JP4930951B2 - ペプチドの不斉合成 - Google Patents

ペプチドの不斉合成 Download PDF

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Publication number
JP4930951B2
JP4930951B2 JP2008530591A JP2008530591A JP4930951B2 JP 4930951 B2 JP4930951 B2 JP 4930951B2 JP 2008530591 A JP2008530591 A JP 2008530591A JP 2008530591 A JP2008530591 A JP 2008530591A JP 4930951 B2 JP4930951 B2 JP 4930951B2
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JP
Japan
Prior art keywords
group
alkyl
phenyl
aryl
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2008530591A
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English (en)
Japanese (ja)
Other versions
JP2009507906A5 (https=
JP2009507906A (ja
Inventor
エム ハーウッド，ローレンス
ヤン，ラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Reading
Original Assignee
University of Reading
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Filing date
Publication date
Application filed by University of Reading filed Critical University of Reading
Publication of JP2009507906A publication Critical patent/JP2009507906A/ja
Publication of JP2009507906A5 publication Critical patent/JP2009507906A5/ja
Application granted granted Critical
Publication of JP4930951B2 publication Critical patent/JP4930951B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • C07D265/32—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings with oxygen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2008530591A 2005-09-13 2005-09-30 ペプチドの不斉合成 Expired - Fee Related JP4930951B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB0518667.1A GB0518667D0 (en) 2005-09-13 2005-09-13 Method
GB0518667.1 2005-09-13
PCT/GB2005/003797 WO2007031698A1 (en) 2005-09-13 2005-09-30 Asymmetric synthesis of peptides

Publications (3)

Publication Number Publication Date
JP2009507906A JP2009507906A (ja) 2009-02-26
JP2009507906A5 JP2009507906A5 (https=) 2009-05-14
JP4930951B2 true JP4930951B2 (ja) 2012-05-16

Family

ID=35221406

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2008530591A Expired - Fee Related JP4930951B2 (ja) 2005-09-13 2005-09-30 ペプチドの不斉合成

Country Status (7)

Country Link
US (1) US8399612B2 (https=)
EP (2) EP2161277B1 (https=)
JP (1) JP4930951B2 (https=)
CN (1) CN101296937B (https=)
CA (1) CA2622173A1 (https=)
GB (1) GB0518667D0 (https=)
WO (1) WO2007031698A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2482739A (en) 2010-08-13 2012-02-15 Univ Reading Processes and compounds useful in peptide synthesis
CN102260224B (zh) * 2011-06-14 2013-04-17 南京信息工程大学 一种合成2-吗啉酮衍生物的方法
CN107629111B (zh) * 2017-10-26 2021-06-04 陕西慧康生物科技有限责任公司 一种乙酰基四肽-2的液相合成方法
JP7327858B2 (ja) * 2021-05-31 2023-08-16 学校法人中部大学 ペプチド化合物の製造方法及びアミド化反応剤

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4251438A (en) * 1979-06-14 1981-02-17 The Upjohn Company Piperazinone and piperazine polypeptides
IL111990A0 (en) * 1993-12-22 1995-03-15 Coca Cola Co Novel intermediates for the synthesis of l-aspartyl d -alpha- aminoalkanoyl (s)-n -alpha- alkylbenzyl amides useful as artificial sweeteners
US5939451A (en) 1996-06-28 1999-08-17 Hoffmann-La Roche Inc. Use of sulfonamides
US6294539B1 (en) * 1999-01-19 2001-09-25 Advanced Syntech, Llc Heterocyclic hydroxamic acid derivatives as MMP inhibitors

Also Published As

Publication number Publication date
CN101296937A (zh) 2008-10-29
WO2007031698A1 (en) 2007-03-22
GB0518667D0 (en) 2005-10-19
EP1937708A1 (en) 2008-07-02
CN101296937B (zh) 2012-05-09
US8399612B2 (en) 2013-03-19
EP2161277B1 (en) 2013-04-10
CA2622173A1 (en) 2007-03-22
EP2161277A3 (en) 2010-10-27
JP2009507906A (ja) 2009-02-26
US20120190816A9 (en) 2012-07-26
US20110275784A1 (en) 2011-11-10
EP2161277A2 (en) 2010-03-10

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