IL177579A - METHOD FOR DETECTING AN EXTRACELLULAR mRNA IN SALIVA AND METHODS AND KITS BASED THEREON - Google Patents
METHOD FOR DETECTING AN EXTRACELLULAR mRNA IN SALIVA AND METHODS AND KITS BASED THEREON Download PDFInfo
- Publication number
- IL177579A IL177579A IL177579A IL17757906A IL177579A IL 177579 A IL177579 A IL 177579A IL 177579 A IL177579 A IL 177579A IL 17757906 A IL17757906 A IL 17757906A IL 177579 A IL177579 A IL 177579A
- Authority
- IL
- Israel
- Prior art keywords
- saliva
- cell
- mrna
- bodily fluid
- detecting
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6834—Enzymatic or biochemical coupling of nucleic acids to a solid phase
- C12Q1/6837—Enzymatic or biochemical coupling of nucleic acids to a solid phase using probe arrays or probe chips
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5014—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity
- G01N33/5017—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing toxicity for testing neoplastic activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/5758—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites
- G01N33/57585—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumours, cancers or neoplasias, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides or metabolites involving compounds identifiable in body fluids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Analytical Chemistry (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US54650704P | 2004-02-20 | 2004-02-20 | |
| US54652104P | 2004-02-21 | 2004-02-21 | |
| PCT/US2005/005263 WO2005081867A2 (en) | 2004-02-20 | 2005-02-17 | Salivary mrna profiling, biomarkers, and related methods and kits of parts |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL177579A0 IL177579A0 (en) | 2006-12-10 |
| IL177579A true IL177579A (en) | 2012-03-29 |
Family
ID=34915575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL177579A IL177579A (en) | 2004-02-20 | 2006-08-20 | METHOD FOR DETECTING AN EXTRACELLULAR mRNA IN SALIVA AND METHODS AND KITS BASED THEREON |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US10072297B2 (enExample) |
| EP (1) | EP1730304B1 (enExample) |
| JP (2) | JP4880484B2 (enExample) |
| KR (2) | KR20070004725A (enExample) |
| CN (1) | CN1977051B (enExample) |
| AU (1) | AU2005216095B2 (enExample) |
| CA (1) | CA2558666C (enExample) |
| IL (1) | IL177579A (enExample) |
| NO (1) | NO340089B1 (enExample) |
| WO (1) | WO2005081867A2 (enExample) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20070004725A (ko) * | 2004-02-20 | 2007-01-09 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 타액 ｍＲＮＡ 프로파일링, 생물 마커 및 관련 방법 및부품 키트 |
| US7727715B2 (en) | 2004-03-30 | 2010-06-01 | Vector Tobacco, Inc. | Global gene expression analysis of human bronchial epithelial cells exposed to cigarette smoke, smoke condensates, or components thereof |
| EP1877574A4 (en) * | 2004-07-21 | 2009-05-06 | Univ California | SPEICHELTRANSKRIPTOMDIAGNOSE |
| WO2008001357A2 (en) * | 2006-06-26 | 2008-01-03 | Technion Research & Development Foundation Ltd. | Methods and kits for diagnosing cancer |
| WO2008044504A1 (fr) | 2006-10-12 | 2008-04-17 | Niigata University | Procédé de diagnostic d'un cancer de la langue |
| JP2008295327A (ja) * | 2007-05-30 | 2008-12-11 | Fujifilm Corp | 口腔扁平上皮癌の検出方法、及び抑制方法 |
| WO2008157501A1 (en) * | 2007-06-15 | 2008-12-24 | The Regents Of The University Of California | Salivary exon core transcriptome |
| JP2010533869A (ja) | 2007-07-16 | 2010-10-28 | カリフォルニア インスティチュート オブ テクノロジー | 標的分子を検出するためのマイクロ流体装置、方法及びシステム |
| WO2010011860A1 (en) * | 2008-07-23 | 2010-01-28 | Diabetomics, Llc | Methods for detecting pre-diabetes and diabetes |
| WO2010015607A2 (en) | 2008-08-04 | 2010-02-11 | Institut Clinident | Method of evaluating oral cancer risk in human |
| US20130143747A1 (en) * | 2011-12-05 | 2013-06-06 | Myriad Genetics, Incorporated | Methods of detecting cancer |
| US9075060B2 (en) | 2009-06-16 | 2015-07-07 | Technion Research & Development Foundation Limited | Methods for diagnosing oral or oral-pharyngeal cancer |
| US10132811B2 (en) * | 2009-06-25 | 2018-11-20 | The Regents Of The University Of California | Salivary transcriptomic and microbial biomarkers for pancreatic cancer |
| EP2475988B1 (en) | 2009-09-09 | 2018-11-14 | The General Hospital Corporation | Use of microvesicles in analyzing nucleic acid profiles |
| US20130029339A1 (en) | 2009-09-09 | 2013-01-31 | The General Hospital Corporation | Use of microvesicles in analyzing kras mutations |
| JP2011072229A (ja) * | 2009-09-29 | 2011-04-14 | Keio Gijuku | バイオマーカーとしてのマイクロｒｎａを用いた下咽頭がんの診断・治療選択 |
| US8309299B2 (en) * | 2010-05-19 | 2012-11-13 | Hoffmann-La Roche Inc. | Combination therapy and method for assessing resistance to treatment |
| WO2012031008A2 (en) | 2010-08-31 | 2012-03-08 | The General Hospital Corporation | Cancer-related biological materials in microvesicles |
| CA2817111C (en) | 2010-11-10 | 2019-03-05 | Exosome Diagnostics, Inc. | Method for isolation of nucleic acid containing particles and extraction of nucleic acids therefrom |
| AU2012314514B2 (en) | 2011-09-26 | 2018-03-15 | Qiagen Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| US11021733B2 (en) | 2011-09-26 | 2021-06-01 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| WO2013045458A1 (en) * | 2011-09-26 | 2013-04-04 | Preanalytix Gmbh | Stabilisation and isolation of extracellular nucleic acids |
| CN104884605B (zh) | 2012-08-24 | 2018-05-18 | 耶鲁大学 | 用于高通量多重检测的系统、装置和方法 |
| JP6608280B2 (ja) | 2012-09-25 | 2019-11-20 | キアゲン ゲーエムベーハー | 生物学的試料の安定化 |
| US20140188442A1 (en) * | 2012-12-27 | 2014-07-03 | Pearson Education, Inc. | System and Method for Selecting Predictors for a Student Risk Model |
| EP2976424B1 (en) | 2013-03-18 | 2018-10-03 | Qiagen GmbH | Stabilisation of biological samples |
| US20160281133A1 (en) | 2013-03-18 | 2016-09-29 | Qiagen Gmbh | Stabilization and isolation of extracellular nucleic acids |
| WO2014182598A1 (en) * | 2013-05-06 | 2014-11-13 | Physicians Choice Laboratory Services, Llc | Diagnostic assay combining cellular and cell free nucleic acid |
| US20160282351A1 (en) * | 2013-10-28 | 2016-09-29 | Salivatech Co., Ltd. | Salivary biomarkers for cancers, methods and devices for assaying the same, and methods for determining salivary biomarkers for cancers |
| US20210005324A1 (en) * | 2018-08-08 | 2021-01-07 | Hc1.Com Inc. | Methods and systems for a health monitoring command center and workforce advisor |
| US12027243B2 (en) | 2017-02-17 | 2024-07-02 | Hc1 Insights, Inc. | System and method for determining healthcare relationships |
| GB201417281D0 (en) * | 2014-09-30 | 2014-11-12 | Ge Healthcare Uk Ltd | Methods and devices relating to the detection of oral cancer biomarkers |
| EP3227684B1 (en) | 2014-12-03 | 2019-10-02 | Isoplexis Corporation | Analysis and screening of cell secretion profiles |
| WO2016130543A1 (en) * | 2015-02-09 | 2016-08-18 | Abogen, Inc. | Devices, solutions and methods for sample collection related applications, analysis and diagnosis |
| US11353448B2 (en) | 2015-02-13 | 2022-06-07 | California Institute Of Technology | Methods and compositions for quantifying metabolites and proteins from single cells |
| EA037995B1 (ru) | 2015-02-24 | 2021-06-21 | Рупрехт-Карлс-Университет Гейдельберг | Панель биомаркеров для обнаружения рака |
| CN120966978A (zh) | 2015-07-01 | 2025-11-18 | 杜克大学 | 诊断和治疗急性呼吸系统感染的方法 |
| CN106446599A (zh) * | 2015-08-11 | 2017-02-22 | 中国科学院青岛生物能源与过程研究所 | 一种筛选婴幼儿龋病的口腔致病性生物标记物的方法 |
| JP7166169B2 (ja) | 2015-11-20 | 2022-11-07 | キアゲン ゲーエムベーハー | 細胞外核酸の滅菌のための滅菌組成物を調製する方法 |
| GB201602210D0 (en) | 2016-02-08 | 2016-03-23 | Ucl Business Plc | Detection of cancer |
| US20200166518A1 (en) | 2016-09-12 | 2020-05-28 | IsoPlexis Corporation | System and methods for multiplexed analysis of cellular and other immunotherapeutics |
| US11493508B2 (en) | 2016-11-11 | 2022-11-08 | IsoPlexis Corporation | Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells |
| US11525783B2 (en) | 2016-11-22 | 2022-12-13 | IsoPlexis Corporation | Systems, devices and methods for cell capture and methods of manufacture thereof |
| WO2018217849A1 (en) * | 2017-05-26 | 2018-11-29 | Board Of Regents, The University Of Texas System | Targeting of anaplastic lymphoma kinase in squamous cell carcinoma |
| US11124833B2 (en) * | 2017-10-27 | 2021-09-21 | Colgate-Palmolive Company | Salivary extracellular RNA biomarkers for gingivitis |
| US20210018507A1 (en) * | 2018-03-04 | 2021-01-21 | Mazumdar Shaw Medical Foundation | Sall.ivary protein biomarkers for the diagnosis and prognosis of head and neck cancers, and precancers |
| EP3671213A1 (en) * | 2018-12-20 | 2020-06-24 | Kromat Muszerforgalmazó Kft. | In vitro method for the diagnosis of malignant conditions |
| WO2020128546A1 (en) * | 2018-12-20 | 2020-06-25 | Kromat Műszerforgalmazó Kft. | A simple, non-invasive method for diagnosing oral cancer |
| JP2020195314A (ja) * | 2019-05-31 | 2020-12-10 | 医薬資源研究所株式会社 | 疾患・体質の分析方法、疾患・体質の分析システム、プログラムおよびコンピュータ読み取り可能な記録媒体 |
| JP7373843B2 (ja) * | 2019-12-19 | 2023-11-06 | 国立大学法人東海国立大学機構 | 感染の原因生物を予測するための予測装置、予測プログラム及び予測方法 |
| CN115176158A (zh) | 2020-02-27 | 2022-10-11 | 伊索普莱克西斯公司 | 用于多路分析的系统、装置及方法 |
| CN113985033B (zh) * | 2021-10-19 | 2025-02-14 | 中山大学附属第八医院（深圳福田） | 一种用于诊断骨质疏松症发生肌少症的生物标记物及检测试剂盒 |
| WO2026094720A1 (ja) * | 2024-10-28 | 2026-05-07 | アークレイ株式会社 | 性質判定モデルの生成方法、性質判定モデル、性質判定方法、性質判定装置、プログラム及び記録媒体 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6511805B1 (en) * | 1996-03-15 | 2003-01-28 | The Penn State Research Foundation | Methods for detecting papillomavirus DNA in blood plasma and serum |
| US6607898B1 (en) | 1996-03-26 | 2003-08-19 | Oncomedx, Inc. | Method for detection of hTR and hTERT telomerase-associated RNA in plasma or serum |
| US6759217B2 (en) | 1996-03-26 | 2004-07-06 | Oncomedx, Inc. | Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer |
| US20020102553A1 (en) | 1997-10-24 | 2002-08-01 | University Of Rochester | Molecular markers for the diagnosis of alzheimer's disease |
| US6294349B1 (en) * | 1999-03-01 | 2001-09-25 | University Of Mississippi Medical Ctr. | Method of diagnosing and monitoring malignant breast carcinomas |
| US6291663B1 (en) * | 1999-03-03 | 2001-09-18 | Board Of Trustees Of The University Of Arkansas | TADG-12: a novel transmembrane serine protease overexpressed in a ovarian carcinoma |
| US6617112B2 (en) * | 2000-10-11 | 2003-09-09 | Monsanto Technology Llc | Methods for gene array analysis of nuclear runoff transcripts |
| ES2367280T3 (es) | 2001-07-25 | 2011-11-02 | Oncomedx Inc. | Métodos para evaluar estados patológicos usando arn extracelular. |
| KR20070004725A (ko) * | 2004-02-20 | 2007-01-09 | 더 리전츠 오브 더 유니버시티 오브 캘리포니아 | 타액 ｍＲＮＡ 프로파일링, 생물 마커 및 관련 방법 및부품 키트 |
-
2005
- 2005-02-17 KR KR1020067018925A patent/KR20070004725A/ko not_active Ceased
- 2005-02-17 EP EP05723309A patent/EP1730304B1/en not_active Expired - Lifetime
- 2005-02-17 AU AU2005216095A patent/AU2005216095B2/en not_active Ceased
- 2005-02-17 US US10/589,788 patent/US10072297B2/en active Active
- 2005-02-17 JP JP2006554246A patent/JP4880484B2/ja not_active Expired - Fee Related
- 2005-02-17 WO PCT/US2005/005263 patent/WO2005081867A2/en not_active Ceased
- 2005-02-17 CA CA2558666A patent/CA2558666C/en not_active Expired - Fee Related
- 2005-02-17 KR KR1020127034042A patent/KR20130018438A/ko not_active Ceased
- 2005-02-17 CN CN2005800124130A patent/CN1977051B/zh not_active Expired - Fee Related
-
2006
- 2006-08-20 IL IL177579A patent/IL177579A/en active IP Right Grant
- 2006-09-19 NO NO20064226A patent/NO340089B1/no not_active IP Right Cessation
-
2011
- 2011-05-24 JP JP2011115333A patent/JP5367760B2/ja not_active Expired - Fee Related
-
2014
- 2014-02-18 US US14/182,672 patent/US9983210B2/en not_active Expired - Fee Related
-
2018
- 2018-08-08 US US16/057,911 patent/US20190040471A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL177579A0 (en) | 2006-12-10 |
| JP5367760B2 (ja) | 2013-12-11 |
| JP4880484B2 (ja) | 2012-02-22 |
| CA2558666A1 (en) | 2005-09-09 |
| JP2007522819A (ja) | 2007-08-16 |
| CN1977051B (zh) | 2013-07-17 |
| HK1095163A1 (en) | 2007-04-27 |
| KR20070004725A (ko) | 2007-01-09 |
| CN1977051A (zh) | 2007-06-06 |
| KR20130018438A (ko) | 2013-02-22 |
| JP2011229532A (ja) | 2011-11-17 |
| WO2005081867A3 (en) | 2006-07-06 |
| US20140249236A1 (en) | 2014-09-04 |
| US9983210B2 (en) | 2018-05-29 |
| EP1730304A4 (en) | 2007-10-24 |
| AU2005216095A1 (en) | 2005-09-09 |
| NO20064226L (no) | 2006-11-16 |
| AU2005216095B2 (en) | 2009-09-17 |
| EP1730304B1 (en) | 2013-01-02 |
| US10072297B2 (en) | 2018-09-11 |
| US20190040471A1 (en) | 2019-02-07 |
| NO340089B1 (no) | 2017-03-06 |
| WO2005081867A2 (en) | 2005-09-09 |
| CA2558666C (en) | 2015-11-24 |
| EP1730304A2 (en) | 2006-12-13 |
| US20080280772A1 (en) | 2008-11-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed | ||
| KB | Patent renewed | ||
| KB | Patent renewed |