JP4763794B2 - 懸濁液における相の体積分率測定装置および手段 - Google Patents
懸濁液における相の体積分率測定装置および手段 Download PDFInfo
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Description
本体と、
本体の内部に形成され、注入口部および前記注入口部に流体的に連結され、かつ注入口部を介して充填することができる閉端チャネルを含むチャネル構造と、
閉端チャネル内の懸濁液の相分離が遠心力によって行われるように、本体に回転を与えるための駆動手段とを含み、
閉端チャネルは、入口部を介して懸濁液を充填したときに、第1の断面領域のほうが第2の断面領域より大きい毛管力を有し、まず注入口部から閉端チャネルの閉端の方向に向かって充填され、次に閉端から注入口部の方向に向かって充填されるような断面構造および/または濡れ性を有することを特徴とする。
注入口部、および注入口部に隣接する閉端チャネルを含むチャネル構造を提供するステップと、
注入口部の内部に懸濁液を充填し、閉端チャネルは、第1の断面領域のほうが第2の断面領域より高い毛管力が働くようなチャネル断面および/または濡れ性を有することにより、まず閉端チャネルの注入口部から閉端の方向に向かって充填され、次に閉端から注入口部の方向に向かって充填されるステップと、
チャネル構造に回転を与えて、遠心力により閉端チャネルにおいて懸濁液の相分離を生じさせるステップとを含む。
Claims (15)
- 懸濁液における相の体積分率を測定するための装置であって、
本体(18)と、
前記本体(18)に形成され、注入口部(30,80)と、前記注入口部(30,80)に流体的に連結されるとともに前記注入口部(30,80)を介して充填される閉端チャネル(32,62)とを含むチャネル構造と、
前記本体に回転を与えて、遠心分離により前記閉端チャネル(32,62)において前記懸濁液の相分離を起こさせるための駆動手段(22,24,26)と、
前記駆動手段を制御するための制御装置とを含み、
前記閉端チャネル(32,62)は、第1断面領域(64)と第2断面領域(68)からなる断面構造および/または前記注入口部(30,80)から懸濁液を充填するときに前記第1の断面領域(64)のほうが前記第2の断面領域(68)より大きい毛管力を有する濡れ性を有し、まず前記第1断面領域(64)が前記閉端チャネル(32,62)の前記注入口部(30,80)から閉端(60)の方向に向かって充填され、次に前記第2断面領域(68)が前記閉端(60)から前記注入口部(30,80)の方向に向かって充填されるように形成され、
前記チャネル構造は、さらに、前記懸濁液の容量調整をするために前記注入口部(30,80)と前記閉端チャネル(32,62)との間に形成されるオーバーフロー構造(36,82)を含み、前記オーバーフロー構造は前記閉端チャネルから分岐してオーバーフロー室に向かって前記回転のほぼ半径方向に延びるオーバーフローチャネルを含み、
前記制御装置は、前記閉端チャネルが前記懸濁液で完全に満たされた状態で、前記オーバーフローチャネルの突破回転数を超えるように回転数が増加して、余分な前記懸濁液が前記オーバーフロー室に流れ込んで規定量の前記懸濁液が前記閉端チャネルに存在するように制御するように構成された、装置。 - 前記本体(18)は、前記閉端チャネル(32,62)に関連して配置されることにより前記閉端チャネル(32,62)における体積分率を読み取ることができるようにした目盛(42)を含む、請求項1に記載の装置。
- 前記本体(18)は、前記チャネル構造が形成された第1の層(12,70)と、蓋を構成する第2の層(16,72)とを含む、請求項1または請求項2に記載の装置。
- 前記本体(18)は、回転軸を有する回転体として形成され、前記駆動手段(22,24,26)は、前記回転体をその回転軸を中心として回転させるように構成される、請求項1ないし請求項3のいずれかに記載の装置。
- 前記駆動手段は、前記本体の外側に配置され、前記本体を保持して、その回転軸を中心として前記本体を回転させるための固定具を含む、請求項1ないし請求項3のいずれかに記載の装置。
- 前記閉端チャネルは、互いに異なる角度で隣接して内部を取り囲む壁を含む、請求項1ないし請求項5のいずれかに記載の装置。
- 前記閉端チャネルは、前記懸濁液に対して異なる親水性を有する壁を有しているか、または、前記懸濁液に対して異なる親水性の部分を含む壁を有している、請求項1ないし請求項6のいずれかに記載の装置。
- 前記閉端チャネル(32,62)は、少なくとも1つの段差部を有する断面を備えた、請求項1ないし請求項7のいずれかに記載の装置。
- 前記閉端チャネルは、T字状のチャネル形状を有する、請求項1ないし請求項8のいずれかに記載の装置。
- 前記閉端チャネルは、上壁と、下壁と、前記上壁および前記下壁に対して90°以外の角度で配置される少なくとも1つの側壁とを含む、請求項1ないし請求項9のいずれかに記載の装置。
- さらに、回転中または回転後に前記閉端チャネルにおける体積分率を測定するための手段を含む、請求項1ないし請求項10のいずれかに記載の装置。
- 回転による遠心力を用いて懸濁液における相の体積分率を測定する方法であって、
注入口部(30,80)と、前記注入口部(30,80)に隣接する閉端チャネル(32,62)と、前記懸濁液の容量調整のために前記注入口部と前記閉端チャネルとの間に設けられ、前記閉端チャネルから分岐してオーバーフロー室に向かって前記回転のほぼ半径方向に延びるオーバーフローチャネルを有するオーバーフロー構造とを含むチャネル構造を提供するステップと、
前記注入口部(30,80)の内部に前記懸濁液を導入し、前記閉端チャネル(32,62)は、第1断面領域(64)のほうが第2断面領域(68)より高い毛管力が働くようなチャネル断面および/または濡れ性を有することにより、まず前記第1断面領域(64)が前記閉端チャネル(32,62)の前記注入口部(30,80)から前記閉端チャネルの閉端(60)の方向に向かって充填され、次に前記第2断面領域(68)が前記閉端(60)から前記注入口部(30,80)の方向に向かって充填されるステップと、
前記閉端チャネルが前記懸濁液で完全に満たされた状態で、前記オーバーフローチャネルの突破回転数を超えるように回転数を増加させて、余分な前記懸濁液を前記オーバーフロー室に流し込んで規定量の前記懸濁液を前記閉端チャネルに存在させるステップと、
前記チャネル構造に回転を与えて、遠心分離により前記閉端チャネル(32,62)において前記懸濁液を相分離させるステップと、
相の体積分率を測定するステップとを含む、方法。 - 前記チャネル構造は、遠心力を利用して充填を速めるために、前記閉端チャネル(32,62)の完全な充填に先立って回転が与えられる、請求項12に記載の方法。
- 前記懸濁液は血液であり、前記チャネル構造の大きさは血液のヘマトクリット値の測定に合わせて決定される、請求項12または請求項13に記載の方法。
- さらに、回転中または回転後に、前記閉端チャネルにおける体積分率を測定するステップを含む、請求項12ないし請求項14のいずれかに記載の方法。
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DE102005048236.8 | 2005-10-07 | ||
DE102005048236A DE102005048236A1 (de) | 2005-10-07 | 2005-10-07 | Vorrichtung und Verfahren zur Bestimmung der Volumenanteile der Phasen in einer Suspension |
PCT/EP2006/009660 WO2007042207A1 (de) | 2005-10-07 | 2006-10-05 | Vorrichtung und verfahren zur bestimmung der volumenanteile der phasen in einer suspension |
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US (1) | US7943386B2 (ja) |
EP (1) | EP1915212B1 (ja) |
JP (1) | JP4763794B2 (ja) |
KR (1) | KR100965667B1 (ja) |
AT (1) | ATE497838T1 (ja) |
DE (2) | DE102005048236A1 (ja) |
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HUE053571T2 (hu) | 2009-11-24 | 2021-07-28 | Opko Diagnostics Llc | Folyadékkeverés és szállítás mikrofluid rendszerekben |
EP2558203A1 (en) | 2010-04-16 | 2013-02-20 | Opko Diagnostics, LLC | Systems and devices for analysis of samples |
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GB201109203D0 (en) * | 2011-06-01 | 2011-07-13 | Carclo Technical Plastics Ltd | Fluid flow control |
EP2747888A1 (en) * | 2011-12-08 | 2014-07-02 | Koninklijke Philips N.V. | Centrifugal microfluidic device and methods of use |
EA030682B1 (ru) | 2012-03-05 | 2018-09-28 | Ой Арктик Партнерс Аб | Способы и аппараты для прогнозирования риска рака предстательной железы и объема предстательной железы |
FR2992574B1 (fr) * | 2012-06-29 | 2014-08-08 | Commissariat Energie Atomique | Separateur centrifuge a flux laminaire |
BR112015002561A2 (pt) * | 2012-08-08 | 2018-05-22 | Koninklijke Philips Nv | sistema para separação de um analito heterogêneo, e método para separação de um analito heterogêneo. |
US9588027B2 (en) | 2013-03-13 | 2017-03-07 | UPKO Diagnostics, LLC | Mixing of fluids in fluidic systems |
KR102261169B1 (ko) | 2014-11-14 | 2021-06-08 | 한국전자통신연구원 | 혈액 분석 장치 및 방법 |
MX2017007576A (es) | 2014-12-12 | 2018-03-09 | Opko Diagnostics Llc | Sistemas fluídicos que comprenden un canal de incubación, que incluye sistemas fluídicos formados por moldeo. |
WO2016143278A1 (en) * | 2015-03-06 | 2016-09-15 | Sony Corporation | Microchip, analysis apparatus, and analysis method |
JP6665548B2 (ja) * | 2015-03-06 | 2020-03-13 | ソニー株式会社 | マイクロチップ、並びに分析装置及び分析方法 |
KR102137306B1 (ko) | 2017-11-20 | 2020-07-23 | 주식회사 엘지화학 | 회전식 디스크 시스템을 활용한 중금속 정성 및 정량 분석 디바이스 및 분석 방법 |
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- 2006-10-05 DE DE502006008884T patent/DE502006008884D1/de active Active
- 2006-10-05 WO PCT/EP2006/009660 patent/WO2007042207A1/de active Application Filing
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Also Published As
Publication number | Publication date |
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US7943386B2 (en) | 2011-05-17 |
KR20080047409A (ko) | 2008-05-28 |
US20080280365A1 (en) | 2008-11-13 |
EP1915212A1 (de) | 2008-04-30 |
WO2007042207A1 (de) | 2007-04-19 |
KR100965667B1 (ko) | 2010-06-24 |
DE502006008884D1 (de) | 2011-03-24 |
EP1915212B1 (de) | 2011-02-09 |
JP2009510465A (ja) | 2009-03-12 |
ATE497838T1 (de) | 2011-02-15 |
DE102005048236A1 (de) | 2007-04-12 |
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