JP4790905B2 - 化学ルミネセンス化合物及び方法 - Google Patents

化学ルミネセンス化合物及び方法 Download PDF

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JP4790905B2
JP4790905B2 JP2000511896A JP2000511896A JP4790905B2 JP 4790905 B2 JP4790905 B2 JP 4790905B2 JP 2000511896 A JP2000511896 A JP 2000511896A JP 2000511896 A JP2000511896 A JP 2000511896A JP 4790905 B2 JP4790905 B2 JP 4790905B2
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substituted
peroxidase
chemiluminescence
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JP2001516589A5 (enExample
JP2001516589A (ja
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ハシェム・アクハヴァン−タフティ
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ルミゲン インク
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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C09K11/07—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials having chemically interreactive components, e.g. reactive chemiluminescent compositions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • C12Q1/28—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase involving peroxidase
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/968—High energy substrates, e.g. fluorescent, chemiluminescent, radioactive

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
JP2000511896A 1997-09-12 1998-08-12 化学ルミネセンス化合物及び方法 Expired - Lifetime JP4790905B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/928,793 1997-09-12
US08/928,793 US5922558A (en) 1997-09-12 1997-09-12 Methods and compositions for generating chemiluminescence with a peroxidase
PCT/US1998/015813 WO1999014358A1 (en) 1997-09-12 1998-08-12 Chemiluminescence compositions and methods

Publications (3)

Publication Number Publication Date
JP2001516589A JP2001516589A (ja) 2001-10-02
JP2001516589A5 JP2001516589A5 (enExample) 2006-01-05
JP4790905B2 true JP4790905B2 (ja) 2011-10-12

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Family Applications (1)

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JP2000511896A Expired - Lifetime JP4790905B2 (ja) 1997-09-12 1998-08-12 化学ルミネセンス化合物及び方法

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US (1) US5922558A (enExample)
EP (1) EP1019525B1 (enExample)
JP (1) JP4790905B2 (enExample)
AT (1) ATE280241T1 (enExample)
AU (1) AU733086C (enExample)
CA (1) CA2300096C (enExample)
DE (1) DE69827152T2 (enExample)
ES (1) ES2230710T3 (enExample)
WO (1) WO1999014358A1 (enExample)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997026245A1 (en) * 1996-01-16 1997-07-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
US6126870A (en) * 1997-09-12 2000-10-03 Lumigen, Inc. Chemiluminescent labeling compounds
US6017769A (en) * 1998-06-17 2000-01-25 Lumigen, Inc. Non-enzymatic methods of generating chemiluminescence from acridan alkenes
US7186568B1 (en) * 2000-06-26 2007-03-06 Lumigen Inc. Electrochemiluminescence from acridan compounds
EP1322670B1 (en) * 2000-06-26 2005-12-21 Lumigen, Inc. Electrochemiluminescence from acridan compounds
US6872828B2 (en) * 2001-12-20 2005-03-29 Lumigen, Inc. Compounds for generating chemiluminescence with a peroxidase
EP1456176B1 (en) * 2001-12-20 2009-03-18 Lumigen, Inc. Improved compounds for generating chemiluminescence with a peroxidase
US7560556B2 (en) * 2001-12-20 2009-07-14 Lumigen, Inc. Assay methods using chemiluminescent detection of peroxidase
US6897036B2 (en) * 2002-06-06 2005-05-24 Lumigen, Inc. Fluorescent detection of peroxidase enzymes
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US7682839B2 (en) * 2005-03-14 2010-03-23 Lumigen, Inc. Methods using novel chemiluminescent labels
US20060205094A1 (en) * 2005-03-14 2006-09-14 Lumigen, Inc. Methods using novel chemiluminescent labels
US7879575B2 (en) * 2005-04-27 2011-02-01 The Trustees Of The University Of Pennsylvania Nanostructures that provide a modified nanoenvironment for the enhancement of luminescence
WO2006116686A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanostructure enhanced luminescent devices
WO2006116687A2 (en) * 2005-04-27 2006-11-02 The Trustees Of The University Of Pennsylvania Nanoassays
US7566573B2 (en) * 2005-12-19 2009-07-28 Idexx Laboratories, Inc. Dual standard curve immunoassay
US7732153B2 (en) 2006-05-09 2010-06-08 Beckman Coulter, Inc. Nonseparation assay methods
US7799534B2 (en) * 2006-05-09 2010-09-21 Beckman Coulter, Inc. Nonseparation assay methods
US7674629B2 (en) * 2007-03-15 2010-03-09 Saint Louis University Method for improving chemiluminescent signal
WO2009062027A1 (en) * 2007-11-07 2009-05-14 Beckman Coulter, Inc. Nonseparation assay methods using peroxide generating enzymes
CN101178402B (zh) * 2007-12-06 2011-08-24 武汉赛欣生物技术有限公司 聚合酶标记抗体的制备方法
US20090162876A1 (en) * 2007-12-20 2009-06-25 Abbott Laboratories Myeloperoxidase assays
US8652442B2 (en) 2008-11-03 2014-02-18 Washington University Bioluminescence imaging of myeloperoxidase activity in vivo, methods, compositions and apparatuses therefor
CN102333885A (zh) 2009-02-27 2012-01-25 贝克曼考尔特公司 使用选择性信号抑制剂的非分离式测定
US9029092B2 (en) 2009-02-27 2015-05-12 Beckman Coulter, Inc. Solution phase homogeneous assays
US20110097723A1 (en) * 2009-09-19 2011-04-28 Qun Liu Methods and reagents for analyte detection
JP6553020B2 (ja) 2013-03-15 2019-07-31 ジーピービー デット ホールディングス トゥー エルエルシー アレルギー及び自己免疫疾患に関する診断分析を行うための自動化された免疫分析計システム
US9383336B2 (en) 2014-04-04 2016-07-05 General Electric Company System and method for flat panel detector gel and blot imaging
CN104761584A (zh) * 2015-02-27 2015-07-08 北京利德曼生化股份有限公司 吖啶酯衍生物及其合成方法和应用
EP3350577B1 (en) * 2015-09-16 2022-02-16 Global Life Sciences Solutions Germany Gmbh System and method for flat panel detector gel and blot imaging
WO2020012391A1 (en) 2018-07-13 2020-01-16 3M Innovative Properties Company Assay
CN112400113B (zh) 2018-07-13 2022-04-15 3M创新有限公司 特异性结合化学发光测定法
CN113295678B (zh) * 2021-05-14 2022-11-08 济南迪曼生物科技有限公司 一种电化学发光清洗液

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04507194A (ja) * 1989-07-13 1992-12-17 エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム 化学発光組成物、化学発光法、及び分析的検定におけるその使用
JPH09189698A (ja) * 1995-12-27 1997-07-22 Behringwerke Ag 免疫学的測定方法
WO1997026277A2 (en) * 1996-01-22 1997-07-24 Creative Biomolecules, Inc. Morphogen analogs and methods for producing them
WO1997026245A1 (en) * 1996-01-16 1997-07-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE68911633T2 (de) * 1988-09-30 1994-04-07 Fujirebio Kk Verfahren zur Bestimmung von Peroxidase-Aktivität unter Verwendung von Chemilumineszenz.
EP0422252B1 (en) * 1989-04-28 1995-07-26 Toray Industries, Inc. Method for detecting a substance using chemiluminescence
US5324835A (en) * 1990-03-30 1994-06-28 Biosensor Laboratories Co., Ltd. Pyridazinoquinoxalinones for use as chemiluminescent agents
US5629168A (en) * 1992-02-10 1997-05-13 British Technology Group Limited Chemiluminescent enhancers
US5552298A (en) * 1992-10-23 1996-09-03 Lumigen, Inc. Enzyme-catalyzed chemiluminescence from hydroxyaryl cyclic diacylhydrazide compounds
US5512451A (en) * 1993-04-01 1996-04-30 British Technology Group Limited Enhancement of chemiluminescent reactions
US5593845A (en) * 1993-05-17 1997-01-14 Lumigen, Inc. Aryl N-alkylacridancarboxylate derivatives useful for chemiluminescent detection
US5670644A (en) * 1993-05-17 1997-09-23 Lumigen, Inc. Acridan compounds
US5491072A (en) * 1993-05-17 1996-02-13 Lumigen, Inc. N-alkylacridan carboxyl derivatives useful for chemiluminescent detection
US5523212A (en) * 1993-05-17 1996-06-04 Lumigen, Inc. Aryl N-alkylacridanthiocarboxylate derivatives useful for chemiluminescent detection
US5723295A (en) * 1993-05-17 1998-03-03 Lumigen, Inc. Methods, acridan compounds and kits for producing light

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH04507194A (ja) * 1989-07-13 1992-12-17 エヌ・ブイ・インノジェネティクス・ソシエテ・アノニム 化学発光組成物、化学発光法、及び分析的検定におけるその使用
JPH09189698A (ja) * 1995-12-27 1997-07-22 Behringwerke Ag 免疫学的測定方法
WO1997026245A1 (en) * 1996-01-16 1997-07-24 Lumigen, Inc. Compounds, compositions and methods for generating chemiluminescence with phosphatase enzymes
WO1997026277A2 (en) * 1996-01-22 1997-07-24 Creative Biomolecules, Inc. Morphogen analogs and methods for producing them

Also Published As

Publication number Publication date
ES2230710T3 (es) 2005-05-01
AU733086C (en) 2002-01-03
CA2300096A1 (en) 1999-03-25
EP1019525B1 (en) 2004-10-20
ATE280241T1 (de) 2004-11-15
EP1019525A4 (en) 2003-01-02
WO1999014358A1 (en) 1999-03-25
AU8897598A (en) 1999-04-05
DE69827152T2 (de) 2006-03-09
JP2001516589A (ja) 2001-10-02
AU733086B2 (en) 2001-05-03
CA2300096C (en) 2010-02-09
DE69827152D1 (de) 2004-11-25
EP1019525A1 (en) 2000-07-19
US5922558A (en) 1999-07-13

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