JP4794432B2 - キメラポリペプチドおよびその使用 - Google Patents
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P33/10—Anthelmintics
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
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- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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- C12Y301/21—Endodeoxyribonucleases producing 5'-phosphomonoesters (3.1.21)
- C12Y301/21004—Type II site-specific deoxyribonuclease (3.1.21.4)
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| ITMI20030821A1 (it) * | 2003-04-18 | 2004-10-19 | Internat Ct For Genetic En Gineering And | Polipeptidi chimerici e loro uso. |
| NL1027479C2 (nl) * | 2004-10-21 | 2006-05-01 | Synvolux Ip B V | Bescherming van biologisch actieve moleculen met behulp van amphifielen. |
| AU2006215413B2 (en) * | 2005-02-18 | 2010-10-07 | Astrazeneca Ab | Method for determining responsiveness to CHK1 inhibitors |
| GB0609119D0 (en) * | 2006-05-09 | 2006-06-21 | Univ Birmingham | Histones |
| US8552168B2 (en) * | 2007-05-11 | 2013-10-08 | The Regents Of The University Of California | Nucleic acids for inducing expression of transcripts and proteins and methods for making and using them |
| CN106164671A (zh) | 2014-02-17 | 2016-11-23 | 克劳德贝尔纳里昂第大学 | 确定组织放射敏感性的预测方法 |
| CN104193826B (zh) * | 2014-09-17 | 2018-02-23 | 山东大学齐鲁医院 | 一种融合多肽及其在制备抗肿瘤药物中的应用 |
| KR20180132833A (ko) * | 2016-04-12 | 2018-12-12 | 이섬 리서치 디벨러프먼트 컴파니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | Mcm 결핍과 관련된 장애의 치료를 위한 메틸말로닐 조효소 a 뮤타아제 (mcm) 융합 구조체 |
| JP6925003B2 (ja) * | 2016-05-10 | 2021-08-25 | 公立大学法人横浜市立大学 | 非相同末端連結欠損細胞及びその利用 |
| MX2018014366A (es) | 2016-05-27 | 2019-04-11 | Synthex Inc | Interfaces de proteina. |
| WO2017211941A1 (en) * | 2016-06-09 | 2017-12-14 | Alma Mater Studiorum Universita Di Bologna | Herpesvirus with modified glycoprotein b |
| MX2019015188A (es) | 2017-06-15 | 2020-08-03 | Univ California | Inserciones de adn no virales orientadas. |
| MX2020004325A (es) | 2017-10-27 | 2020-11-09 | Univ California | Reemplazo dirigido de receptores de células t endógenos. |
| GB2584210B (en) | 2017-11-22 | 2022-03-16 | Synthex Inc | Peptides for inhibiting RAD51 |
| WO2023064928A2 (en) | 2021-10-14 | 2023-04-20 | Arsenal Biosciences, Inc. | Immune cells having co-expressed shrnas and logic gate systems |
| EP4448556A1 (en) | 2021-12-16 | 2024-10-23 | RDP Pharma AG | Cell penetrating polypeptides (cpps) and their use in human therapy |
| CN116023512A (zh) * | 2023-02-16 | 2023-04-28 | 浙江大学 | 一条靶向dna损伤修复蛋白的多肽及其用途 |
| EP4480497A1 (en) | 2023-06-21 | 2024-12-25 | RDP Pharma AG | Bio-conjugates for oncology |
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| US5674980A (en) * | 1989-12-21 | 1997-10-07 | Biogen Inc | Fusion protein comprising tat-derived transport moiety |
| AU775001B2 (en) * | 1999-03-31 | 2004-07-15 | Invitrogen Corporation | Delivery of functional protein sequences by translocating polypeptides |
| AU4430701A (en) * | 2000-04-03 | 2001-10-15 | Antisoma Research Limited | Compounds for targeting |
| GB0112818D0 (en) * | 2001-05-25 | 2001-07-18 | Lorantis Ltd | Conjugate |
| EP1342781A1 (en) * | 2002-03-09 | 2003-09-10 | ARTEMIS Pharmaceuticals GmbH | Recombinase fusion protein with enhanced cellular uptake |
| US9447434B2 (en) * | 2002-09-05 | 2016-09-20 | California Institute Of Technology | Use of chimeric nucleases to stimulate gene targeting |
| ITMI20030821A1 (it) * | 2003-04-18 | 2004-10-19 | Internat Ct For Genetic En Gineering And | Polipeptidi chimerici e loro uso. |
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| ATE374826T1 (de) | 2007-10-15 |
| CN1768142A (zh) | 2006-05-03 |
| DE602004009301T2 (de) | 2008-07-17 |
| JP2011182792A (ja) | 2011-09-22 |
| WO2004092194A3 (en) | 2005-03-17 |
| KR20060003029A (ko) | 2006-01-09 |
| KR20110074948A (ko) | 2011-07-04 |
| ES2293247T3 (es) | 2008-03-16 |
| US20060292629A1 (en) | 2006-12-28 |
| CY1107115T1 (el) | 2012-01-25 |
| AU2004230254B2 (en) | 2008-10-02 |
| WO2004092194A2 (en) | 2004-10-28 |
| US20110033384A1 (en) | 2011-02-10 |
| KR101360781B1 (ko) | 2014-04-24 |
| DK1616011T3 (da) | 2008-02-04 |
| AU2004230254A1 (en) | 2004-10-28 |
| CA2522525A1 (en) | 2004-10-28 |
| EP1616011A2 (en) | 2006-01-18 |
| EP1616011B1 (en) | 2007-10-03 |
| KR101247704B1 (ko) | 2013-03-26 |
| CN100584950C (zh) | 2010-01-27 |
| PL1616011T3 (pl) | 2008-05-30 |
| PT1616011E (pt) | 2008-01-07 |
| JP2006523448A (ja) | 2006-10-19 |
| US20150018409A1 (en) | 2015-01-15 |
| DE602004009301D1 (de) | 2007-11-15 |
| ITMI20030821A1 (it) | 2004-10-19 |
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