JP4869232B2 - カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 - Google Patents

カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 Download PDF

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JP4869232B2
JP4869232B2 JP2007528007A JP2007528007A JP4869232B2 JP 4869232 B2 JP4869232 B2 JP 4869232B2 JP 2007528007 A JP2007528007 A JP 2007528007A JP 2007528007 A JP2007528007 A JP 2007528007A JP 4869232 B2 JP4869232 B2 JP 4869232B2
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carboxylic acid
acid amide
pyrrole
thieno
alkyl
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JP2008510712A (ja
JP2008510712A5 (enExample
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デイヴィッド・マーク・フィンク
ユーリン・チアーン
ニコーラ・ドーン・カラー
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アベンティス・ファーマスーティカルズ・インコーポレイテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2007528007A 2004-08-19 2005-08-18 カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 Expired - Fee Related JP4869232B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60334704P 2004-08-19 2004-08-19
US60/603,347 2004-08-19
PCT/US2005/029383 WO2006021000A2 (en) 2004-08-19 2005-08-18 Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i epsilon

Publications (3)

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JP2008510712A JP2008510712A (ja) 2008-04-10
JP2008510712A5 JP2008510712A5 (enExample) 2008-10-02
JP4869232B2 true JP4869232B2 (ja) 2012-02-08

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JP2007528007A Expired - Fee Related JP4869232B2 (ja) 2004-08-19 2005-08-18 カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物

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US (2) US7393867B2 (enExample)
EP (1) EP1784409B1 (enExample)
JP (1) JP4869232B2 (enExample)
KR (1) KR20070045263A (enExample)
CN (1) CN100562521C (enExample)
AR (1) AR051008A1 (enExample)
AT (1) ATE471326T1 (enExample)
AU (1) AU2005272584B2 (enExample)
BR (1) BRPI0514419A (enExample)
CA (1) CA2577879C (enExample)
CY (1) CY1110775T1 (enExample)
DE (1) DE602005021889D1 (enExample)
DK (1) DK1784409T3 (enExample)
ES (1) ES2347166T3 (enExample)
GT (1) GT200500215A (enExample)
HR (1) HRP20100475T1 (enExample)
IL (1) IL181158A0 (enExample)
JO (1) JO2629B1 (enExample)
MY (1) MY139831A (enExample)
PA (1) PA8642801A1 (enExample)
PE (1) PE20060630A1 (enExample)
PL (1) PL1784409T3 (enExample)
PT (1) PT1784409E (enExample)
RS (1) RS51413B (enExample)
RU (1) RU2403257C2 (enExample)
SI (1) SI1784409T1 (enExample)
SV (1) SV2006002190A (enExample)
TW (1) TWI372149B (enExample)
UY (1) UY29077A1 (enExample)
WO (1) WO2006021000A2 (enExample)

Families Citing this family (14)

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Publication number Priority date Publication date Assignee Title
NZ548212A (en) 2003-12-29 2010-07-30 Sepracor Inc Pyrrole and pyrazole DAAO inhibitors
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
KR101294014B1 (ko) 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
DK2816024T3 (en) 2006-03-31 2017-10-30 Sunovion Pharmaceuticals Inc CHIRALE AMINER
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP1955699A1 (en) * 2007-02-08 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Use of flibanserin for the treatment of insomnia
MX2009012685A (es) 2007-05-31 2009-12-14 Sepracor Inc Cicloalquilaminas sustituidas con fenilo como inhibidores de la reabsorcion de monoamina.
JP4748823B2 (ja) * 2009-02-12 2011-08-17 株式会社ファルマデザイン カゼインキナーゼ１δ及びカゼインキナーゼ１ε阻害剤
UA106082C2 (uk) * 2009-05-28 2014-07-25 Вертекс Фармасьютікалз Інкорпорейтед АМІНОПІРАЗОЛ ТРИАЗОЛОТІАДІАЗОЛЬНІ ІНГІБІТОРИ ПРОТЕЇНКІНАЗИ c-МЕТ
MX2012004997A (es) * 2009-10-28 2012-06-12 Pfizer Derivados de imidazol como inhibidores de la caseina quinasa.
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
CN104803997A (zh) * 2010-08-09 2015-07-29 株式会社创药分子设计 酪蛋白激酶1δ及酪蛋白激酶1ε抑制剂
CN109748927A (zh) * 2017-11-03 2019-05-14 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
KR100722176B1 (ko) * 1999-06-08 2007-05-29 아벤티스 파마슈티칼스 인크. 일주기 리듬 단백질을 변화시키기 위한 스크리닝 방법
CN100439367C (zh) * 2003-12-11 2008-12-03 安万特药物公司 作为酪蛋白激酶Iε抑制剂的取代的1H-吡咯并[3,2-b、3,2-c和2,3-c]吡啶-2-甲酰胺以及相关类似物

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Publication number Publication date
HK1105198A1 (en) 2008-02-06
PE20060630A1 (es) 2006-08-03
CN100562521C (zh) 2009-11-25
BRPI0514419A (pt) 2008-06-10
AR051008A1 (es) 2006-12-13
US7393867B2 (en) 2008-07-01
RS51413B (sr) 2011-02-28
PA8642801A1 (es) 2006-05-16
JP2008510712A (ja) 2008-04-10
ES2347166T3 (es) 2010-10-26
DE602005021889D1 (en) 2010-07-29
JO2629B1 (en) 2012-06-24
RU2007109812A (ru) 2008-09-27
CY1110775T1 (el) 2015-06-10
WO2006021000A2 (en) 2006-02-23
US20070299112A1 (en) 2007-12-27
HRP20100475T1 (hr) 2010-10-31
AU2005272584A1 (en) 2006-02-23
GT200500215A (es) 2006-03-27
US7652046B2 (en) 2010-01-26
CN101001861A (zh) 2007-07-18
TWI372149B (en) 2012-09-11
MY139831A (en) 2009-10-30
AU2005272584B2 (en) 2010-11-11
US20080227822A1 (en) 2008-09-18
PT1784409E (pt) 2010-09-06
ATE471326T1 (de) 2010-07-15
UY29077A1 (es) 2006-03-31
TW200621788A (en) 2006-07-01
SV2006002190A (es) 2006-05-24
KR20070045263A (ko) 2007-05-02
CA2577879C (en) 2011-07-12
SI1784409T1 (sl) 2010-10-29
WO2006021000A3 (en) 2006-06-15
IL181158A0 (en) 2007-07-04
RU2403257C2 (ru) 2010-11-10
EP1784409A2 (en) 2007-05-16
CA2577879A1 (en) 2006-02-23
PL1784409T3 (pl) 2010-10-29
DK1784409T3 (da) 2010-09-27
EP1784409B1 (en) 2010-06-16

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