JP4846665B2 - ピラゾロ［１，５−ａ］ピリミジン化合物 - Google Patents

ピラゾロ［１，５−ａ］ピリミジン化合物 Download PDF

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Publication number
JP4846665B2
JP4846665B2 JP2007175769A JP2007175769A JP4846665B2 JP 4846665 B2 JP4846665 B2 JP 4846665B2 JP 2007175769 A JP2007175769 A JP 2007175769A JP 2007175769 A JP2007175769 A JP 2007175769A JP 4846665 B2 JP4846665 B2 JP 4846665B2
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Japan
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group
chlorophenyl
carbamoyl
pyrimidine
alkyl
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JP2007175769A
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Japanese (ja)
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JP2008285464A (ja
JP2008285464A5 (https=
Inventor
晃一 谷本
真利子 大井
康範 坪井
恭典 盛谷
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Tanabe Pharma Corp
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Mitsubishi Tanabe Pharma Corp
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Priority to JP2007175769A priority Critical patent/JP4846665B2/ja
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007175769A 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物 Expired - Fee Related JP4846665B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2006185036 2006-07-05
JP2006185036 2006-07-05
JP2007009706 2007-01-19
JP2007009706 2007-01-19
JP2007059332 2007-03-09
JP2007059332 2007-03-09
JP2007111340 2007-04-20
JP2007111340 2007-04-20
JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Publications (3)

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JP2008285464A JP2008285464A (ja) 2008-11-27
JP2008285464A5 JP2008285464A5 (https=) 2009-04-09
JP4846665B2 true JP4846665B2 (ja) 2011-12-28

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JP2007175769A Expired - Fee Related JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

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JP (1) JP4846665B2 (https=)
TW (2) TW201345908A (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR059035A1 (es) * 2006-01-16 2008-03-12 Syngenta Participations Ag Insecticidas derivados de antranilamida
PT2350075E (pt) 2008-09-22 2014-06-09 Array Biopharma Inc Compostos imidazo[1,2b]piridazina substituídos como inibidores da trk cinase
AR074052A1 (es) 2008-10-22 2010-12-22 Array Biopharma Inc Compuestos pirazolo{1,5-a}pirimidina sustituida como inhibidores de trk cinasa
CN102271515B (zh) * 2008-10-31 2014-07-02 健泰科生物技术公司 吡唑并嘧啶jak抑制剂化合物和方法
AR077468A1 (es) * 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
NZ604708A (en) 2010-05-20 2015-05-29 Array Biopharma Inc Macrocyclic compounds as trk kinase inhibitors
JP5859544B2 (ja) * 2010-08-31 2016-02-10 株式会社アモーレパシフィックＡｍｏｒｅｐａｃｉｆｉｃ Ｃｏｒｐｏｒａｔｉｏｎ カンナビノイド１受容体阻害剤としての新規化合物
US8796305B2 (en) * 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
HUE061448T2 (hu) 2014-11-16 2023-07-28 Array Biopharma Inc (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-il)-pirazolo[1,5-A]pirimidin-3-il) -3-hidroxipirrolidin-1-karboxamid-hidrogénszulfát kristályos formája
EP4585268A3 (en) * 2015-09-14 2025-10-15 Twelve Therapeutics, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
CN108697708A (zh) 2015-10-26 2018-10-23 洛克索肿瘤学股份有限公司 Trk抑制剂抗性癌症中的点突变以及与此相关的方法
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
ES2987474T3 (es) 2016-04-04 2024-11-15 Loxo Oncology Inc Formulaciones líquidas de (S)-N-(5-((R)-2-(2,5-difluorofenil)-pirrolidin-1-IL)-pirazolo[1,5-A]pirimidin-3-IL)-3-hidroxipirrolidina-1-carboxamida
ES2836222T3 (es) 2016-05-18 2021-06-24 Loxo Oncology Inc Preparación de (S)-N-(5-((R)-2-(2,5-difluorofenil)pirrolidin-1-il)pirazolo[1,5-a]pirimidin-3-il)-3-hidroxipirrolidina-1-carboxamida
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7196111B2 (en) * 2002-06-04 2007-03-27 Schering Corporation Pyrazolo[1,5a]pyrimidine compounds as antiviral agents
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
DE102004008807A1 (de) * 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
WO2005103052A1 (en) * 2004-04-21 2005-11-03 Pfizer Products Inc. Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
AU2006305104B2 (en) * 2005-10-21 2009-10-22 Mitsubishi Tanabe Pharma Corporation Pyrazolo[1,5-a]pyrimidine compounds as cannabinoid receptor antagonists
JP4847275B2 (ja) * 2005-10-21 2011-12-28 田辺三菱製薬株式会社 ピラゾロ［１，５−ａ］ピリミジン化合物

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Publication number Publication date
JP2008285464A (ja) 2008-11-27
TW201345908A (zh) 2013-11-16
TWI419889B (zh) 2013-12-21
TW200811177A (en) 2008-03-01

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