JP4978485B2 - Optical biometric device - Google Patents

Description

The present invention relates to an optical biometric apparatus that measures brain activity non-invasively. In particular, photobiological measurement that can be used as an oxygen monitor or the like for diagnosing whether or not a living tissue is normal by measuring temporal changes in blood flow in each part of the brain and changes in oxygen supply over time Relates to the device.

Hemoglobin plays a role in carrying oxygen in the blood. Since the concentration of hemoglobin contained in blood increases or decreases according to the expansion / contraction of blood vessels, it is known to detect the expansion / contraction of blood vessels by measuring the concentration of hemoglobin.
In view of this, there has been known a biological measurement method that uses light to measure the inside of a living body simply and non-invasively by utilizing the fact that the concentration of hemoglobin corresponds to the oxygen metabolism function inside the living body. The concentration of hemoglobin can be obtained from the amount of light obtained through the living body by irradiating the living body with light having a wavelength from visible light to the near infrared region.

Furthermore, hemoglobin is combined with oxygen to become oxyhemoglobin (hereinafter also referred to as “oxyHb”), and away from oxygen to be deoxyhemoglobin (hereinafter also referred to as “deoxyHb”). It is also known that in the brain, oxygen is supplied to a site activated by blood flow redistribution, and the concentration of oxyhemoglobin combined with oxygen increases. Therefore, by measuring the concentration of oxyhemoglobin, it can be applied to the observation of brain activity. Since oxyhemoglobin and deoxyhemoglobin have different spectral absorption spectrum characteristics from visible light to near-infrared region, for example, oxyhemoglobin concentration and deoxyhemoglobin concentration can be obtained using near-infrared light.

Therefore, in order to measure brain activity non-invasively, an optical biometric apparatus including a light transmitting probe and a light receiving probe has been developed. In the optical biometric apparatus, the brain is irradiated with near-infrared light by a light-transmitting probe placed on the subject's head skin surface, and emitted from the brain by a light-receiving probe placed on the head skin surface. Detect the amount of near infrared light. Near-infrared light passes through the head skin tissue and bone tissue and is absorbed by oxyhemoglobin and deoxyhemoglobin in the blood. Therefore, by using the light-transmitting probe and the light-receiving probe, the oxyhemoglobin concentration and deoxyhemoglobin concentration at the measurement site of the brain, and further the change over time in the total hemoglobin concentration calculated from these can be obtained as measurement data. FIG. 8 is a diagram illustrating an example of measurement data. In addition, a vertical axis | shaft shows a density | concentration and a horizontal axis shows time.

Here, the relationship between the probe interval (channel) between the light transmitting probe and the light receiving probe and the measurement site of the brain will be described. FIG. 9A is a cross-sectional view showing the relationship between the pair of light transmitting probe 12 and light receiving probe 13 and the measurement site of the brain, and FIG. 9B is a plan view of FIG. 9A. .
The light transmitting probe 12 is pressed against the light transmitting point T on the subject's head skin surface, and the light receiving probe 13 is pressed against the light receiving point R on the subject's head skin surface. And while irradiating light from the light transmission probe 12, the light reception probe 13 is made to detect the light discharge | released from the head skin surface. At this time, the light that has passed through the banana shape (measurement region) among the light emitted from the light transmission point T on the head skin surface reaches the light receiving point R on the head skin surface. Thereby, in the measurement region, in particular, the midpoint M of the line L connecting the light transmitting point T and the light receiving point R at the shortest distance along the surface of the head skin of the subject (in this specification, the head A depth L / 2 that is half the distance of the line connecting the light transmitting point T and the light receiving point R along the surface of the subject's head skin at the shortest distance from the “measurement related position” on the skin surface) Light receiving amount information (oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration calculated from these) of the site S of the subject (also referred to as “measurement-related position” on the brain surface in this specification) It is said that will be found.

In addition, each part of the brain and brain function will be described. FIG. 10 is a diagram showing an example of the cerebral cortex of the human brain. For convenience, the brain is divided into four parts: frontal lobe 71, parietal lobe 72, occipital lobe 73, and temporal lobe 74. A Sylvian groove 77 separates the temporal lobe 74 from other parts. A central groove 78 separates the frontal lobe 71 and the parietal lobe 72. Further, the parietal lobe 72 and the occipital lobe 73 are divided by a portion called angular turn (not shown).
A motor area 75 that transmits a command of movement to each part of the body is in front of the central groove 78 and occupies a part of the frontal lobe 71. A somatosensory area 76 that recognizes somatic sensations such as touch, pain, and pressure is behind the central groove 78 and occupies a part of the parietal lobe 72. The visual cortex 80 is in a part behind the occipital lobe 73. The auditory area 79 occupies a part of the temporal lobe 74. Furthermore, the motorized language center 81 occupies a part of the frontal lobe 71.

Therefore, in recent years, an optical biometric apparatus applied to the medical field such as brain function diagnosis and circulatory system failure diagnosis by measuring the hemoglobin concentration and the like of the measurement site of the brain related to brain functions such as movement, sense and thought It has been developed.
In such a photobiological measurement device, for example, a near-infrared spectrometer (hereinafter abbreviated as NIRS) or the like is used (see, for example, Patent Document 1).
In NIRS, a holder is used to bring a plurality of light transmitting probes and a plurality of light receiving probes into close contact with the subject's head skin surface in a predetermined arrangement. As such a holder, for example, a molded holder is used which is molded into a bowl shape in accordance with the shape of the head skin surface. The molding holder has a plurality of through-holes, and the light transmission probe and the light-receiving probe are inserted into the through-holes, so that the channel becomes constant, and the received light amount information at a specific depth is obtained from the head skin surface. ing.
FIG. 11 is a plan view showing the positional relationship between 12 light transmitting probes and 12 light receiving probes in NIRS as described above. The light transmitting probes 12a to 12l and the light receiving probes 13a to 13l are arranged alternately in the oblique direction. The light emitted from the light transmitting probes 12a to 12l is also detected by the light receiving probes 13a to 13l apart from the adjacent light receiving probes 13a to 13l. However, in order to simplify the description here, the adjacent light receiving probes are used. It is assumed that only 13a to 13l are detected. Therefore, a total of 36 received light amount information (measurement data) is obtained.
In general, a channel with a channel of 30 mm is used, and when the channel is 30 mm, it is considered that the received light amount information with a depth of 15 mm to 20 mm from the midpoint of the channel can be obtained as described above. . In other words, the position at a depth of 15 mm to 20 mm from the surface of the head skin substantially corresponds to the brain surface region, and the received light amount information (measurement data) related to the brain activity is obtained.

The measurement data regarding brain activity obtained by NIRS is displayed as an image in order to be observed by a doctor or the like. FIG. 12 is a diagram showing an example of a monitor screen on which 36 pieces of measurement data are displayed by a conventional photobiological measurement apparatus.
On the monitor screen, 36 pieces of measurement data # 1 to # 36 are displayed. At this time, in the plan view shown in FIG. 11, the light irradiated from the light transmitting probe 12 to each midpoint of the line connecting the light transmitting probe 12 and the light receiving probe 13 at the shortest distance is used as the light receiving probe 13. The measurement data obtained when they are detected in the above are arranged and displayed so as to be arranged. Specifically, measurement data # 1 when the light irradiated from the light transmitting probe 12a is detected by the light receiving probe 13a is arranged at the upper left, and the light irradiated from the light transmitting probe 12a is detected by the light receiving probe 13d. The measured data # 2 is arranged under the measured data # 1, and the measured data # 7 when the light irradiated from the light transmitting probe 12b is detected by the light receiving probe 13a is the measured data # 1. The 36 pieces of measurement data # 1 to # 36 are arranged and arranged so as to be arranged on the right side.
JP 2006-109964 A

However, since the 36 pieces of measurement data # 1 to # 36 are only arranged as described above, there is no display indicating the brain, and it is grasped from which part of the measurement part of the brain the measurement data is obtained. It was difficult to do.
In addition, there are individual differences in the anatomical structure of the brain, and the shape of the brain is different for each person, resulting in a problem that measurement data cannot be considered accurately.
Accordingly, an object of the present invention is to provide an optical biometric apparatus that can easily grasp the measurement site of the brain from which the measurement data is obtained while observing the measurement data.

The optical biometric apparatus of the present invention made to solve the above-described problems includes a plurality of light-transmitting probes disposed on the surface of the head skin of the subject and a plurality of light-transmitting probes disposed on the surface of the head skin. By controlling the light transmitting / receiving part having the light receiving probe and the light transmitting probe to irradiate light on the head skin surface and to detect the light emitted from the head skin surface, An optical biometric apparatus comprising a light transmission / reception unit control unit for obtaining measurement data relating to brain activity and a measurement data display control unit for displaying the measurement data, wherein the positional relationship between the head skin surface and the brain surface of the subject A three-dimensional morphological image data acquisition unit that acquires three-dimensional morphological image data, a brain surface image display control unit that displays a brain surface image based on the three-dimensional morphological image data, and the three-dimensional morphological image data. Based on A head skin surface image display control unit for displaying the head skin surface image, and the image display control unit that determines to display at least one image of the brain surface image and head skin surface image, the measurement data A measurement-related position calculation unit that calculates a measurement-related position on the brain surface of the subject from which the measurement-related position calculation unit is displayed during display of the head skin surface image. The position of the head skin surface image corresponding to the position of the light transmitting probe arranged on the skin surface and the position of the light receiving probe is designated by the input device, whereby the brain surface of the subject from which the measurement data is obtained The above measurement-related position is calculated, and the measurement data display control unit displays measurement data in the measurement-related position of the brain surface image when the brain surface image is displayed.

Here, the “three-dimensional morphological image data indicating the brain surface of the subject” is, for example, from the video data of the subject created by a nuclear magnetic resonance imaging apparatus (hereinafter abbreviated as MRI), a CT image, or the like. This refers to 3D image data created by extracting video data representing the brain surface, template data representing a standard 3D brain surface, and the like.
According to the optical biometric apparatus of the present invention, the three-dimensional morphological image data acquisition unit acquires three-dimensional morphological image data indicating the brain surface of the subject. In addition, the measurement related position calculation unit calculates a measurement related position on the brain surface of the subject from which the measurement data is obtained (for example, a perpendicular bisector of a line connecting the position of the light transmitting probe and the position of the light receiving probe, and the brain The position where the surface intersects is calculated.
Accordingly, when the brain surface image display control unit displays the brain surface image based on the three-dimensional morphological image data, the measurement data display control unit displays the measurement data in the measurement-related position of the brain surface image. That is, the measurement data is displayed superimposed on the brain surface image.

Therefore, according to the photobiological measurement device of the present invention, since the measurement data is displayed superimposed on the brain surface image, the measurement site of the brain from which the measurement data can be obtained can be easily grasped while observing the measurement data. be able to.

(Means and effects for solving other problems)
In the photobiological measurement apparatus according to the present invention, the three-dimensional morphological image data acquisition unit acquires three-dimensional morphological image data indicating a positional relationship between a head skin surface and a brain surface of the subject, Based on the three-dimensional form image data, a head skin surface image display control unit that displays a head skin surface image, and an image display that is determined to display at least one of the brain surface image and the head skin surface image A control unit, and the measurement-related position calculation unit is configured to display a position of the light transmitting probe and a position of the light receiving probe disposed on the head skin surface of the subject during display of the head skin surface image. A measurement-related position on the brain surface of the subject from which the measurement data is obtained may be calculated by designating the corresponding position in the head skin surface image with the input device.

Here, “three-dimensional morphological image data indicating the surface of the subject's head skin” is, for example, extracting video data indicating the surface of the head skin from the image data of the subject created by MRI, CT images, or the like. 3D image data created by doing this, template data indicating a standard 3D head skin surface, and the like.
According to the photobiological measurement device of the present invention, the three-dimensional morphological image data acquisition unit acquires three-dimensional morphological image data indicating the positional relationship between the head skin surface and the brain surface of the subject, thereby obtaining the head skin. The positional relationship between the surface and the brain surface can be accurately recognized. Then, the image display control unit determines to display at least one of the brain surface image and the head skin surface image by an operation signal from the input device or the like.
Thereby, first, when the image display control unit determines to display the head skin surface image, the head skin surface image display control unit displays the head skin surface image based on the three-dimensional morphological image data. Then, the measurement-related position calculation unit designates a position in the head skin surface image corresponding to the position of the light transmitting probe and the position of the light receiving probe arranged on the head skin surface of the subject with the input device. Thus, the measurement-related position on the brain surface of the subject from which the measurement data is obtained is calculated. At this time, since the positional relationship between the head skin surface and the brain surface is accurately recognized, the brain measurement site where measurement data is obtained can be accurately obtained despite individual differences in the anatomical structure of the brain. Can be calculated.
Next, when the image display control unit determines to display the brain surface image, the brain surface image display control unit displays the brain surface image based on the three-dimensional morphological image data, and the measurement data display control unit Display measurement data in measurement-related positions on the surface image. That is, the measurement data is displayed superimposed on the brain surface image.
Therefore, according to the photobiological measurement apparatus of the present invention, the measurement data of the brain can be obtained accurately because the measurement site of the brain from which the measurement data can be obtained is accurately calculated regardless of individual differences in the anatomical structure of the brain. The measurement data can be observed while accurately grasping the measurement site of the brain.

In the photobiological measurement device according to the present invention, the measurement-related position calculation unit calculates a measurement-related position on the skin surface of the subject from which measurement data is obtained, and the measurement data display control unit includes the head When the partial skin surface image is displayed, the measurement data may be displayed in the measurement-related position of the head skin surface image.
In the optical biometric apparatus of the present invention, the measurement-related position is a line connecting the position of the light transmitting probe and the position of the light receiving probe along the head skin surface at the shortest distance on the head skin surface. The position of the midpoint may be a position that intersects the perpendicular bisector of the line connecting the position of the light transmitting probe and the position of the light receiving probe on the brain surface.
In the photobiological apparatus of the present invention, the measurement data may be data indicating a temporal change in hemoglobin concentration.

Furthermore, the photobiological measurement device of the present invention may be configured such that the brain surface image and / or the head skin surface image are displayed in such a manner that the direction can be changed so that the image is viewed from a desired direction. Good.
According to the optical biometric apparatus of the present invention, the brain surface image can be displayed so as to be an image viewed from a desired direction, so that the measurement data obtained at the measurement site of the brain to be particularly focused is at the center. Can be displayed.

Hereinafter, embodiments of the present invention will be described with reference to the drawings. In addition, this invention is not limited to the following embodiment, It cannot be overemphasized that various aspects are included in the range which does not deviate from the meaning of this invention.

FIG. 1 is a block diagram showing a configuration of an optical biometric apparatus according to an embodiment of the present invention. The photobiological measuring device 1 includes a light transmitting / receiving unit 11, a light emitting unit 2, a light detecting unit 3, and a control unit (computer) 20 that controls the entire photobiological measuring device 1.
FIG. 2 is a plan view showing the positional relationship between the nine light transmitting probes 12a to 12i and the eight light receiving probes 13a to 13h in the light transmitting / receiving unit 11.
Furthermore, FIG. 3 is a figure which shows an example of the monitor screen 23a displayed by the optical biometric apparatus 1 which concerns on this invention. On the monitor screen 23a, a head skin surface image 24a, a brain surface image 24b, and 24 pieces of measurement data # 1 to # 24 are displayed. The head skin surface image 24a is displayed in a translucent manner. FIG. 4 is a diagram showing another example of the monitor screen 23a displayed by the photobiological measurement apparatus 1 according to the present invention. A head skin surface image 24a and 24 pieces of measurement data # 1 to # 24 are displayed on the monitor screen 23a.

As shown in FIG. 2, the light transmitting / receiving unit 11 has nine light transmitting probes 12a to 12i and eight light receiving probes 13a to 13h, and the light transmitting probes 12a to 12i and the light receiving probes 13a to 13h are provided. They are arranged alternately in an oblique direction. The distance between the light transmitting probes 12a to 12i and the light receiving probes 13a to 13h is 30 mm. Further, the nine light transmitting probes 12a to 12i emit light, while the eight light receiving probes 13a to 13h detect the amount of light.
The light emitting unit 2 transmits light to one light transmitting probe selected from among the nine light transmitting probes 12a to 12i by a drive signal input from the computer 20. As the light, near infrared light (for example, two-wavelength light of 780 nm and 850 nm) is used.
The light detection unit 3 individually detects near-infrared light (for example, two-wavelength light of 780 nm and 850 nm) received by the eight light receiving probes 13a to 13h, so that eight light receiving signals (measurement data) are detected. Is output to the computer 20.

The computer 20 includes a CPU 21, and further includes a memory 25, a display device 23 having a monitor screen 23 a and the like, and a keyboard 22 a and a mouse 22 b which are input devices 22.
Further, the functions processed by the CPU 21 will be described in the form of blocks. The light transmission / reception unit control unit 4 that controls the light emitting unit 2 and the light detection unit 3, the morphological image data acquisition unit 31, and the three-dimensional morphological image data acquisition unit 32 The head skin surface image display control unit 33, the brain surface image display control unit 34, the measurement related position calculation unit 35, the pointer display control unit 36, the measurement data display control unit 37, and the image display control unit 38 Have
The memory 25 includes a measurement data storage unit 52 that stores measurement data, and an image data storage unit 53 that stores morphological video data, 3D head skin surface image data, 3D brain surface image data, and the like.

The light transmission / reception unit control unit 4 stores the measurement data in the measurement data storage unit 52 by receiving the light emission control unit 42 that outputs a drive signal to the light emission unit 2 and the light reception signal (measurement data) from the light detection unit 3. And a light detection controller 43.
The light emission control unit 42 performs control to output a drive signal for transmitting light to the light transmission probe 12 to the light emitting unit 2.
The light detection control unit 43 performs control to store the eight measurement data detected from the eight light receiving probes 13 a to 13 h in the measurement data storage unit 52 by receiving the light reception signal from the light detection unit 3. It is. That is, every time light is transmitted from one light transmission probe, eight measurement data are stored in the measurement data storage unit 52.

The morphological video data acquisition unit 31 acquires morphological video data created by MRI and controls the morphological video data to be stored in the image data storage unit 53. Note that the MRI is a device that creates morphological video data indicating a two-dimensional image taken from three directions as shown in FIG. Here, the morphological image data indicates a subject including a head skin surface and a brain surface, and refers to data composed of a plurality of pixels having numerical values such as intensity information and phase information of MR signals. .

The three-dimensional morphological image data acquisition unit 32 extracts the morphological video data indicating the head skin surface based on the morphological video data stored in the image data storage unit 53, thereby obtaining the three-dimensional head skin surface image data. 3D brain surface image data is obtained by extracting morphological image data indicating the brain surface, and the 3D head skin surface image data and 3D brain surface image data are acquired by an image data storage unit. Control to be stored in 53 is performed (see FIG. 6).
As the extraction method described above, for example, by using a plurality of pixels having numerical values such as MR signal intensity information and phase information, an image region dividing method such as region expansion method, region merging method, heuristic method, boundary element, etc. And a method of extracting a region by connecting them, a method of using a method of extracting a region by deforming a closed curve, and the like. By extracting morphological image data in this way, 3D head skin surface image data and 3D brain surface image data are obtained, so that the positional relationship between the head skin surface and the brain surface was accurately recognized. Three-dimensional image data can be acquired.

The head skin surface image display control unit 33 performs control to display the head skin surface image 24a on the monitor screen 23a based on the three-dimensional head skin surface image data stored in the image data storage unit 53. is there. Note that the operator can change and display the head skin surface image 24a viewed from a desired direction by using the input device 22. Further, the head skin surface image 24a can be displayed in a semi-transparent or non-transparent manner.
The brain surface image display control unit 34 performs control to display the brain surface image 24b on the monitor screen 23a based on the three-dimensional brain surface image data stored in the image data storage unit 53. The operator can use the input device 22 to change and display the brain surface image 24b viewed from a desired direction.

The image display control unit 38 determines that the head skin surface image 24a is displayed on the head skin surface image display control unit 33 when the operator inputs an operation signal using the input device 22, or the brain. It is determined that the surface image 24b is displayed on the brain surface image display control unit 34, or the head skin surface image 24a is displayed on the head skin surface image display control unit 33. At the same time, the brain surface image 24b is displayed on the brain surface image. Control for determining to be displayed on the control unit 34 is performed.
The pointer display control unit 36 displays a pointer (not shown) on the monitor screen 23a, moves the pointer displayed on the monitor screen 23a based on an operation signal output from the mouse 22b, and positions the pointer with the pointer. Control to specify.

The measurement-related position calculation unit 35 designates the three-dimensional head skin surface image data, the three-dimensional brain surface image data, and the like by designating a predetermined position of the head skin surface image 24a displayed on the monitor screen 23a with a pointer. Based on this positional relationship, control is performed to calculate a measurement-related position between the surface of the subject's brain and the surface of the head skin. At this time, the measurement-related position on the head skin surface is the midpoint position of the line connecting the position of the light transmitting probe 12 and the position of the light receiving probe 13 along the head skin surface at the shortest distance, and the brain surface. The upper measurement-related position is a position that intersects the perpendicular bisector of the line connecting the position of the light transmitting probe 12 and the position of the light receiving probe 13.

The measurement data display control unit 37 acquires light reception amount information (measurement data) from the light transmission probe 12 to the light reception probe 13 adjacent to the light transmission probe 12 in the measurement data stored in the measurement data storage unit 52. Then, based on the acquired measurement data, the oxyhemoglobin concentration, deoxyhemoglobin concentration, and total hemoglobin concentration are determined from the passing light intensity of each wavelength (oxyhemoglobin absorption wavelength and deoxyhemoglobin absorption wavelength), and measurement-related positions Based on the measurement-related position calculated by the calculation unit 35, control for displaying measurement data in the measurement-related position is performed. At this time, when the brain surface image 24b and the head skin surface image 24a are displayed, the measurement data # 1 to # 24 are displayed in the measurement-related positions on the brain surface (see FIG. 3). When only the brain surface image 24b is displayed, the measurement data # 1 to # 24 are displayed in the measurement related positions on the brain surface. When only the head skin surface image 24a is displayed, the measurement data # 1 to # 24 are displayed in the measurement related positions on the head skin surface (see FIG. 4). Further, in the optical biometric apparatus 1, the brain surface image 24b and the head skin surface image 24a can be displayed so that the direction can be changed so as to be an image viewed from a desired direction. Accordingly, the measurement data display control unit 37 also moves the positions where the measurement data # 1 to # 24 are displayed.

Next, a display method for displaying measurement data using the optical biometric apparatus 1 will be described. FIG. 7 is a flowchart for explaining an example of the display method by the optical biometric apparatus 1.
First, in the process of step S101, the morphological video data acquisition unit 31 acquires morphological video data indicating the subject including the head skin surface and the brain surface from the MRI and stores the morphological video data in the image data storage unit 53. Remember (see FIG. 5). At this time, the morphological image data is stored in the image data storage unit 53 using a storage medium or the like from a separately provided MRI.

Next, in the process of step S102, the three-dimensional morphological image data acquisition unit 32 extracts morphological video data indicating the skin surface of the head based on the morphological video data stored in the image data storage unit 53. The three-dimensional head skin surface image data is acquired, and the three-dimensional head skin surface image data is stored in the image data storage unit 53. At this time, for example, morphological image data indicating the head skin surface is extracted by a surface rendering method (see FIG. 6A).
Next, in the process of step S103, the three-dimensional morphological image data acquisition unit 32 extracts the morphological video data indicating the brain surface based on the morphological video data stored in the image data storage unit 53, thereby The brain surface image data is acquired, and the three-dimensional brain surface image data is stored in the image data storage unit 53. At this time, for example, morphological image data indicating the brain surface is extracted by a volume rendering method (see FIG. 6B).

Next, in the process of step S104, the light transmitting / receiving unit 11 is arranged on the surface of the head skin of the sample.
Next, in the process of step S105, the head skin surface image display control unit 33 displays the head skin surface image on the monitor screen 23a based on the three-dimensional head skin surface image data stored in the image data storage unit 53. To display.
Next, in the process of step S106, the measurement related position calculation unit 35 designates a predetermined position of the head skin surface image 24a displayed on the monitor screen 23a with a pointer, so that the head skin surface image 24a is displayed. The arrangement positions of the light transmitting probe 12 and the light receiving probe 13 are determined, and on the brain surface and the head skin surface of the subject based on the positional relationship between the three-dimensional head skin surface image data and the three-dimensional brain surface image data. The measurement-related position of is calculated.

Next, in the process of step S107, the light emission control unit 42 and the light detection control unit 43 output the drive signal to the light emission unit 2 and receive the light reception signal (measurement data) from the light detection unit 3 to measure the measurement data. Is stored in the measurement data storage unit 52.
Next, in the process of step S <b> 108, the image display control unit 38 inputs the operation signal using the input device 22 by the operator, whereby the head skin surface image 24 a is transferred to the head skin surface image display control unit 33. It is determined to be displayed (see FIG. 4), the brain surface image 24b is determined to be displayed on the brain surface image display control unit 34, or the head skin surface image 24a is determined to be displayed on the head skin surface image display control unit 33. At the same time, the brain surface image 24b is determined to be displayed on the brain surface image display control unit 34 (see FIG. 3).

Next, in the process of step S109, the measurement data display control unit 37 shifts the measurement data # 1 to # 24 in the measurement related position based on the measurement data stored in the measurement data storage unit 52 and the measurement related position. indicate. At this time, since the brain surface image 24b and the head skin surface image 24a can be displayed so that the direction can be changed so as to be an image seen from a desired direction, the measurement data is moved along with the movement of the measurement related position. The display control unit 37 also moves the positions for displaying the measurement data # 1 to # 24.
Next, in the process of step S110, the image display control unit 38 determines whether or not an operation signal for switching an image to be displayed is input.
When it is determined that an operation signal for switching the image to be displayed is input, the process returns to step S108.
On the other hand, when it is determined that the operation signal for switching the image to be displayed has not been input, this flowchart is ended.

As described above, according to the optical biometric apparatus 1, since the measurement data # 1 to # 24 are superimposed and displayed on the head skin surface image 24a and the brain surface image 24b, the measurement data # 1 to # 24 are displayed. , The measurement site of the brain from which the measurement data # 1 to # 24 are obtained can be easily grasped.

(Other embodiments)
In the optical biometric apparatus 1 described above, the light transmitting / receiving unit 11 including the nine light transmitting probes 12a to 12i and the eight light receiving probes 13a to 13h is shown. However, a different number, for example, twelve light transmitting probes and It is good also as a light transmission / reception part which has 12 light reception probes.

The present invention can be used as an oxygen monitor or the like for diagnosing whether or not a living body tissue is normal by measuring a temporal change in blood flow in each part of the brain and a temporal change in oxygen supply.

It is a block diagram which shows the structure of the optical biometric apparatus which is one Embodiment of this invention. It is a top view which shows the positional relationship of nine light transmission probes and eight light reception probes. It is a figure which shows an example of the monitor screen displayed by the optical biometric apparatus which concerns on this invention. It is a figure which shows another example of the monitor screen displayed by the optical biometric apparatus which concerns on this invention. It is a figure which shows the two-dimensional image of 3 directions obtained by MRI. It is a figure which shows 3D head skin surface form image data and 3D brain surface form image data. It is a flowchart for demonstrating an example of the display method by an optical biometric apparatus. It is a figure which shows an example of measurement data. It is a figure which shows the relationship between a pair of light transmission probe and light reception probe, and the measurement site | part of a brain. It is a figure which shows an example of the cerebral cortex of a human brain. It is a top view which shows the positional relationship of 12 light transmission probes and 12 light reception probes. It is a figure which shows an example of the monitor screen displayed by the conventional optical biometric apparatus.

Explanation of symbols

1: Optical biometric device 4: Transmitter / receiver controller 11: Transmitter / receiver 12: Transmitter probe 13: Receiver probe 22: Input device 23: Display device 31: Morphological image data acquisition unit 32: Acquire three-dimensional morphological image data Unit 34: Brain surface image display control unit 35: Measurement related position calculation unit 37: Measurement data display control unit T: Light transmission point R: Light reception point M: Measurement point

Claims (5)

A plurality of light-transmitting probes disposed on the surface of the head skin of the subject, and a plurality of light-receiving probes disposed on the surface of the head skin;
The light transmission / reception unit control for obtaining measurement data relating to brain activity by controlling the light transmission probe to irradiate light on the skin surface of the head and to detect the light emitted from the surface of the head skin. And
A photobiological measuring device comprising a measurement data display control unit for displaying the measurement data,
A three-dimensional morphological image data acquisition unit for acquiring three-dimensional morphological image data indicating a positional relationship between the head skin surface and the brain surface of the subject;
A brain surface image display control unit for displaying a brain surface image based on the three-dimensional morphological image data;
A head skin surface image display control unit for displaying a head skin surface image based on the three-dimensional form image data;
An image display control unit for determining to display at least one of the brain surface image and the head skin surface image;
A measurement-related position calculation unit that calculates a measurement-related position on the brain surface of the subject from which the measurement data is obtained;
The measurement-related position calculation unit is configured to display the head skin surface corresponding to the position of the light transmitting probe and the position of the light receiving probe arranged on the head skin surface of the subject during the display of the head skin surface image. By specifying the position in the image with the input device, the measurement-related position on the brain surface of the subject from which the measurement data is obtained is calculated,
The optical biometric apparatus, wherein the measurement data display control unit displays measurement data in a measurement-related position of the brain surface image when the brain surface image is displayed. The measurement related position calculation unit calculates a measurement related position on the surface of the head skin of the subject from which measurement data is obtained,
The measurement data display control unit can display measurement data in a measurement-related position of the head skin surface image when the head skin surface image is displayed. Item 4. The optical biometric apparatus according to Item 1 . The measurement-related position is a position of a midpoint of a line connecting a light transmitting probe position and a light receiving probe position along the head skin surface at the shortest distance on the head skin surface, Then, it is set as the position which cross | intersects the perpendicular bisector of the line | wire which connected the position of the light transmission probe and the position of the light reception probe, The optical biometric apparatus of Claim 1 or Claim 2 characterized by the above-mentioned. The measurement data, optical biometric device according to any one of claims 1 to 3, characterized in that data showing the time course of hemoglobin concentration. The brain surface image and / or head skin surface image, so that the image seen from a desired direction, any one of claims 1 to 4, characterized in that display the direction changeable The optical biometric apparatus according to 1.