JP4777246B2 - ビアリールオキサゾリジノンの合成方法 - Google Patents

ビアリールオキサゾリジノンの合成方法 Download PDF

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Publication number
JP4777246B2
JP4777246B2 JP2006522029A JP2006522029A JP4777246B2 JP 4777246 B2 JP4777246 B2 JP 4777246B2 JP 2006522029 A JP2006522029 A JP 2006522029A JP 2006522029 A JP2006522029 A JP 2006522029A JP 4777246 B2 JP4777246 B2 JP 4777246B2
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mmol
compound
reaction mixture
reduced pressure
under reduced
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JP2006522029A
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English (en)
Japanese (ja)
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JP2007500708A5 (https=
JP2007500708A (ja
Inventor
ウ・ユシェン
チェン・シリ
チェン・イ
ロジェ・アンセルマン
ロウ・ロンリアン
チャチェン・チョウ
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Melinta Subsidiary Corp
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Rib X Pharmaceuticals Inc
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Publication date
Priority claimed from US10/859,476 external-priority patent/US6969726B2/en
Application filed by Rib X Pharmaceuticals Inc filed Critical Rib X Pharmaceuticals Inc
Priority claimed from PCT/US2004/024339 external-priority patent/WO2005012271A2/en
Publication of JP2007500708A publication Critical patent/JP2007500708A/ja
Publication of JP2007500708A5 publication Critical patent/JP2007500708A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
JP2006522029A 2003-07-29 2004-07-28 ビアリールオキサゾリジノンの合成方法 Expired - Fee Related JP4777246B2 (ja)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US49085503P 2003-07-29 2003-07-29
US60/490,855 2003-07-29
US52973103P 2003-12-15 2003-12-15
US60/529,731 2003-12-15
US53037103P 2003-12-17 2003-12-17
US60/530,371 2003-12-17
US53158403P 2003-12-19 2003-12-19
US60/531,584 2003-12-19
US57616304P 2004-06-02 2004-06-02
US60/576,163 2004-06-02
US10/859,476 US6969726B2 (en) 2003-06-03 2004-06-02 Biaryl heterocyclic compounds and methods of making and using the same
US10/859,476 2004-06-02
PCT/US2004/024339 WO2005012271A2 (en) 2003-07-29 2004-07-28 Process for the synthesis of biaryl oxazolidinones

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011021739A Division JP5558385B2 (ja) 2003-07-29 2011-02-03 ビアリールオキサゾリジノンの合成方法

Publications (3)

Publication Number Publication Date
JP2007500708A JP2007500708A (ja) 2007-01-18
JP2007500708A5 JP2007500708A5 (https=) 2007-07-12
JP4777246B2 true JP4777246B2 (ja) 2011-09-21

Family

ID=44348781

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2006522029A Expired - Fee Related JP4777246B2 (ja) 2003-07-29 2004-07-28 ビアリールオキサゾリジノンの合成方法
JP2011021739A Expired - Fee Related JP5558385B2 (ja) 2003-07-29 2011-02-03 ビアリールオキサゾリジノンの合成方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011021739A Expired - Fee Related JP5558385B2 (ja) 2003-07-29 2011-02-03 ビアリールオキサゾリジノンの合成方法

Country Status (2)

Country Link
JP (2) JP4777246B2 (https=)
ES (1) ES2536001T3 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011137007A (ja) * 2003-07-29 2011-07-14 Rib-X Pharmaceuticals Inc ビアリールオキサゾリジノンの合成方法
US8895741B2 (en) 2003-06-03 2014-11-25 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005012270A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JPH0841056A (ja) * 1994-07-20 1996-02-13 Bayer Ag ６員の窒素含有ヘテロアリール−オキサゾリジノン類
JPH08151578A (ja) * 1994-11-30 1996-06-11 Canon Inc 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
WO2003022824A1 (en) * 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
JP2005526647A (ja) * 2002-02-28 2005-09-08 ダイムラークライスラー・アクチェンゲゼルシャフト 車両に配置された少なくとも１つの車両安定化装置の作動モードに介入するための装置及び方法
JP2006508192A (ja) * 2002-11-28 2006-03-09 アストラゼネカ アクチボラグ 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体
JP2006512352A (ja) * 2002-12-19 2006-04-13 アストラゼネカ アクチボラグ オキサゾリジノン誘導体及び抗菌薬としてのそれらの使用
JP2006519247A (ja) * 2003-03-01 2006-08-24 アストラゼネカ アクチボラグ 抗生物質として有用なヒドロキシメチル置換ジヒドロイソオキサゾール誘導体
JP2007500707A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH02124877A (ja) * 1988-07-29 1990-05-14 E I Du Pont De Nemours & Co アミノメチルオキソオキサゾリジニルアリールベンゼン誘導体
JPH0841056A (ja) * 1994-07-20 1996-02-13 Bayer Ag ６員の窒素含有ヘテロアリール−オキサゾリジノン類
JPH08151578A (ja) * 1994-11-30 1996-06-11 Canon Inc 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
WO2003022824A1 (en) * 2001-09-11 2003-03-20 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
JP2005526647A (ja) * 2002-02-28 2005-09-08 ダイムラークライスラー・アクチェンゲゼルシャフト 車両に配置された少なくとも１つの車両安定化装置の作動モードに介入するための装置及び方法
JP2006508192A (ja) * 2002-11-28 2006-03-09 アストラゼネカ アクチボラグ 抗細菌薬としてのオキサゾリジノンおよび／またはイソオキサゾリン誘導体
JP2006512352A (ja) * 2002-12-19 2006-04-13 アストラゼネカ アクチボラグ オキサゾリジノン誘導体及び抗菌薬としてのそれらの使用
JP2006519247A (ja) * 2003-03-01 2006-08-24 アストラゼネカ アクチボラグ 抗生物質として有用なヒドロキシメチル置換ジヒドロイソオキサゾール誘導体
JP2007500707A (ja) * 2003-07-29 2007-01-18 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールヘテロ環状のアミン、アミドおよび硫黄−含有化合物、並びに該化合物の製造方法および使用方法

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895741B2 (en) 2003-06-03 2014-11-25 Melinta Therapeutics, Inc. Process for the synthesis of biaryl oxazolidinones
JP2011137007A (ja) * 2003-07-29 2011-07-14 Rib-X Pharmaceuticals Inc ビアリールオキサゾリジノンの合成方法

Also Published As

Publication number Publication date
JP2011137007A (ja) 2011-07-14
ES2536001T3 (es) 2015-05-19
JP5558385B2 (ja) 2014-07-23
JP2007500708A (ja) 2007-01-18

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