JP5853777B2 - Optical biological measurement device - Google Patents

Description

  The present invention relates to an optical biological measurement apparatus that acquires light detection signals related to a measurement site using light. In particular, the present invention is used as an optical brain functional imaging device that measures the activity state of a measurement site in the brain non-invasively using near-infrared light, and an oxygen monitor that monitors the oxygen consumption of the measurement site in a living body. .

Hemoglobin plays a role in carrying oxygen in the blood. The concentration of total hemoglobin (hereinafter also referred to as “totalHb”) contained in the blood increases or decreases according to the expansion / contraction of the blood vessels. Therefore, it is possible to detect the expansion / contraction of the blood vessels by measuring the concentration of total hemoglobin. It has been known. Further, hemoglobin is combined with oxygen to become oxyhemoglobin (hereinafter also referred to as “oxyHb”), and separated from oxygen to become deoxyhemoglobin (hereinafter also referred to as “deoxyHb”). It is also known that in the brain, oxygen is supplied to a site activated by blood flow redistribution, and the concentration of oxyhemoglobin combined with oxygen increases.
In view of this, there is known a living body measuring method that uses light to measure the inside of a living body simply and non-invasively. Oxyhemoglobin and deoxyhemoglobin have different spectral absorption spectrum characteristics from visible light to the near infrared region. For example, the amount of light obtained by irradiating a living body with near infrared light. From this, the concentration of oxyhemoglobin and the concentration of deoxyhemoglobin can be determined.

  In order to observe the activity state of the brain using such a living body measuring method, an optical living body measuring apparatus including a light transmitting probe and a light receiving probe at a set interval (channel) has been developed. In such an optical biometric apparatus, a near-infrared light is irradiated to the brain by a light transmitting probe disposed on the scalp surface of a subject, and a near-infrared light emitted from the brain by a light-receiving probe disposed on the scalp surface. Detect the amount of infrared light. Near-infrared light passes through scalp tissue and bone tissue and is absorbed by oxyhemoglobin and deoxyhemoglobin in blood. Therefore, by using a light-transmitting probe and a light-receiving probe, the concentration of oxyhemoglobin at the measurement site of the brain (precisely, oxyhemoglobin concentration change × average optical path length, but the average optical path length is constant (set interval) ), Deoxyhemoglobin concentration (exactly deoxyhemoglobin concentration change x average optical path length, but the average optical path length is omitted as constant), and total hemoglobin concentration calculated from these (exact Is a change in the concentration of total hemoglobin × average optical path length, but the average optical path length is omitted as being constant). FIG. 8 is a diagram illustrating an example of measurement data (trend graph). In addition, a vertical axis | shaft shows a density | concentration and a horizontal axis shows time.

Here, the relationship between the positions of the light transmitting probe and the light receiving probe and the measurement site of the brain will be described. FIG. 9A is a cross-sectional view showing the relationship between the pair of light transmitting probe 12 and light receiving probe 13 and the measurement site of the brain, and FIG. 9B is a plan view of FIG. 9A. .
The light transmission probe 12 is pressed against the light transmission point T on the scalp surface of the subject, and the light receiving probe 13 is pressed against the light reception point R on the scalp surface of the subject. And while irradiating light from the light transmission probe 12, the light reception probe 13 is made to detect the light discharge | released from the scalp surface. At this time, of the light irradiated from the light transmission point T on the scalp surface, the light passing through the banana shape (measurement region) reaches the light receiving point R on the scalp surface. Thereby, in the measurement region, in particular, from the midpoint M of the line L (set interval) connecting the light transmission point T and the light receiving point R along the scalp surface of the subject at the shortest distance, the light transmission point T and Information on the amount of received light (the concentration of oxyhemoglobin, the concentration of deoxyhemoglobin) having a depth L / 2 that is half the distance of the line connecting the light receiving point R with the shortest distance along the scalp surface of the subject In addition, the total hemoglobin concentration calculated from these is obtained.

Furthermore, in recent years, by measuring the oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration at the measurement site of the brain with respect to the entire brain surface, it has been applied to medical fields such as brain function diagnosis and circulatory system disorder diagnosis. An optical biometric device has been developed. As such a photobiological measuring device, for example, a near-infrared spectrometer (hereinafter abbreviated as NIRS) is used (for example, see Patent Document 1).
In NIRS, a holder is used to bring a plurality of light-transmitting probes and a plurality of light-receiving probes into close contact with the scalp surface of the subject in a predetermined arrangement. As such a holder, for example, a molded holder that is molded into a scissors shape in accordance with the shape of the scalp surface is used. The molding holder has a plurality of through-holes, and the light transmission probe and the light-receiving probe are inserted into the through-holes, so that the set interval (channel) is constant, and the received light amount information at a specific depth from the scalp surface. Have gained.

FIG. 2 is a plan view showing the positional relationship between the 14 light transmitting probes and the 13 light receiving probes in the NIRS as described above. In the light transmitting / receiving unit 11, the light transmitting probes 12a to 12n and the light receiving probes 13a to 13m are arranged alternately in the vertical direction and the horizontal direction. The light emitted from the light transmitting probes 12a to 12n is also detected by the light receiving probes 13a to 13m apart from the adjacent light receiving probes 13a to 13m. However, in order to simplify the description here, the adjacent light receiving probes are used. It is assumed that only 13a to 13l are detected. Therefore, a total of 42 received light amount information (light detection signals) can be obtained.
In general, a holder having a set interval (channel) of 30 mm is used. When the channel is 30 mm, the received light amount information with a depth of 15 mm to 20 mm from the midpoint of the channel is obtained as described above. It is believed that In other words, the position at a depth of 15 mm to 20 mm from the scalp surface substantially corresponds to the surface area of the brain, and the received light amount information relating to the activity state of the brain can be obtained.

Changes over time in the respective concentrations of oxyhemoglobin, deoxyhemoglobin and total hemoglobin calculated from the received light amount information (light detection signal) obtained by such NIRS are displayed as measurement data (trend graph) on the display device, Observed by etc.
FIG. 10 is a diagram showing an example of a monitor screen on which 42 pieces of measurement data (trend graph) are displayed by a conventional photobiological measuring device.
On the monitor screen, 42 pieces of measurement data # 1 to # 42 are displayed. At this time, in the plan view shown in FIG. 2, the light irradiated from the light transmitting probes 12a to 12n to each midpoint of the line connecting the light transmitting probes 12a to 12n and the light receiving probes 13a to 13n at the shortest distance. Are aligned and displayed so that the measurement data obtained when they are detected by the light receiving probes 13a to 13m are arranged. Specifically, measurement data # 1 when the light irradiated from the light transmitting probe 12a is detected by the light receiving probe 13a is arranged on the upper left, and the light irradiated from the light transmitting probe 12b is detected by the light receiving probe 13a. The measurement data # 2 is arranged to the right of the measurement data # 1, and the measurement data # 9 when the light irradiated from the light transmitting probe 12e is detected by the light receiving probe 13a is the measurement data # 1. Forty-two measurement data # 1 to # 42 are arranged and arranged so as to be arranged at the lower left.

  However, in the display method shown in FIG. 10, only the relationship between each concentration of oxygenated hemoglobin, deoxygenated hemoglobin, and total hemoglobin and time is displayed in 42 measurement data # 1 to # 42. An observer such as a doctor cannot easily diagnose which part of the subject's (patient) brain has a pathological condition such as cerebral ischemia or epilepsy, making it difficult to perform the examination.

On the other hand, an analysis unit that extracts a plurality of types of feature quantities (integral value and inclination (centroid value, etc.)) from measurement data (hemoglobin signal), a classification unit that classifies into a plurality of types by a combination of integral value and inclination, A living body light measurement system provided with a display part which displays an analysis result is indicated (for example, refer to patent documents 2). According to such biological light measurement, for example, the display unit creates a scatter diagram with the integrated value as the vertical axis and the centroid value as the horizontal axis, and plots the combination of the integrated value and the centroid value on the scatter diagram. In addition to the display, the classification unit displays on the scatter diagram the enclosing lines that define the types classified into Group1, Group2, and Group3 by the combination of the integral value and the centroid value. FIG. 11 is a diagram illustrating an example of a scatter diagram displayed by biological light measurement.
Thereby, an observer such as a doctor can recognize at a glance which disease group (Group1, Group2, Group3) the subject is likely to correspond to.

JP 2006-109964 A Japanese Patent No. 4518281

  However, in the display method shown in FIG. 11, it has not been considered to examine which part of the subject's brain has a disease state. Therefore, in the display method shown in FIG. 11, when plotting and displaying combinations of integrated values and centroid values obtained at a plurality of (for example, 42) measurement sites on the scatter diagram, which plot shows which part of the brain It was difficult to see if the patient was responding to the medical checkup.

Therefore, the present inventor has examined an optical biometric apparatus that allows an observer to examine in which part of the subject's brain a disease state such as cerebral ischemia or epilepsy has occurred.
By the way, in the conventional photobiological measuring device, in addition to the display method shown in FIG. 10, the contour line (color map) of the concentration of oxygenated hemoglobin at a specific time in the measurement data (trend graph) over the entire brain surface is displayed. Has been done. FIG. 12 is a diagram illustrating an example of a monitor screen on which contour lines (color map) of the concentration of oxygenated hemoglobin at a specific time in the measurement data are displayed on the entire brain surface. On the monitor screen, a three-dimensional brain surface image 24b and a three-dimensional scalp surface image 24a are displayed. A contour line indicating the concentration of oxygenated hemoglobin at a specific time (t = 100) is superimposed and displayed on the three-dimensional brain surface image 24b. At this time, the contour lines are displayed such that the color tone changes each time the oxygenated hemoglobin concentration rises or falls within a predetermined width with reference to the base value.

However, in the display method shown in FIG. 12, since there is a display of the brain part, it is easy to grasp the measurement part of the brain, but only the oxygenated hemoglobin concentration at a specific time (t = 100) is grasped. I couldn't. For this reason, it is difficult to examine which part of the brain has a pathological condition such as cerebral ischemia or epilepsy, making it difficult to examine.
Therefore, a plurality of feature quantities are extracted from the measurement data and the like, and a color table having the same number of dimensions as the number of feature quantities is created, and a morphological image such as a three-dimensional brain surface image is measured using the color table. It was found that the color tone is superimposed on the region.

That is, the optical biometric apparatus of the present invention includes a plurality of light transmitting / receiving probes disposed on the skin surface of the subject, and a plurality of light receiving / transmitting probes disposed on the skin surface, The light transmitting probe irradiates light on the skin surface, and the light receiving probe is controlled so as to detect light emitted from the skin surface, thereby acquiring a light detection signal relating to a measurement site in the subject. It is an intermediate time between the light receiving unit control unit, the integrated value that is the peak area value during the time-dependent change in the hemoglobin concentration calculated from the light detection signal, and the peak start time and the peak end time. A table for storing a color table in which a different color tone is assigned to each of the two-dimensional coordinates of the integrated value and the centroid value, the optical biometric device including an analysis unit that extracts the centroid value By applying a combination of a storage unit, a morphological image storage unit that stores a morphological image indicating the subject, and the integration value and the centroid value extracted by the analysis unit to a color table, the integration value and the A color tone corresponding to the combination with the centroid value is determined, and a display control unit that superimposes and displays the color tone on the measurement site of the morphological image is provided.

  Here, the “morphological image” refers to extracting video data indicating the scalp surface or the brain surface from the video data of the subject created by a nuclear magnetic resonance imaging apparatus (hereinafter abbreviated as MRI) or CT image. It may be a three-dimensional morphological image data created by this, or may be a template showing a human form.

  According to the optical biological measurement apparatus of the present invention, the table storage unit stores in advance a color table having the same number of dimensions as the number of types of feature amounts. For example, before measuring the subject, the integrated value of the change in hemoglobin concentration calculated from the photodetection signal over time is taken as the vertical axis, and the center of gravity value of the change in hemoglobin concentration calculated from the photodetection signal is plotted horizontally. In the two-dimensional table used as an axis, a color table in which different tone is associated with each predetermined coordinate range is stored.

And when measuring a subject, after a light transmission / reception part control part acquires a light detection signal, an analysis part extracts a some feature-value from a light detection signal. For example, the integrated value and the centroid value are extracted from the temporal change in the hemoglobin concentration calculated from the light detection signal.
Thereafter, when an observer such as a doctor examines the subject, the display control unit applies the combination of the integral value and the centroid value extracted by the analysis unit to the color table stored in the table storage unit. The color tone is determined, and the color tone is superimposed and displayed on the measurement site of the morphological image. Thereby, an observer such as a doctor can easily examine which part has a medical condition by grasping the color tone of each coordinate range in the two-dimensional table.

  Therefore, according to the photobiological measuring device of the present invention, since the color tone is superimposed and displayed on the measurement site of the morphological image, an observer such as a doctor can easily examine which site the disease condition has occurred. .

(Means and effects for solving other problems)
In the optical biometric apparatus of the present invention, the light transmitting probe and the light receiving probe are disposed on the scalp surface of the subject, and a light detection signal is obtained from information on an arrangement position of the light transmitting probe and the light receiving probe. A position calculation unit that calculates a position of the measurement site to be measured, and the display control unit displays the color tone superimposed on the measurement site of the three-dimensional brain surface image or the three-dimensional scalp surface image that is the morphological image. Good .

According to the optical biometric apparatus of the present invention, the color tone is superimposed and displayed on the measurement site of the three-dimensional brain surface image or the three-dimensional scalp surface image. The position of the part can be easily grasped .

The block diagram which shows the structure of the optical biological measuring device which is one Embodiment of this invention. The top view which shows the positional relationship of 14 light transmission probes and 13 light reception probes in a light transmission / reception part. The figure which shows an example of the monitor screen displayed by the optical biological measuring apparatus of this invention. The figure which shows an example of a color table. The figure which shows another example of a color table. The figure which shows an example which displayed between each measurement site | parts, such as a three-dimensional scalp surface template image, by the contour line (color map). The figure which shows an example which displayed between the 42 measurement site | parts of the three-dimensional brain surface image by the contour line (color map). The figure which shows an example of measurement data (trend graph). The figure which shows the relationship between a pair of light transmission probe and light reception probe, and the measurement site | part of a brain. The figure which shows an example of the monitor screen on which 42 measurement data (trend graph) were displayed by the conventional optical biological measurement apparatus. The figure which shows an example of the scatter diagram displayed by biological light measurement. The figure which shows an example of the monitor screen on which the contour line (color map) in the whole brain surface of the density | concentration of oxygenated hemoglobin of the specific time in measurement data was displayed.

  Hereinafter, embodiments of the present invention will be described with reference to the drawings. The present invention is not limited to the embodiments described below, and includes various modes without departing from the spirit of the present invention.

FIG. 1 is a block diagram showing a configuration of an optical biological measurement apparatus according to an embodiment of the present invention. In addition, the same code | symbol is attached | subjected about the thing similar to the optical biological measurement apparatus mentioned above.
The photobiological measuring device 1 includes a light transmitting / receiving unit 11, a light emitting unit 2, a light detecting unit 3, and a control unit (computer) 20 that controls the entire photobiological measuring device 1.

  The light emitting unit 2 transmits light to one light transmission probe 12 selected from among the 14 light transmission probes 12 by a drive signal input from the computer 20. Near-infrared light (for example, three-wavelength light of 780 nm, 805 nm, and 830 nm) is used as the light. Further, the light detection unit 3 individually detects near-infrared light (for example, three-wavelength light of 780 nm, 805 nm, and 830 nm) received by the 13 light receiving probes 13, thereby obtaining 13 light detection signals. Output to the computer 20.

  The photobiological measurement apparatus 1 of the present embodiment extracts a centroid value (Factor B) and an integrated value (Factor A) of oxygenated hemoglobin over time, and uses a combination of the centroid value and the integrated value for cerebral ischemia or This examines whether or not a medical condition such as epilepsy has occurred. The centroid value and the integral value are obtained as numerical values by scanning the waveform of the oxygenated hemoglobin over time along the time axis. Specifically, first, the amount of inclination of the waveform of oxygenated hemoglobin over time is sequentially examined, and when the amount of inclination exceeds a predetermined value, it is determined that it is the starting point of the peak, and the amount of inclination is zero. When it turns negative, the peak is determined to be the peak top, and when the inclination amount exceeds a predetermined value, it is determined to be the peak end point. The barycentric value is a time that is intermediate between the peak start time and the peak end time, and the integral value is the peak area value.

  Then, in order for an observer such as a doctor to examine which part of the subject's brain has a pathological condition such as cerebral ischemia or epilepsy, 42 measurement sites # 1 to # 2 on the subject's brain surface The time-dependent change of oxygenated hemoglobin is acquired from # 42 (see FIG. 2). FIG. 3 is a diagram showing an example of the monitor screen 23a displayed by the photobiological measuring device 1 according to the present invention. The color tone is displayed on each of the 42 measurement sites # 1 to # 42 of the three-dimensional scalp surface image 24a.

  Therefore, the computer 20 that executes the display method shown in FIG. 3 includes a CPU 21, and further includes a memory 25, a display device 23 having a monitor screen 23 a and the like, and a keyboard 22 a and a mouse 22 b that are input devices 22. ing. Further, the functions processed by the CPU 21 will be described as a block. The light transmission / reception unit control unit 4 that controls the light emitting unit 2 and the light detection unit 3, the analysis unit 31, the position calculation unit 32, and the display control unit 34 are provided. Have. In addition, the memory 25 includes a measurement data storage unit 52 that stores a light detection signal and measurement data, a table storage unit 53 that stores in advance a color table that associates a combination of an integral value and a centroid value with a color tone, And a morphological image storage unit 54 that stores in advance a three-dimensional scalp surface image 24a showing the subject.

  In the table storage unit 53, a two-dimensional table having a horizontal axis representing the integral value of the change over time in the oxygenated hemoglobin concentration and a vertical axis representing the centroid value of the change over time in the oxygenated hemoglobin concentration is provided for each predetermined coordinate range. A color table in which different colors are associated with each other is stored in advance. FIG. 4A is a diagram illustrating an example of a color table. Specifically, the minimum value and maximum value of the centroid value (Factor B) are determined, the size of the centroid value is equally divided into three, and the minimum value and maximum value of the integral value (Factor A) are determined. Are classified into nine coordinate ranges so that the magnitude of the integrated value is equally divided into three. Then, “red” is associated with the first coordinate range having a small integral value and a small centroid value, and “orange” is associated with the second coordinate range having an intermediate integral value and a small centroid value. Each color tone is associated with the nine-week coordinate range so that “yellow” is associated with the third coordinate range with a large and low center-of-gravity value. That is, an observer such as a doctor can grasp which of the nine types just by observing the color tone.

  In the morphological image storage unit 54, a three-dimensional scalp surface image 24a showing a subject is stored in advance. The three-dimensional scalp surface image 24a is created by acquiring scalp surface morphological image data by extracting morphological video data indicating the scalp surface based on morphological video data captured by MRI. As the extraction method described above, for example, by using a plurality of pixels having numerical values such as intensity information and phase information of the MRI signal, an image region dividing method such as region expansion method, region merging method, heuristic method, Examples include a method of extracting a region by connecting boundary elements, a method of using a method of extracting a region by deforming a closed curve, and the like.

The light transmission / reception unit controller 4 stores the light detection signal in the measurement data storage unit 52 when the light emission control unit 42 that outputs a drive signal to the light emitting unit 2 and the light detection signal from the light detection unit 3 are input. And a light detection control unit 43.
The light emission control unit 42 performs control to output a drive signal for transmitting light to the light transmission probe 12 to the light emitting unit 2. In addition, the light detection control unit 43 causes the measurement data storage unit 52 to store the 13 light detection signals detected from the 13 light receiving probes 13 when the light detection signal from the light detection unit 3 is input. It performs control to go. That is, every time light is transmitted from one light transmission probe 12, 13 light detection signals are stored in the measurement data storage unit 52. Since the light detection signal of the light to the light receiving probe 13 adjacent to the light transmitting probe 12 is received light amount information obtained from the measurement site of the brain, after light is transmitted from all the light transmitting probes 12 Thus, 42 photodetection signals selected from 14 × 13 = 182 photodetection signals are obtained.

  The position calculation unit 32 performs control to calculate the positions of 42 measurement parts # 1 to # 42 from which light detection signals are obtained from information on the arrangement positions of the 14 light transmission probes 12 and the 13 light reception probes 13. Is. For example, the position calculation unit 32 receives the object stored in the morphological image storage unit 54 by inputting information on the arrangement positions of the four light transmitting probes 12 and the thirteen light receiving probes 13 through the input device 22. In the three-dimensional scalp surface image 24a shown, the positions of the measurement sites # 1 to # 42 are calculated so as to be the midpoint of the line connecting the position of the light transmitting probe 12 and the position of the light receiving probe 13.

The analysis unit 31 acquires 42 light detection signals to the light receiving probe 13 adjacent to the light transmission probe 12 in the light detection signals stored in the measurement data storage unit 52, and acquires the 42 light detection signals thus acquired. Based on the above, the measurement data (trend graph) indicating the change with time of the oxygenated hemoglobin concentration is calculated and stored in the measurement data storage unit 52. At this time, in the light transmission / reception unit 11 shown in FIG. 2, the measurement data (trend graph) at the 42 measurement parts # 1 to # 42 is calculated.
And the analysis part 31 performs control which extracts an integrated value and a gravity center value from 42 measurement data (trend graph), respectively. That is, the combination of the integrated value and the barycentric value at 42 measurement parts # 1 to # 42 is calculated.

  The display control unit 34 determines the color tone by applying the combination of the integrated value and the centroid value extracted by the analysis unit 31 to the color table, and the 42 pieces of the three-dimensional scalp surface images 24a displayed on the monitor screen 23a. Control to display the color tone on the measurement sites # 1 to # 42 is performed. As a result, as shown in FIG. 3, a color tone is displayed on each of the 42 measurement sites # 1 to # 42 of the three-dimensional scalp surface image 24a. Thereby, for example, since “red” is displayed on the measurement parts # 1 to # 5 and # 8 to # 12, an observer such as a doctor can measure the measurement parts # 1 to # 5 and # 8 to # 8. In # 12, it can be understood that the integral value is small and the center of gravity value is small, and “yellow” is displayed on the measurement parts # 6 and # 9. 7 can grasp that the integral value is large and the centroid value is small. It should be noted that an observer such as a doctor can easily figure out which state is just by observing the color tone, as shown in FIG. The color table shown in a) may be displayed.

  As described above, according to the photobiological measuring device 1 of the present invention, since the color tone is superimposed and displayed on the 42 measurement sites # 1 to # 42 of the three-dimensional scalp surface image 24a, an observer such as a doctor can It is possible to easily examine which part of the brain # 1 to # 42 has a pathological condition such as cerebral ischemia or epilepsy.

<Other embodiments>
(1) In the optical biological measuring apparatus 1 described above, the light transmission / reception unit 11 including the 14 light transmission probes 12 and the 13 light reception probes 13 is shown, but a different number, for example, 12 light transmission probes and 12 It is good also as a light transmission / reception part which has a single light reception probe.

(2) In the above-described photobiological measuring device 1, it has been shown that the color table classified into nine coordinate ranges is used. However, a different number, for example, a color table classified into 16 coordinate ranges is used. Also good. FIG. 4B is a diagram illustrating another example of the color table.
Further, a color table whose color tone gradually changes without being classified into coordinate ranges may be used. FIGS. 5A and 5B are diagrams showing still another example of the color table.

(3) In the optical biometric device 1 described above, it has been shown that the color tone is displayed on the 42 measurement sites # 1 to # 42 of the three-dimensional scalp surface image 24a. The contours (color map) may be displayed by complementing the color tone between the measurement sites (see FIG. 6), and between the 42 measurement sites # 1 to # 42 of the three-dimensional brain surface image. Also, it may be displayed with contour lines (color map) by complementing the color tone (see FIG. 7).

(4) In the optical biometric device 1 described above, it has been shown that the centroid value (Factor B) and the integral value (Factor A) of the time-dependent change of oxygenated hemoglobin are extracted, but the centroid value (Factor B) and the integral value are extracted. The value may not be the value (Factor A), and may be three or more feature values. The value of oxygenated hemoglobin (Factor A), the value of deoxygenated hemoglobin (Factor B), and the value of total hemoglobin (Factor C) may be extracted.

  INDUSTRIAL APPLICABILITY The present invention is used as a non-invasive optical brain functional imaging device that measures the activity state of a brain measurement site using near-infrared light, an oxygen monitor that monitors the oxygen consumption of a measurement site in a living body, and the like. be able to.

1: Optical biological measuring device 4: Transmitting / receiving unit controller 11: Transmitting / receiving unit 12: Transmitting probe 13: Light receiving probe 22: Input device 23: Display unit 31: Analysis unit 34: Display control unit 53: Table storage unit 54 : Morphological image storage unit T: Light transmitting point R: Light receiving point

Claims (2)

A plurality of light transmitting / receiving probes disposed on the skin surface of the subject, and a plurality of light receiving / transmitting probes disposed on the skin surface;
The light transmitting probe irradiates light on the skin surface, and the light receiving probe is controlled so as to detect light emitted from the skin surface, thereby acquiring a light detection signal relating to a measurement site in the subject. A light receiving unit control unit;
An integrated value that is an area value of a peak during a time-dependent change in hemoglobin concentration calculated from the light detection signal and a centroid value that is an intermediate time between the start time of the peak and the end time of the peak are extracted. An optical biometric device comprising an analysis unit,
A table storage unit for storing a color table in which different tones are assigned to the respective coordinates including the integral value and the centroid value;
A morphological image storage unit for storing a morphological image indicating the subject;
A color tone corresponding to the combination of the integral value and the centroid value is determined by applying a combination of the integral value and the centroid value extracted by the analysis unit to a color table, and the measurement part of the morphological image An optical biological measurement apparatus comprising: a display control unit that displays a color tone superimposed thereon. The light transmitting probe and the light receiving probe are disposed on the scalp surface of the subject,
A position calculator that calculates the position of the measurement site from which the light detection signal is obtained from the information of the arrangement positions of the light transmitting probe and the light receiving probe;
The photobiological measurement apparatus according to claim 1, wherein the display control unit superimposes and displays a color tone on a measurement site of the three-dimensional brain surface image or the three-dimensional scalp surface image that is the morphological image.