ES2536001T3 - Procedimiento para la síntesis de biariloxazolidinonas - Google Patents

Procedimiento para la síntesis de biariloxazolidinonas Download PDF

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Publication number
ES2536001T3
ES2536001T3 ES04779405.2T ES04779405T ES2536001T3 ES 2536001 T3 ES2536001 T3 ES 2536001T3 ES 04779405 T ES04779405 T ES 04779405T ES 2536001 T3 ES2536001 T3 ES 2536001T3
Authority
ES
Spain
Prior art keywords
mmol
nhac
compound
fluoro
ylmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES04779405.2T
Other languages
English (en)
Spanish (es)
Inventor
Yusheng Wu
Shili Chen
Yi Chen
Roger Hanselmann
Rongliang Lou
Jiacheng Zhou
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Melinta Subsidiary Corp
Original Assignee
Melinta Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/859,476 external-priority patent/US6969726B2/en
Application filed by Melinta Therapeutics Inc filed Critical Melinta Therapeutics Inc
Priority claimed from PCT/US2004/024339 external-priority patent/WO2005012271A2/en
Application granted granted Critical
Publication of ES2536001T3 publication Critical patent/ES2536001T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
ES04779405.2T 2003-07-29 2004-07-28 Procedimiento para la síntesis de biariloxazolidinonas Expired - Lifetime ES2536001T3 (es)

Applications Claiming Priority (13)

Application Number Priority Date Filing Date Title
US49085503P 2003-07-29 2003-07-29
US490855P 2003-07-29
US52973103P 2003-12-15 2003-12-15
US529731P 2003-12-15
US53037103P 2003-12-17 2003-12-17
US530371P 2003-12-17
US53158403P 2003-12-19 2003-12-19
US531584P 2003-12-19
US57616304P 2004-06-02 2004-06-02
US576163P 2004-06-02
US859476 2004-06-02
US10/859,476 US6969726B2 (en) 2003-06-03 2004-06-02 Biaryl heterocyclic compounds and methods of making and using the same
PCT/US2004/024339 WO2005012271A2 (en) 2003-07-29 2004-07-28 Process for the synthesis of biaryl oxazolidinones

Publications (1)

Publication Number Publication Date
ES2536001T3 true ES2536001T3 (es) 2015-05-19

Family

ID=44348781

Family Applications (1)

Application Number Title Priority Date Filing Date
ES04779405.2T Expired - Lifetime ES2536001T3 (es) 2003-07-29 2004-07-28 Procedimiento para la síntesis de biariloxazolidinonas

Country Status (2)

Country Link
JP (2) JP4777246B2 (https=)
ES (1) ES2536001T3 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8324398B2 (en) 2003-06-03 2012-12-04 Rib-X Pharmaceuticals, Inc. Process for the synthesis of biaryl oxazolidinones
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
WO2005012270A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4948801A (en) * 1988-07-29 1990-08-14 E. I. Du Pont De Nemours And Company Aminomethyloxooxazolidinyl arylbenzene derivatives useful as antibacterial agents
DE4425612A1 (de) * 1994-07-20 1996-04-04 Bayer Ag 6-gliedrige stickstoffhaltige Heteroaryl-oxazolidinone
JPH08151578A (ja) * 1994-11-30 1996-06-11 Canon Inc 光学活性化合物、それを含有する液晶組成物、それを有する液晶素子及びそれらを用いた表示方法、液晶装置
US7396847B2 (en) * 2001-09-11 2008-07-08 Astrazeneca Ab Oxazolidinone and/or isoxazoline as antibacterial agents
WO2003072410A2 (de) * 2002-02-28 2003-09-04 Daimlerchrysler Ag Vorrichtung und verfahren zur beeinflussung der arbeitsweise wenigstens einer in einem fahrzeug angeordneten fahrzeugstabilisierungsvorrichtung
US20060116400A1 (en) * 2002-11-28 2006-06-01 Astrazeneca Ab Oxazolidinone and/or isoxazoline derivatives as antibacterial agents
GB0229526D0 (en) * 2002-12-19 2003-01-22 Astrazeneca Ab Chemical compounds
TW200500360A (en) * 2003-03-01 2005-01-01 Astrazeneca Ab Hydroxymethyl compounds
JP4777246B2 (ja) * 2003-07-29 2011-09-21 リブ−エックス ファーマシューティカルズ，インコーポレイテッド ビアリールオキサゾリジノンの合成方法
WO2005012270A2 (en) * 2003-07-29 2005-02-10 Rib-X Pharmaceuticals, Inc. Biaryl heterocyclic amines, amides, and sulfur-containing compounds and methods of making and using the same

Also Published As

Publication number Publication date
JP2011137007A (ja) 2011-07-14
JP4777246B2 (ja) 2011-09-21
JP5558385B2 (ja) 2014-07-23
JP2007500708A (ja) 2007-01-18

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