JP4846665B2 - ピラゾロ［１，５−ａ］ピリミジン化合物 - Google Patents

ピラゾロ［１，５−ａ］ピリミジン化合物 Download PDF

Info

Publication number
JP4846665B2
JP4846665B2 JP2007175769A JP2007175769A JP4846665B2 JP 4846665 B2 JP4846665 B2 JP 4846665B2 JP 2007175769 A JP2007175769 A JP 2007175769A JP 2007175769 A JP2007175769 A JP 2007175769A JP 4846665 B2 JP4846665 B2 JP 4846665B2
Authority
JP
Japan
Prior art keywords
group
chlorophenyl
carbamoyl
pyrimidine
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2007175769A
Other languages
English (en)
Japanese (ja)
Other versions
JP2008285464A (ja
JP2008285464A5 (https=
Inventor
晃一 谷本
真利子 大井
康範 坪井
恭典 盛谷
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Tanabe Pharma Corp
Original Assignee
Mitsubishi Tanabe Pharma Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Tanabe Pharma Corp filed Critical Mitsubishi Tanabe Pharma Corp
Priority to JP2007175769A priority Critical patent/JP4846665B2/ja
Publication of JP2008285464A publication Critical patent/JP2008285464A/ja
Publication of JP2008285464A5 publication Critical patent/JP2008285464A5/ja
Application granted granted Critical
Publication of JP4846665B2 publication Critical patent/JP4846665B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Landscapes

  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2007175769A 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物 Expired - Fee Related JP4846665B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
JP2006185036 2006-07-05
JP2006185036 2006-07-05
JP2007009706 2007-01-19
JP2007009706 2007-01-19
JP2007059332 2007-03-09
JP2007059332 2007-03-09
JP2007111340 2007-04-20
JP2007111340 2007-04-20
JP2007175769A JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Publications (3)

Publication Number Publication Date
JP2008285464A JP2008285464A (ja) 2008-11-27
JP2008285464A5 JP2008285464A5 (https=) 2009-04-09
JP4846665B2 true JP4846665B2 (ja) 2011-12-28

Family

ID=40145540

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2007175769A Expired - Fee Related JP4846665B2 (ja) 2006-07-05 2007-07-04 ピラゾロ［１，５−ａ］ピリミジン化合物

Country Status (2)

Country Link
JP (1) JP4846665B2 (https=)
TW (2) TWI419889B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY30090A1 (es) * 2006-01-16 2007-08-31 Syngenta Participations Ag Insecticidas novedosos
WO2010033941A1 (en) 2008-09-22 2010-03-25 Array Biopharma Inc. Substituted imidazo[1,2b]pyridazine compounds as trk kinase inhibitors
MY169791A (en) 2008-10-22 2019-05-15 Array Biopharma Inc Substituted pyrazolo [1,5-a] pyrimidine compounds as trk kinase inhibitors
EP2348860B1 (en) * 2008-10-31 2015-05-27 Genentech, Inc. Pyrazolopyrimidine jak inhibitor compounds and methods
AR077468A1 (es) 2009-07-09 2011-08-31 Array Biopharma Inc Compuestos de pirazolo (1,5 -a) pirimidina sustituidos como inhibidores de trk- quinasa
ME03376B (me) 2010-05-20 2020-01-20 Array Biopharma Inc Makrociklička jedinjenja kао inhibiтori trk kinaze
WO2012030170A2 (ko) * 2010-08-31 2012-03-08 (주)아모레퍼시픽 카나비노이드 1 수용체 저해제로 작용하는 신규 화합물
US8796305B2 (en) * 2012-11-05 2014-08-05 Bayer Pharma Aktiengesellschaft Carboxy-substituted imidazo[1,2-a]pyridinecarboxamides and their use
CN113354649B (zh) 2014-11-16 2024-12-10 阵列生物制药公司 一种新的晶型
WO2017048702A1 (en) * 2015-09-14 2017-03-23 Infinity Pharmaceuticals, Inc. Solid forms of isoquinolinone derivatives, process of making, compositions comprising, and methods of using the same
EP3156405A1 (en) 2015-10-13 2017-04-19 Boehringer Ingelheim International GmbH Spirocyclic ether derivatives of pyrazolo[1,5-a]pyrimidine-3-carboxamide
EP3368039A1 (en) 2015-10-26 2018-09-05 The Regents of The University of Colorado, A Body Corporate Point mutations in trk inhibitor-resistant cancer and methods relating to the same
US10045991B2 (en) 2016-04-04 2018-08-14 Loxo Oncology, Inc. Methods of treating pediatric cancers
FI3439662T3 (fi) 2016-04-04 2024-09-04 Loxo Oncology Inc (s)-n-(5-((r)-2-(2,5-difluorifenyyli)pyrrolidin-1-yyli)pyratsolo[1,5-a]pyrimidin-3-yyli)-3-hydroksipyrrolidiini-1-karboksamidin nesteformulaatioita
EP3458456B1 (en) 2016-05-18 2020-11-25 Loxo Oncology Inc. Preparation of (s)-n-(5-((r)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide
JOP20190092A1 (ar) 2016-10-26 2019-04-25 Array Biopharma Inc عملية لتحضير مركبات بيرازولو[1، 5-a]بيريميدين وأملاح منها
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003240488A1 (en) * 2002-06-04 2003-12-19 Neogenesis Pharmaceuticals, Inc. Pyrazolo` 1,5a! pyrimidine compounds as antiviral agents
US7329658B2 (en) * 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
US7176210B2 (en) * 2003-02-10 2007-02-13 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
DE102004008807A1 (de) * 2004-02-20 2005-09-08 Bayer Cropscience Ag Pyrazolopyrimidine
WO2005103052A1 (en) * 2004-04-21 2005-11-03 Pfizer Products Inc. Pyrazolo [1,5-a] pyrimidin-7-one compounds and uses thereof
JP4847275B2 (ja) * 2005-10-21 2011-12-28 田辺三菱製薬株式会社 ピラゾロ［１，５−ａ］ピリミジン化合物
AR056876A1 (es) * 2005-10-21 2007-10-31 Tanabe Seiyaku Co Compuestos de pirazolo[1-5-a]pirimidina, antagonistas de receptores canabinoides cb1, composiciones farmaceuticas que los contienen y usos en el tratamiento de enfermedades del sistema nervioso central, tales como trastornos psicoticos, neurologicos y similares

Also Published As

Publication number Publication date
TWI419889B (zh) 2013-12-21
TW201345908A (zh) 2013-11-16
JP2008285464A (ja) 2008-11-27
TW200811177A (en) 2008-03-01

Similar Documents

Publication Publication Date Title
JP4846665B2 (ja) ピラゾロ［１，５−ａ］ピリミジン化合物
ES2441017T3 (es) Compuesto de pirazolo[1,5-A]pirimidina como antagonista del receptor CB1
KR101071438B1 (ko) 카나비노이드 수용체 길항제로서의피라졸로[1,5-ａ]피리미딘 화합물
EP3541390B1 (en) Pyrrolopyrimidines as cftr potentiators
JP6854817B2 (ja) Ｐｉ３ｋ−ガンマ阻害薬としての複素環式化合物
TWI388560B (zh) 可用於治療伴隨血管新生之過度增生病症與疾病之經取代之４-胺基-吡咯并三衍生物
CA3013618A1 (en) Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors
PT1569937E (pt) Indazolilpirrolotriazinas modificadas em c-6
JP4837701B2 (ja) 医薬組成物
EP2089394A1 (en) Substituted pyrrolo-pyrazole derivatives as kinase inhibitors
JP2009506006A (ja) ｐ３８ＭＡＰキナーゼ阻害剤およびその使用方法
CN104837844B (zh) 作为酪蛋白激酶1 d/e抑制剂的吡唑取代的咪唑并哌嗪
RS57532B1 (sr) Biciklično jedinjenje koje sadrži sumpor
JP6856648B2 (ja) Ｃｘｃｒ４受容体アンタゴニスト
JP4847275B2 (ja) ピラゾロ［１，５−ａ］ピリミジン化合物
JP4994295B2 (ja) 医薬組成物
CN102918035A (zh) 用作jnk的抑制剂的2-氨基-嘧啶衍生物
BRPI0617659A2 (pt) composto de pirazolo[1,5-a]pirimidina e composição farmacêutica que o contém
CA3044050C (en) Pyrrolopyrimidines as cftr potentiators
HK40014108B (en) Pyrrolopyrimidines as cftr potentiators
HK40014108A (en) Pyrrolopyrimidines as cftr potentiators

Legal Events

Date Code Title Description
A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20090223

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20090223

RD04 Notification of resignation of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7424

Effective date: 20090415

RD03 Notification of appointment of power of attorney

Free format text: JAPANESE INTERMEDIATE CODE: A7423

Effective date: 20110530

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20110726

A521 Written amendment

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20110909

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20111004

A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20111012

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20141021

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees