIRS are displayed as an image on the monitor screen in order to be observed by a doctor, a laboratory technician, or the like. .
JP 2006-109964 A Masako Okamoto et al ,. “Three-dimensional probabilistic anatomical cranio-cerebral correlation via the international 10-20 system oriented for transcranial functional brain mapping” NeuroImage 21 (2004) 99-111

However, even if the brain activity is measured by placing the light transmitting probe and the light receiving probe at positions based on coordinates according to the International 10-20 method, there are individual differences in the anatomical structure of the brain. Because each person has a different shape, the brain activity (such as the motor cortex 75) to be measured is not measured, and the measurement results obtained between different subjects are simply compared. There was a problem that I could not.
On the other hand, in order to recognize from which part of the brain the measurement data is obtained, after obtaining the measurement data, three-dimensional morphological image data indicating the positional relationship between the scalp surface and the brain surface of the subject is obtained, There are optical biometric devices that display surface images and map them on the brain surface image, but because there is a skull outside the brain, the position of the light transmitting probe and light receiving probe can be determined while checking the position of the brain. The position cannot be determined. That is, there is a problem that the brain activity of the part of the brain to be measured is not measured even though it can be recognized from which part of the brain the measurement data is obtained.

Therefore, the present invention provides an optical biometric apparatus capable of determining the arrangement positions of a light transmission probe and a light reception probe so that measurement data from a brain region to be measured can be obtained, and a holder arrangement support system used therefor The purpose is to provide.
Furthermore, even if the arrangement positions of the light transmitting probe and the light receiving probe are not arranged at positions based on the coordinates according to the international 10-20 method, measurement data from the brain part from which the measurement data has been obtained previously can be obtained. An object of the present invention is to provide an optical biometric apparatus capable of determining the arrangement positions of a light transmitting probe and a light receiving probe and a holder arrangement supporting system used therefor.

An optical biometric device of the present invention made to solve the above-mentioned problems is a holder having a light-transmitting probe disposed on the scalp surface of a subject, a light-receiving probe disposed on the scalp surface, The light transmitting probe irradiates light on the scalp surface, and the light receiving probe is controlled to detect light emitted from the scalp surface, whereby a light transmitting / receiving unit control unit for obtaining measurement data relating to brain activity; A three-dimensional morphological image display control unit for acquiring three-dimensional morphological image data indicating a positional relationship between the scalp surface and the brain surface of the specimen and displaying the scalp surface image and the brain surface image on a display device; and the head of the subject A magnetic field source that generates a magnetic field in a surrounding space including the head of the subject and a designation for detecting the magnetic field for designating a reference position on the scalp surface of the subject. Magnetic A pencil having a sensor and at least three reference positions on the scalp surface of the subject are designated by the pencil, thereby obtaining a detection signal from the pencil, thereby obtaining the magnetic field source and at least three reference positions. And at least three reference position images and at least three reference position images are designated by the input device in the scalp surface image and brain surface image. A photobiological measuring device comprising a correspondence data creating unit that creates correspondence data indicating correspondence with three reference position images, the holder magnetic sensor being fixed to the holder and detecting the magnetic field; Stores holder information data indicating the positional relationship between the fixed position of the holder magnetic sensor on the holder and the fixed positions of the light transmitting probe and the light receiving probe. An arrangement position for acquiring arrangement positional relationship data indicating a positional relation between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe based on the storage unit, the detection signal from the holder magnetic sensor, and the holder information data Based on the relationship data acquisition unit, the correspondence relationship data, and the placement position relationship data, the placement position related image related to the placement positions of the light transmitting probe and the light receiving probe is superimposed on the scalp surface image and the brain surface image. An arrangement position-related image display control unit for displaying the image, and the arrangement position-related image display control unit changes the arrangement position when the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface are changed. The arrangement position related images are displayed so as to be updated in conjunction with each other.

Here, “three-dimensional morphological image data indicating the positional relationship between the scalp surface and the brain surface of the subject” refers to the subject created by a nuclear magnetic resonance imaging diagnostic apparatus (hereinafter abbreviated as MRI), a CT image, or the like. 3D image data created by extracting video data showing the scalp surface and brain surface from the video data (see FIG. 5).
The “pencil” is for designating a reference position (for example, nasal root, left auricle, right auricle) on the scalp surface of the subject. For example, a designation magnetic sensor is provided at the tip. The rod-shaped thing etc. which have are mentioned.
The “position-related image related to the arrangement position of the light transmission probe and the light reception probe” may be an image showing the arrangement position of the light transmission probe and the arrangement position of the light reception probe. It is also possible to display an image showing the midpoint between the position of the light receiving probe and the position of the light receiving probe. It may be an image showing a position that is half the depth of the line connected by the shortest distance (see FIG. 13).

According to the optical biometric apparatus of the present invention, first, the three-dimensional morphological image display control unit acquires three-dimensional morphological image data indicating the scalp surface and the brain surface of the subject. The three-dimensional morphological image display control unit displays the scalp surface image and the brain surface image based on the three-dimensional morphological image data (see FIG. 5). Thereby, doctors, laboratory technicians, and the like can accurately recognize the scalp surface and the brain surface of the subject to be measured, although there are individual differences in the anatomical structure of the brain.
Further, the magnetic field source is fixed at a set position (for example, the subject's jaw). The magnetic field source generates a magnetic field in the surrounding space including the head of the subject. Thereby, the position of the magnetic sensor for designation and the holder magnetic sensor which will be described later can be detected.

Then, in a state where a magnetic field is generated in the surrounding space including the head of the subject, a doctor, a laboratory technician, or the like uses at least three reference positions on the scalp surface of the subject (for example, Specify nasal root, left pinna, right pinna). Thereby, the reference position relationship acquisition unit acquires the position relationship between the magnetic field source and at least three reference positions. On the other hand, doctors, laboratory technicians, and the like use an input device to at least three reference position images (for example, nasal root images, left auricle images) corresponding to at least three reference positions in the scalp surface image and brain surface image. , Right auricle image). As a result, the correspondence data creation unit creates correspondence data indicating the correspondence between at least three reference positions and at least three reference position images. That is, in the optical biometric apparatus, the scalp surface and the brain surface of the subject are collated with the scalp surface image and the brain surface image.

Thus, in a state where the scalp surface and brain surface of the subject are collated with the scalp surface image and the brain surface image, a doctor, a laboratory technician, or the like places the holder on the scalp surface of the subject. At this time, in the photobiological measurement device of the present invention, the holder is arranged so as to obtain measurement data from a part of the brain to be measured by using an arrangement position related image display control unit to be described later. What is necessary is just to arrange | position a holder in an appropriate position.
Therefore, in the photobiological measurement device of the present invention, the storage unit can transmit the fixed position of the holder magnetic sensor on the holder and the transmission position so that the holder can be arranged so as to obtain measurement data from the brain region to be measured. Holder information data indicating the positional relationship between the fixed positions of the optical probe and the light receiving probe is stored. Thereby, in the optical biometric apparatus, if the position of the holder magnetic sensor is known, the light transmitting probe and the light receiving probe can be known.

Therefore, when the holder is arranged on the scalp surface of the subject, the arrangement positional relationship data acquisition unit obtains the positional relationship between the magnetic field source and the holder magnetic sensor based on the detection signal from the holder magnetic sensor, and further Based on the holder information data, arrangement positional relationship data indicating the positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe is acquired. Then, the arrangement position related image display control unit, based on the arrangement position relation data, in the scalp surface image and brain surface image, the arrangement position related image (for example, light transmission probe) related to the arrangement position of the light transmitting probe and the light receiving probe. The probe arrangement position image and the light receiving probe arrangement position image) are superimposed and displayed.
Thereafter, the arrangement positional relationship data acquisition unit continues to acquire arrangement positional relationship data indicating the positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe based on the detection signal from the holder magnetic sensor, The related image display control unit displays an arrangement position related image so as to update (in real time) in conjunction with the change of the arrangement position when the arrangement position of the light transmitting probe and the light receiving probe on the scalp surface is changed. To do.

As described above, according to the optical biometric apparatus of the present invention, when the arrangement position of the light transmitting probe and the light receiving probe on the scalp surface is changed, it is updated (in real time) in conjunction with the change of the arrangement position. Since the scalp surface image and the placement position related image in the brain surface image are displayed, doctors and laboratory technicians can observe the position of the placement position related image in the brain surface image of the subject while observing the position of the brain to be measured. Thus, the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface can be determined so as to obtain the measurement data.

(Means and effects for solving other problems)
Further, in the photobiological measurement device according to the present invention, the holder has at least three holder magnetic sensors, and the holder information data includes a fixed position of at least three holder magnetic sensors on the holder and a light transmission probe. The positional relationship with the fixed position of the light receiving probe may also be shown.

The optical biometric apparatus of the present invention also includes a holder having a light transmitting probe disposed on the scalp surface of a subject, a light receiving probe disposed on the scalp surface, and the light transmitting probe on the scalp surface. A light transmitting / receiving unit controller that obtains measurement data relating to brain activity by irradiating light and controlling the light receiving probe to detect light emitted from the scalp surface, and the scalp surface and brain surface of the subject. 3D morphological image data indicating the positional relationship between the three-dimensional morphological image display controller and a three-dimensional morphological image display control unit for displaying a scalp surface image and a brain surface image on a display device; A magnetic field source for generating a magnetic field in a surrounding space including the head of the subject, and a pencil having a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject. , By acquiring at least three reference positions on the scalp surface of the subject with a pencil and obtaining a detection signal from the pencil, a positional relationship between the magnetic field source and at least three reference positions is obtained. And at least three reference position images and at least three reference position images when the input device designates at least three reference position images in the scalp surface image and the brain surface image. An optical biometric apparatus comprising a correspondence data creation unit for creating correspondence data indicating a correspondence relationship between the scalp surface image and the brain surface image based on a detection signal and correspondence data from the pencil. A pencil position image display control unit that superimposes and displays a pencil position image corresponding to the position of the pencil, and a scalp surface on the subject. An arrangement position indicating the positional relationship between the magnetic field source and the arrangement positions of the light transmission probe and the light reception probe by obtaining a detection signal from the pencil by specifying the arrangement positions of the light transmission probe and the light reception probe with a pencil. It is related to the arrangement position of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image based on the arrangement relation data acquisition unit for acquiring the relation data, and the correspondence relation data and the arrangement position relation data. An arrangement position related image display control unit that superimposes and displays an arrangement position related image, and the pencil position image display control unit is interlocked with the change of the position of the pencil when the position of the pencil is changed. The pencil position image is displayed so as to be updated.

According to the optical biometric apparatus of the present invention, first, the three-dimensional morphological image display control unit acquires three-dimensional morphological image data indicating the scalp surface and the brain surface of the subject. The three-dimensional morphological image display control unit displays a scalp surface image and a brain surface image based on the three-dimensional morphological image data.
The magnetic field source is fixed at a set position. The magnetic field source generates a magnetic field in the surrounding space including the head of the subject.
In a state where a magnetic field is generated in the surrounding space including the head of the subject, a doctor, a laboratory technician, or the like designates at least three reference positions on the scalp surface of the subject using a designation magnetic sensor. Thereby, the reference position relationship acquisition unit acquires the position relationship between the magnetic field source and at least three reference positions. On the other hand, doctors, laboratory technicians, and the like use the input device to designate at least three reference position images corresponding to at least three reference positions in the scalp surface image and the brain surface image. As a result, the correspondence data creation unit creates correspondence data indicating the correspondence between at least three reference positions and at least three reference position images.

In this manner, the holder is placed on the scalp surface of the subject in a state in which the scalp surface and brain surface of the subject are collated with the scalp surface image and the brain surface image. At this time, in the photobiological measurement device of the present invention, since the light transmitting probe and the light receiving probe are arranged so as to obtain measurement data from a part of the brain to be measured using a pencil position image display control unit described later, What is necessary is just to arrange | position a light transmission probe and a light reception probe in an appropriate position at a local point.
Therefore, when the holder is placed on the scalp surface of the subject, the pencil position image display control unit, based on the detection signal from the pencil, in the scalp surface image and the brain surface image corresponds to the pencil position. The position image is superimposed and displayed. Thereafter, when the position of the pencil is changed, the pencil position image display control unit displays the pencil position image so as to be updated (in real time) in conjunction with the change of the position of the pencil.

Then, in a state where the pencil position image is displayed so as to be updated in conjunction with the change in the position of the pencil, the arrangement position relationship data acquisition unit determines that the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface of the subject. By specifying with the pencil, arrangement positional relationship data indicating the positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe is acquired. The arrangement position related image display control unit superimposes and displays an arrangement position related image related to the arrangement positions of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image.

As described above, according to the photobiological measurement device of the present invention, when the position of the pencil is changed, it is updated (in real time) in association with the change of the position of the pencil in the scalp surface image and the brain surface image. Since the pencil position image is displayed, doctors and laboratory technicians can observe the position of the pencil position image on the brain surface image of the subject while obtaining the measurement data from the brain region to be measured. The arrangement position of the light transmitting probe and the light receiving probe in can be determined.

The optical biometric apparatus of the present invention is also related to the arrangement position and the scalp surface image and the brain surface image, which are the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface finally determined to obtain the measurement data. A final arrangement position data acquisition unit that stores final arrangement position data indicating a positional relationship with the image in the storage unit; and a final arrangement position that displays a previously stored final arrangement position-related image based on the final arrangement position data. You may make it provide a related image display control part.
According to the optical biometric apparatus of the present invention, the storage unit has a scalp surface image and a brain surface image, which are the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface finally determined to obtain measurement data, and Since the final placement position data indicating the positional relationship with the placement position related image is stored, the final placement position related image display control unit stores the previously stored final placement position related image based on the final placement position data. Can be displayed. Therefore, by displaying the previously stored final placement position related image, the doctor or laboratory technician can observe the position of the final placement position related image while measuring the data from the brain part from which the measurement data was previously obtained. So that the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface can be determined.

In the optical biometric apparatus of the present invention, the holder may include a plurality of light transmitting probes and a plurality of light receiving probes.
The holder placement support system of the present invention includes a holder having a light transmitting probe disposed on the scalp surface of a subject, a light receiving probe disposed on the scalp surface, and the light transmitting probe on the scalp surface. A light transmitting / receiving unit controller that obtains measurement data relating to brain activity by irradiating light and controlling the light receiving probe to detect light emitted from the scalp surface, and the scalp surface and brain surface of the subject. 3D morphological image data indicating the positional relationship between the three-dimensional morphological image display controller and a three-dimensional morphological image display control unit for displaying a scalp surface image and a brain surface image on a display device; A magnetic field source for generating a magnetic field in a surrounding space including the head of the subject and a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject. The sill and at least three reference positions on the scalp surface of the subject are designated by the pencil, and a detection signal from the pencil is obtained, whereby the position of the magnetic field source and the at least three reference positions. A reference position relationship acquisition unit for acquiring a relationship, and at least three reference position images are designated by the input device in the scalp surface image and the brain surface image, so that at least three reference positions and at least three reference positions are specified. Holder placement support used in a photobiological measurement device comprising correspondence data creation unit that creates correspondence data indicating a correspondence with a reference position image and a holder magnetic sensor that is fixed to the holder and detects the magnetic field A system for indicating a positional relationship between a fixed position of a holder magnetic sensor on the holder and fixed positions of a light transmitting probe and a light receiving probe. Based on a storage system for storing information data, a detection signal from the holder magnetic sensor, and holder information data, arrangement positional relationship data indicating a positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe is obtained. An arrangement position relation data acquisition system to be obtained, and an arrangement position relation related to the arrangement positions of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image based on the correspondence relation data and the arrangement position relation data. An arrangement position-related image display control system for displaying an image in an overlapping manner, and the arrangement position-related image display control system is arranged when the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface are changed. The arrangement position related image is displayed so as to be updated in conjunction with the change of the position.

Furthermore, the holder placement support system of the present invention includes a holder having a light transmission probe disposed on the scalp surface of a subject, a light receiving probe disposed on the scalp surface, and the light transmission probe on the scalp surface. A light transmitting / receiving unit controller that obtains measurement data relating to brain activity by irradiating light and controlling the light receiving probe to detect light emitted from the scalp surface, and the scalp surface and brain surface of the subject. 3D morphological image data indicating the positional relationship between the three-dimensional morphological image display controller and a three-dimensional morphological image display control unit for displaying a scalp surface image and a brain surface image on a display device; A magnetic field source for generating a magnetic field in a surrounding space including the head of the subject and a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject. The sill and at least three reference positions on the scalp surface of the subject are designated by the pencil, and a detection signal from the pencil is obtained, whereby the position of the magnetic field source and the at least three reference positions. A reference position relationship acquisition unit for acquiring a relationship, and at least three reference position images are designated by the input device in the scalp surface image and the brain surface image, so that at least three reference positions and at least three reference positions are specified. A holder arrangement support system for use in an optical biometric apparatus including a correspondence data creating unit that creates correspondence data indicating a correspondence with a reference position image, the detection signal from the pencil and correspondence data Based on the pencil position image, the pencil position image corresponding to the position of the pencil is superimposed on the scalp surface image and the brain surface image. The display control system, and the arrangement positions of the light transmitting probe and the light receiving probe on the scalp surface of the subject are designated by a pencil, thereby obtaining a detection signal from the pencil, whereby the magnetic field source, the light transmitting probe, and In the scalp surface image and the brain surface image, based on the arrangement positional relationship data acquisition system that acquires the arrangement positional relationship data indicating the positional relationship with the arrangement position of the light receiving probe, the correspondence relationship data and the arrangement positional relationship data, An arrangement position related image display control system that superimposes and displays an arrangement position related image related to the arrangement positions of the light transmitting probe and the light receiving probe, and the pencil position image display control system is configured such that the position of the pencil is changed. Then, the pencil position image is displayed so as to be updated in conjunction with the change of the position of the pencil. I am doing so.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, this invention is not limited to the following embodiment, It cannot be overemphasized that various aspects are included in the range which does not deviate from the meaning of this invention.

<First embodiment>
FIG. 1 is a block diagram showing a configuration of an optical biometric apparatus according to an embodiment of the present invention. The optical biometric apparatus 1 includes a fiber holder 11 disposed on the scalp surface of a subject, a light emitting unit 2, a light detecting unit 3, and a magnetic field that generates an alternating magnetic field in a surrounding space including the subject's head. It comprises a source 4, a rod-shaped pencil 5 having a designation magnetic sensor 5 a for detecting an alternating magnetic field at its tip, and a control unit (computer) 20 that controls the entire optical biometric apparatus 1.
FIG. 2 is a plan view showing the positional relationship among the ten light transmitting probes 12, the ten light receiving probes 13, and the four holder magnetic sensors 14 in the fiber holder 11 according to the first embodiment. is there.
FIG. 3 shows a fiber holder 11 arranged on the subject, a magnetic field source 4 fixed to a set position (subject's jaw), and a pencil 5 operated by a doctor, a laboratory technician, or the like (not shown). It is a figure which shows the relationship.
Furthermore, FIG. 4 is a figure which shows an example of the monitor screen 23a displayed by the optical biometric apparatus 1 which concerns on this invention. A scalp surface image 24a and a brain surface image 24b are displayed on the monitor screen 23a. Further, a pointer 24c, a light transmission probe arrangement position image (arrangement position related image) 25 indicated by a black circle, and a light receiving probe arrangement position image (arrangement position related image) 26 indicated by a white circle are displayed. The scalp surface image 24a is displayed in a translucent manner. In the first embodiment, when the arrangement position of the fiber holder 11 on the scalp surface of the subject is changed, the light transmission probe arrangement position image 25 and the light receiving probe arrangement are updated in real time so as to be updated in conjunction with the change of the arrangement position. The position image 26 is displayed.

The magnetic field source 4 is composed of, for example, a solenoid coil or the like in which a conducting wire covered with an insulating hard cylindrical core is wound, and generates an alternating magnetic field. Then, as shown in FIG. 3, the magnetic field source 4 is fixed at a set position which is a jaw of the subject so as to generate an alternating magnetic field in a surrounding space including the head of the subject.
As shown in FIG. 3, the pencil 5 has a bar shape and has a designation magnetic sensor 5 a at the tip. In the designation magnetic sensor 5a, conductive wires are wound in three directions so that the coil surfaces are orthogonal to each other, and each coil detects a detection signal proportional to the intensity of the magnetic field of the axial component orthogonal to the coil surface. . Then, a doctor, a laboratory technician, or the like designates three reference positions (for example, nasal root B1, left auricle B2, and right auricle) on the scalp surface of the subject with the pencil 5, so that a reference position relationship described later is provided. A detection signal can be output to the acquisition unit 35.

As shown in FIG. 2, the fiber holder 11 includes ten light transmitting probes 12, ten light receiving probes 13, and four holder magnetic sensors 14.
Ten light transmitting probes 12 and ten light receiving probes 13 are fixed so as to alternate in the vertical direction and the horizontal direction. Ten light transmitting probes 12 emit light, while ten light receiving probes 13 detect light intensity. Note that the distance between the light transmitting probe 12 and the light receiving probe 13 is 30 mm.
The four holder magnetic sensors 14 are fixed to the four corners of the fiber holder 11, respectively. As in the case of the designation magnetic sensor 5a, one holder magnetic sensor 14 is wound with a conducting wire in three directions so that the coil surfaces are orthogonal to each other, and each coil has an axial component orthogonal to the coil surface. A detection signal proportional to the strength of the magnetic field is detected. The four holder magnetic sensors 14 can always output detection signals to the arrangement positional relationship data acquisition unit 37 described later.
The positional relationship among the fixed positions of the ten light transmitting probes 12, the fixed positions of the ten light receiving probes 13, and the fixed positions of the four holder magnetic sensors 14 on the fiber holder 11 is holder information described later. Pre-stored in the data storage area 51. Thereby, in the computer 20, if the positions of the four holder magnetic sensors 14 are known, the positions of the ten light transmitting probes 12 and the ten light receiving probes 13 can be known.

The light emitting unit 2 transmits light to one light transmission probe 12 selected from the ten light transmission probes 12 by a drive signal input from the computer 20. As the light, near infrared light (for example, 780 nm, 805 nm, 830 nm) is used.
The light detection unit 3 outputs ten received light signals (measurement data) to the computer 20 by individually detecting near-infrared light (for example, 780 nm, 805 nm, and 830 nm) received by the ten light receiving probes 13. To do.

The MRI 6 creates three-dimensional morphological image data indicating the positional relationship between the subject's scalp surface and brain surface. Specifically, first, morphological image data indicating a two-dimensional image in three directions is acquired by photographing the scalp surface and the brain surface of the subject. Here, the morphological image data indicates a subject including a scalp surface and a brain surface having three reference positions (for example, nasal root B1, left auricle B2, and right auricle). The morphological image data is composed of a plurality of pixels having numerical values such as intensity information and phase information of the MR signal. Then, the scalp surface morphological image data is created by extracting the morphological video data showing the scalp surface, and the brain surface morphological image data is created by extracting the morphological video data showing the brain surface. Three-dimensional morphological image data indicating the positional relationship between the scalp surface and the brain surface of the specimen is created (see FIG. 5).
As the extraction method described above, for example, by using a plurality of pixels having numerical values such as intensity information and phase information of MR signals, an image region dividing method such as region expansion method, region merging method, heuristic method, Examples include a method of extracting a region by connecting boundary elements, a method of using a method of extracting a region by deforming a closed curve, and the like. By extracting the morphological image data in this way, the skull surface morphological image data and the brain surface morphological image data are acquired, so that clear image data can be acquired.

The computer 20 includes a CPU 21, and further includes a memory (storage unit) 25, a display device 23 having a monitor screen 23 a and the like, and a keyboard 22 a and a mouse 22 b that are input devices 22.
Further, the functions processed by the CPU 21 will be described in the form of blocks. The light transmitting / receiving unit control unit 31 that controls the light emitting unit 2 and the light detection unit 3, the three-dimensional form image display control unit 33, the pointer display control unit 34, Reference position relationship acquisition unit 35, correspondence relationship data creation unit 36, layout position relationship data acquisition unit 37, layout position related image display control unit 38, final layout position data acquisition unit 39, and final layout position related image display And a control unit 40.

The memory 25 also includes a holder information data storage area (storage system) 51 for storing holder information data, an image data storage area 52 for storing three-dimensional form image data, and final arrangement position data for storing final arrangement position data. And a storage area 53.
The holder information data is data indicating the positional relationship between the fixed positions of the four holder magnetic sensors 14 in the fiber holder 11, the fixed positions of the ten light transmitting probes 12, and the fixed positions of the ten light receiving probes 13. Yes, there are board design data created by CAD (see FIG. 2).
As described above, the three-dimensional morphological image data is three-dimensional image data created by extracting video data indicating the scalp surface and the brain surface from the video data of the subject created by the MRI 6 (FIG. 5). reference).

The three-dimensional morphological image display control unit 33 acquires the three-dimensional morphological image data indicating the positional relationship between the scalp surface and the brain surface of the subject from the MRI 6 and stores the acquired three-dimensional morphological image data in the image data storage area 52. Based on this, control is performed to display the scalp surface image 24a and the brain surface image 24b on the monitor screen 23a (see FIG. 5). Accordingly, doctors, laboratory technicians, and the like can accurately recognize the scalp surface and the brain surface of the subject themselves, although there are individual differences in the anatomical structure of the brain. Also, doctors, laboratory technicians, and the like can use the input device 22 to change the direction so that the scalp surface image 24a and the brain surface image 24b viewed from a desired direction can be displayed. Yes. Note that the three-dimensional form image data may be acquired from a separately provided MRI using a storage medium or the like.
The pointer display control unit 34 displays the pointer 24c on the monitor screen 23a, moves the pointer 24c displayed on the monitor screen 23a based on the operation signal output from the mouse 22b, and designates the position with the pointer 24c. Control.

The reference position relationship acquisition unit 35 designates three reference positions (for example, nasal root B1, left auricle B2, and right auricle) on the scalp surface of the subject with a pencil 5 by a doctor, a laboratory technician, or the like. Thus, by obtaining a detection signal from the pencil 5, control for acquiring the positional relationship between the magnetic field source 4 and the three reference positions is performed.
The correspondence relationship data creation unit 36 includes three reference position images corresponding to three reference positions (for example, nasal root B1, left pinna B2, and right pinna) in the scalp surface image 24a and the brain surface image 24b. (For example, the nose root image, the left auricle image, the right auricle image B3G) is designated by the pointer 24c, and correspondence data indicating the correspondence between the three reference positions and the three reference position images is obtained. Control to create. That is, the computer 20 collates the scalp surface and the brain surface of the subject with the scalp surface image 24a and the brain surface image 24b.

The arrangement positional relationship data acquisition unit 37 indicates the positional relationship between the magnetic field source 4 and the arrangement positions of the light transmission probe 12 and the light receiving probe 13 based on the detection signal from the holder magnetic sensor 14 and the holder information data. Control to acquire data (arrangement position relationship data acquisition system).
Specifically, the positional relationship between the magnetic field source 4 and the four holder magnetic sensors 14 is acquired by obtaining detection signals from the four holder magnetic sensors 14. Holder information data indicating the positional relationship among the fixed positions of the four holder magnetic sensors 14, the fixed positions of the ten light transmitting probes 12, and the fixed positions of the ten light receiving probes 13 is stored in the holder information data storage area 51. Since it is stored, arrangement position relationship data indicating the position relationship between the arrangement positions of the magnetic field source 4, the ten light transmission probes 12 and the ten light receiving probes 13 is acquired.

The arrangement position related image display control unit 38, based on the correspondence relation data and the arrangement position relation data, includes a light transmission probe arrangement position image corresponding to the arrangement position of the light transmission probe 12 in the scalp surface image 24a and the brain surface image 24b. 25 is superimposed and displayed, and the light receiving probe arrangement position image 26 corresponding to the arrangement position of the light receiving probe 13 is superimposed and displayed (arrangement position related image display control system, see FIG. 4).
Specifically, the light transmission probe arrangement position image 25 is displayed as a black circle, and the light receiving probe arrangement position image 26 is displayed as a white circle. Thereby, a doctor, a laboratory technician, or the like observes the positions of the light transmitting probe arrangement position image 25 and the light receiving probe arrangement position image 26 in the brain surface image 24b, so that measurement data can be obtained from any part of the brain in the current arrangement state. It is possible to recognize whether it can be obtained.
Further, when the arrangement positions of the light transmission probe 12 and the light reception probe 13 on the scalp surface are changed, the light transmission probe arrangement is performed in real time so as to be updated in conjunction with the change of the arrangement position, for example, as shown in FIG. The position image 25 ′ and the light receiving probe arrangement position image 26 ′ are displayed. In other words, when a doctor, a laboratory technician, or the like recognizes that measurement data cannot be obtained from a region to be measured in the current arrangement state, the measurement data is obtained from the region to be measured so that the measurement data can be obtained from the region to be measured. While observing the positions of the optical probe arrangement position image 25 and the light receiving probe arrangement position image 26, the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface can be changed.
Further, in the optical biometric apparatus 1, the brain surface image 24b and the scalp surface 24a and the scalp surface can be displayed so that the direction can be changed so that the brain surface image 24b and the scalp surface image 24a are viewed from a desired direction. As the image 24a moves, both the light transmission probe arrangement position image 25 and the light receiving probe arrangement position image 26 are moved.

The final placement position data acquisition unit 39 sends the light to the scalp surface image 24a and the brain surface image 24b, which are the placement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface finally determined to obtain measurement data. Control is performed to store the final arrangement position data indicating the positional relationship between the probe arrangement position image 25 and the light receiving probe arrangement position image 26 in the final arrangement position data storage area 53.
The final arrangement position image display control unit 40 performs control to display the previously stored final arrangement position image based on the final arrangement position data. Therefore, by displaying the previously stored final placement position related image, the doctor or laboratory technician can observe the position of the final placement position related image while measuring the data from the brain part from which the measurement data was previously obtained. So that the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface can be determined.

The light transmission / reception unit control unit 31 includes a light emission control unit 42 that outputs a drive signal to the light emitting unit 2 and a light detection control unit 43 that receives a light reception signal (measurement data) from the light detection unit 3.
The light emission control unit 42 performs control to output a drive signal for transmitting light to the light transmission probe 12 to the light emitting unit 2. For example, light is sequentially transmitted so that light is transmitted to one light transmission probe 12 for 0.15 seconds, and then light is transmitted to another light transmission probe 12 for 0.15 seconds. A drive signal for transmitting light to the probe 12 is output to the light emitting unit 2.
The light detection control unit 43 performs control to receive ten measurement data detected from the ten light receiving probes 13 from the light detection unit 3.

Next, a measurement method for obtaining measurement data using the optical biometric apparatus 1 will be described. FIG. 7 is a flowchart for explaining an example of the measuring method by the optical biometric apparatus 1.
First, in the process of step S101, the three-dimensional morphological image display control unit 33 acquires three-dimensional morphological image data indicating the positional relationship between the scalp surface and the brain surface of the subject from the MRI 6, and converts the three-dimensional morphological image data into the three-dimensional morphological image data. Based on this, the scalp surface image 24a and the brain surface image 24b are displayed on the monitor screen 23a (see FIG. 5).
Next, in the process of step S102, a doctor, a laboratory technician, or the like fixes the magnetic field source 4 to a set position (for example, the subject's jaw) and places the fiber holder 11 on the scalp surface of the subject. At this time, the fiber holder 11 may be disposed at an appropriate position.

Next, in the process of step S103, a doctor, a laboratory technician, or the like designates three reference positions (for example, the nasal root B1, the left auricle B2, and the right auricle) with the pencil 5 on the scalp surface of the subject.
Next, in the process of step S104, the reference positional relationship acquisition unit 35 obtains a detection signal from the pencil 5, thereby obtaining the magnetic field source 4 and three reference positions (for example, the nasal root B1, the left auricle B2, the right The positional relationship with the auricle is acquired.
Next, in the process of step S105, doctors, laboratory technicians, and the like correspond to three reference positions (for example, nasal root B1, left auricle B2, and right auricle) in scalp surface image 24a and brain surface image 24b. Three reference position images (for example, nasal root image, left pinna image, and right pinna image B3G) are designated by the pointer 24c.

Next, in the process of step S106, the correspondence relationship data creation unit 36 includes three reference positions (for example, nasal root B1, left auricle B2, and right auricle) and three reference position images (for example, nasal root). Correspondence relationship data indicating the correspondence relationship between the image, the left auricle image, and the right auricle image B3G) is created.
Next, in the process of step S107, the arrangement position relationship data acquisition unit 37 arranges the magnetic field source 4, the light transmitting probe 12, and the light receiving probe 13 based on the detection signal from the holder magnetic sensor 14 and the holder information data. Arrangement positional relationship data indicating the positional relationship is acquired.

Next, in the process of step S108, the arrangement position related image display control unit 38 arranges the arrangement position of the light transmission probe 12 in the scalp surface image 24a and the brain surface image 24b based on the correspondence relation data and the arrangement position relation data. And a light receiving probe arrangement position image 26 corresponding to the arrangement position of the light receiving probe 13 are superimposed and displayed (see FIG. 4).
Next, in step S109, a doctor, a laboratory technician, or the like determines whether or not to move the fiber holder 11 on the scalp surface of the specimen. When a doctor, a laboratory technician, or the like cannot obtain measurement data from a part of the brain to be measured at the current arrangement position of the fiber holder 11, when determining that the fiber holder 11 is moved on the scalp surface of the specimen, The process returns to step S107. At this time, when the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface are changed, the arrangement position related image display control unit 38 performs real-time transmission so as to update in conjunction with the change of the arrangement position. An optical probe arrangement position image 25 ′ and a light receiving probe arrangement position image 26 ′ are displayed (see FIG. 6).
On the other hand, doctors, laboratory technicians, and the like can obtain measurement data from the part of the brain that is desired to be measured at the current position of the fiber holder 11, and therefore decide not to move the fiber holder 11 on the scalp surface of the specimen. In this case, in the process of step S110, the final arrangement position data acquisition unit 39 is a scalp surface image that is the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface finally determined to obtain measurement data. The final placement position data storage area 53 stores final placement position data indicating the positional relationship between the 24a and brain surface image 24b and the light transmission probe placement position image 25 and the light receiving probe placement position image 26.

Next, in the process of step S111, the light emission control unit 42 and the light detection control unit 43 output a drive signal to the light emission unit 2 and receive a light reception signal (measurement data) from the light detection unit 3.
When the process of step S111 is completed, this flowchart is terminated.

As described above, according to the optical biometric apparatus 1, when the arrangement position of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface is changed, the transmission is performed in real time so as to be updated in conjunction with the change of the arrangement position. Since the optical probe arrangement position image 25 and the light reception probe arrangement position image 26 are displayed, a doctor, a laboratory technician, or the like observes the light transmission probe arrangement position image 25 and the light reception probe arrangement position image 26 in the brain surface image 24b of the subject. On the other hand, the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface can be determined so that measurement data from the brain region to be measured can be obtained.
Further, according to the optical biometric apparatus 1 of the present invention, the final arrangement position data storage area 54 is the arrangement of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface finally determined to obtain measurement data. Since the final arrangement position data indicating the positional relationship between the scalp surface image 24a and the brain surface image 24b and the light transmission probe arrangement position image 25 and the light receiving probe arrangement position image 26 are stored. An arrangement position image can be displayed. Thus, the light transmitting probe 12 and the light receiving probe on the scalp surface can be obtained so that doctors, laboratory technicians, and the like can obtain measurement data from the part of the brain from which the measurement data was previously obtained while observing the final placement position related image. 13 can be determined.

<Second Embodiment>
FIG. 8 is a block diagram showing another example of the configuration of the optical biometric apparatus according to the embodiment of the present invention. The optical biometric apparatus 60 includes a fiber holder 61, a light emitting unit 2, a light detecting unit 3, a magnetic field source 4 that generates an alternating magnetic field in the surrounding space including the head of the subject, and a designation for detecting the alternating magnetic field. It is comprised by the rod-shaped pencil 5 which has the magnetic sensor 5a for a tip at the front-end | tip part, the computer 70 which controls the optical biometric apparatus 60 whole, and MRI6. In addition, the same code | symbol is attached | subjected about the thing similar to the optical biometric apparatus 1 mentioned above.
FIG. 9 is a plan view showing the positional relationship between the ten light transmitting probes 12 and the ten light receiving probes 13 in the fiber holder 61 according to the second embodiment. In the second embodiment, the ten light transmitting probes 12 and the ten light receiving probes 13 may be formed so as to be movable with respect to the fiber holder 61.
Furthermore, FIG. 10 is a figure which shows an example of the monitor screen 23a displayed by the optical biometric apparatus 60 which concerns on this invention. A scalp surface image 24a and a brain surface image 24b are displayed on the monitor screen 23a. Further, a pointer 24c and a pencil position image 27 are displayed. In the second embodiment, when the position of the pencil 5 is changed, the pencil position image 27 is displayed in real time so as to be updated in conjunction with the change of the position of the pencil 5.

The computer 70 includes a CPU 21, and further includes a memory 25, a display device 23 having a monitor screen 23 a and the like, and a keyboard 22 a and a mouse 22 b that are input devices 22.
Further, the functions processed by the CPU 21 will be described in the form of blocks. The light transmitting / receiving unit control unit 31 that controls the light emitting unit 2 and the light detection unit 3, the three-dimensional form image display control unit 33, the pointer display control unit 34, Reference position relationship acquisition unit 35, correspondence relationship data creation unit 36, layout position relationship data acquisition unit 71, layout position related image display control unit 72, final layout position data acquisition unit 39, and final layout related position image display It has the control part 40 and the pencil position image display control part 73.

The pencil position image display control unit 73 superimposes the pencil position image 27 corresponding to the position of the pencil 5 on the scalp surface image 24a and the brain surface image 24b based on the detection signal from the pencil 5 and the correspondence data. Display control is performed (pencil position image display control system, see FIG. 10).
Thereby, a doctor, a laboratory technician, or the like designates the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface of the subject with the pencil 5, and observes the position of the pencil position image 27 in the brain surface image 24b. Thus, it is recognized from which part of the brain the measurement data can be obtained in the current arrangement state.
In addition, when the position of the pencil 5 is changed, a pencil position image 27 ′ is displayed in real time so as to be updated in conjunction with the change of the position of the pencil 5, for example, as shown in FIG. That is, when a doctor, a laboratory technician, or the like recognizes that measurement data cannot be obtained from a site to be measured in the current arrangement state, the pencil in the brain surface image 24b of the subject is obtained so that the measurement data can be obtained from the site to be measured. While observing the position of the position image 27, the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface can be changed.

The arrangement position relationship data acquisition unit 71 obtains a detection signal from the pencil 5 by designating the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface of the subject, thereby obtaining a magnetic field source. 4 is controlled to acquire arrangement positional relationship data indicating the positional relationship between the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 (arrangement positional relationship data acquisition system).
Specifically, by obtaining a detection signal from the pencil 5 in a state where the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface of the subject are specified by the pencil 5, the magnetic field source 4 and the light transmitting light are transmitted. The positional relationship with the arrangement positions of the probe 12 and the light receiving probe 13 is acquired.
The arrangement position image display control unit 72, based on the correspondence data and the arrangement position relation data, includes the light transmission probe arrangement position image 25 corresponding to the arrangement position of the light transmission probe 12 in the scalp surface image 24a and the brain surface image 24b. Are superimposed and displayed, and a control is performed to superimpose and display the light receiving probe arrangement position image 26 corresponding to the arrangement position of the light receiving probe 13 (arrangement position related image display control system).

Next, a measurement method for obtaining measurement data using the optical biometric apparatus 60 will be described. FIG. 12 is a flowchart for explaining an example of the measurement method by the optical biometric apparatus 60. In addition, since the process of step S201-206 is the same as the process of step S101-106 of the optical biometric apparatus 1, the description is abbreviate | omitted.

In the process of step S207, the pencil position image display control unit 73 selects the pencil position corresponding to the position of the pencil 5 in the scalp surface image 24a and the brain surface image 24b based on the detection signal from the pencil 5 and the correspondence data. The image 27 is superimposed and displayed (see FIG. 10).
Next, in the process of step S <b> 208, a doctor, a laboratory technician, or the like moves the pencil 5.
Next, in the process of step S209, the pencil position image display control unit 73 corresponds to the position of the pencil 5 in the scalp surface image 24a and the brain surface image 24b based on the detection signal from the pencil 5 and the correspondence data. The pencil position image 27 to be displayed is superimposed and displayed (see FIG. 11). That is, when the position of the pencil 5 is changed, the pencil position image 27 is displayed in real time so as to be updated in conjunction with the change of the position of the pencil 5.

Next, in the process of step S210, a doctor, a laboratory technician, or the like designates the arrangement position of the light transmitting probe 12 or the light receiving probe 13 on the scalp surface of the subject with the pencil 5.
Next, in the process of step S211, the arrangement positional relationship data acquisition unit 71 obtains a detection signal from the pencil 5 to indicate the positional relationship between the magnetic field source 4 and the arrangement position of the light transmitting probe 12 or the light receiving probe 13. Obtain placement position relationship data.
Next, in the process of step S212, a doctor, a laboratory technician, or the like determines whether or not the placement position of the light transmitting probe 12 or the light receiving probe 13 on the scalp surface of the subject is still designated with the pencil 5. When a doctor, a laboratory technician, or the like determines that the arrangement position of the light transmitting probe 12 or the light receiving probe 13 on the scalp surface of the subject is still designated by the pencil 5, the process returns to the process of step S208.
On the other hand, when a doctor, a laboratory technician, or the like determines that the arrangement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface of the subject are no longer designated by the pencil 5, the arrangement position related image display control is performed in the process of step S213. The unit 72 superimposes and displays the light transmission probe arrangement position image 25 corresponding to the arrangement position of the light transmission probe 12 on the scalp surface image 24a and the brain surface image 24b based on the correspondence relation data and the arrangement position relation data. At the same time, the light receiving probe arrangement position image 26 corresponding to the arrangement position of the light receiving probe 13 is superimposed and displayed.

Next, in the process of step S214, the final placement position data acquisition unit 39 is a scalp surface image that is the placement positions of the light transmitting probe 12 and the light receiving probe 13 on the scalp surface finally determined to obtain measurement data. The final placement position data storage area 53 stores final placement position data indicating the positional relationship between the 24a and brain surface image 24b and the light transmission probe placement position image 25 and the light receiving probe placement position image 26.
Next, in step S215, the light emission control unit 42 and the light detection control unit 43 output a drive signal to the light emitting unit 2 and receive a light reception signal (measurement data) from the light detection unit 3.
When the process of step S215 is completed, this flowchart is terminated.

As described above, according to the optical biometric device 60, when the position of the pencil 5 is changed, the pencil position image 27 is displayed in real time so as to be updated in conjunction with the change of the position of the pencil 5, so that the doctor The position of the light-transmitting probe 12 and the light-receiving probe 13 on the scalp surface so that a laboratory technician or the like can obtain measurement data from a part of the brain to be measured while observing the pencil position image 27 in the brain surface image 24b. Can be determined.

The present invention relates to an oxygen monitor and an optical brain functional imaging apparatus for diagnosing whether or not a living tissue is normal by measuring a temporal change in blood flow and a temporal change in oxygen supply in each part of the brain. Can be used as etc.

It is a block diagram which shows the structure of the optical biometric apparatus which is one Embodiment of this invention. It is a top view which shows the positional relationship of ten light transmission probes, ten light receiving probes, and four holder magnetic sensors in the fiber holder which concerns on 1st embodiment. It is a figure which shows the relationship between the fiber holder arrange | positioned at the subject, the magnetic field source arrange | positioned in a setting position, and the pencil operated by a doctor, a laboratory technician, etc. It is a figure which shows an example of the monitor screen displayed by the optical biometric apparatus which concerns on this invention. It is a figure which shows 3D form image data. It is a figure which shows another example of the monitor screen displayed by the optical biometric apparatus 1 which concerns on this invention. 4 is a flowchart for explaining an example of a measuring method by the optical biometric apparatus 1. It is a block diagram which shows another example of a structure of the optical biometric apparatus which is one Embodiment of this invention. It is a top view which shows the positional relationship of 10 light transmission probes and 10 light reception probes in the fiber holder which concerns on 2nd embodiment. It is a figure which shows an example of the monitor screen 23a displayed by the optical biometric apparatus 60 which concerns on this invention. It is a figure which shows an example of the monitor screen 23a displayed by the optical biometric apparatus 60 which concerns on this invention. 5 is a flowchart for explaining an example of a measurement method by the optical biometric apparatus 60. It is a figure which shows the relationship between a pair of light transmission probe and light reception probe, and the measurement site | part of a brain. It is a figure which shows an example of the cerebral cortex of a human brain. It is a figure for demonstrating the international 10-20 law.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1, 60: Optical biometric device 4: Magnetic field source 5: Pencil 11: Fiber holder 12: Light transmission probe 13: Light reception probe 14: Holder magnetic sensor 22: Input device 23: Display device 25: Light transmission probe arrangement position image ( Placement position related image)
26: Light receiving probe arrangement position image (arrangement position related image)
31: Transmission / reception unit control unit 33: Three-dimensional form image display control unit 35: Reference positional relationship acquisition unit 36: Correspondence relationship data generation unit 37: Arrangement positional relationship data acquisition unit 38: Arrangement position related image display control unit T: Transmission Light spot R: Light receiving point

Claims (7)

A holder having a light-transmitting probe disposed on the scalp surface of the subject, and a light-receiving probe disposed on the scalp surface;
The light transmitting probe irradiates light on the scalp surface, and the light receiving probe controls to detect light emitted from the scalp surface, thereby obtaining measurement data relating to brain activity; and
A three-dimensional morphological image display control unit that acquires three-dimensional morphological image data indicating a positional relationship between the scalp surface and the brain surface of the subject, and displays the scalp surface image and the brain surface image on a display device;
A magnetic field source that is fixed at a set position of the subject's head and generates a magnetic field in a surrounding space including the subject's head;
A pencil having a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject;
By acquiring at least three reference positions on the scalp surface of the subject with a pencil and obtaining a detection signal from the pencil, a positional relationship between the magnetic field source and at least three reference positions is acquired. A reference position relationship acquisition unit to
In the scalp surface image and the brain surface image, at least three reference position images are designated by the input device, thereby indicating a correspondence relationship between at least three reference positions and at least three reference position images. An optical biometric apparatus comprising a correspondence data creation unit for creating data,
A holder magnetic sensor fixed to the holder and detecting the magnetic field;
A storage unit for storing holder information data indicating a positional relationship between a fixed position of the holder magnetic sensor on the holder and a fixed position of the light transmitting probe and the light receiving probe;
An arrangement positional relationship data acquisition unit for acquiring arrangement positional relationship data indicating a positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe based on a detection signal from the holder magnetic sensor and holder information data; ,
Based on the correspondence relation data and the arrangement position relation data, the arrangement position related image that superimposes and displays the arrangement position related image related to the arrangement position of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image is displayed. An image display control unit,
The arrangement position related image display control unit is configured to update the arrangement position related image so as to be updated in conjunction with the change of the arrangement position when the arrangement position of the light transmitting probe and the light receiving probe on the scalp surface is changed. An optical biometric apparatus characterized by displaying. The holder has at least three holder magnetic sensors;
2. The photobiological measurement according to claim 1, wherein the holder information data indicates a positional relationship between a fixed position of at least three holder magnetic sensors on the holder and a fixed position of a light transmitting probe and a light receiving probe. apparatus.
A holder having a light-transmitting probe disposed on the scalp surface of the subject, and a light-receiving probe disposed on the scalp surface;
The light transmitting probe irradiates light on the scalp surface, and the light receiving probe controls to detect light emitted from the scalp surface, thereby obtaining measurement data relating to brain activity; and
A three-dimensional morphological image display control unit that acquires three-dimensional morphological image data indicating a positional relationship between the scalp surface and the brain surface of the subject, and displays the scalp surface image and the brain surface image on a display device;
A magnetic field source that is fixed at a set position of the subject's head and generates a magnetic field in a surrounding space including the subject's head;
A pencil having a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject;
By acquiring at least three reference positions on the scalp surface of the subject with a pencil and obtaining a detection signal from the pencil, a positional relationship between the magnetic field source and at least three reference positions is acquired. A reference position relationship acquisition unit to
In the scalp surface image and the brain surface image, at least three reference position images are designated by the input device, thereby indicating a correspondence relationship between at least three reference positions and at least three reference position images. An optical biometric apparatus comprising a correspondence data creation unit for creating data,
A pencil position image display control unit that superimposes and displays a pencil position image corresponding to the position of the pencil in the scalp surface image and the brain surface image based on the detection signal and the correspondence data from the pencil;
The arrangement position of the light transmitting probe and the light receiving probe on the scalp surface of the subject is designated by a pencil, and by obtaining a detection signal from the pencil, the arrangement position of the magnetic field source, the light transmitting probe, and the light receiving probe An arrangement positional relationship data acquisition unit for acquiring arrangement positional relationship data indicating the positional relationship with
Based on the correspondence relation data and the arrangement position relation data, the arrangement position related image that superimposes and displays the arrangement position related image related to the arrangement position of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image is displayed. An image display control unit,
When the position of the pencil is changed, the pencil position image display control unit displays the pencil position image so as to be updated in conjunction with the change of the position of the pencil. . The final placement position data indicating the positional relationship between the scalp surface image and the brain surface image and the placement position related image, which are the placement positions of the light transmitting probe and the light receiving probe on the scalp surface finally determined to obtain the measurement data A final arrangement position data acquisition unit for storing
The final arrangement position related image display control part which displays the final arrangement position related image memorize | stored previously based on the said final arrangement position data is provided. Optical biometric device. The optical biometric apparatus according to claim 1, wherein the holder includes a plurality of light transmitting probes and a plurality of light receiving probes. A holder having a light transmitting probe disposed on the scalp surface of the subject, a light receiving probe disposed on the scalp surface, the light transmitting probe irradiates light on the scalp surface, and the light receiving probe Three-dimensional morphological image data indicating the positional relationship between the transmitter / receiver controller that obtains measurement data related to brain activity by controlling to detect light emitted from the surface, and the scalp surface and brain surface of the subject And a three-dimensional morphological image display control unit that displays a scalp surface image and a brain surface image on a display device, and a fixed position of the subject's head, and a surrounding area including the subject's head A magnetic field source for generating a magnetic field in space; a pencil having a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject; and at least on the scalp surface of the subject. The reference position relationship acquisition unit that acquires the position relationship between the magnetic field source and at least three reference positions by obtaining a detection signal from the pencil by designating three reference positions with a pencil; Correspondence relation data indicating correspondence relation between at least three reference positions and at least three reference position images by designating at least three reference position images in the scalp surface image and brain surface image by the input device. A holder arrangement support system used in an optical biometric apparatus including a correspondence data creation unit that creates a holder magnetic sensor that is fixed to the holder and detects the magnetic field,
A storage system for storing holder information data indicating a positional relationship between a fixed position of the holder magnetic sensor on the holder and a fixed position of the light transmitting probe and the light receiving probe;
An arrangement positional relationship data acquisition system for acquiring arrangement positional relationship data indicating a positional relationship between the magnetic field source and the arrangement positions of the light transmitting probe and the light receiving probe based on a detection signal from the holder magnetic sensor and holder information data; ,
Based on the correspondence relation data and the arrangement position relation data, the arrangement position related image that superimposes and displays the arrangement position related image related to the arrangement position of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image is displayed. An image display control system,
The arrangement position related image display control system updates the arrangement position related image so as to be updated in conjunction with the change of the arrangement position when the arrangement position of the light transmitting probe and the light receiving probe on the scalp surface is changed. A holder arrangement support system characterized by displaying. A holder having a light transmitting probe disposed on the scalp surface of the subject, a light receiving probe disposed on the scalp surface, the light transmitting probe irradiates light on the scalp surface, and the light receiving probe Three-dimensional morphological image data indicating the positional relationship between the transmitter / receiver controller that obtains measurement data related to brain activity by controlling to detect light emitted from the surface, and the scalp surface and brain surface of the subject And a three-dimensional morphological image display control unit that displays a scalp surface image and a brain surface image on a display device, and a fixed position of the subject's head, and a surrounding area including the subject's head A magnetic field source for generating a magnetic field in space; a pencil having a designation magnetic sensor for detecting the magnetic field for designating a reference position on the scalp surface of the subject; and at least on the scalp surface of the subject. The reference position relationship acquisition unit that acquires the position relationship between the magnetic field source and at least three reference positions by obtaining a detection signal from the pencil by designating three reference positions with a pencil; Correspondence relation data indicating correspondence relation between at least three reference positions and at least three reference position images by designating at least three reference position images in the scalp surface image and brain surface image by the input device. A holder placement support system used in an optical biometric apparatus comprising a correspondence data creation unit for creating
A pencil position image display control system that superimposes and displays a pencil position image corresponding to the position of the pencil in the scalp surface image and the brain surface image based on the detection signal and correspondence data from the pencil;
The arrangement position of the light transmitting probe and the light receiving probe on the scalp surface of the subject is designated by a pencil, and by obtaining a detection signal from the pencil, the arrangement position of the magnetic field source, the light transmitting probe, and the light receiving probe An arrangement positional relationship data acquisition system for acquiring arrangement positional relationship data indicating the positional relationship between
Based on the correspondence relation data and the arrangement position relation data, the arrangement position related image that superimposes and displays the arrangement position related image related to the arrangement position of the light transmitting probe and the light receiving probe in the scalp surface image and the brain surface image is displayed. An image display control system,
The pencil position image display control system displays the pencil position image so as to be updated in conjunction with the change in the position of the pencil when the position of the pencil is changed. .