JP4861340B2 - カンプトセシンサブユニットの新規の合成法 - Google Patents
カンプトセシンサブユニットの新規の合成法 Download PDFInfo
- Publication number
- JP4861340B2 JP4861340B2 JP2007555511A JP2007555511A JP4861340B2 JP 4861340 B2 JP4861340 B2 JP 4861340B2 JP 2007555511 A JP2007555511 A JP 2007555511A JP 2007555511 A JP2007555511 A JP 2007555511A JP 4861340 B2 JP4861340 B2 JP 4861340B2
- Authority
- JP
- Japan
- Prior art keywords
- formula
- compound
- reaction
- alkyl
- converted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 0 CC1C(*(C23CCC2)C3=C)[C@@]2C1C(C1)C1CC2 Chemical compound CC1C(*(C23CCC2)C3=C)[C@@]2C1C(C1)C1CC2 0.000 description 15
- WTQIZFCJMGWUGZ-BPLDGKMQSA-N C[C@H](CC[C@H]1C(C)(C)c2ccccc2)C[C@H]1O Chemical compound C[C@H](CC[C@H]1C(C)(C)c2ccccc2)C[C@H]1O WTQIZFCJMGWUGZ-BPLDGKMQSA-N 0.000 description 2
- KEJGAYKWRDILTF-WYCDGMCDSA-N CC(C)(OC1)O[C@@H]1[C@@H]1O[C@H]2OC(C)(C)O[C@H]2[C@H]1O Chemical compound CC(C)(OC1)O[C@@H]1[C@@H]1O[C@H]2OC(C)(C)O[C@H]2[C@H]1O KEJGAYKWRDILTF-WYCDGMCDSA-N 0.000 description 1
- KEJGAYKWRDILTF-VVULQXIFSA-N CC(C)(OC1)O[C@H]1[C@H]1O[C@@H]2OC(C)(C)O[C@@H]2[C@@H]1O Chemical compound CC(C)(OC1)O[C@H]1[C@H]1O[C@@H]2OC(C)(C)O[C@@H]2[C@@H]1O KEJGAYKWRDILTF-VVULQXIFSA-N 0.000 description 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N CC(C)[C@H](CC[C@@H](C)C1)[C@@H]1O Chemical compound CC(C)[C@H](CC[C@@H](C)C1)[C@@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- DAJHQXANOCVDMM-LHAVAQOQSA-N CCC/C=C/N(C=N1)c2c(CN(C3=CC([C@@]4(CC)O)=C5COC4=O)C5=O)c3nc3c2c1ccc3 Chemical compound CCC/C=C/N(C=N1)c2c(CN(C3=CC([C@@]4(CC)O)=C5COC4=O)C5=O)c3nc3c2c1ccc3 DAJHQXANOCVDMM-LHAVAQOQSA-N 0.000 description 1
- NPAAFPODGAKMTC-SANMLTNESA-N CCCCCN(C=N1)c2c(CN(C3=CC([C@]4(CC)O)=C5COC4=O)C5=O)c3nc3c2c1ccc3 Chemical compound CCCCCN(C=N1)c2c(CN(C3=CC([C@]4(CC)O)=C5COC4=O)C5=O)c3nc3c2c1ccc3 NPAAFPODGAKMTC-SANMLTNESA-N 0.000 description 1
- XBVLMZYIQGVMKW-CIUDSAMLSA-N CC[C@@H](CC[C@H](C)C1)[C@H]1O Chemical compound CC[C@@H](CC[C@H](C)C1)[C@H]1O XBVLMZYIQGVMKW-CIUDSAMLSA-N 0.000 description 1
- VSJKWCGYPAHWDS-HXUWFJFHSA-N CC[C@@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)O Chemical compound CC[C@@](C(C=C1N2Cc3cc(cccc4)c4nc13)=C(CO1)C2=O)(C1=O)O VSJKWCGYPAHWDS-HXUWFJFHSA-N 0.000 description 1
- BUXBOOPDBDMDFZ-SNVBAGLBSA-N CC[C@@](C(C=CN1)=C(CO2)C1=O)(C2=O)O Chemical compound CC[C@@](C(C=CN1)=C(CO2)C1=O)(C2=O)O BUXBOOPDBDMDFZ-SNVBAGLBSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05101338 | 2005-02-22 | ||
| EP05101338.1 | 2005-02-22 | ||
| PCT/EP2006/001306 WO2006089657A1 (en) | 2005-02-22 | 2006-02-14 | New synthesis of a camptothecin subunit |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531487A JP2008531487A (ja) | 2008-08-14 |
| JP2008531487A5 JP2008531487A5 (https=) | 2011-03-17 |
| JP4861340B2 true JP4861340B2 (ja) | 2012-01-25 |
Family
ID=36177738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555511A Expired - Fee Related JP4861340B2 (ja) | 2005-02-22 | 2006-02-14 | カンプトセシンサブユニットの新規の合成法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7423152B2 (https=) |
| EP (1) | EP1856124B1 (https=) |
| JP (1) | JP4861340B2 (https=) |
| KR (1) | KR100916175B1 (https=) |
| CN (1) | CN101128467B (https=) |
| AT (1) | ATE531719T1 (https=) |
| CA (1) | CA2597388A1 (https=) |
| IL (1) | IL185015A (https=) |
| MX (1) | MX2007010033A (https=) |
| TW (1) | TWI314932B (https=) |
| WO (1) | WO2006089657A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7632540B2 (en) * | 2003-07-01 | 2009-12-15 | Transitions Optical, Inc. | Alignment facilities for optical dyes |
| EP2351780B1 (en) * | 2008-07-31 | 2018-10-10 | The Lubrizol Corporation | Novel copolymers and lubricating compositions thereof |
| CN101544651B (zh) * | 2009-04-24 | 2011-11-02 | 华东师范大学 | 多取代吡啶酮化合物的合成方法 |
| CN101591342B (zh) * | 2009-07-03 | 2011-07-27 | 华东师范大学 | 用于喜树碱类化合物制备的关键中间体合成方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162532A (en) * | 1990-12-20 | 1992-11-10 | North Carolina State University | Intermediates and method of making camptothecin and camptothecin analogs |
| US5491237A (en) * | 1994-05-03 | 1996-02-13 | Glaxo Wellcome Inc. | Intermediates in pharmaceutical camptothecin preparation |
-
2006
- 2006-02-14 CA CA002597388A patent/CA2597388A1/en not_active Abandoned
- 2006-02-14 WO PCT/EP2006/001306 patent/WO2006089657A1/en not_active Ceased
- 2006-02-14 KR KR1020077019083A patent/KR100916175B1/ko not_active Expired - Fee Related
- 2006-02-14 AT AT06706913T patent/ATE531719T1/de active
- 2006-02-14 MX MX2007010033A patent/MX2007010033A/es active IP Right Grant
- 2006-02-14 JP JP2007555511A patent/JP4861340B2/ja not_active Expired - Fee Related
- 2006-02-14 EP EP06706913A patent/EP1856124B1/en not_active Expired - Lifetime
- 2006-02-14 CN CN2006800056195A patent/CN101128467B/zh not_active Expired - Fee Related
- 2006-02-17 US US11/357,273 patent/US7423152B2/en not_active Expired - Fee Related
- 2006-02-20 TW TW095105638A patent/TWI314932B/zh not_active IP Right Cessation
-
2007
- 2007-08-02 IL IL185015A patent/IL185015A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| TWI314932B (en) | 2009-09-21 |
| US7423152B2 (en) | 2008-09-09 |
| US20060189807A1 (en) | 2006-08-24 |
| EP1856124B1 (en) | 2011-11-02 |
| KR100916175B1 (ko) | 2009-09-08 |
| IL185015A0 (en) | 2007-12-03 |
| CN101128467B (zh) | 2010-12-22 |
| JP2008531487A (ja) | 2008-08-14 |
| ATE531719T1 (de) | 2011-11-15 |
| MX2007010033A (es) | 2007-10-04 |
| IL185015A (en) | 2012-07-31 |
| TW200640935A (en) | 2006-12-01 |
| WO2006089657A1 (en) | 2006-08-31 |
| CA2597388A1 (en) | 2006-08-31 |
| EP1856124A1 (en) | 2007-11-21 |
| KR20070104424A (ko) | 2007-10-25 |
| CN101128467A (zh) | 2008-02-20 |
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