JP4926064B2 - モニタされた心臓血管パラメータに基づいた圧反射調節 - Google Patents
モニタされた心臓血管パラメータに基づいた圧反射調節 Download PDFInfo
- Publication number
- JP4926064B2 JP4926064B2 JP2007531174A JP2007531174A JP4926064B2 JP 4926064 B2 JP4926064 B2 JP 4926064B2 JP 2007531174 A JP2007531174 A JP 2007531174A JP 2007531174 A JP2007531174 A JP 2007531174A JP 4926064 B2 JP4926064 B2 JP 4926064B2
- Authority
- JP
- Japan
- Prior art keywords
- stimulation
- baroreflex
- various embodiments
- heart rate
- cardiovascular parameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 230000035581 baroreflex Effects 0.000 title claims description 145
- 230000002526 effect on cardiovascular system Effects 0.000 title claims description 39
- 230000000638 stimulation Effects 0.000 claims description 306
- 230000000747 cardiac effect Effects 0.000 claims description 115
- 210000002216 heart Anatomy 0.000 claims description 102
- 230000036772 blood pressure Effects 0.000 claims description 65
- 238000002560 therapeutic procedure Methods 0.000 claims description 60
- 230000008859 change Effects 0.000 claims description 51
- 230000001537 neural effect Effects 0.000 claims description 35
- 230000001965 increasing effect Effects 0.000 claims description 26
- 238000011282 treatment Methods 0.000 claims description 20
- 230000007423 decrease Effects 0.000 claims description 17
- 230000011514 reflex Effects 0.000 claims description 9
- 210000005003 heart tissue Anatomy 0.000 claims description 7
- 230000002441 reversible effect Effects 0.000 claims description 6
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 238000007634 remodeling Methods 0.000 claims description 4
- 230000036387 respiratory rate Effects 0.000 claims description 2
- 108091008698 baroreceptors Proteins 0.000 description 163
- 210000001774 pressoreceptor Anatomy 0.000 description 163
- 230000000694 effects Effects 0.000 description 80
- 238000000034 method Methods 0.000 description 74
- 210000001147 pulmonary artery Anatomy 0.000 description 50
- 210000005036 nerve Anatomy 0.000 description 48
- 206010020772 Hypertension Diseases 0.000 description 42
- 230000006870 function Effects 0.000 description 37
- 230000027288 circadian rhythm Effects 0.000 description 31
- 230000029058 respiratory gaseous exchange Effects 0.000 description 30
- 230000003276 anti-hypertensive effect Effects 0.000 description 25
- 230000008569 process Effects 0.000 description 24
- 208000010125 myocardial infarction Diseases 0.000 description 23
- 230000004044 response Effects 0.000 description 20
- 210000000577 adipose tissue Anatomy 0.000 description 19
- 230000033764 rhythmic process Effects 0.000 description 19
- 230000004872 arterial blood pressure Effects 0.000 description 18
- 210000001326 carotid sinus Anatomy 0.000 description 18
- 230000006854 communication Effects 0.000 description 18
- 238000004891 communication Methods 0.000 description 18
- 230000036279 refractory period Effects 0.000 description 18
- 230000002411 adverse Effects 0.000 description 17
- 210000003403 autonomic nervous system Anatomy 0.000 description 17
- 238000007726 management method Methods 0.000 description 17
- 210000002376 aorta thoracic Anatomy 0.000 description 16
- 230000004936 stimulating effect Effects 0.000 description 16
- 230000000241 respiratory effect Effects 0.000 description 14
- 230000009885 systemic effect Effects 0.000 description 14
- 210000001002 parasympathetic nervous system Anatomy 0.000 description 13
- 238000009423 ventilation Methods 0.000 description 13
- 230000001746 atrial effect Effects 0.000 description 11
- 210000004204 blood vessel Anatomy 0.000 description 11
- 238000001514 detection method Methods 0.000 description 11
- 210000005241 right ventricle Anatomy 0.000 description 11
- 206010019280 Heart failures Diseases 0.000 description 9
- 230000002503 metabolic effect Effects 0.000 description 9
- 210000002820 sympathetic nervous system Anatomy 0.000 description 9
- 210000001186 vagus nerve Anatomy 0.000 description 9
- 210000000709 aorta Anatomy 0.000 description 8
- 210000001640 nerve ending Anatomy 0.000 description 8
- 230000002829 reductive effect Effects 0.000 description 8
- 230000002861 ventricular Effects 0.000 description 8
- 230000001133 acceleration Effects 0.000 description 7
- 230000002889 sympathetic effect Effects 0.000 description 7
- 230000004913 activation Effects 0.000 description 6
- 230000006978 adaptation Effects 0.000 description 6
- 230000005284 excitation Effects 0.000 description 6
- 210000003205 muscle Anatomy 0.000 description 6
- 230000024883 vasodilation Effects 0.000 description 6
- 210000002620 vena cava superior Anatomy 0.000 description 6
- 230000001631 hypertensive effect Effects 0.000 description 5
- 238000002513 implantation Methods 0.000 description 5
- WABPQHHGFIMREM-UHFFFAOYSA-N lead(0) Chemical compound [Pb] WABPQHHGFIMREM-UHFFFAOYSA-N 0.000 description 5
- 230000000670 limiting effect Effects 0.000 description 5
- 230000007774 longterm Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 210000005245 right atrium Anatomy 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000001519 tissue Anatomy 0.000 description 5
- 230000001457 vasomotor Effects 0.000 description 5
- 210000003462 vein Anatomy 0.000 description 5
- 206010007559 Cardiac failure congestive Diseases 0.000 description 4
- 230000008602 contraction Effects 0.000 description 4
- 230000006378 damage Effects 0.000 description 4
- 230000010339 dilation Effects 0.000 description 4
- 210000002837 heart atrium Anatomy 0.000 description 4
- 208000028867 ischemia Diseases 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 4
- 210000000653 nervous system Anatomy 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 210000003102 pulmonary valve Anatomy 0.000 description 4
- 210000003492 pulmonary vein Anatomy 0.000 description 4
- 230000009467 reduction Effects 0.000 description 4
- 210000001044 sensory neuron Anatomy 0.000 description 4
- 230000035488 systolic blood pressure Effects 0.000 description 4
- 210000001631 vena cava inferior Anatomy 0.000 description 4
- 239000002131 composite material Substances 0.000 description 3
- 210000003748 coronary sinus Anatomy 0.000 description 3
- 230000029087 digestion Effects 0.000 description 3
- 210000002468 fat body Anatomy 0.000 description 3
- 230000010247 heart contraction Effects 0.000 description 3
- 208000019622 heart disease Diseases 0.000 description 3
- 230000000302 ischemic effect Effects 0.000 description 3
- 210000005246 left atrium Anatomy 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 238000012544 monitoring process Methods 0.000 description 3
- 230000007383 nerve stimulation Effects 0.000 description 3
- 230000036513 peripheral conductance Effects 0.000 description 3
- 230000002093 peripheral effect Effects 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 208000003663 ventricular fibrillation Diseases 0.000 description 3
- 206010001497 Agitation Diseases 0.000 description 2
- 206010003658 Atrial Fibrillation Diseases 0.000 description 2
- 241001632160 Dismorphiinae Species 0.000 description 2
- 206010016654 Fibrosis Diseases 0.000 description 2
- 206010061216 Infarction Diseases 0.000 description 2
- 206010067482 No adverse event Diseases 0.000 description 2
- 230000017488 activation-induced cell death of T cell Effects 0.000 description 2
- 206010000891 acute myocardial infarction Diseases 0.000 description 2
- 206010003119 arrhythmia Diseases 0.000 description 2
- 206010003668 atrial tachycardia Diseases 0.000 description 2
- 210000003169 central nervous system Anatomy 0.000 description 2
- 230000001627 detrimental effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 230000008713 feedback mechanism Effects 0.000 description 2
- 230000004761 fibrosis Effects 0.000 description 2
- 210000001308 heart ventricle Anatomy 0.000 description 2
- 230000007574 infarction Effects 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 210000005240 left ventricle Anatomy 0.000 description 2
- 230000003278 mimic effect Effects 0.000 description 2
- 230000003843 mucus production Effects 0.000 description 2
- 230000003680 myocardial damage Effects 0.000 description 2
- 210000004165 myocardium Anatomy 0.000 description 2
- 230000008035 nerve activity Effects 0.000 description 2
- 230000007230 neural mechanism Effects 0.000 description 2
- 230000007604 neuronal communication Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 230000001151 other effect Effects 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- 230000035479 physiological effects, processes and functions Effects 0.000 description 2
- 230000002685 pulmonary effect Effects 0.000 description 2
- 210000001747 pupil Anatomy 0.000 description 2
- 108020003175 receptors Proteins 0.000 description 2
- 210000003296 saliva Anatomy 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 230000000392 somatic effect Effects 0.000 description 2
- 210000005070 sphincter Anatomy 0.000 description 2
- 238000010561 standard procedure Methods 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 210000000591 tricuspid valve Anatomy 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 206010047302 ventricular tachycardia Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 206010049765 Bradyarrhythmia Diseases 0.000 description 1
- 208000024172 Cardiovascular disease Diseases 0.000 description 1
- 208000002251 Dissecting Aneurysm Diseases 0.000 description 1
- 208000000059 Dyspnea Diseases 0.000 description 1
- 206010013975 Dyspnoeas Diseases 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 229920002527 Glycogen Polymers 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 208000001953 Hypotension Diseases 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- 206010024119 Left ventricular failure Diseases 0.000 description 1
- 208000014139 Retinal vascular disease Diseases 0.000 description 1
- 208000034189 Sclerosis Diseases 0.000 description 1
- 208000006011 Stroke Diseases 0.000 description 1
- 206010049447 Tachyarrhythmia Diseases 0.000 description 1
- 208000001871 Tachycardia Diseases 0.000 description 1
- 206010047139 Vasoconstriction Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 208000008784 apnea Diseases 0.000 description 1
- 230000006793 arrhythmia Effects 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000002457 bidirectional effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000000157 blood function Effects 0.000 description 1
- 230000036760 body temperature Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 210000005242 cardiac chamber Anatomy 0.000 description 1
- 229940030602 cardiac therapy drug Drugs 0.000 description 1
- 210000001168 carotid artery common Anatomy 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 208000035850 clinical syndrome Diseases 0.000 description 1
- 238000011443 conventional therapy Methods 0.000 description 1
- 230000035487 diastolic blood pressure Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 206010013663 drug dependence Diseases 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007717 exclusion Effects 0.000 description 1
- 230000030135 gastric motility Effects 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 210000001932 glossopharyngeal nerve Anatomy 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940096919 glycogen Drugs 0.000 description 1
- 230000004217 heart function Effects 0.000 description 1
- 239000005555 hypertensive agent Substances 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000012153 long-term therapy Methods 0.000 description 1
- 208000012866 low blood pressure Diseases 0.000 description 1
- 230000005226 mechanical processes and functions Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004899 motility Effects 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000000107 myocyte Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 230000001734 parasympathetic effect Effects 0.000 description 1
- 210000005037 parasympathetic nerve Anatomy 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000037081 physical activity Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 230000000644 propagated effect Effects 0.000 description 1
- 230000035485 pulse pressure Effects 0.000 description 1
- 230000009153 reflex inhibition Effects 0.000 description 1
- 230000029865 regulation of blood pressure Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 210000001013 sinoatrial node Anatomy 0.000 description 1
- 230000009943 skeletal muscle blood flow Effects 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000004622 sleep time Effects 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 208000011117 substance-related disease Diseases 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002459 sustained effect Effects 0.000 description 1
- 230000008700 sympathetic activation Effects 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000007838 tissue remodeling Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 210000003932 urinary bladder Anatomy 0.000 description 1
- 230000025033 vasoconstriction Effects 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 230000002747 voluntary effect Effects 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
- A61N1/36139—Control systems using physiological parameters with automatic adjustment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
- A61N1/36117—Cardiac control, e.g. by vagal stimulation for treating hypertension
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36053—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/3606—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for a particular treatment
- A61N1/36114—Cardiac control, e.g. by vagal stimulation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/365—Heart stimulators controlled by a physiological parameter, e.g. heart potential
- A61N1/36514—Heart stimulators controlled by a physiological parameter, e.g. heart potential controlled by a physiological quantity other than heart potential, e.g. blood pressure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/372—Arrangements in connection with the implantation of stimulators
- A61N1/37211—Means for communicating with stimulators
- A61N1/37235—Aspects of the external programmer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/362—Heart stimulators
- A61N1/3627—Heart stimulators for treating a mechanical deficiency of the heart, e.g. congestive heart failure or cardiomyopathy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Physiology (AREA)
- Hematology (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/939,544 US7647114B2 (en) | 2003-12-24 | 2004-09-13 | Baroreflex modulation based on monitored cardiovascular parameter |
| US10/939,544 | 2004-09-13 | ||
| PCT/US2005/028393 WO2006031331A1 (en) | 2004-09-13 | 2005-08-10 | Baroreflex modulation based on monitored cardiovascular parameter |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237712A Division JP2012020185A (ja) | 2004-09-13 | 2011-10-28 | モニタされた心臓血管パラメータに基づいた圧反射調節 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008512180A JP2008512180A (ja) | 2008-04-24 |
| JP2008512180A5 JP2008512180A5 (enExample) | 2008-09-11 |
| JP4926064B2 true JP4926064B2 (ja) | 2012-05-09 |
Family
ID=35466095
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007531174A Expired - Fee Related JP4926064B2 (ja) | 2004-09-13 | 2005-08-10 | モニタされた心臓血管パラメータに基づいた圧反射調節 |
| JP2011237712A Withdrawn JP2012020185A (ja) | 2004-09-13 | 2011-10-28 | モニタされた心臓血管パラメータに基づいた圧反射調節 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011237712A Withdrawn JP2012020185A (ja) | 2004-09-13 | 2011-10-28 | モニタされた心臓血管パラメータに基づいた圧反射調節 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US7647114B2 (enExample) |
| EP (1) | EP1807150B1 (enExample) |
| JP (2) | JP4926064B2 (enExample) |
| WO (1) | WO2006031331A1 (enExample) |
Families Citing this family (145)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8086314B1 (en) | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| US7840271B2 (en) | 2000-09-27 | 2010-11-23 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US7499742B2 (en) | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
| US7623926B2 (en) | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US7616997B2 (en) | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7189204B2 (en) | 2002-12-04 | 2007-03-13 | Cardiac Pacemakers, Inc. | Sleep detection using an adjustable threshold |
| US20060111626A1 (en) * | 2003-03-27 | 2006-05-25 | Cvrx, Inc. | Electrode structures having anti-inflammatory properties and methods of use |
| US7887493B2 (en) | 2003-09-18 | 2011-02-15 | Cardiac Pacemakers, Inc. | Implantable device employing movement sensing for detecting sleep-related disorders |
| US8606356B2 (en) | 2003-09-18 | 2013-12-10 | Cardiac Pacemakers, Inc. | Autonomic arousal detection system and method |
| US8002553B2 (en) | 2003-08-18 | 2011-08-23 | Cardiac Pacemakers, Inc. | Sleep quality data collection and evaluation |
| WO2005028029A2 (en) | 2003-08-18 | 2005-03-31 | Cardiac Pacemakers, Inc. | Patient monitoring, diagnosis, and/or therapy systems and methods |
| US7657312B2 (en) * | 2003-11-03 | 2010-02-02 | Cardiac Pacemakers, Inc. | Multi-site ventricular pacing therapy with parasympathetic stimulation |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| US7769450B2 (en) | 2004-11-18 | 2010-08-03 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with neural sensor |
| US8396560B2 (en) * | 2004-11-18 | 2013-03-12 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US7509166B2 (en) | 2003-12-24 | 2009-03-24 | Cardiac Pacemakers, Inc. | Automatic baroreflex modulation responsive to adverse event |
| US7668594B2 (en) | 2005-08-19 | 2010-02-23 | Cardiac Pacemakers, Inc. | Method and apparatus for delivering chronic and post-ischemia cardiac therapies |
| US20080015659A1 (en) * | 2003-12-24 | 2008-01-17 | Yi Zhang | Neurostimulation systems and methods for cardiac conditions |
| US7643875B2 (en) * | 2003-12-24 | 2010-01-05 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system to reduce hypertension |
| US7486991B2 (en) * | 2003-12-24 | 2009-02-03 | Cardiac Pacemakers, Inc. | Baroreflex modulation to gradually decrease blood pressure |
| US7873413B2 (en) * | 2006-07-24 | 2011-01-18 | Cardiac Pacemakers, Inc. | Closed loop neural stimulation synchronized to cardiac cycles |
| US7647114B2 (en) | 2003-12-24 | 2010-01-12 | Cardiac Pacemakers, Inc. | Baroreflex modulation based on monitored cardiovascular parameter |
| US7706884B2 (en) | 2003-12-24 | 2010-04-27 | Cardiac Pacemakers, Inc. | Baroreflex stimulation synchronized to circadian rhythm |
| US8126560B2 (en) * | 2003-12-24 | 2012-02-28 | Cardiac Pacemakers, Inc. | Stimulation lead for stimulating the baroreceptors in the pulmonary artery |
| US7869881B2 (en) * | 2003-12-24 | 2011-01-11 | Cardiac Pacemakers, Inc. | Baroreflex stimulator with integrated pressure sensor |
| US20050149132A1 (en) * | 2003-12-24 | 2005-07-07 | Imad Libbus | Automatic baroreflex modulation based on cardiac activity |
| US7460906B2 (en) * | 2003-12-24 | 2008-12-02 | Cardiac Pacemakers, Inc. | Baroreflex stimulation to treat acute myocardial infarction |
| US9020595B2 (en) * | 2003-12-24 | 2015-04-28 | Cardiac Pacemakers, Inc. | Baroreflex activation therapy with conditional shut off |
| US8024050B2 (en) | 2003-12-24 | 2011-09-20 | Cardiac Pacemakers, Inc. | Lead for stimulating the baroreceptors in the pulmonary artery |
| US20050149133A1 (en) * | 2003-12-24 | 2005-07-07 | Imad Libbus | Sensing with compensation for neural stimulator |
| US8126559B2 (en) | 2004-11-30 | 2012-02-28 | Cardiac Pacemakers, Inc. | Neural stimulation with avoidance of inappropriate stimulation |
| US8200331B2 (en) * | 2004-11-04 | 2012-06-12 | Cardiac Pacemakers, Inc. | System and method for filtering neural stimulation |
| US7747323B2 (en) | 2004-06-08 | 2010-06-29 | Cardiac Pacemakers, Inc. | Adaptive baroreflex stimulation therapy for disordered breathing |
| US7596413B2 (en) * | 2004-06-08 | 2009-09-29 | Cardiac Pacemakers, Inc. | Coordinated therapy for disordered breathing including baroreflex modulation |
| US7999806B2 (en) * | 2004-07-23 | 2011-08-16 | Panasonic Corporation | Three-dimensional shape drawing device and three-dimensional shape drawing method |
| US8175705B2 (en) * | 2004-10-12 | 2012-05-08 | Cardiac Pacemakers, Inc. | System and method for sustained baroreflex stimulation |
| US8332047B2 (en) * | 2004-11-18 | 2012-12-11 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US9089691B2 (en) * | 2004-12-07 | 2015-07-28 | Cardiac Pacemakers, Inc. | Stimulator for auricular branch of vagus nerve |
| US7295874B2 (en) * | 2005-01-06 | 2007-11-13 | Cardiac Pacemakers, Inc. | Intermittent stress augmentation pacing for cardioprotective effect |
| US7587238B2 (en) | 2005-03-11 | 2009-09-08 | Cardiac Pacemakers, Inc. | Combined neural stimulation and cardiac resynchronization therapy |
| US7660628B2 (en) | 2005-03-23 | 2010-02-09 | Cardiac Pacemakers, Inc. | System to provide myocardial and neural stimulation |
| US8473049B2 (en) | 2005-05-25 | 2013-06-25 | Cardiac Pacemakers, Inc. | Implantable neural stimulator with mode switching |
| US7542800B2 (en) * | 2005-04-05 | 2009-06-02 | Cardiac Pacemakers, Inc. | Method and apparatus for synchronizing neural stimulation to cardiac cycles |
| US8406876B2 (en) * | 2005-04-05 | 2013-03-26 | Cardiac Pacemakers, Inc. | Closed loop neural stimulation synchronized to cardiac cycles |
| US7493161B2 (en) * | 2005-05-10 | 2009-02-17 | Cardiac Pacemakers, Inc. | System and method to deliver therapy in presence of another therapy |
| US7555341B2 (en) | 2005-04-05 | 2009-06-30 | Cardiac Pacemakers, Inc. | System to treat AV-conducted ventricular tachyarrhythmia |
| US7499748B2 (en) * | 2005-04-11 | 2009-03-03 | Cardiac Pacemakers, Inc. | Transvascular neural stimulation device |
| US7881782B2 (en) * | 2005-04-20 | 2011-02-01 | Cardiac Pacemakers, Inc. | Neural stimulation system to prevent simultaneous energy discharges |
| US9555252B2 (en) * | 2005-04-25 | 2017-01-31 | Cardiac Pacemakers, Inc. | Systems for providing neural markers for sensed autonomic nervous system activity |
| US7917210B2 (en) * | 2005-05-13 | 2011-03-29 | Cardiac Pacemakers, Inc. | Method and apparatus for cardiac protection pacing |
| US20060259088A1 (en) * | 2005-05-13 | 2006-11-16 | Pastore Joseph M | Method and apparatus for delivering pacing pulses using a coronary stent |
| US7894896B2 (en) * | 2005-05-13 | 2011-02-22 | Cardiac Pacemakers, Inc. | Method and apparatus for initiating and delivering cardiac protection pacing |
| US7617003B2 (en) * | 2005-05-16 | 2009-11-10 | Cardiac Pacemakers, Inc. | System for selective activation of a nerve trunk using a transvascular reshaping lead |
| US7922669B2 (en) | 2005-06-08 | 2011-04-12 | Cardiac Pacemakers, Inc. | Ischemia detection using a heart sound sensor |
| WO2007013065A2 (en) | 2005-07-25 | 2007-02-01 | Rainbow Medical Ltd. | Electrical stimulation of blood vessels |
| US20070036770A1 (en) * | 2005-08-12 | 2007-02-15 | Wagner Darrell O | Biologic device for regulation of gene expression and method therefor |
| US7616990B2 (en) * | 2005-10-24 | 2009-11-10 | Cardiac Pacemakers, Inc. | Implantable and rechargeable neural stimulator |
| US7570999B2 (en) | 2005-12-20 | 2009-08-04 | Cardiac Pacemakers, Inc. | Implantable device for treating epilepsy and cardiac rhythm disorders |
| US7885710B2 (en) * | 2005-12-23 | 2011-02-08 | Cardiac Pacemakers, Inc. | Method and apparatus for tissue protection against ischemia using remote conditioning |
| US7874992B2 (en) * | 2006-01-31 | 2011-01-25 | Medtronic, Inc. | Method for continuous baroreflex sensitivity measurement |
| CA2637787A1 (en) * | 2006-02-03 | 2007-08-16 | Synecor, Llc | Intravascular device for neuromodulation |
| US8126538B2 (en) * | 2006-06-06 | 2012-02-28 | Cardiac Pacemakers, Inc. | Method and apparatus for introducing endolymphatic instrumentation |
| US8634930B2 (en) * | 2006-06-30 | 2014-01-21 | Cardiac Pacemakers, Inc. | System for providing diabetic therapy |
| US8170668B2 (en) | 2006-07-14 | 2012-05-01 | Cardiac Pacemakers, Inc. | Baroreflex sensitivity monitoring and trending for tachyarrhythmia detection and therapy |
| US8457734B2 (en) * | 2006-08-29 | 2013-06-04 | Cardiac Pacemakers, Inc. | System and method for neural stimulation |
| US20080058881A1 (en) * | 2006-09-01 | 2008-03-06 | Cardiac Pacemakers, Inc | Method and system for treating post-mi patients |
| US7925342B2 (en) * | 2006-10-06 | 2011-04-12 | Cardiac Pacemakers, Inc. | Implantable device for responsive neural stimulation therapy |
| US8600499B2 (en) * | 2006-12-05 | 2013-12-03 | Cardiac Pacemakers, Inc. | Method and device for cardiac vasoactive therapy |
| US20080167690A1 (en) * | 2007-01-05 | 2008-07-10 | Cvrx, Inc. | Treatment of peripheral vascular disease by baroreflex activation |
| US8615296B2 (en) * | 2007-03-06 | 2013-12-24 | Cardiac Pacemakers, Inc. | Method and apparatus for closed-loop intermittent cardiac stress augmentation pacing |
| US20090018596A1 (en) * | 2007-05-15 | 2009-01-15 | Cvrx, Inc. | Baroreflex activation therapy device with pacing cardiac electrical signal detection capability |
| US8755892B2 (en) * | 2007-05-16 | 2014-06-17 | Cardiac Pacemakers, Inc. | Systems for stimulating neural targets |
| US9185489B2 (en) | 2007-05-30 | 2015-11-10 | Medtronic, Inc. | Automatic voiding diary |
| US8295933B2 (en) * | 2007-05-30 | 2012-10-23 | Medtronic, Inc. | Implantable medical lead including voiding event sensor |
| US8594794B2 (en) | 2007-07-24 | 2013-11-26 | Cvrx, Inc. | Baroreflex activation therapy with incrementally changing intensity |
| US8934971B1 (en) * | 2007-11-14 | 2015-01-13 | Pacesetter, Inc. | Implantable cardiac stimulation device and method that stabilizes ventricular rate during episodes of atrial fibrillation |
| EP2224847A4 (en) | 2007-12-28 | 2013-01-23 | Cvrx Inc | MEASURE THE PHYSIOLOGICAL PARAMETERS OF A PATIENT |
| JP5199394B2 (ja) * | 2008-01-29 | 2013-05-15 | カーディアック ペースメイカーズ， インコーポレイテッド | 構成可能な間欠ペーシング治療 |
| US8538535B2 (en) | 2010-08-05 | 2013-09-17 | Rainbow Medical Ltd. | Enhancing perfusion by contraction |
| US9005106B2 (en) | 2008-01-31 | 2015-04-14 | Enopace Biomedical Ltd | Intra-aortic electrical counterpulsation |
| US8483826B2 (en) * | 2008-03-17 | 2013-07-09 | Cardiac Pacemakers, Inc. | Deactivation of intermittent pacing therapy |
| US7925352B2 (en) * | 2008-03-27 | 2011-04-12 | Synecor Llc | System and method for transvascularly stimulating contents of the carotid sheath |
| US20100211131A1 (en) * | 2008-04-07 | 2010-08-19 | Williams Michael S | Intravascular system and method for blood pressure control |
| US8401652B2 (en) | 2008-06-16 | 2013-03-19 | Cvrx, Inc. | Devices and methods for treatment of heart failure and associated conditions |
| US8326430B2 (en) * | 2008-06-16 | 2012-12-04 | Cvrx, Inc. | Devices and methods for treatment of heart failure and associated conditions |
| US8321024B2 (en) | 2008-06-16 | 2012-11-27 | Cvrx, Inc. | Devices and methods for treatment of heart failure and associated conditions |
| JP5427233B2 (ja) | 2008-07-08 | 2014-02-26 | カーディアック ペースメイカーズ， インコーポレイテッド | 迷走神経刺激を送達する医療システム |
| US8457747B2 (en) * | 2008-10-20 | 2013-06-04 | Cyberonics, Inc. | Neurostimulation with signal duration determined by a cardiac cycle |
| WO2010132203A1 (en) | 2009-05-15 | 2010-11-18 | Cardiac Pacemakers, Inc. | Pacing system with safety control during mode transition |
| US8958873B2 (en) | 2009-05-28 | 2015-02-17 | Cardiac Pacemakers, Inc. | Method and apparatus for safe and efficient delivery of cardiac stress augmentation pacing |
| JP5567131B2 (ja) * | 2009-07-27 | 2014-08-06 | カーディアック ペースメイカーズ， インコーポレイテッド | 血液量再配分によって心不全を治療するための医療用デバイス |
| US8812104B2 (en) | 2009-09-23 | 2014-08-19 | Cardiac Pacemakers, Inc. | Method and apparatus for automated control of pacing post-conditioning |
| US8412326B2 (en) * | 2009-10-30 | 2013-04-02 | Cardiac Pacemakers, Inc. | Pacemaker with vagal surge monitoring and response |
| EP2509683B1 (en) | 2009-12-08 | 2017-08-23 | Cardiac Pacemakers, Inc. | Concurrent therapy detection in implantable medical devices |
| WO2011130488A2 (en) | 2010-04-15 | 2011-10-20 | Cardiac Pacemakers, Inc. | Autonomic modulation using transient response with intermittent neural stimulation |
| JP5775678B2 (ja) * | 2010-08-31 | 2015-09-09 | オリンパス株式会社 | 神経刺激装置 |
| EP2701795B1 (en) | 2011-04-28 | 2020-12-09 | Interventional Autonomics Corporation | Neuromodulation systems for treating acute heart failure syndromes |
| EP2766086A4 (en) | 2011-07-11 | 2015-09-30 | Interventional Autonomics Corp | SYSTEM AND METHOD FOR NEUROMODULATION |
| US9446240B2 (en) | 2011-07-11 | 2016-09-20 | Interventional Autonomics Corporation | System and method for neuromodulation |
| US20130072995A1 (en) | 2011-07-11 | 2013-03-21 | Terrance Ransbury | Catheter system for acute neuromodulation |
| US9526637B2 (en) | 2011-09-09 | 2016-12-27 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
| US8577458B1 (en) | 2011-12-07 | 2013-11-05 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with leadless heart rate monitoring |
| US10188856B1 (en) | 2011-12-07 | 2019-01-29 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction |
| US8918191B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| US8918190B2 (en) | 2011-12-07 | 2014-12-23 | Cyberonics, Inc. | Implantable device for evaluating autonomic cardiovascular drive in a patient suffering from chronic cardiac dysfunction |
| US8700150B2 (en) | 2012-01-17 | 2014-04-15 | Cyberonics, Inc. | Implantable neurostimulator for providing electrical stimulation of cervical vagus nerves for treatment of chronic cardiac dysfunction with bounded titration |
| US8812130B2 (en) | 2012-02-07 | 2014-08-19 | Cardiac Pacemakers, Inc. | Control of neural modulation therapy using cervical impedance |
| US9037236B2 (en) * | 2012-06-29 | 2015-05-19 | Pacesetter, Inc. | Method and system to select a neurostimulation system configuration based on cardiac rhythm feedback |
| US8688212B2 (en) | 2012-07-20 | 2014-04-01 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing bradycardia through vagus nerve stimulation |
| US9061145B2 (en) | 2012-09-17 | 2015-06-23 | Donald A. Rhodes | Technique for determining optimum treatment parameters |
| US8923964B2 (en) * | 2012-11-09 | 2014-12-30 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing heart failure patient awakening through vagus nerve stimulation |
| US9452290B2 (en) * | 2012-11-09 | 2016-09-27 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmia through vagus nerve stimulation |
| US9643008B2 (en) | 2012-11-09 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for enhancing post-exercise recovery through vagus nerve stimulation |
| WO2014126934A1 (en) * | 2013-02-18 | 2014-08-21 | Cardiac Pacemakers, Inc. | Medical device for algorithm adaptation to an external impact on the data |
| JP6190033B2 (ja) | 2013-03-14 | 2017-08-30 | カーディアック ペースメイカーズ， インコーポレイテッド | 再入院を回避するための心不全管理 |
| US9101275B2 (en) | 2013-03-14 | 2015-08-11 | Cardiac Pacemakers, Inc. | Determining systolic time intervals using heart sounds |
| US9643011B2 (en) | 2013-03-14 | 2017-05-09 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing tachyarrhythmic risk during sleep through vagus nerve stimulation |
| WO2014204980A1 (en) | 2013-06-18 | 2014-12-24 | Cardiac Pacemakers, Inc. | System and method for mapping baroreceptors |
| US9999773B2 (en) | 2013-10-30 | 2018-06-19 | Cyberonics, Inc. | Implantable neurostimulator-implemented method utilizing multi-modal stimulation parameters |
| WO2015068167A2 (en) | 2013-11-06 | 2015-05-14 | Enopace Biomedical Ltd. | Wireless endovascular stent-based electrodes |
| US9511228B2 (en) | 2014-01-14 | 2016-12-06 | Cyberonics, Inc. | Implantable neurostimulator-implemented method for managing hypertension through renal denervation and vagus nerve stimulation |
| US9950169B2 (en) | 2014-04-25 | 2018-04-24 | Cyberonics, Inc. | Dynamic stimulation adjustment for identification of a neural fulcrum |
| US9415224B2 (en) | 2014-04-25 | 2016-08-16 | Cyberonics, Inc. | Neurostimulation and recording of physiological response for the treatment of chronic cardiac dysfunction |
| US9713719B2 (en) | 2014-04-17 | 2017-07-25 | Cyberonics, Inc. | Fine resolution identification of a neural fulcrum for the treatment of chronic cardiac dysfunction |
| US9409024B2 (en) | 2014-03-25 | 2016-08-09 | Cyberonics, Inc. | Neurostimulation in a neural fulcrum zone for the treatment of chronic cardiac dysfunction |
| US9272143B2 (en) | 2014-05-07 | 2016-03-01 | Cyberonics, Inc. | Responsive neurostimulation for the treatment of chronic cardiac dysfunction |
| US10130809B2 (en) | 2014-06-13 | 2018-11-20 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
| US9782584B2 (en) | 2014-06-13 | 2017-10-10 | Nervana, LLC | Transcutaneous electrostimulator and methods for electric stimulation |
| JP6262405B2 (ja) | 2014-07-01 | 2018-01-17 | カーディアック ペースメイカーズ， インコーポレイテッド | 医学的処置を検出するためのシステム |
| US9770599B2 (en) | 2014-08-12 | 2017-09-26 | Cyberonics, Inc. | Vagus nerve stimulation and subcutaneous defibrillation system |
| US9533153B2 (en) | 2014-08-12 | 2017-01-03 | Cyberonics, Inc. | Neurostimulation titration process |
| US9737716B2 (en) | 2014-08-12 | 2017-08-22 | Cyberonics, Inc. | Vagus nerve and carotid baroreceptor stimulation system |
| JP2016077520A (ja) * | 2014-10-16 | 2016-05-16 | オリンパス株式会社 | 神経刺激装置 |
| US9504832B2 (en) | 2014-11-12 | 2016-11-29 | Cyberonics, Inc. | Neurostimulation titration process via adaptive parametric modification |
| CN105288849B (zh) * | 2015-03-19 | 2017-11-28 | 北京品驰医疗设备有限公司 | 一种具有调制模式的植入式神经电刺激系统 |
| US20160317050A1 (en) | 2015-04-28 | 2016-11-03 | Federico Perego Costa | Hemodynamic parameter (Hdp) monitoring system for diagnosis of a health condition of a patient |
| BR112019012284A8 (pt) * | 2016-12-15 | 2023-03-28 | Autem Medical Llc | Sistema para diagnosticar uma condição de saúde de um paciente, sistema para estabelecer valores indicadores do parâmetro hemodinâmico ou valores indicadores sub-rogados do parâmetro hemodinâmico, método para diagnosticar uma condição de saúde de um paciente e gerador programável |
| WO2018156644A1 (en) | 2017-02-21 | 2018-08-30 | Vascular Dynamics, Inc. | Baroreceptor testing prior to implantation methods and apparatus |
| NL2019106B1 (en) * | 2017-06-22 | 2019-01-07 | Frederick Benson Jacobus | Blood pressure regulating device |
| US10646710B2 (en) | 2018-06-01 | 2020-05-12 | Feinstein Patents, Llc | Medical wound covering employing electrical stimulation to control blood flow |
| US10456573B1 (en) | 2018-06-18 | 2019-10-29 | Feinstein Patents, Llc | Medical cuff employing electrical stimulation to control blood flow |
| US11338143B2 (en) * | 2019-03-20 | 2022-05-24 | Neuroceuticals, Inc. | Control apparatus for treating myocardial infarction and control method for treating myocardial infarction |
| BR112021020351A2 (pt) | 2019-04-10 | 2021-12-07 | Autem Medical Llc | Sistema para prognosticar um resultado em um paciente, método para prognosticar uma condição de saúde de um paciente e método para prognosticar um resultado associado a um paciente |
| GB201907605D0 (en) * | 2019-05-29 | 2019-07-10 | Bios Health Ltd | System and method for cardiac control |
| US11400299B1 (en) | 2021-09-14 | 2022-08-02 | Rainbow Medical Ltd. | Flexible antenna for stimulator |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6073048A (en) * | 1995-11-17 | 2000-06-06 | Medtronic, Inc. | Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure |
| WO2002026318A1 (en) * | 2000-09-26 | 2002-04-04 | Medtronic, Inc. | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure |
| JP2004526471A (ja) * | 2000-09-27 | 2004-09-02 | シーブイアールエックス， インコーポレイテッド | 心血管性反射制御のための装置および方法 |
Family Cites Families (211)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3421511A (en) | 1965-12-10 | 1969-01-14 | Medtronic Inc | Implantable electrode for nerve stimulation |
| US3522811A (en) | 1969-02-13 | 1970-08-04 | Medtronic Inc | Implantable nerve stimulator and method of use |
| SE346468B (enExample) | 1969-02-24 | 1972-07-10 | Lkb Medical Ab | |
| US3557796A (en) * | 1969-03-10 | 1971-01-26 | Cordis Corp | Digital counter driven pacer |
| US5190035A (en) | 1981-06-18 | 1993-03-02 | Cardiac Pacemakers, Inc. | Biomedical method and apparatus for controlling the administration of therapy to a patient in response to changes in physiological demand |
| US4936304A (en) | 1985-10-07 | 1990-06-26 | Thomas Jefferson University | Pacing system and method for cardiac pacing as a function of determined myocardial contractility |
| US4770177A (en) | 1986-02-18 | 1988-09-13 | Telectronics N.V. | Apparatus and method for adjusting heart/pacer relative to changes in venous diameter during exercise to obtain a required cardiac output. |
| US4791931A (en) | 1987-08-13 | 1988-12-20 | Pacesetter Infusion, Ltd. | Demand pacemaker using an artificial baroreceptor reflex |
| US4960129A (en) | 1988-12-05 | 1990-10-02 | Trustees Of The University Of Pennsylvania | Methods of observing autonomic neural stimulation and diagnosing cardiac dynamical dysfunction using heartbeat interval data to analyze cardioventilatory interactions |
| US5052388A (en) | 1989-12-22 | 1991-10-01 | Medtronic, Inc. | Method and apparatus for implementing activity sensing in a pulse generator |
| US5024222A (en) | 1990-02-21 | 1991-06-18 | Siemens-Pacesetter, Inc. | Hemodynamically rate responsive pacemaker and method of automatically adjusting the escape and A-V intervals |
| US5111815A (en) | 1990-10-15 | 1992-05-12 | Cardiac Pacemakers, Inc. | Method and apparatus for cardioverter/pacer utilizing neurosensing |
| US5437285A (en) | 1991-02-20 | 1995-08-01 | Georgetown University | Method and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac electrical stability |
| US5199428A (en) | 1991-03-22 | 1993-04-06 | Medtronic, Inc. | Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload |
| US5318592A (en) | 1991-09-12 | 1994-06-07 | BIOTRONIK, Mess- und Therapiegerate GmbH & Co., Ingenieurburo Berlin | Cardiac therapy system |
| US5374282A (en) | 1991-10-31 | 1994-12-20 | Medtronic, Inc. | Automatic sensitivity adjust for cardiac pacemakers |
| US5193539A (en) | 1991-12-18 | 1993-03-16 | Alfred E. Mann Foundation For Scientific Research | Implantable microstimulator |
| US5203326A (en) | 1991-12-18 | 1993-04-20 | Telectronics Pacing Systems, Inc. | Antiarrhythmia pacer using antiarrhythmia pacing and autonomic nerve stimulation therapy |
| US5330507A (en) | 1992-04-24 | 1994-07-19 | Medtronic, Inc. | Implantable electrical vagal stimulation for prevention or interruption of life threatening arrhythmias |
| US5243980A (en) | 1992-06-30 | 1993-09-14 | Medtronic, Inc. | Method and apparatus for discrimination of ventricular and supraventricular tachycardia |
| AU661179B2 (en) | 1992-06-30 | 1995-07-13 | Medtronic, Inc. | Method and apparatus for treatment of angina |
| WO1994000190A1 (en) | 1992-06-30 | 1994-01-06 | Medtronic, Inc. | Method and apparatus for treatment of heart disorders |
| AU5205493A (en) | 1992-12-01 | 1994-06-16 | Siemens Aktiengesellschaft | Cardiac event detection in implantable medical devices |
| US5792187A (en) | 1993-02-22 | 1998-08-11 | Angeion Corporation | Neuro-stimulation to control pain during cardioversion defibrillation |
| US5411531A (en) | 1993-09-23 | 1995-05-02 | Medtronic, Inc. | Method and apparatus for control of A-V interval |
| US5522854A (en) | 1994-05-19 | 1996-06-04 | Duke University | Method and apparatus for the prevention of arrhythmia by nerve stimulation |
| EP0688579B1 (en) | 1994-06-24 | 2001-08-22 | St. Jude Medical AB | Device for heart therapy |
| EP0688578B1 (en) | 1994-06-24 | 1999-11-10 | Pacesetter AB | Arrhythmia detector |
| US5562711A (en) | 1994-11-30 | 1996-10-08 | Medtronic, Inc. | Method and apparatus for rate-responsive cardiac pacing |
| US5540730A (en) | 1995-06-06 | 1996-07-30 | Cyberonics, Inc. | Treatment of motility disorders by nerve stimulation |
| US5662689A (en) | 1995-09-08 | 1997-09-02 | Medtronic, Inc. | Method and apparatus for alleviating cardioversion shock pain |
| US5707400A (en) | 1995-09-19 | 1998-01-13 | Cyberonics, Inc. | Treating refractory hypertension by nerve stimulation |
| US5700282A (en) | 1995-10-13 | 1997-12-23 | Zabara; Jacob | Heart rhythm stabilization using a neurocybernetic prosthesis |
| US6035233A (en) | 1995-12-11 | 2000-03-07 | Intermedics Inc. | Implantable medical device responsive to heart rate variability analysis |
| US5913876A (en) | 1996-02-20 | 1999-06-22 | Cardiothoracic Systems, Inc. | Method and apparatus for using vagus nerve stimulation in surgery |
| US5690681A (en) | 1996-03-29 | 1997-11-25 | Purdue Research Foundation | Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation |
| US6735471B2 (en) | 1996-04-30 | 2004-05-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
| US6006134A (en) | 1998-04-30 | 1999-12-21 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
| US7269457B2 (en) | 1996-04-30 | 2007-09-11 | Medtronic, Inc. | Method and system for vagal nerve stimulation with multi-site cardiac pacing |
| US6532388B1 (en) | 1996-04-30 | 2003-03-11 | Medtronic, Inc. | Method and system for endotracheal/esophageal stimulation prior to and during a medical procedure |
| USRE38705E1 (en) | 1996-04-30 | 2005-02-22 | Medtronic, Inc. | Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers |
| US6628987B1 (en) | 2000-09-26 | 2003-09-30 | Medtronic, Inc. | Method and system for sensing cardiac contractions during vagal stimulation-induced cardiopalegia |
| USRE40279E1 (en) | 1997-06-26 | 2008-04-29 | Sherwood Services Ag | Method and system for neural tissue modification |
| US6479523B1 (en) | 1997-08-26 | 2002-11-12 | Emory University | Pharmacologic drug combination in vagal-induced asystole |
| US6141590A (en) | 1997-09-25 | 2000-10-31 | Medtronic, Inc. | System and method for respiration-modulated pacing |
| US6076015A (en) | 1998-02-27 | 2000-06-13 | Cardiac Pacemakers, Inc. | Rate adaptive cardiac rhythm management device using transthoracic impedance |
| US6058331A (en) | 1998-04-27 | 2000-05-02 | Medtronic, Inc. | Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control |
| WO1999056818A1 (en) * | 1998-04-30 | 1999-11-11 | Medtronic, Inc. | Multiple electrode lead body for spinal cord stimulation |
| WO1999065561A1 (en) | 1998-06-19 | 1999-12-23 | Cordis Webster, Inc. | Method and apparatus for transvascular treatment of tachycardia and fibrillation |
| US6240316B1 (en) | 1998-08-14 | 2001-05-29 | Advanced Bionics Corporation | Implantable microstimulation system for treatment of sleep apnea |
| DE19847446B4 (de) | 1998-10-08 | 2010-04-22 | Biotronik Gmbh & Co. Kg | Nervenelektrodenanordnung |
| US7076307B2 (en) | 2002-05-09 | 2006-07-11 | Boveja Birinder R | Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders |
| US20030212440A1 (en) | 2002-05-09 | 2003-11-13 | Boveja Birinder R. | Method and system for modulating the vagus nerve (10th cranial nerve) using modulated electrical pulses with an inductively coupled stimulation system |
| US6169918B1 (en) | 1998-10-28 | 2001-01-02 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with cross-chamber soft blanking |
| US6134470A (en) | 1998-11-09 | 2000-10-17 | Medtronic, Inc. | Method and apparatus for treating a tachyarrhythmic patient |
| US6181966B1 (en) | 1998-12-28 | 2001-01-30 | Biotronik Mess- und Therapieger{umlaut over (a)}te GmbH & Co. | Heart therapy apparatus with therapy correction means |
| DE69918657T2 (de) | 1999-01-28 | 2005-09-08 | Sorin Biomedica Crm S.R.L., Saluggia | Herzstimulationsgerät mit elektrotonischer Blockade |
| US6411845B1 (en) | 1999-03-04 | 2002-06-25 | Mower Chf Treatment Irrevocable Trust | System for multiple site biphasic stimulation to revert ventricular arrhythmias |
| US6115628A (en) * | 1999-03-29 | 2000-09-05 | Medtronic, Inc. | Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals |
| US6178349B1 (en) | 1999-04-15 | 2001-01-23 | Medtronic, Inc. | Drug delivery neural stimulation device for treatment of cardiovascular disorders |
| US6341236B1 (en) | 1999-04-30 | 2002-01-22 | Ivan Osorio | Vagal nerve stimulation techniques for treatment of epileptic seizures |
| US6285907B1 (en) | 1999-05-21 | 2001-09-04 | Cardiac Pacemakers, Inc. | System providing ventricular pacing and biventricular coordination |
| US6285909B1 (en) * | 1999-05-27 | 2001-09-04 | Cardiac Pacemakers, Inc. | Preserving patient specific data in implantable pulse generator systems |
| JP2003503119A (ja) | 1999-06-25 | 2003-01-28 | エモリ ユニバーシティ | 迷走神経刺激用機器及び方法 |
| DE19929705A1 (de) | 1999-06-29 | 2001-01-04 | Biotronik Mess & Therapieg | Verfahren zur Bestimmung der Baroreflex-Latenzzeit und Baroreflex-Sensitivität |
| US6272377B1 (en) | 1999-10-01 | 2001-08-07 | Cardiac Pacemakers, Inc. | Cardiac rhythm management system with arrhythmia prediction and prevention |
| US6473644B1 (en) | 1999-10-13 | 2002-10-29 | Cyberonics, Inc. | Method to enhance cardiac capillary growth in heart failure patients |
| US6942622B1 (en) | 1999-11-10 | 2005-09-13 | Pacesetter, Inc. | Method for monitoring autonomic tone |
| US7300449B2 (en) | 1999-12-09 | 2007-11-27 | Mische Hans A | Methods and devices for the treatment of neurological and physiological disorders |
| EP1106206B1 (de) | 1999-11-30 | 2007-06-27 | BIOTRONIK GmbH & Co. KG | Gerät zur Regelung der Herzfrequenz und der Herzpumpkraft |
| US6611713B2 (en) | 1999-11-30 | 2003-08-26 | Patrick Schauerte | Implantable device for diagnosing and distinguishing supraventricular and ventricular tachycardias |
| US6885888B2 (en) | 2000-01-20 | 2005-04-26 | The Cleveland Clinic Foundation | Electrical stimulation of the sympathetic nerve chain |
| US6438423B1 (en) | 2000-01-20 | 2002-08-20 | Electrocore Technique, Llc | Method of treating complex regional pain syndromes by electrical stimulation of the sympathetic nerve chain |
| US6487450B1 (en) | 2000-02-24 | 2002-11-26 | Cedars-Sinai Medical Center | System and method for preventing Sudden Cardiac Death by nerve sprouting from right stellate ganglion |
| EP1142608A2 (en) | 2000-04-05 | 2001-10-10 | Pacesetter, Inc. | System and method for prevention of recurrent vasovagal syncope using cardiac pacing |
| US6466822B1 (en) | 2000-04-05 | 2002-10-15 | Neuropace, Inc. | Multimodal neurostimulator and process of using it |
| US6640135B1 (en) | 2000-04-06 | 2003-10-28 | Cardiac Pacemakers, Inc. | Apparatus and method for spatially and temporally distributing cardiac electrical stimulation |
| US6371922B1 (en) | 2000-04-07 | 2002-04-16 | Cardiac Pacemakers, Inc. | Method for measuring baroreflex sensitivity and therapy optimization in heart failure patients |
| US7239914B2 (en) | 2000-05-13 | 2007-07-03 | Cardiac Pacemakers, Inc. | Rate smoothing control |
| US6647295B2 (en) | 2000-05-15 | 2003-11-11 | Pacesetter, Inc. | Implantable cardiac stimulation device with detection and therapy for patients with vasovagal syncope |
| US6610713B2 (en) | 2000-05-23 | 2003-08-26 | North Shore - Long Island Jewish Research Institute | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
| FR2809630B1 (fr) | 2000-06-05 | 2003-01-24 | Ela Medical Sa | Dispositif medical implantable actif tel que stimulateur cardiaque, defibrillateur, cardioverteur et/ou dispositif multisite a detection perfectionnee des extrasystoles auriculaires tardives |
| US6511500B1 (en) | 2000-06-06 | 2003-01-28 | Marc Mounir Rahme | Use of autonomic nervous system neurotransmitters inhibition and atrial parasympathetic fibers ablation for the treatment of atrial arrhythmias and to preserve drug effects |
| US6526318B1 (en) | 2000-06-16 | 2003-02-25 | Mehdi M. Ansarinia | Stimulation method for the sphenopalatine ganglia, sphenopalatine nerve, or vidian nerve for treatment of medical conditions |
| EP1172125B1 (en) | 2000-07-11 | 2005-03-09 | SORIN BIOMEDICA CRM S.r.l. | An implantable heart stimulation system with automatic mode switching controlled by sympatho-vagal balance |
| US7616997B2 (en) | 2000-09-27 | 2009-11-10 | Kieval Robert S | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7158832B2 (en) | 2000-09-27 | 2007-01-02 | Cvrx, Inc. | Electrode designs and methods of use for cardiovascular reflex control devices |
| US8086314B1 (en) | 2000-09-27 | 2011-12-27 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| US7499742B2 (en) | 2001-09-26 | 2009-03-03 | Cvrx, Inc. | Electrode structures and methods for their use in cardiovascular reflex control |
| US7623926B2 (en) | 2000-09-27 | 2009-11-24 | Cvrx, Inc. | Stimulus regimens for cardiovascular reflex control |
| US6850801B2 (en) | 2001-09-26 | 2005-02-01 | Cvrx, Inc. | Mapping methods for cardiovascular reflex control devices |
| US6522926B1 (en) | 2000-09-27 | 2003-02-18 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control |
| CA2426810A1 (en) | 2000-10-26 | 2002-06-13 | Medtronic, Inc. | Method and apparatus for electrically stimulating the nervous system to improve ventricular dysfunction, heart failure, and other cardiac comditions |
| CA2426944A1 (en) | 2000-10-26 | 2002-05-02 | Medtronic, Inc. | Method and apparatus to minimize the effects of a cardiac insult |
| DE60139411D1 (de) | 2000-10-26 | 2009-09-10 | Medtronic Inc | Gerät zur minimierung der wirkungen einer herzverletzung |
| US7011638B2 (en) | 2000-11-14 | 2006-03-14 | Science Medicus, Inc. | Device and procedure to treat cardiac atrial arrhythmias |
| US6904315B2 (en) | 2000-12-14 | 2005-06-07 | Medtronic, Inc. | Atrial aware VVI: a method for atrial synchronous ventricular (VDD/R) pacing using the subcutaneous electrode array and a standard pacing lead |
| US7519421B2 (en) | 2001-01-16 | 2009-04-14 | Kenergy, Inc. | Vagal nerve stimulation using vascular implanted devices for treatment of atrial fibrillation |
| US6600954B2 (en) | 2001-01-25 | 2003-07-29 | Biocontrol Medical Bcm Ltd. | Method and apparatus for selective control of nerve fibers |
| US6564096B2 (en) | 2001-02-28 | 2003-05-13 | Robert A. Mest | Method and system for treatment of tachycardia and fibrillation |
| US6662052B1 (en) | 2001-04-19 | 2003-12-09 | Nac Technologies Inc. | Method and system for neuromodulation therapy using external stimulator with wireless communication capabilites |
| WO2002085448A2 (en) | 2001-04-20 | 2002-10-31 | The Board Of Regents Of The University Of Oklahoma | Cardiac neuromodulation and methods of using same |
| US6684105B2 (en) | 2001-08-31 | 2004-01-27 | Biocontrol Medical, Ltd. | Treatment of disorders by unidirectional nerve stimulation |
| US6907295B2 (en) | 2001-08-31 | 2005-06-14 | Biocontrol Medical Ltd. | Electrode assembly for nerve control |
| US6889078B2 (en) | 2001-04-26 | 2005-05-03 | Medtronic, Inc. | Hysteresis activation of accelerated pacing |
| US6928320B2 (en) | 2001-05-17 | 2005-08-09 | Medtronic, Inc. | Apparatus for blocking activation of tissue or conduction of action potentials while other tissue is being therapeutically activated |
| JP2004533297A (ja) | 2001-05-29 | 2004-11-04 | メドトロニック・インコーポレーテッド | 心臓病の予防及び処置のための閉ループ神経調節システム |
| WO2002102239A2 (en) | 2001-06-19 | 2002-12-27 | Mouse Specifics, Inc. | Method of early detection of duchenne muscular dystrophy and other neuromuscular disease |
| US6748271B2 (en) | 2001-07-27 | 2004-06-08 | Cardiac Pacemakers, Inc. | Method and system for treatment of neurocardiogenic syncope |
| US7481759B2 (en) | 2001-08-03 | 2009-01-27 | Cardiac Pacemakers, Inc. | Systems and methods for treatment of coronary artery disease |
| US6622041B2 (en) | 2001-08-21 | 2003-09-16 | Cyberonics, Inc. | Treatment of congestive heart failure and autonomic cardiovascular drive disorders |
| WO2003020364A2 (en) | 2001-08-28 | 2003-03-13 | Medtronic, Inc. | Implantable medical device for treating cardiac mechanical dysfunction by electrical stimulation |
| US7778711B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Reduction of heart rate variability by parasympathetic stimulation |
| US7734355B2 (en) | 2001-08-31 | 2010-06-08 | Bio Control Medical (B.C.M.) Ltd. | Treatment of disorders by unidirectional nerve stimulation |
| US7778703B2 (en) | 2001-08-31 | 2010-08-17 | Bio Control Medical (B.C.M.) Ltd. | Selective nerve fiber stimulation for treating heart conditions |
| US6934583B2 (en) | 2001-10-22 | 2005-08-23 | Pacesetter, Inc. | Implantable lead and method for stimulating the vagus nerve |
| US6973349B2 (en) | 2001-12-05 | 2005-12-06 | Cardiac Pacemakers, Inc. | Method and apparatus for minimizing post-infarct ventricular remodeling |
| US7155284B1 (en) | 2002-01-24 | 2006-12-26 | Advanced Bionics Corporation | Treatment of hypertension |
| US20030149450A1 (en) | 2002-02-01 | 2003-08-07 | Mayberg Marc R. | Brainstem and cerebellar modulation of cardiovascular response and disease |
| US7236821B2 (en) | 2002-02-19 | 2007-06-26 | Cardiac Pacemakers, Inc. | Chronically-implanted device for sensing and therapy |
| US6937896B1 (en) | 2002-02-26 | 2005-08-30 | Pacesetter, Inc. | Sympathetic nerve stimulator and/or pacemaker |
| JP2005519680A (ja) | 2002-03-14 | 2005-07-07 | ブレインズゲート リミティド | 血圧制御技術 |
| US7689276B2 (en) | 2002-09-13 | 2010-03-30 | Leptos Biomedical, Inc. | Dynamic nerve stimulation for treatment of disorders |
| US7123959B2 (en) | 2002-03-25 | 2006-10-17 | Cardiac Pacemakers, Inc. | Method and apparatus for preventing cardiac arrhythmias with endovascular stimulation |
| WO2003082403A2 (en) | 2002-03-27 | 2003-10-09 | Cvrx, Inc. | Devices and methods for cardiovascular reflex control via coupled electrodes |
| US7162303B2 (en) | 2002-04-08 | 2007-01-09 | Ardian, Inc. | Renal nerve stimulation method and apparatus for treatment of patients |
| US7235050B2 (en) | 2002-04-11 | 2007-06-26 | Alfred E. Mann Foundation For Scientific Research | Implantable device for processing neurological signals |
| US6990372B2 (en) | 2002-04-11 | 2006-01-24 | Alfred E. Mann Foundation For Scientific Research | Programmable signal analysis device for detecting neurological signals in an implantable device |
| US20030195571A1 (en) * | 2002-04-12 | 2003-10-16 | Burnes John E. | Method and apparatus for the treatment of central sleep apnea using biventricular pacing |
| US7123967B2 (en) | 2002-05-13 | 2006-10-17 | Pacesetter, Inc. | Implantable neural stimulation device providing activity, rest, and long term closed-loop peripheral vascular disease therapy and method |
| US7321793B2 (en) | 2003-06-13 | 2008-01-22 | Biocontrol Medical Ltd. | Vagal stimulation for atrial fibrillation therapy |
| US7885711B2 (en) | 2003-06-13 | 2011-02-08 | Bio Control Medical (B.C.M.) Ltd. | Vagal stimulation for anti-embolic therapy |
| US7277761B2 (en) | 2002-06-12 | 2007-10-02 | Pacesetter, Inc. | Vagal stimulation for improving cardiac function in heart failure or CHF patients |
| US7225017B1 (en) * | 2002-06-12 | 2007-05-29 | Pacesetter, Inc. | Parasympathetic nerve stimulation for ICD and/or ATP patients |
| US7139607B1 (en) | 2002-06-12 | 2006-11-21 | Pacesetter, Inc. | Arrhythmia discrimination |
| US7123961B1 (en) | 2002-06-13 | 2006-10-17 | Pacesetter, Inc. | Stimulation of autonomic nerves |
| US7860570B2 (en) | 2002-06-20 | 2010-12-28 | Boston Scientific Neuromodulation Corporation | Implantable microstimulators and methods for unidirectional propagation of action potentials |
| US20040015205A1 (en) | 2002-06-20 | 2004-01-22 | Whitehurst Todd K. | Implantable microstimulators with programmable multielectrode configuration and uses thereof |
| US7292890B2 (en) | 2002-06-20 | 2007-11-06 | Advanced Bionics Corporation | Vagus nerve stimulation via unidirectional propagation of action potentials |
| WO2004012814A1 (ja) | 2002-08-05 | 2004-02-12 | Japan As Represented By President Of National Cardiovascular Center | 生体調節機能代替を用いた治療用システム並びに該システムに基づく心臓ペーシングシステム、血圧調節システム及び心疾患治療用システム |
| US7027858B2 (en) | 2002-09-11 | 2006-04-11 | Medtronic, Inc. | Methods and apparatus for cardiac R-wave sensing in a subcutaneous ECG waveform |
| US6965797B2 (en) | 2002-09-13 | 2005-11-15 | Cardiac Pacemakers, Inc. | Method and apparatus for assessing and treating myocardial wall stress |
| US7103418B2 (en) | 2002-10-02 | 2006-09-05 | Medtronic, Inc. | Active fluid delivery catheter |
| WO2004033034A1 (en) | 2002-10-04 | 2004-04-22 | Microchips, Inc. | Medical device for neural stimulation and controlled drug delivery |
| US7277757B2 (en) | 2002-10-31 | 2007-10-02 | Medtronic, Inc. | Respiratory nerve stimulation |
| US20030229380A1 (en) | 2002-10-31 | 2003-12-11 | Adams John M. | Heart failure therapy device and method |
| US7065405B2 (en) | 2002-11-15 | 2006-06-20 | Cardiac Pacemakers, Inc. | Stress reduction pacing mode for arrhythmia prevention |
| US7305265B2 (en) | 2002-11-25 | 2007-12-04 | Terumo Kabushiki Kaisha | Heart treatment equipment for treating heart failure |
| US7142917B2 (en) | 2002-12-04 | 2006-11-28 | Terumo Kabushiki Kaisha | Heart treatment equipment and method for preventing fatal arrhythmia |
| US7555351B2 (en) | 2002-12-19 | 2009-06-30 | Cardiac Pacemakers, Inc. | Pulmonary artery lead for atrial therapy and atrial pacing and sensing |
| US20040122498A1 (en) | 2002-12-19 | 2004-06-24 | Yongxing Zhang | Pulmonary artery lead for atrial therapy |
| US7392094B2 (en) | 2002-12-19 | 2008-06-24 | Cardiac Pacemakers, Inc. | Implantable lead for septal placement of pacing electrodes |
| US20040260374A1 (en) | 2002-12-19 | 2004-12-23 | Cardiac Pacemakers, Inc. | Implantable lead with fixation mechanism in the pulmonary artery |
| US7890188B2 (en) | 2002-12-19 | 2011-02-15 | Cardiac Pacemakers, Inc. | Implantable lead for septal placement of electrode with fixation mechanism in the pulmonary artery |
| US6928323B2 (en) | 2002-12-30 | 2005-08-09 | Cardiac Pacemakers, Inc. | Adaptive sensing threshold for cross-chamber refractory period |
| WO2004062470A2 (en) | 2003-01-03 | 2004-07-29 | Advanced Neuromodulation Systems, Inc. | System and method for stimulation of a person’s brain stem |
| US7025730B2 (en) | 2003-01-10 | 2006-04-11 | Medtronic, Inc. | System and method for automatically monitoring and delivering therapy for sleep-related disordered breathing |
| US7092755B2 (en) | 2003-03-18 | 2006-08-15 | Pacesetter, Inc. | System and method of cardiac pacing during sleep apnea |
| JP4252830B2 (ja) | 2003-03-24 | 2009-04-08 | テルモ株式会社 | 心臓治療装置 |
| JP4252833B2 (ja) | 2003-03-27 | 2009-04-08 | テルモ株式会社 | 心臓治療装置 |
| US6928326B1 (en) | 2003-03-31 | 2005-08-09 | Pacesetter, Inc. | Diagnosis of fusion or pseudofusion |
| US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
| US7463928B2 (en) * | 2003-04-25 | 2008-12-09 | Medtronic, Inc. | Identifying combinations of electrodes for neurostimulation therapy |
| US7221979B2 (en) | 2003-04-30 | 2007-05-22 | Medtronic, Inc. | Methods and apparatus for the regulation of hormone release |
| JP4213522B2 (ja) | 2003-05-30 | 2009-01-21 | テルモ株式会社 | 心臓治療装置 |
| US7149574B2 (en) | 2003-06-09 | 2006-12-12 | Palo Alto Investors | Treatment of conditions through electrical modulation of the autonomic nervous system |
| WO2004110549A2 (en) | 2003-06-13 | 2004-12-23 | Biocontrol Medical Ltd. | Applications of vagal stimulation |
| US20050055060A1 (en) * | 2003-09-05 | 2005-03-10 | Steve Koh | Determination of respiratory characteristics from AV conduction intervals |
| US20050059897A1 (en) | 2003-09-17 | 2005-03-17 | Snell Jeffery D. | Statistical analysis for implantable cardiac devices |
| US20050065555A1 (en) | 2003-09-24 | 2005-03-24 | Siew Er | Collection and analysis of procedural information |
| US7418292B2 (en) | 2003-10-01 | 2008-08-26 | Medtronic, Inc. | Device and method for attenuating an immune response |
| US20050075702A1 (en) | 2003-10-01 | 2005-04-07 | Medtronic, Inc. | Device and method for inhibiting release of pro-inflammatory mediator |
| US7480532B2 (en) | 2003-10-22 | 2009-01-20 | Cvrx, Inc. | Baroreflex activation for pain control, sedation and sleep |
| US20050131467A1 (en) | 2003-11-02 | 2005-06-16 | Boveja Birinder R. | Method and apparatus for electrical stimulation therapy for at least one of atrial fibrillation, congestive heart failure, inappropriate sinus tachycardia, and refractory hypertension |
| US7657312B2 (en) | 2003-11-03 | 2010-02-02 | Cardiac Pacemakers, Inc. | Multi-site ventricular pacing therapy with parasympathetic stimulation |
| US7783353B2 (en) | 2003-12-24 | 2010-08-24 | Cardiac Pacemakers, Inc. | Automatic neural stimulation modulation based on activity and circadian rhythm |
| WO2005063332A1 (en) | 2003-12-24 | 2005-07-14 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system |
| US8126559B2 (en) | 2004-11-30 | 2012-02-28 | Cardiac Pacemakers, Inc. | Neural stimulation with avoidance of inappropriate stimulation |
| US8024050B2 (en) * | 2003-12-24 | 2011-09-20 | Cardiac Pacemakers, Inc. | Lead for stimulating the baroreceptors in the pulmonary artery |
| US7869881B2 (en) | 2003-12-24 | 2011-01-11 | Cardiac Pacemakers, Inc. | Baroreflex stimulator with integrated pressure sensor |
| ATE439891T1 (de) | 2003-12-24 | 2009-09-15 | Cardiac Pacemakers Inc | Leitung zur stimulierung der barorezeptoren in der pulmonalarterie |
| US20050149133A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Sensing with compensation for neural stimulator |
| US7643875B2 (en) | 2003-12-24 | 2010-01-05 | Cardiac Pacemakers, Inc. | Baroreflex stimulation system to reduce hypertension |
| US7647114B2 (en) * | 2003-12-24 | 2010-01-12 | Cardiac Pacemakers, Inc. | Baroreflex modulation based on monitored cardiovascular parameter |
| US7706884B2 (en) | 2003-12-24 | 2010-04-27 | Cardiac Pacemakers, Inc. | Baroreflex stimulation synchronized to circadian rhythm |
| US7460906B2 (en) | 2003-12-24 | 2008-12-02 | Cardiac Pacemakers, Inc. | Baroreflex stimulation to treat acute myocardial infarction |
| US7509166B2 (en) | 2003-12-24 | 2009-03-24 | Cardiac Pacemakers, Inc. | Automatic baroreflex modulation responsive to adverse event |
| US8396560B2 (en) | 2004-11-18 | 2013-03-12 | Cardiac Pacemakers, Inc. | System and method for closed-loop neural stimulation |
| US7486991B2 (en) | 2003-12-24 | 2009-02-03 | Cardiac Pacemakers, Inc. | Baroreflex modulation to gradually decrease blood pressure |
| US20050149129A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Baropacing and cardiac pacing to control output |
| US9020595B2 (en) | 2003-12-24 | 2015-04-28 | Cardiac Pacemakers, Inc. | Baroreflex activation therapy with conditional shut off |
| US7769450B2 (en) | 2004-11-18 | 2010-08-03 | Cardiac Pacemakers, Inc. | Cardiac rhythm management device with neural sensor |
| US8126560B2 (en) | 2003-12-24 | 2012-02-28 | Cardiac Pacemakers, Inc. | Stimulation lead for stimulating the baroreceptors in the pulmonary artery |
| US20050149132A1 (en) | 2003-12-24 | 2005-07-07 | Imad Libbus | Automatic baroreflex modulation based on cardiac activity |
| US7422555B2 (en) | 2003-12-30 | 2008-09-09 | Jacob Zabara | Systems and methods for therapeutically treating neuro-psychiatric disorders and other illnesses |
| US7260431B2 (en) | 2004-05-20 | 2007-08-21 | Cardiac Pacemakers, Inc. | Combined remodeling control therapy and anti-remodeling therapy by implantable cardiac device |
| US20060074453A1 (en) | 2004-10-04 | 2006-04-06 | Cvrx, Inc. | Baroreflex activation and cardiac resychronization for heart failure treatment |
| US8175705B2 (en) | 2004-10-12 | 2012-05-08 | Cardiac Pacemakers, Inc. | System and method for sustained baroreflex stimulation |
| US9089691B2 (en) | 2004-12-07 | 2015-07-28 | Cardiac Pacemakers, Inc. | Stimulator for auricular branch of vagus nerve |
| US7333854B1 (en) | 2005-01-31 | 2008-02-19 | Pacesetter, Inc. | Orthostatic cardiac output response pacer for heart failure patients and diabetic patients |
| US8406876B2 (en) * | 2005-04-05 | 2013-03-26 | Cardiac Pacemakers, Inc. | Closed loop neural stimulation synchronized to cardiac cycles |
| US7493161B2 (en) | 2005-05-10 | 2009-02-17 | Cardiac Pacemakers, Inc. | System and method to deliver therapy in presence of another therapy |
| US7366568B2 (en) | 2005-05-06 | 2008-04-29 | Cardiac Pacemakers, Inc. | Controlled delivery of intermittent stress augmentation pacing for cardioprotective effect |
| US7617003B2 (en) * | 2005-05-16 | 2009-11-10 | Cardiac Pacemakers, Inc. | System for selective activation of a nerve trunk using a transvascular reshaping lead |
| US7551958B2 (en) * | 2005-05-24 | 2009-06-23 | Cardiac Pacemakers, Inc. | Safety control system for implantable neural stimulator |
| US7380565B2 (en) | 2005-08-12 | 2008-06-03 | Eichler Donald Gary | Spill prevention system with safety valves |
| KR20070034698A (ko) | 2005-09-26 | 2007-03-29 | 한국표준과학연구원 | 초음파를 이용한 진공용기의 압력 측정 시스템 |
| US7616990B2 (en) | 2005-10-24 | 2009-11-10 | Cardiac Pacemakers, Inc. | Implantable and rechargeable neural stimulator |
| US20070191904A1 (en) | 2006-02-14 | 2007-08-16 | Imad Libbus | Expandable stimulation electrode with integrated pressure sensor and methods related thereto |
| US8014866B2 (en) * | 2006-07-13 | 2011-09-06 | Cardiac Pacemakers, Inc. | Variable voltage compliance for current output generator |
| US8224436B2 (en) * | 2007-04-02 | 2012-07-17 | Cardiac Research, Inc. | Unidirectional neural stimulation systems, devices and methods |
-
2004
- 2004-09-13 US US10/939,544 patent/US7647114B2/en not_active Expired - Fee Related
-
2005
- 2005-08-10 JP JP2007531174A patent/JP4926064B2/ja not_active Expired - Fee Related
- 2005-08-10 EP EP05787559.3A patent/EP1807150B1/en not_active Expired - Lifetime
- 2005-08-10 WO PCT/US2005/028393 patent/WO2006031331A1/en not_active Ceased
-
2010
- 2010-01-04 US US12/651,515 patent/US8442640B2/en not_active Expired - Fee Related
-
2011
- 2011-10-28 JP JP2011237712A patent/JP2012020185A/ja not_active Withdrawn
-
2013
- 2013-04-23 US US13/868,287 patent/US8805513B2/en not_active Expired - Fee Related
-
2014
- 2014-07-01 US US14/321,406 patent/US9440078B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6073048A (en) * | 1995-11-17 | 2000-06-06 | Medtronic, Inc. | Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure |
| WO2002026318A1 (en) * | 2000-09-26 | 2002-04-04 | Medtronic, Inc. | Method and system for nerve stimulation and cardiac sensing prior to and during a medical procedure |
| JP2004526471A (ja) * | 2000-09-27 | 2004-09-02 | シーブイアールエックス， インコーポレイテッド | 心血管性反射制御のための装置および方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| US20100106226A1 (en) | 2010-04-29 |
| US20050143779A1 (en) | 2005-06-30 |
| US8442640B2 (en) | 2013-05-14 |
| US20130231717A1 (en) | 2013-09-05 |
| EP1807150B1 (en) | 2017-02-15 |
| WO2006031331A1 (en) | 2006-03-23 |
| EP1807150A1 (en) | 2007-07-18 |
| US9440078B2 (en) | 2016-09-13 |
| US8805513B2 (en) | 2014-08-12 |
| JP2012020185A (ja) | 2012-02-02 |
| US20140316488A1 (en) | 2014-10-23 |
| JP2008512180A (ja) | 2008-04-24 |
| US7647114B2 (en) | 2010-01-12 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4926064B2 (ja) | モニタされた心臓血管パラメータに基づいた圧反射調節 | |
| JP4755111B2 (ja) | 圧反射刺激システム | |
| US9314635B2 (en) | Automatic baroreflex modulation responsive to adverse event | |
| US7643875B2 (en) | Baroreflex stimulation system to reduce hypertension | |
| US8321023B2 (en) | Baroreflex modulation to gradually decrease blood pressure | |
| US8626301B2 (en) | Automatic baroreflex modulation based on cardiac activity | |
| US8805501B2 (en) | Baroreflex stimulation to treat acute myocardial infarction | |
| US8818513B2 (en) | Baroreflex stimulation synchronized to circadian rhythm | |
| US20050149129A1 (en) | Baropacing and cardiac pacing to control output | |
| US20110106216A1 (en) | Baroreflex stimulator with integrated pressure sensor |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080725 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20080725 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090227 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7422 Effective date: 20090227 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20090401 |
|
| RD04 | Notification of resignation of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7424 Effective date: 20090401 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20110428 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20110428 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110725 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110801 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20110826 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20110902 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20111028 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20120111 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20120207 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20150217 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4926064 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D03 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |