JP4880484B2 - 唾液ｍＲＮＡプロファイリング、バイオマーカーならびに関連した方法およびキット - Google Patents

唾液ｍＲＮＡプロファイリング、バイオマーカーならびに関連した方法およびキット Download PDF

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JP4880484B2
JP4880484B2 JP2006554246A JP2006554246A JP4880484B2 JP 4880484 B2 JP4880484 B2 JP 4880484B2 JP 2006554246 A JP2006554246 A JP 2006554246A JP 2006554246 A JP2006554246 A JP 2006554246A JP 4880484 B2 JP4880484 B2 JP 4880484B2
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saliva
mrna
oscc
rna
cancer
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JP2007522819A (ja
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デイビッド ティー． ダブリュ． ウォン
ジョン マイエ エー． アール． エスティー．
ヤン リー
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University of California
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
    • C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
    • G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
    • G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
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  • Biochemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Public Health (AREA)
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JP2006554246A 2004-02-20 2005-02-17 唾液ｍＲＮＡプロファイリング、バイオマーカーならびに関連した方法およびキット Expired - Fee Related JP4880484B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US54650704P 2004-02-20 2004-02-20
US60/546,507 2004-02-20
US54652104P 2004-02-21 2004-02-21
US60/546,521 2004-02-21
PCT/US2005/005263 WO2005081867A2 (en) 2004-02-20 2005-02-17 Salivary mrna profiling, biomarkers, and related methods and kits of parts

Related Child Applications (1)

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JP2011115333A Division JP5367760B2 (ja) 2004-02-20 2011-05-24 唾液ｍＲＮＡプロファイリング、バイオマーカーならびに関連した方法およびキット

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JP2007522819A JP2007522819A (ja) 2007-08-16
JP4880484B2 true JP4880484B2 (ja) 2012-02-22

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JP2011115333A Expired - Fee Related JP5367760B2 (ja) 2004-02-20 2011-05-24 唾液ｍＲＮＡプロファイリング、バイオマーカーならびに関連した方法およびキット

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US (3) US10072297B2 (enExample)
EP (1) EP1730304B1 (enExample)
JP (2) JP4880484B2 (enExample)
KR (2) KR20070004725A (enExample)
CN (1) CN1977051B (enExample)
AU (1) AU2005216095B2 (enExample)
CA (1) CA2558666C (enExample)
IL (1) IL177579A (enExample)
NO (1) NO340089B1 (enExample)
WO (1) WO2005081867A2 (enExample)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20070004725A (ko) * 2004-02-20 2007-01-09 더 리전츠 오브 더 유니버시티 오브 캘리포니아 타액 ｍＲＮＡ 프로파일링, 생물 마커 및 관련 방법 및부품 키트
US7727715B2 (en) 2004-03-30 2010-06-01 Vector Tobacco, Inc. Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof
EP1877574A4 (en) * 2004-07-21 2009-05-06 Univ California SPEICHELTRANSKRIPTOMDIAGNOSE
WO2008001357A2 (en) * 2006-06-26 2008-01-03 Technion Research & Development Foundation Ltd. Methods and kits for diagnosing cancer
WO2008044504A1 (fr) 2006-10-12 2008-04-17 Niigata University Procédé de diagnostic d'un cancer de la langue
JP2008295327A (ja) * 2007-05-30 2008-12-11 Fujifilm Corp 口腔扁平上皮癌の検出方法、及び抑制方法
WO2008157501A1 (en) * 2007-06-15 2008-12-24 The Regents Of The University Of California Salivary exon core transcriptome
JP2010533869A (ja) 2007-07-16 2010-10-28 カリフォルニア インスティチュート オブ テクノロジー 標的分子を検出するためのマイクロ流体装置、方法及びシステム
WO2010011860A1 (en) * 2008-07-23 2010-01-28 Diabetomics, Llc Methods for detecting pre-diabetes and diabetes
WO2010015607A2 (en) 2008-08-04 2010-02-11 Institut Clinident Method of evaluating oral cancer risk in human
US20130143747A1 (en) * 2011-12-05 2013-06-06 Myriad Genetics, Incorporated Methods of detecting cancer
US9075060B2 (en) 2009-06-16 2015-07-07 Technion Research & Development Foundation Limited Methods for diagnosing oral or oral-pharyngeal cancer
US10132811B2 (en) * 2009-06-25 2018-11-20 The Regents Of The University Of California Salivary transcriptomic and microbial biomarkers for pancreatic cancer
EP2475988B1 (en) 2009-09-09 2018-11-14 The General Hospital Corporation Use of microvesicles in analyzing nucleic acid profiles
US20130029339A1 (en) 2009-09-09 2013-01-31 The General Hospital Corporation Use of microvesicles in analyzing kras mutations
JP2011072229A (ja) * 2009-09-29 2011-04-14 Keio Gijuku バイオマーカーとしてのマイクロｒｎａを用いた下咽頭がんの診断・治療選択
US8309299B2 (en) * 2010-05-19 2012-11-13 Hoffmann-La Roche Inc. Combination therapy and method for assessing resistance to treatment
WO2012031008A2 (en) 2010-08-31 2012-03-08 The General Hospital Corporation Cancer-related biological materials in microvesicles
CA2817111C (en) 2010-11-10 2019-03-05 Exosome Diagnostics, Inc. Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom
AU2012314514B2 (en) 2011-09-26 2018-03-15 Qiagen Gmbh Stabilisation and isolation of extracellular nucleic acids
US11021733B2 (en) 2011-09-26 2021-06-01 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
WO2013045458A1 (en) * 2011-09-26 2013-04-04 Preanalytix Gmbh Stabilisation and isolation of extracellular nucleic acids
CN104884605B (zh) 2012-08-24 2018-05-18 耶鲁大学 用于高通量多重检测的系统、装置和方法
JP6608280B2 (ja) 2012-09-25 2019-11-20 キアゲン ゲーエムベーハー 生物学的試料の安定化
US20140188442A1 (en) * 2012-12-27 2014-07-03 Pearson Education, Inc. System and Method for Selecting Predictors for a Student Risk Model
EP2976424B1 (en) 2013-03-18 2018-10-03 Qiagen GmbH Stabilisation of biological samples
US20160281133A1 (en) 2013-03-18 2016-09-29 Qiagen Gmbh Stabilization and isolation of extracellular nucleic acids
WO2014182598A1 (en) * 2013-05-06 2014-11-13 Physicians Choice Laboratory Services, Llc Diagnostic assay combining cellular and cell free nucleic acid
US20160282351A1 (en) * 2013-10-28 2016-09-29 Salivatech Co., Ltd. Salivary biomarkers for cancers, methods and devices for assaying the same, and methods for determining salivary biomarkers for cancers
US20210005324A1 (en) * 2018-08-08 2021-01-07 Hc1.Com Inc. Methods and systems for a health monitoring command center and workforce advisor
US12027243B2 (en) 2017-02-17 2024-07-02 Hc1 Insights, Inc. System and method for determining healthcare relationships
GB201417281D0 (en) * 2014-09-30 2014-11-12 Ge Healthcare Uk Ltd Methods and devices relating to the detection of oral cancer biomarkers
EP3227684B1 (en) 2014-12-03 2019-10-02 Isoplexis Corporation Analysis and screening of cell secretion profiles
WO2016130543A1 (en) * 2015-02-09 2016-08-18 Abogen, Inc. Devices, solutions and methods for sample collection related applications, analysis and diagnosis
US11353448B2 (en) 2015-02-13 2022-06-07 California Institute Of Technology Methods and compositions for quantifying metabolites and proteins from single cells
EA037995B1 (ru) 2015-02-24 2021-06-21 Рупрехт-Карлс-Университет Гейдельберг Панель биомаркеров для обнаружения рака
CN120966978A (zh) 2015-07-01 2025-11-18 杜克大学 诊断和治疗急性呼吸系统感染的方法
CN106446599A (zh) * 2015-08-11 2017-02-22 中国科学院青岛生物能源与过程研究所 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法
JP7166169B2 (ja) 2015-11-20 2022-11-07 キアゲン ゲーエムベーハー 細胞外核酸の滅菌のための滅菌組成物を調製する方法
GB201602210D0 (en) 2016-02-08 2016-03-23 Ucl Business Plc Detection of cancer
US20200166518A1 (en) 2016-09-12 2020-05-28 IsoPlexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
US11493508B2 (en) 2016-11-11 2022-11-08 IsoPlexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
US11525783B2 (en) 2016-11-22 2022-12-13 IsoPlexis Corporation Systems, devices and methods for cell capture and methods of manufacture thereof
WO2018217849A1 (en) * 2017-05-26 2018-11-29 Board Of Regents, The University Of Texas System Targeting of anaplastic lymphoma kinase in squamous cell carcinoma
US11124833B2 (en) * 2017-10-27 2021-09-21 Colgate-Palmolive Company Salivary extracellular RNA biomarkers for gingivitis
US20210018507A1 (en) * 2018-03-04 2021-01-21 Mazumdar Shaw Medical Foundation Sall.ivary protein biomarkers for the diagnosis and prognosis of head and neck cancers, and precancers
EP3671213A1 (en) * 2018-12-20 2020-06-24 Kromat Muszerforgalmazó Kft. In vitro method for the diagnosis of malignant conditions
WO2020128546A1 (en) * 2018-12-20 2020-06-25 Kromat Műszerforgalmazó Kft. A simple, non-invasive method for diagnosing oral cancer
JP2020195314A (ja) * 2019-05-31 2020-12-10 医薬資源研究所株式会社 疾患・体質の分析方法、疾患・体質の分析システム、プログラムおよびコンピュータ読み取り可能な記録媒体
JP7373843B2 (ja) * 2019-12-19 2023-11-06 国立大学法人東海国立大学機構 感染の原因生物を予測するための予測装置、予測プログラム及び予測方法
CN115176158A (zh) 2020-02-27 2022-10-11 伊索普莱克西斯公司 用于多路分析的系统、装置及方法
CN113985033B (zh) * 2021-10-19 2025-02-14 中山大学附属第八医院（深圳福田） 一种用于诊断骨质疏松症发生肌少症的生物标记物及检测试剂盒
WO2026094720A1 (ja) * 2024-10-28 2026-05-07 アークレイ株式会社 性質判定モデルの生成方法、性質判定モデル、性質判定方法、性質判定装置、プログラム及び記録媒体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2002537791A (ja) * 1999-03-03 2002-11-12 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー 卵巣癌において過剰発現される膜貫通型セリンプロテアーゼおよびその使用
WO2003028531A2 (en) * 2001-09-28 2003-04-10 Oncomedx, Inc. Detection of tumor rna in plasma and serum
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6511805B1 (en) * 1996-03-15 2003-01-28 The Penn State Research Foundation Methods for detecting papillomavirus DNA in blood plasma and serum
US20020102553A1 (en) 1997-10-24 2002-08-01 University Of Rochester Molecular markers for the diagnosis of alzheimer's disease
US6294349B1 (en) * 1999-03-01 2001-09-25 University Of Mississippi Medical Ctr. Method of diagnosing and monitoring malignant breast carcinomas
US6617112B2 (en) * 2000-10-11 2003-09-09 Monsanto Technology Llc Methods for gene array analysis of nuclear runoff transcripts
ES2367280T3 (es) 2001-07-25 2011-11-02 Oncomedx Inc. Métodos para evaluar estados patológicos usando arn extracelular.
KR20070004725A (ko) * 2004-02-20 2007-01-09 더 리전츠 오브 더 유니버시티 오브 캘리포니아 타액 ｍＲＮＡ 프로파일링, 생물 마커 및 관련 방법 및부품 키트

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6607898B1 (en) * 1996-03-26 2003-08-19 Oncomedx, Inc. Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum
JP2002537791A (ja) * 1999-03-03 2002-11-12 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティー オブ アーカンソー 卵巣癌において過剰発現される膜貫通型セリンプロテアーゼおよびその使用
WO2003028531A2 (en) * 2001-09-28 2003-04-10 Oncomedx, Inc. Detection of tumor rna in plasma and serum

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IL177579A0 (en) 2006-12-10
JP5367760B2 (ja) 2013-12-11
CA2558666A1 (en) 2005-09-09
JP2007522819A (ja) 2007-08-16
CN1977051B (zh) 2013-07-17
HK1095163A1 (en) 2007-04-27
IL177579A (en) 2012-03-29
KR20070004725A (ko) 2007-01-09
CN1977051A (zh) 2007-06-06
KR20130018438A (ko) 2013-02-22
JP2011229532A (ja) 2011-11-17
WO2005081867A3 (en) 2006-07-06
US20140249236A1 (en) 2014-09-04
US9983210B2 (en) 2018-05-29
EP1730304A4 (en) 2007-10-24
AU2005216095A1 (en) 2005-09-09
NO20064226L (no) 2006-11-16
AU2005216095B2 (en) 2009-09-17
EP1730304B1 (en) 2013-01-02
US10072297B2 (en) 2018-09-11
US20190040471A1 (en) 2019-02-07
NO340089B1 (no) 2017-03-06
WO2005081867A2 (en) 2005-09-09
CA2558666C (en) 2015-11-24
EP1730304A2 (en) 2006-12-13
US20080280772A1 (en) 2008-11-13

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