JP4745500B2 - 経皮的な薬物の放出および分析物の抽出 - Google Patents

経皮的な薬物の放出および分析物の抽出 Download PDF

Info

Publication number
JP4745500B2
JP4745500B2 JP2000580699A JP2000580699A JP4745500B2 JP 4745500 B2 JP4745500 B2 JP 4745500B2 JP 2000580699 A JP2000580699 A JP 2000580699A JP 2000580699 A JP2000580699 A JP 2000580699A JP 4745500 B2 JP4745500 B2 JP 4745500B2
Authority
JP
Japan
Prior art keywords
current
electrodes
stratum corneum
skin
power source
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
JP2000580699A
Other languages
English (en)
Japanese (ja)
Other versions
JP2002529159A (ja
JP2002529159A5 (https=
Inventor
アブラハミ，ゾハー
Original Assignee
トランスファーマ リミティド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22696221&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=JP4745500(B2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by トランスファーマ リミティド filed Critical トランスファーマ リミティド
Publication of JP2002529159A publication Critical patent/JP2002529159A/ja
Publication of JP2002529159A5 publication Critical patent/JP2002529159A5/ja
Application granted granted Critical
Publication of JP4745500B2 publication Critical patent/JP4745500B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/327—Applying electric currents by contact electrodes alternating or intermittent currents for enhancing the absorption properties of tissue, e.g. by electroporation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/20—Applying electric currents by contact electrodes continuous direct currents
    • A61N1/30—Apparatus for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body, or cataphoresis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/325—Applying electric currents by contact electrodes alternating or intermittent currents for iontophoresis, i.e. transfer of media in ionic state by an electromotoric force into the body

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Electrotherapy Devices (AREA)
  • Surgical Instruments (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
JP2000580699A 1998-11-09 1999-11-01 経皮的な薬物の放出および分析物の抽出 Expired - Fee Related JP4745500B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/189,170 US6148232A (en) 1998-11-09 1998-11-09 Transdermal drug delivery and analyte extraction
US09/189,170 1998-11-09
PCT/IL1999/000580 WO2000027473A1 (en) 1998-11-09 1999-11-01 Transdermal drug delivery and analyte extraction

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2011002458A Division JP2011143251A (ja) 1998-11-09 2011-01-07 経皮的な薬物の放出および分析物の抽出

Publications (3)

Publication Number Publication Date
JP2002529159A JP2002529159A (ja) 2002-09-10
JP2002529159A5 JP2002529159A5 (https=) 2011-03-03
JP4745500B2 true JP4745500B2 (ja) 2011-08-10

Family

ID=22696221

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2000580699A Expired - Fee Related JP4745500B2 (ja) 1998-11-09 1999-11-01 経皮的な薬物の放出および分析物の抽出
JP2011002458A Pending JP2011143251A (ja) 1998-11-09 2011-01-07 経皮的な薬物の放出および分析物の抽出

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2011002458A Pending JP2011143251A (ja) 1998-11-09 2011-01-07 経皮的な薬物の放出および分析物の抽出

Country Status (7)

Country Link
US (4) US6148232A (https=)
EP (1) EP1128870B1 (https=)
JP (2) JP4745500B2 (https=)
AU (1) AU768938B2 (https=)
CA (1) CA2349169C (https=)
IL (1) IL143014A0 (https=)
WO (1) WO2000027473A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10322296B2 (en) 2009-07-20 2019-06-18 Syneron Medical Ltd. Method and apparatus for fractional skin treatment

Families Citing this family (222)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6956032B1 (en) 1986-04-18 2005-10-18 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US7758537B1 (en) * 1995-11-22 2010-07-20 Arthrocare Corporation Systems and methods for electrosurgical removal of the stratum corneum
US6527716B1 (en) 1997-12-30 2003-03-04 Altea Technologies, Inc. Microporation of tissue for delivery of bioactive agents
US8287483B2 (en) * 1998-01-08 2012-10-16 Echo Therapeutics, Inc. Method and apparatus for enhancement of transdermal transport
US6757560B1 (en) * 1999-04-09 2004-06-29 Novosis Pharma Ag Transdermal delivery system (TDS) with electrode network
EP1124607B1 (en) 1998-07-14 2008-11-12 Altea Therapeutics Corporation Controlled removal of biological membrane by pyrotechnic charge for transmembrane transport
DE69921489T2 (de) 1998-08-31 2005-10-27 Johnson & Johnson Consumer Companies, Inc. Elektrotransportvorrichtung mit klingen
US6148231A (en) 1998-09-15 2000-11-14 Biophoretic Therapeutic Systems, Llc Iontophoretic drug delivery electrodes and method
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6597946B2 (en) * 1998-11-09 2003-07-22 Transpharma Ltd. Electronic card for transdermal drug delivery and analyte extraction
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US20040171980A1 (en) 1998-12-18 2004-09-02 Sontra Medical, Inc. Method and apparatus for enhancement of transdermal transport
EP1163024B1 (en) * 1999-01-28 2003-12-17 Cyto Pulse Sciences, Inc. Delivery of macromolecules into cells
US6553253B1 (en) * 1999-03-12 2003-04-22 Biophoretic Therapeutic Systems, Llc Method and system for electrokinetic delivery of a substance
US6477410B1 (en) 2000-05-31 2002-11-05 Biophoretic Therapeutic Systems, Llc Electrokinetic delivery of medicaments
US6792306B2 (en) 2000-03-10 2004-09-14 Biophoretic Therapeutic Systems, Llc Finger-mounted electrokinetic delivery system for self-administration of medicaments and methods therefor
US7127285B2 (en) 1999-03-12 2006-10-24 Transport Pharmaceuticals Inc. Systems and methods for electrokinetic delivery of a substance
CA2370349C (en) 1999-04-16 2013-01-29 Johnson & Johnson Consumer Companies, Inc. Electrotransport delivery system comprising internal sensors
US7171264B1 (en) * 1999-05-10 2007-01-30 Genetronics, Inc. Intradermal delivery of active agents by needle-free injection and electroporation
ATE324922T1 (de) * 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
AU5764800A (en) 1999-07-01 2001-01-22 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US6762158B2 (en) 1999-07-01 2004-07-13 Johnson & Johnson Consumer Companies, Inc. Personal care compositions comprising liquid ester mixtures
US20050009717A1 (en) * 1999-07-01 2005-01-13 Lukenbach Elvin R. Foaming make-up removing cleansing compositions
US7074747B1 (en) 1999-07-01 2006-07-11 Johnson & Johnson Consumer Companies, Inc. Cleansing compositions
US20030078499A1 (en) * 1999-08-12 2003-04-24 Eppstein Jonathan A. Microporation of tissue for delivery of bioactive agents
US7113821B1 (en) * 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling
JP4162813B2 (ja) * 1999-10-28 2008-10-08 久光製薬株式会社 イオントフォレーシス装置
US8012500B2 (en) * 2000-01-01 2011-09-06 Beta-O2 Technologies Ltd. Implantable device
EP1257197A4 (en) * 2000-02-25 2008-07-16 Health Research Inc PROCESS FOR TRANSDERMAL SAMPLING OF ANALYTES
IL136008A0 (en) * 2000-05-07 2001-05-20 Elecsys Ltd Electrically-mediated transdermal drug injection
USRE44145E1 (en) 2000-07-07 2013-04-09 A.V. Topchiev Institute Of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
IT1315449B1 (it) * 2000-09-22 2003-02-11 Elisabetta Rossi Dispositivo e metodo per il trasporto molecolare transdermico
WO2002072781A2 (en) * 2001-03-13 2002-09-19 University Of South Florida Electromanipulation device and method
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US8206738B2 (en) 2001-05-01 2012-06-26 Corium International, Inc. Hydrogel compositions with an erodible backing member
AU2002316053A1 (en) * 2001-05-01 2002-11-11 A.V. Topchiev Institute Of Petrochemical Synthesis Two-phase, water-absorbent bioadhesive composition
US8840918B2 (en) 2001-05-01 2014-09-23 A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences Hydrogel compositions for tooth whitening
US20050113510A1 (en) 2001-05-01 2005-05-26 Feldstein Mikhail M. Method of preparing polymeric adhesive compositions utilizing the mechanism of interaction between the polymer components
WO2002087645A1 (en) 2001-05-01 2002-11-07 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions
US8541021B2 (en) * 2001-05-01 2013-09-24 A.V. Topchiev Institute Of Petrochemical Synthesis Hydrogel compositions demonstrating phase separation on contact with aqueous media
DE10141254C1 (de) * 2001-08-23 2003-04-03 Susann Edel Iontophorese-Kaltkontaktelektrodensystem zur gleichzeitigen Anwendung der Kühlung und der Iontophorese
US20030135166A1 (en) * 2001-09-28 2003-07-17 Gonnelli Robert R. Switchable microneedle arrays and systems and methods relating to same
US7429258B2 (en) * 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US7349733B2 (en) * 2001-11-02 2008-03-25 Ceramatel, Inc. Iontophoretic drug delivery systems
AU2002353444A1 (en) 2001-11-07 2003-05-19 Transpharma Medical Ltd. Integrated transdermal drug delivery system
US6952604B2 (en) 2001-12-21 2005-10-04 Becton, Dickinson And Company Minimally-invasive system and method for monitoring analyte levels
CA2478822C (en) 2002-03-11 2016-07-12 Passport Technologies, Inc. Transdermal drug delivery patch system, method of making same and method of using same
US8116860B2 (en) * 2002-03-11 2012-02-14 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US9918665B2 (en) 2002-03-11 2018-03-20 Nitto Denko Corporation Transdermal porator and patch system and method for using same
WO2003089043A2 (en) * 2002-04-19 2003-10-30 Transpharma Medical Ltd. Handheld transdermal drug delivery and analyte extraction
GB0210397D0 (en) 2002-05-07 2002-06-12 Ferring Bv Pharmaceutical formulations
US6922586B2 (en) * 2002-05-20 2005-07-26 Richard J. Davies Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue
US8262575B2 (en) 2002-05-20 2012-09-11 Epi-Sci, Llc Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue
US7630759B2 (en) * 2002-05-20 2009-12-08 Epi-Sci, Llc Method and system for detecting electrophysiological changes in pre-cancerous and cancerous breast tissue and epithelium
IL152575A (en) * 2002-10-31 2008-12-29 Transpharma Medical Ltd A skin-to-skin transmission system of water-insoluble drugs
US7662404B2 (en) * 2002-10-31 2010-02-16 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized peptides and polypeptides
US7383084B2 (en) * 2002-10-31 2008-06-03 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
IL152574A (en) * 2002-10-31 2009-09-22 Transpharma Medical Ltd A system for passing through the skin of dry items or dried medicines
IL152573A (en) * 2002-10-31 2009-11-18 Transpharma Medical Ltd A system for the transmission through the skin of a medical preparation against vomiting and nausea
US8133505B2 (en) * 2002-10-31 2012-03-13 Transpharma Medical Ltd. Transdermal delivery system for dried particulate or lyophilized medications
AU2004208580A1 (en) * 2003-01-29 2004-08-12 E-Pill Pharma Ltd. Active drug delivery in the gastrointestinal tract
US20040267240A1 (en) * 2003-01-29 2004-12-30 Yossi Gross Active drug delivery in the gastrointestinal tract
US6745071B1 (en) * 2003-02-21 2004-06-01 Birch Point Medical, Inc. Iontophoretic drug delivery system
EP1720605A4 (en) * 2003-06-23 2007-10-24 Transpharma Medical Ltd TRANSDERMAL DELIVERY SYSTEM FOR COSMETIC AGENTS
IL156789A0 (en) * 2003-07-06 2004-02-08 Adapter for multi-element contact-probe
US20050038489A1 (en) * 2003-08-14 2005-02-17 Grill Warren M. Electrode array for use in medical stimulation and methods thereof
GB2432321B (en) 2003-09-30 2007-10-17 Synapse Medical Solutions Ltd Dressing for tissue treatment
US8016811B2 (en) 2003-10-24 2011-09-13 Altea Therapeutics Corporation Method for transdermal delivery of permeant substances
IL159273A0 (en) * 2003-12-09 2004-06-01 Transpharma Medical Ltd Transdermal delivery system for sustained release of polypeptides
CN1889994A (zh) * 2003-12-10 2007-01-03 艾克若克斯Dds有限公司 伴随透皮或局部药物输送的不希望的效果的治疗方法
IL160033A0 (en) * 2004-01-25 2004-06-20 Transpharma Medical Ltd Transdermal delivery system for polynucleotides
WO2005074894A1 (en) 2004-01-30 2005-08-18 Corium International Rapidly dissolving film for delivery of an active agent
US7666341B2 (en) * 2004-02-07 2010-02-23 Tnt Holdings, Llc Screed mold method
WO2005096979A1 (en) 2004-04-01 2005-10-20 The General Hospital Corporation Method and apparatus for dermatological treatment and tissue reshaping
EP1768742A4 (en) * 2004-07-06 2007-10-17 Transpharma Medical Ltd ADMINISTRATION SYSTEM FOR TRANSDERMAL IMMUNIZATION
EP1616551A1 (fr) 2004-07-13 2006-01-18 L'oreal Procédé de traitement cosmétique pour prévenir ou retarder les signes du vieillissement cutané
MX2007001512A (es) * 2004-08-05 2007-04-20 Corium Int Inc Composicion adhesiva.
US20060047281A1 (en) * 2004-09-01 2006-03-02 Syneron Medical Ltd. Method and system for invasive skin treatment
CA2587780A1 (en) * 2004-11-18 2006-05-26 Transpharma Medical Ltd. Combined micro-channel generation and iontophoresis for transdermal delivery of pharmaceutical agents
US20060147423A1 (en) * 2004-12-07 2006-07-06 Jean-Yves Legendre Transungual device
FR2878745B1 (fr) 2004-12-07 2007-03-09 Oreal Dispositif transungeal
JP2008522778A (ja) * 2004-12-14 2008-07-03 イー−ピル ファーマ リミティド 電気透過性増加を用いた薬物又は物質の局所輸送
US20090299262A1 (en) 2005-04-18 2009-12-03 Pantec Biosolutions Ag Microporator for Creating a Permeation Surface
WO2006111201A1 (en) * 2005-04-18 2006-10-26 Pantec Biosolutions Ag Laser microporator
US20090306576A1 (en) * 2005-04-18 2009-12-10 Pantec Biosolutions Ag System for Transmembrane Administration of a Permeant and Method for Administering a Permeant
EP1874212A1 (en) * 2005-04-18 2008-01-09 Pantec Biosolutions AG Microporator for porating a biological membran and integrated permeant administering system
US20100049117A1 (en) * 2005-04-18 2010-02-25 Pantec Biosolutions Ag Microporator for Porating a Biological Membrane and Integrated Permeant Administering System
US7853319B2 (en) * 2005-04-21 2010-12-14 Epi-Sci, Llc Method and system for detecting electrophysiological changes in pre-cancerous and cancerous tissue and epithelium
US7856263B2 (en) * 2005-04-22 2010-12-21 Travanti Pharma Inc. Transdermal systems for the delivery of therapeutic agents including granisetron using iontophoresis
US8467868B1 (en) * 2005-04-26 2013-06-18 University Of South Florida Method of transdermal drug delivery
WO2006124639A1 (en) * 2005-05-11 2006-11-23 Corium International, Inc. Permeabilization of biological membranes
CN101175529A (zh) * 2005-05-19 2008-05-07 埃-皮尔制药公司 用于在组织中产生一氧化氮的可摄入装置
US20080274166A1 (en) * 2005-06-10 2008-11-06 Transpharma Medical Ltd. Patch for Transdermal Drug Delivery
TWI419717B (zh) * 2005-06-17 2013-12-21 Altea Therapeutics Corp 滲透傳送系統及其使用方法
US20070009542A1 (en) * 2005-07-05 2007-01-11 Galit Levin Method and device for transdermal immunization
US20070185432A1 (en) * 2005-09-19 2007-08-09 Transport Pharmaceuticals, Inc. Electrokinetic system and method for delivering methotrexate
US20070066934A1 (en) * 2005-09-19 2007-03-22 Transport Pharmaceuticals, Inc. Electrokinetic delivery system and methods therefor
US20070078502A1 (en) * 2005-10-05 2007-04-05 Thermage, Inc. Method and apparatus for estimating a local impedance factor
US7957815B2 (en) * 2005-10-11 2011-06-07 Thermage, Inc. Electrode assembly and handpiece with adjustable system impedance, and methods of operating an energy-based medical system to treat tissue
US8702691B2 (en) * 2005-10-19 2014-04-22 Thermage, Inc. Treatment apparatus and methods for delivering energy at multiple selectable depths in tissue
US20090169602A1 (en) * 2005-11-23 2009-07-02 Universität Zürich Allergy Treatment by Epicutaneous Allergen Administration
CN101583620B (zh) 2005-11-28 2016-08-17 马里纳斯医药公司 加奈索酮组合物及其制备和使用方法
WO2007099460A2 (en) * 2006-01-17 2007-09-07 Endymion Medical Ltd. Electrosurgical methods and devices employing phase-controlled radiofrequency energy
AU2007245011A1 (en) * 2006-04-12 2007-11-08 Lumenis Ltd. System and method for microablation of tissue
US20080234626A1 (en) * 2006-04-26 2008-09-25 Chelak Todd M Multi-stage microporation device
US8246611B2 (en) 2006-06-14 2012-08-21 Candela Corporation Treatment of skin by spatial modulation of thermal heating
ES2993941T3 (en) * 2006-10-17 2025-01-14 Inovio Pharmaceuticals Inc Electroporation devices for electroporation of cells in mammals
US20100004582A1 (en) * 2006-10-25 2010-01-07 Pantec Biosolutions Ag Wide-Area Parasystemic Treatment of Skin Related Conditions
KR100730582B1 (ko) * 2006-11-20 2007-06-20 아람휴비스(주) 이온토포레시스 장치
WO2008062417A2 (en) * 2006-11-22 2008-05-29 Beta O2 Technologies Ltd. Protecting algae from body fluids
US20100076367A1 (en) * 2006-11-24 2010-03-25 Koninklijke Philips Electronics N. V. Iontophoretic device
AU2007325628A1 (en) 2006-11-28 2008-06-05 Marinus Pharmaceuticals Nanoparticulate formulations and methods for the making and use thereof
ES2659988T3 (es) * 2006-11-28 2018-03-20 Beta O2 Technologies Ltd. Suministro de oxígeno para el transplante celular y la vascularización
FR2909552B1 (fr) 2006-12-12 2009-11-20 Oreal Utilisation cosmetique de l'acide anisique pour favoriser la desquamation
WO2008091878A1 (en) 2007-01-22 2008-07-31 Altea Therapeutics Corporation Transdermal porator and patch system and method for using same
US20080177219A1 (en) * 2007-01-23 2008-07-24 Joshi Ashok V Method for Iontophoretic Fluid Delivery
WO2008091983A2 (en) * 2007-01-25 2008-07-31 Thermage, Inc. Treatment apparatus and methods for inducing microburn patterns in tissue
US9283029B2 (en) * 2007-01-31 2016-03-15 Alma Lasers Ltd. Skin treatment using a multi-discharge applicator
US8425488B2 (en) 2007-04-19 2013-04-23 Acclarent, Inc. System and method for the simultaneous bilateral treatment of target tissues within the ears using a guide block structure
US20080269735A1 (en) * 2007-04-26 2008-10-30 Agustina Vila Echague Optical array for treating biological tissue
JP2010525881A (ja) 2007-04-27 2010-07-29 エコー セラピューティクス， インコーポレイテッド 被検体の検知または経皮的薬物送達のための皮膚透過装置
US7853320B1 (en) 2007-05-31 2010-12-14 Purdue Pharma L.P. Transdermal device having mechanical assist for porator-to-skin contact
US8095213B1 (en) * 2007-05-31 2012-01-10 Purdue Pharma L.P. Transdermal patch
US8197844B2 (en) 2007-06-08 2012-06-12 Activatek, Inc. Active electrode for transdermal medicament administration
US20080312651A1 (en) * 2007-06-15 2008-12-18 Karl Pope Apparatus and methods for selective heating of tissue
US8047399B1 (en) 2007-07-05 2011-11-01 Purdue Pharma L.P. Dispenser for transdermal devices
US8216218B2 (en) * 2007-07-10 2012-07-10 Thermage, Inc. Treatment apparatus and methods for delivering high frequency energy across large tissue areas
JP5451613B2 (ja) 2007-08-06 2014-03-26 アラーガン、インコーポレイテッド デスモプレシン薬物送達のための方法及びデバイス
WO2009047628A2 (en) * 2007-08-17 2009-04-16 Endymed Medical Ltd. Electrosurgical methods and devices employing inductive energy
US20100121307A1 (en) * 2007-08-24 2010-05-13 Microfabrica Inc. Microneedles, Microneedle Arrays, Methods for Making, and Transdermal and/or Intradermal Applications
US8821431B2 (en) * 2007-09-07 2014-09-02 Beta O2 Technologies Ltd. Air gap for supporting cells
CA2704740C (en) * 2007-10-09 2016-05-17 Transpharma Ltd. Magnetic patch coupling
CA2696227A1 (en) * 2007-10-17 2009-04-23 Transpharma Medical Ltd. Dissolution rate verification
CA2704164A1 (en) * 2007-10-29 2009-05-07 Transpharma Medical Ltd. Vertical patch drying
JP2011505899A (ja) 2007-12-05 2011-03-03 シネロン メディカル リミテッド 使い捨て可能な電磁気エネルギーアプリケータ及びそれを使用する方法
US8192420B2 (en) 2007-12-20 2012-06-05 Acclarent, Inc. Iontophoresis methods
US20090171346A1 (en) * 2007-12-28 2009-07-02 Greg Leyh High conductivity inductively equalized electrodes and methods
US20090171341A1 (en) * 2007-12-28 2009-07-02 Karl Pope Dispersive return electrode and methods
EP2240105B1 (en) * 2008-01-17 2012-09-26 Syneron Medical Ltd. A hair removal apparatus for personal use and the method of using same
US8862223B2 (en) 2008-01-18 2014-10-14 Activatek, Inc. Active transdermal medicament patch and circuit board for same
CN101951851B (zh) 2008-01-24 2013-02-06 赛诺龙医疗公司 肥胖组织治疗的装置和器具
WO2009124096A1 (en) * 2008-03-31 2009-10-08 Altea Therapeutics Corporation Permeant delivery system and methods for use thereof
US20100286045A1 (en) 2008-05-21 2010-11-11 Bjarke Mirner Klein Methods comprising desmopressin
NO3085381T3 (https=) 2008-05-21 2018-09-15
US20090291127A1 (en) * 2008-05-21 2009-11-26 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US11963995B2 (en) 2008-05-21 2024-04-23 Ferring B.V. Methods comprising desmopressin
US8172835B2 (en) 2008-06-05 2012-05-08 Cutera, Inc. Subcutaneous electric field distribution system and methods
US20090306647A1 (en) * 2008-06-05 2009-12-10 Greg Leyh Dynamically controllable multi-electrode apparatus & methods
US9314293B2 (en) 2008-07-16 2016-04-19 Syneron Medical Ltd RF electrode for aesthetic and body shaping devices and method of using same
US20100017750A1 (en) 2008-07-16 2010-01-21 Avner Rosenberg User interface
US20100022999A1 (en) * 2008-07-24 2010-01-28 Gollnick David A Symmetrical rf electrosurgical system and methods
US8452392B2 (en) 2008-07-31 2013-05-28 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
US8840602B2 (en) 2008-07-31 2014-09-23 Acclarent, Inc. Systems and methods for anesthetizing ear tissue
WO2010029552A1 (en) * 2008-09-10 2010-03-18 Transpharma Medical Ltd. Transdermal delivery of oligosaccharides
US9446168B2 (en) 2010-06-07 2016-09-20 Beta-O2 Technologies Ltd. Multiple-layer immune barrier for donor cells
US9540630B2 (en) * 2008-09-17 2017-01-10 Beta O2 Technologies Ltd. Optimization of alginate encapsulation of islets for transplantation
WO2010032235A1 (en) 2008-09-21 2010-03-25 Syneron Medical Ltd. A method and apparatus for personal skin treatment
CA2733265A1 (en) * 2008-09-30 2010-04-08 Teikoku Pharma Usa, Inc. Transdermal extended-delivery donepezil compositions and methods for using the same
US8043271B2 (en) * 2008-11-26 2011-10-25 Beta 02 Technologies Ltd. Apparatus for transportation of oxygen to implanted cells
US8882758B2 (en) * 2009-01-09 2014-11-11 Solta Medical, Inc. Tissue treatment apparatus and systems with pain mitigation and methods for mitigating pain during tissue treatments
US8506506B2 (en) 2009-01-12 2013-08-13 Solta Medical, Inc. Tissue treatment apparatus with functional mechanical stimulation and methods for reducing pain during tissue treatments
CA2751884C (en) 2009-01-14 2018-09-25 Corium International, Inc. Transdermal administration of tamsulosin
US8606366B2 (en) 2009-02-18 2013-12-10 Syneron Medical Ltd. Skin treatment apparatus for personal use and method for using same
CA2747767A1 (en) * 2009-02-25 2010-09-02 Transpharma Medical Ltd. Electrical skin rejuvenation
US8728139B2 (en) * 2009-04-16 2014-05-20 Lazure Technologies, Llc System and method for energy delivery to a tissue using an electrode array
US20100286587A1 (en) * 2009-05-07 2010-11-11 Yossi Gross Sublingual electrical drug delivery
US8414559B2 (en) 2009-05-07 2013-04-09 Rainbow Medical Ltd. Gastroretentive duodenal pill
WO2011005894A1 (en) * 2009-07-07 2011-01-13 Naya Touch, Inc. Dermal roller with therapeutic microstructures
US8788060B2 (en) * 2009-07-16 2014-07-22 Solta Medical, Inc. Tissue treatment systems with high powered functional electrical stimulation and methods for reducing pain during tissue treatments
WO2011011774A2 (en) * 2009-07-24 2011-01-27 Cool Palms Llc Device and method for extracting heat from the palm of a hand
US8685038B2 (en) * 2009-12-07 2014-04-01 Incube Labs, Llc Iontophoretic apparatus and method for marking of the skin
US20100178307A1 (en) * 2010-01-13 2010-07-15 Jianye Wen Transdermal anti-dementia active agent formulations and methods for using the same
US20110202048A1 (en) * 2010-02-12 2011-08-18 Solta Medical, Inc. Methods for pain reduction with functional thermal stimulation and tissue treatment systems
US8788045B2 (en) 2010-06-08 2014-07-22 Bluewind Medical Ltd. Tibial nerve stimulation
US9457186B2 (en) 2010-11-15 2016-10-04 Bluewind Medical Ltd. Bilateral feedback
US9186504B2 (en) 2010-11-15 2015-11-17 Rainbow Medical Ltd Sleep apnea treatment
US20130005708A1 (en) 2011-06-29 2013-01-03 Lalwani Dinusha N Histamine antagonist treatment of inflammatory skin disorders
MX2014001073A (es) 2011-07-25 2014-03-21 Acclarent Inc Sistema y metodo personalizable para anestesiar la membrana timpanica.
US9849270B2 (en) 2011-12-16 2017-12-26 3M Innovative Properties Company Foldable adhesive composite dressing
US20150018728A1 (en) 2012-01-26 2015-01-15 Bluewind Medical Ltd. Wireless neurostimulators
SI3677252T1 (sl) 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
US9364648B2 (en) 2012-05-30 2016-06-14 Tusker Medical, Inc. Adhesive earplugs useful for sealing the ear canal
KR101979746B1 (ko) 2012-09-13 2019-05-17 (주)아모레퍼시픽 전기 천공 장치
JP5580383B2 (ja) * 2012-10-05 2014-08-27 株式会社 資生堂 美容機器及び通電方法及び記録媒体
US9861812B2 (en) 2012-12-06 2018-01-09 Blue Wind Medical Ltd. Delivery of implantable neurostimulators
US10130808B2 (en) 2013-03-14 2018-11-20 Tusker Medical, Inc. System and method for providing iontophoresis at tympanic membrane
WO2014207750A1 (en) * 2013-06-28 2014-12-31 Yosef Gross International Technologies Ltd. Skin-care system
US20160228698A1 (en) * 2013-09-19 2016-08-11 Koninklijke Philips N.V. Treatment device for the skin using radio-frequency electric current
JP6312057B2 (ja) * 2014-03-17 2018-04-18 国立大学法人東京工業大学 マイクロニードル及びそれを含むデバイス
RU2699278C2 (ru) * 2014-05-02 2019-09-04 Конинклейке Филипс Н.В. Устройство для инактивации бактерий
AU2015370443B2 (en) * 2014-07-24 2020-04-09 Sasi Solomon Device and methods for delivery of stimulation to a body tissue
GB201415611D0 (en) 2014-09-03 2014-10-15 Univ Strathclyde Apparatus for topical application of material
US9839644B2 (en) 2014-09-09 2017-12-12 ARKAY Therapeutics, LLC Formulations and methods for treatment of metabolic syndrome
WO2016059635A1 (en) 2014-10-13 2016-04-21 Glusense Ltd. Analyte-sensing device
US10179229B2 (en) 2014-12-23 2019-01-15 Edge Systems Llc Devices and methods for treating the skin using a porous member
US9764146B2 (en) 2015-01-21 2017-09-19 Bluewind Medical Ltd. Extracorporeal implant controllers
US10004896B2 (en) 2015-01-21 2018-06-26 Bluewind Medical Ltd. Anchors and implant devices
US9597521B2 (en) 2015-01-21 2017-03-21 Bluewind Medical Ltd. Transmitting coils for neurostimulation
WO2016169971A1 (en) 2015-04-20 2016-10-27 Pantec Biosolutions Ag Laser-assisted intradermal administration of active substances
US9782589B2 (en) 2015-06-10 2017-10-10 Bluewind Medical Ltd. Implantable electrostimulator for improving blood flow
US10016304B2 (en) 2015-07-16 2018-07-10 Tusker Medical, Inc. Earplug assembly for iontophoresis system
US10105540B2 (en) 2015-11-09 2018-10-23 Bluewind Medical Ltd. Optimization of application of current
US9713707B2 (en) 2015-11-12 2017-07-25 Bluewind Medical Ltd. Inhibition of implant migration
KR102687585B1 (ko) * 2016-02-05 2024-07-24 패스포트 테크놀로지스, 인크. 경피 침투제 도포 장치
EP3445872A1 (en) 2016-04-20 2019-02-27 Glusense Ltd. Fret-based glucose-detection molecules
US10124178B2 (en) 2016-11-23 2018-11-13 Bluewind Medical Ltd. Implant and delivery tool therefor
EP3342452A1 (en) * 2017-01-03 2018-07-04 L'oreal Systems including association of ellagic acid and microcurrent
EP3384904A1 (en) 2017-04-03 2018-10-10 tesa Labtec GmbH Pharmaceutical preparation for dermal administration
US20180353764A1 (en) 2017-06-13 2018-12-13 Bluewind Medical Ltd. Antenna configuration
US11251635B2 (en) 2017-12-19 2022-02-15 Welch Allyn, Inc. Vital signs monitor with a removable and dischargable battery
DE102018210051A1 (de) * 2018-06-20 2019-12-24 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Messvorrichtung und Verfahren zur Bestimmung zumindest eines respiratorischen Parameters
EP3876830B1 (en) 2018-11-11 2025-06-25 Biobeat Technologies Ltd Wearable apparatus and method for monitoring medical properties
KR102156034B1 (ko) * 2019-09-17 2020-09-15 (주)제이시스메디칼 무선주파수를 이용한 피부 처리 장치
US10813578B1 (en) 2019-12-26 2020-10-27 Biobeat Technologies Ltd. Sensor device for optical measurement of biological properties
IL273038B (en) 2020-03-03 2022-02-01 Ben Zion Karmon bone graft
US11896293B2 (en) 2020-07-21 2024-02-13 Inmode Ltd. Nasal tissue treatment method and related device
US11400299B1 (en) 2021-09-14 2022-08-02 Rainbow Medical Ltd. Flexible antenna for stimulator
USD1116120S1 (en) 2021-10-11 2026-03-03 Hydrafacial Llc Skin treatment device
USD1112778S1 (en) 2022-03-04 2026-02-10 Hydrafacial Llc Light therapy device for skin care
USD1084369S1 (en) 2023-02-10 2025-07-15 Hydrafacial Llc Skin treatment tip

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
US4775361A (en) 1986-04-10 1988-10-04 The General Hospital Corporation Controlled removal of human stratum corneum by pulsed laser to enhance percutaneous transport
US4943290A (en) 1987-06-23 1990-07-24 Concept Inc. Electrolyte purging electrode tip
EP0398960B1 (en) 1988-01-21 1995-12-06 Massachusetts Institute Of Technology Transport of molecules across tissue using electroporation
CA2071321C (en) * 1989-05-10 2000-12-12 Dan Sibalis Multi-signal electrical transdermal drug applicator
US5135478A (en) 1989-05-10 1992-08-04 Drug Delivery Systems Inc. Multi-signal electrical transdermal drug applicator
WO1992013265A1 (en) 1991-01-24 1992-08-06 The University Of Maryland Method and apparatus for multi-dimensional phase fluorescence lifetime imaging
US5648269A (en) 1991-05-03 1997-07-15 Joseph R. Lakowicz pH and pCO2 sensing by luminescent lifetimes and energy transfer
WO1992019957A2 (en) 1991-05-03 1992-11-12 University Of Maryland At Baltimore Method for optically measuring chemical analytes
US5196709A (en) 1991-05-03 1993-03-23 University Of Maryland Systems Fluorometry method and apparatus using a semiconductor laser diode as a light source
US5421817A (en) 1991-05-21 1995-06-06 E.P., Inc. Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
US5571149A (en) * 1991-05-21 1996-11-05 E.P., Inc. Non-intrusive analgesic neuroaugmentive and iontophoretic delivery apparatus and management system
US5203328A (en) 1991-07-17 1993-04-20 Georgia Tech Research Corporation Apparatus and methods for quantitatively measuring molecular changes in the ocular lens
US5281825A (en) 1991-09-05 1994-01-25 The University Of Maryland School Of Medicine Phase fluorometry using a modulated electroluminescent lamp as a light source
US5423803A (en) 1991-10-29 1995-06-13 Thermotrex Corporation Skin surface peeling process using laser
ATE143279T1 (de) * 1991-12-03 1996-10-15 Alza Corp Iontophoretische verbreichungsvorrichtung und versorgungsnetz dafür
CA2084734C (en) * 1991-12-17 1998-12-01 John L. Haynes Iontophoresis system having features for reducing skin irritation
US6024733A (en) 1995-06-07 2000-02-15 Arthrocare Corporation System and method for epidermal tissue ablation
US5697882A (en) * 1992-01-07 1997-12-16 Arthrocare Corporation System and method for electrosurgical cutting and ablation
US6159194A (en) 1992-01-07 2000-12-12 Arthrocare Corporation System and method for electrosurgical tissue contraction
US6142992A (en) * 1993-05-10 2000-11-07 Arthrocare Corporation Power supply for limiting power in electrosurgery
US6210402B1 (en) * 1995-11-22 2001-04-03 Arthrocare Corporation Methods for electrosurgical dermatological treatment
US5902272A (en) * 1992-01-07 1999-05-11 Arthrocare Corporation Planar ablation probe and method for electrosurgical cutting and ablation
US5246867A (en) 1992-01-17 1993-09-21 University Of Maryland At Baltimore Determination and quantification of saccharides by luminescence lifetimes and energy transfer
DE69326967T2 (de) 1992-01-17 2000-06-15 Lakowicz, Joseph R. Phasenmodulationsenergieübertragungsfluoroimmunassay
US5165418B1 (en) 1992-03-02 1999-12-14 Nikola I Tankovich Blood sampling device and method using a laser
US5232441A (en) 1992-05-18 1993-08-03 Physion S.R.L. Method of treating schistosomal infestations by iontophoresis
US5688233A (en) * 1992-08-17 1997-11-18 Genetronics, Inc. Electronincorporation enhanced transdermal delivery of molecules
US5462520A (en) 1992-08-17 1995-10-31 Genetronics, Inc. Transsurface drug delivery by electrofusion of microbubbles to the tissue surface
US5464386A (en) 1992-08-17 1995-11-07 Genetronics, Inc. Transdermal drug delivery by electroincorporation of vesicles
US5318514A (en) * 1992-08-17 1994-06-07 Btx, Inc. Applicator for the electroporation of drugs and genes into surface cells
US5720772A (en) * 1992-10-20 1998-02-24 Esc Medical Systems Ltd. Method and apparatus for therapeutic electromagnetic treatment
US5409835A (en) 1992-12-30 1995-04-25 The University Of Maryland At Baltimore Long-wavelength fluorescent probe compounds for calcium ions and their use in ratiometrically measuring calcium ion concentrations
US5380272A (en) * 1993-01-28 1995-01-10 Scientific Innovations Ltd. Transcutaneous drug delivery applicator
JP2916736B2 (ja) 1993-03-04 1999-07-05 宇部興産株式会社 種子消毒剤
FR2703253B1 (fr) * 1993-03-30 1995-06-23 Centre Nat Rech Scient Applicateur d'impulsions electriques pour traitement de tissus biologiques.
US5439440A (en) 1993-04-01 1995-08-08 Genetronics, Inc. Electroporation system with voltage control feedback for clinical applications
US6117109A (en) * 1995-11-22 2000-09-12 Arthrocare Corporation Systems and methods for electrosurgical incisions on external skin surfaces
US6235020B1 (en) * 1993-05-10 2001-05-22 Arthrocare Corporation Power supply and methods for fluid delivery in electrosurgery
US5445609A (en) * 1993-05-28 1995-08-29 Alza Corporation Electrotransport agent delivery device having a disposable component and a removable liner
US5458140A (en) 1993-11-15 1995-10-17 Non-Invasive Monitoring Company (Nimco) Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers
US5885211A (en) 1993-11-15 1999-03-23 Spectrix, Inc. Microporation of human skin for monitoring the concentration of an analyte
IL108775A (en) * 1994-02-25 2003-09-17 Univ Ramot Method for efficient incorporation of molecules into cells
AU2947795A (en) * 1994-06-24 1996-01-19 Cygnus, Inc. Pulsatile delivery systems of biologically active agents using electro voltage pulsing for controlling membrane permeability
US5660991A (en) 1994-10-28 1997-08-26 Lakowicz; Joseph R. Long lifetime anisotropy (polarization) probes for clinical chemistry, immunoassays, affinity assays and biomedical research
US5697896A (en) * 1994-12-08 1997-12-16 Alza Corporation Electrotransport delivery device
US5651765A (en) * 1995-04-27 1997-07-29 Avecor Cardiovascular Inc. Blood filter with concentric pleats and method of use
US5628310A (en) 1995-05-19 1997-05-13 Joseph R. Lakowicz Method and apparatus to perform trans-cutaneous analyte monitoring
US5983130A (en) * 1995-06-07 1999-11-09 Alza Corporation Electrotransport agent delivery method and apparatus
US6238391B1 (en) * 1995-06-07 2001-05-29 Arthrocare Corporation Systems for tissue resection, ablation and aspiration
US6041253A (en) 1995-12-18 2000-03-21 Massachusetts Institute Of Technology Effect of electric field and ultrasound for transdermal drug delivery
US5983131A (en) * 1995-08-11 1999-11-09 Massachusetts Institute Of Technology Apparatus and method for electroporation of tissue
AU707065B2 (en) 1995-08-29 1999-07-01 Nitto Denko Corporation Microporation of human skin for drug delivery and monitoring applications
US5688232A (en) * 1995-09-28 1997-11-18 Becton Dickinson And Company Iontophoretic drug delivery device having an improved controller
US6228078B1 (en) * 1995-11-22 2001-05-08 Arthrocare Corporation Methods for electrosurgical dermatological treatment
US6090106A (en) 1996-01-09 2000-07-18 Gyrus Medical Limited Electrosurgical instrument
US6002482A (en) 1996-01-17 1999-12-14 Spectrx, Inc. Disposable calibration device
US5792049A (en) 1996-01-17 1998-08-11 Spectrx, Inc. Spectroscopic system with disposable calibration device
US6045502A (en) 1996-01-17 2000-04-04 Spectrx, Inc. Analyzing system with disposable calibration device
US5860421A (en) 1996-01-17 1999-01-19 Spectrx, Inc. Apparatus and method for calibrating measurement systems
US5924981A (en) 1996-01-17 1999-07-20 Spectrx, Inc. Disposable calibration target
EP0914178B1 (en) * 1996-06-18 2003-03-12 Alza Corporation Device for enhancing transdermal agent delivery or sampling
CA2259437C (en) 1996-07-03 2006-12-05 Altea Technologies, Inc. Multiple mechanical microporation of skin or mucosa
US5911223A (en) * 1996-08-09 1999-06-15 Massachusetts Institute Of Technology Introduction of modifying agents into skin by electroporation
US5759767A (en) 1996-10-11 1998-06-02 Joseph R. Lakowicz Two-photon and multi-photon measurement of analytes in animal and human tissues and fluids
US6076012A (en) * 1996-12-19 2000-06-13 Ep Technologies, Inc. Structures for supporting porous electrode elements
US5938657A (en) * 1997-02-05 1999-08-17 Sahar Technologies, Inc. Apparatus for delivering energy within continuous outline
US6030399A (en) 1997-06-04 2000-02-29 Spectrx, Inc. Fluid jet blood sampling device and methods
US6009344A (en) * 1997-07-25 1999-12-28 Becton, Dickinson And Company Iontophoretic drug delivery system
JP4061022B2 (ja) 1997-12-11 2008-03-12 アルザ・コーポレーション 経皮輸送剤の流量促進装置
CA2313698C (en) 1997-12-11 2008-04-15 Alza Corporation Device for enhancing transdermal agent flux
US6055451A (en) 1997-12-12 2000-04-25 Spectrx, Inc. Apparatus and method for determining tissue characteristics
US6104952A (en) * 1998-01-07 2000-08-15 Tu; Lily Chen Devices for treating canker sores, tissues and methods thereof
US6022316A (en) * 1998-03-06 2000-02-08 Spectrx, Inc. Apparatus and method for electroporation of microporated tissue for enhancing flux rates for monitoring and delivery applications
US6173202B1 (en) 1998-03-06 2001-01-09 Spectrx, Inc. Method and apparatus for enhancing flux rates of a fluid in a microporated biological tissue
US6148232A (en) 1998-11-09 2000-11-14 Elecsys Ltd. Transdermal drug delivery and analyte extraction
US6088606A (en) 1999-03-22 2000-07-11 Spectrx, Inc. Method and apparatus for determining a duration of a medical condition
AU771818B2 (en) 1999-05-17 2004-04-01 Stephen T Flock Remote and local controlled delivery of pharmaceutical compounds using electromagnetic energy
ATE324922T1 (de) 1999-06-08 2006-06-15 Altea Therapeutics Corp Vorrichtung zur mikroporation eines biologischen gewebes mittels einer filmgewebe schnittstellenvorrichtung und verfahren
US7113821B1 (en) 1999-08-25 2006-09-26 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery
US7133717B2 (en) 1999-08-25 2006-11-07 Johnson & Johnson Consumer Companies, Inc. Tissue electroperforation for enhanced drug delivery and diagnostic sampling

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10322296B2 (en) 2009-07-20 2019-06-18 Syneron Medical Ltd. Method and apparatus for fractional skin treatment

Also Published As

Publication number Publication date
CA2349169C (en) 2012-08-14
EP1128870A4 (en) 2008-04-23
IL143014A0 (en) 2002-04-21
US6711435B2 (en) 2004-03-23
EP1128870B1 (en) 2016-08-17
EP1128870A1 (en) 2001-09-05
AU768938B2 (en) 2004-01-08
US20030097127A1 (en) 2003-05-22
JP2002529159A (ja) 2002-09-10
US20040158240A1 (en) 2004-08-12
US7123957B2 (en) 2006-10-17
US6615079B1 (en) 2003-09-02
JP2011143251A (ja) 2011-07-28
WO2000027473A1 (en) 2000-05-18
CA2349169A1 (en) 2000-05-18
US6148232A (en) 2000-11-14
AU6486899A (en) 2000-05-29

Similar Documents

Publication Publication Date Title
JP4745500B2 (ja) 経皮的な薬物の放出および分析物の抽出
JP4262985B2 (ja) 経皮で薬物送達と被検体抽出を行うための手持ち式装置と方法
AU2002307781A1 (en) Handheld apparatus for transdermal drug delivery and analyte extraction
US9028480B2 (en) Method and apparatus for fractional skin treatment
US6597946B2 (en) Electronic card for transdermal drug delivery and analyte extraction
JP4638130B2 (ja) 皮膚を通じた薬剤供給装置
IL143014A (en) Transdermal drug delivery and analyte extraction
IL158582A (en) Handheld apparatus for transdermal drug delivery and analyte extraction

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20061031

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20061031

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20090915

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20091214

A602 Written permission of extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A602

Effective date: 20091221

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20100302

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20100907

A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A524

Effective date: 20110107

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20110316

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20110412

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20110512

FPAY Renewal fee payment (event date is renewal date of database)

Free format text: PAYMENT UNTIL: 20140520

Year of fee payment: 3

R150 Certificate of patent or registration of utility model

Ref document number: 4745500

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150

Free format text: JAPANESE INTERMEDIATE CODE: R150

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

R250 Receipt of annual fees

Free format text: JAPANESE INTERMEDIATE CODE: R250

LAPS Cancellation because of no payment of annual fees