JP4869232B2 - カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 - Google Patents

カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 Download PDF

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JP4869232B2
JP4869232B2 JP2007528007A JP2007528007A JP4869232B2 JP 4869232 B2 JP4869232 B2 JP 4869232B2 JP 2007528007 A JP2007528007 A JP 2007528007A JP 2007528007 A JP2007528007 A JP 2007528007A JP 4869232 B2 JP4869232 B2 JP 4869232B2
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carboxylic acid
acid amide
pyrrole
thieno
alkyl
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JP2008510712A (ja
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デイヴィッド・マーク・フィンク
ユーリン・チアーン
ニコーラ・ドーン・カラー
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アベンティス・ファーマスーティカルズ・インコーポレイテツド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
JP2007528007A 2004-08-19 2005-08-18 カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物 Expired - Fee Related JP4869232B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60334704P 2004-08-19 2004-08-19
US60/603,347 2004-08-19
PCT/US2005/029383 WO2006021000A2 (en) 2004-08-19 2005-08-18 Substituted thienopyrrole carboxylic acid amides, pyrrolothiazole carboxylic acid amides, and related analogs as inhibitors of casein kinase i epsilon

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JP2008510712A JP2008510712A (ja) 2008-04-10
JP2008510712A5 JP2008510712A5 (enExample) 2008-10-02
JP4869232B2 true JP4869232B2 (ja) 2012-02-08

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JP2007528007A Expired - Fee Related JP4869232B2 (ja) 2004-08-19 2005-08-18 カゼイン・キナーゼＩε阻害剤としての、置換チエノピロールカルボン酸アミド、ピロロチアゾールカルボン酸アミド及び関連する類似化合物

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US (2) US7393867B2 (enExample)
EP (1) EP1784409B1 (enExample)
JP (1) JP4869232B2 (enExample)
KR (1) KR20070045263A (enExample)
CN (1) CN100562521C (enExample)
AR (1) AR051008A1 (enExample)
AT (1) ATE471326T1 (enExample)
AU (1) AU2005272584B2 (enExample)
BR (1) BRPI0514419A (enExample)
CA (1) CA2577879C (enExample)
CY (1) CY1110775T1 (enExample)
DE (1) DE602005021889D1 (enExample)
DK (1) DK1784409T3 (enExample)
ES (1) ES2347166T3 (enExample)
GT (1) GT200500215A (enExample)
HR (1) HRP20100475T1 (enExample)
IL (1) IL181158A0 (enExample)
JO (1) JO2629B1 (enExample)
MY (1) MY139831A (enExample)
PA (1) PA8642801A1 (enExample)
PE (1) PE20060630A1 (enExample)
PL (1) PL1784409T3 (enExample)
PT (1) PT1784409E (enExample)
RS (1) RS51413B (enExample)
RU (1) RU2403257C2 (enExample)
SI (1) SI1784409T1 (enExample)
SV (1) SV2006002190A (enExample)
TW (1) TWI372149B (enExample)
UY (1) UY29077A1 (enExample)
WO (1) WO2006021000A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2004312530A1 (en) 2003-12-29 2005-07-21 Sepracor Inc. Pyrrole and pyrazole DAAO inhibitors
US8053603B2 (en) 2006-01-06 2011-11-08 Sunovion Pharmaceuticals Inc. Tetralone-based monoamine reuptake inhibitors
CA2636324C (en) 2006-01-06 2012-03-20 Sepracor Inc. Cycloalkylamines as monoamine reuptake inhibitors
AU2007233041B2 (en) 2006-03-31 2013-05-02 Sepracor Inc. Preparation of chiral amides and amines
US7884124B2 (en) 2006-06-30 2011-02-08 Sepracor Inc. Fluoro-substituted inhibitors of D-amino acid oxidase
US7902252B2 (en) 2007-01-18 2011-03-08 Sepracor, Inc. Inhibitors of D-amino acid oxidase
EP1955699A1 (en) * 2007-02-08 2008-08-13 Boehringer Ingelheim Pharma GmbH & Co. KG Use of flibanserin for the treatment of insomnia
JP5420534B2 (ja) 2007-05-31 2014-02-19 サノビオン ファーマシューティカルズ インク モノアミン再取り込み阻害薬としてのフェニル置換シクロアルキルアミン
EP2397481B1 (en) * 2009-02-12 2014-03-12 Pharmadesign, Inc. Inhibitor of casein kinase 1delta and casein kinase 1epsilon
EP2435443B1 (en) * 2009-05-28 2013-07-31 Vertex Pharmaceuticals Incorporated Aminopyrazole triazolothiadiazole inhibitors of c-met protien kinase
HRP20140252T1 (hr) * 2009-10-28 2014-04-25 Pfizer Inc. Derivati imidazola kao inhibitori kazeinske kinaze
DE102009058280A1 (de) * 2009-12-14 2011-06-16 Merck Patent Gmbh Thiazolderivate
RU2562833C2 (ru) 2010-08-09 2015-09-10 НБ Хелс Лаборатори Ко. Лтд. Ингибитор казеинкиназы 1 дельта и казеинкиназы 1 е
CN109748927A (zh) * 2017-11-03 2019-05-14 上海交通大学医学院附属瑞金医院 杂芳基酰胺类化合物、其制备方法、药用组合物及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9702001D0 (sv) * 1997-05-28 1997-05-28 Astra Pharma Prod Novel compounds
WO2000075669A1 (en) * 1999-06-08 2000-12-14 Aventis Pharmaceuticals Inc. Screening methods for altering circadian rhythm proteins
AU2004303826A1 (en) * 2003-12-11 2005-07-07 Aventis Pharmaceuticals Inc. Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase I Epsilon

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Publication number Publication date
CY1110775T1 (el) 2015-06-10
TW200621788A (en) 2006-07-01
GT200500215A (es) 2006-03-27
DK1784409T3 (da) 2010-09-27
PE20060630A1 (es) 2006-08-03
HK1105198A1 (en) 2008-02-06
JP2008510712A (ja) 2008-04-10
EP1784409B1 (en) 2010-06-16
EP1784409A2 (en) 2007-05-16
CA2577879A1 (en) 2006-02-23
AU2005272584B2 (en) 2010-11-11
BRPI0514419A (pt) 2008-06-10
TWI372149B (en) 2012-09-11
PA8642801A1 (es) 2006-05-16
KR20070045263A (ko) 2007-05-02
US20070299112A1 (en) 2007-12-27
HRP20100475T1 (hr) 2010-10-31
JO2629B1 (en) 2012-06-24
PL1784409T3 (pl) 2010-10-29
US7393867B2 (en) 2008-07-01
SI1784409T1 (sl) 2010-10-29
ATE471326T1 (de) 2010-07-15
RU2403257C2 (ru) 2010-11-10
AU2005272584A1 (en) 2006-02-23
CN101001861A (zh) 2007-07-18
RU2007109812A (ru) 2008-09-27
SV2006002190A (es) 2006-05-24
IL181158A0 (en) 2007-07-04
US7652046B2 (en) 2010-01-26
CA2577879C (en) 2011-07-12
CN100562521C (zh) 2009-11-25
WO2006021000A3 (en) 2006-06-15
RS51413B (sr) 2011-02-28
MY139831A (en) 2009-10-30
DE602005021889D1 (en) 2010-07-29
WO2006021000A2 (en) 2006-02-23
PT1784409E (pt) 2010-09-06
US20080227822A1 (en) 2008-09-18
AR051008A1 (es) 2006-12-13
ES2347166T3 (es) 2010-10-26
UY29077A1 (es) 2006-03-31

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