JP4728956B2 - 生体細胞との通信のための電子装置 - Google Patents

生体細胞との通信のための電子装置 Download PDF

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JP4728956B2
JP4728956B2 JP2006516796A JP2006516796A JP4728956B2 JP 4728956 B2 JP4728956 B2 JP 4728956B2 JP 2006516796 A JP2006516796 A JP 2006516796A JP 2006516796 A JP2006516796 A JP 2006516796A JP 4728956 B2 JP4728956 B2 JP 4728956B2
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cell
electrode
micronail
cells
surface substrate
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JP2006527380A5 (https=
JP2006527380A (ja
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ミカ スピーラ
ソロモ イツハク
ヨセフ シャピール
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イサム リサーチ デベロップメント カンパニー オブ ザ ヘブルー ユニバーシティ オブ エルサレム
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y10/00—Nanotechnology for information processing, storage or transmission, e.g. quantum computing or single electron logic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G01N33/48707—Physical analysis of biological material of liquid biological material by electrical means
    • G01N33/48728—Investigating individual cells, e.g. by patch clamp, voltage clamp
    • H—ELECTRICITY
    • H10—SEMICONDUCTOR DEVICES; ELECTRIC SOLID-STATE DEVICES NOT OTHERWISE PROVIDED FOR
    • H10D—INORGANIC ELECTRIC SEMICONDUCTOR DEVICES
    • H10D30/00—Field-effect transistors [FET]
    • H10D30/60—Insulated-gate field-effect transistors [IGFET]
    • H10D30/68—Floating-gate IGFETs
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/916—Hydrolases (3) acting on ester bonds (3.1), e.g. phosphatases (3.1.3), phospholipases C or phospholipases D (3.1.4)
    • G01N2333/918—Carboxylic ester hydrolases (3.1.1)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/403—Cells and electrode assemblies
    • G01N27/414—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS
    • G01N27/4146—Ion-sensitive or chemical field-effect transistors, i.e. ISFETS or CHEMFETS involving nanosized elements, e.g. nanotubes, nanowires

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nanotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biotechnology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Theoretical Computer Science (AREA)
  • Composite Materials (AREA)
  • Mathematical Physics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Pathology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
JP2006516796A 2003-06-10 2004-06-10 生体細胞との通信のための電子装置 Expired - Lifetime JP4728956B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47703703P 2003-06-10 2003-06-10
US60/477,037 2003-06-10
PCT/IL2004/000502 WO2004109282A1 (en) 2003-06-10 2004-06-10 Electronic device for communication with living cells

Publications (3)

Publication Number Publication Date
JP2006527380A JP2006527380A (ja) 2006-11-30
JP2006527380A5 JP2006527380A5 (https=) 2007-05-10
JP4728956B2 true JP4728956B2 (ja) 2011-07-20

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JP2006516796A Expired - Lifetime JP4728956B2 (ja) 2003-06-10 2004-06-10 生体細胞との通信のための電子装置

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US (1) US7795039B2 (https=)
EP (1) EP1634075B1 (https=)
JP (1) JP4728956B2 (https=)
WO (1) WO2004109282A1 (https=)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1634075B1 (en) 2003-06-10 2015-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Electronic device for communication with living cells
GB0322010D0 (en) * 2003-09-19 2003-10-22 Univ Cambridge Tech Detection of molecular interactions using field effect transistors
CA2643997A1 (en) * 2006-03-15 2008-03-06 President And Fellows Of Harvard College Nanobioelectronics
US9102521B2 (en) 2006-06-12 2015-08-11 President And Fellows Of Harvard College Nanosensors and related technologies
WO2008021758A1 (en) * 2006-08-11 2008-02-21 Home Diagnostics, Inc. Methods for fabricating a biosensor with a surface texture
WO2008127314A1 (en) 2006-11-22 2008-10-23 President And Fellows Of Harvard College High-sensitivity nanoscale wire sensors
US7948015B2 (en) 2006-12-14 2011-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US11339430B2 (en) 2007-07-10 2022-05-24 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
US8349167B2 (en) 2006-12-14 2013-01-08 Life Technologies Corporation Methods and apparatus for detecting molecular interactions using FET arrays
US8262900B2 (en) 2006-12-14 2012-09-11 Life Technologies Corporation Methods and apparatus for measuring analytes using large scale FET arrays
WO2008111047A1 (en) * 2007-03-09 2008-09-18 Imec Vzw Micro-nails for use in electrical interaction with cells
US10202711B2 (en) * 2007-05-09 2019-02-12 Massachusetts Institute Of Technology Tunable surface
JP5712129B2 (ja) * 2008-09-02 2015-05-07 ザ ガバニング カウンシル オブ ザ ユニバーシティ オブ トロント ナノ構造化微小電極およびそれを組み込んだバイオセンシング装置
US20100137143A1 (en) 2008-10-22 2010-06-03 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
US20100301398A1 (en) 2009-05-29 2010-12-02 Ion Torrent Systems Incorporated Methods and apparatus for measuring analytes
WO2010121130A2 (en) 2009-04-16 2010-10-21 President And Fellows Of Harvard College Molecular delivery with nanowires
US20120261274A1 (en) 2009-05-29 2012-10-18 Life Technologies Corporation Methods and apparatus for measuring analytes
US8776573B2 (en) 2009-05-29 2014-07-15 Life Technologies Corporation Methods and apparatus for measuring analytes
US9297796B2 (en) 2009-09-24 2016-03-29 President And Fellows Of Harvard College Bent nanowires and related probing of species
US8487790B2 (en) 2010-06-30 2013-07-16 Life Technologies Corporation Chemical detection circuit including a serializer circuit
EP2588850B1 (en) 2010-06-30 2016-12-28 Life Technologies Corporation Method for dry testing isfet arrays
AU2011226767B1 (en) 2010-06-30 2011-11-10 Life Technologies Corporation Ion-sensing charge-accumulation circuits and methods
US11307166B2 (en) 2010-07-01 2022-04-19 Life Technologies Corporation Column ADC
CN103168341B (zh) 2010-07-03 2016-10-05 生命科技公司 具有轻度掺杂的排出装置的化学敏感的传感器
EP2617061B1 (en) 2010-09-15 2021-06-30 Life Technologies Corporation Methods and apparatus for measuring analytes
JP5913323B2 (ja) 2010-09-24 2016-04-27 ライフ テクノロジーズ コーポレーション マッチドペアトランジスタ回路
US9629995B2 (en) 2011-05-26 2017-04-25 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Biomolecular electronic device and process of use
US9595685B2 (en) 2011-06-10 2017-03-14 President And Fellows Of Harvard College Nanoscale wires, nanoscale wire FET devices, and nanotube-electronic hybrid devices for sensing and other applications
US9762233B2 (en) * 2011-08-16 2017-09-12 Erez Halahmi System for a contactless control of a field effect transistor
KR101366391B1 (ko) * 2011-10-05 2014-02-25 한양대학교 산학협력단 세포 계수용 칩
US9970984B2 (en) 2011-12-01 2018-05-15 Life Technologies Corporation Method and apparatus for identifying defects in a chemical sensor array
US8786331B2 (en) 2012-05-29 2014-07-22 Life Technologies Corporation System for reducing noise in a chemical sensor array
US9080968B2 (en) 2013-01-04 2015-07-14 Life Technologies Corporation Methods and systems for point of use removal of sacrificial material
US9841398B2 (en) 2013-01-08 2017-12-12 Life Technologies Corporation Methods for manufacturing well structures for low-noise chemical sensors
US8963216B2 (en) 2013-03-13 2015-02-24 Life Technologies Corporation Chemical sensor with sidewall spacer sensor surface
US9835585B2 (en) 2013-03-15 2017-12-05 Life Technologies Corporation Chemical sensor with protruded sensor surface
CN105264366B (zh) 2013-03-15 2019-04-16 生命科技公司 具有一致传感器表面区域的化学传感器
US20140264471A1 (en) * 2013-03-15 2014-09-18 Life Technologies Corporation Chemical device with thin conductive element
US20140336063A1 (en) 2013-05-09 2014-11-13 Life Technologies Corporation Windowed Sequencing
US10458942B2 (en) 2013-06-10 2019-10-29 Life Technologies Corporation Chemical sensor array having multiple sensors per well
TWI647842B (zh) * 2013-08-22 2019-01-11 美商生命技術公司 具薄導電元件之化學裝置
US10077472B2 (en) 2014-12-18 2018-09-18 Life Technologies Corporation High data rate integrated circuit with power management
CN111505087A (zh) 2014-12-18 2020-08-07 生命科技公司 使用大规模 fet 阵列测量分析物的方法和装置
EP3234576B1 (en) 2014-12-18 2023-11-22 Life Technologies Corporation High data rate integrated circuit with transmitter configuration
US20180169403A1 (en) 2015-01-09 2018-06-21 President And Fellows Of Harvard College Nanowire arrays for neurotechnology and other applications
GB201512600D0 (en) * 2015-07-17 2015-08-26 Koniku Ltd Cell culture, transport and investigation
US11474103B2 (en) 2017-02-17 2022-10-18 Koniku Inc. Systems for detection
CN107085097B (zh) * 2017-05-14 2020-08-28 浙江达普生物科技有限公司 一种血检芯片及其制作方法
KR20250125660A (ko) * 2024-02-15 2025-08-22 서울대학교산학협력단 수직 나노구조체가 적용된 전계 효과 트랜지스터를 포함하는 세포 신호 측정 소자와 그 제조 및 동작 방법

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546083A (en) * 1983-04-22 1985-10-08 Stolle Research & Development Corporation Method and device for cell culture growth
US6846654B1 (en) * 1983-11-29 2005-01-25 Igen International, Inc. Catalytic antibodies as chemical sensors
CA2157388C (en) * 1993-03-01 1998-12-15 Daniel P. Witt Analogs for specific oligosaccharide-protein interactions and uses thereof
DE19841337C1 (de) 1998-05-27 1999-09-23 Micronas Intermetall Gmbh Verfahren und Vorrichtung zur intrazellulären Manipulation einer biologischen Zelle
JP3515908B2 (ja) 1998-09-24 2004-04-05 エヌ・ティ・ティ・アドバンステクノロジ株式会社 微少量オンラインバイオセンサー及びその製造方法
IL145020A0 (en) * 1999-02-22 2002-06-30 Yissum Res Dev Co A hybrid electrical device with biological components
JP2001156398A (ja) 1999-05-19 2001-06-08 Canon Inc 半導体素子の製造方法、半導体素子、及びジャイロ
NZ518057A (en) 1999-10-01 2004-01-30 Sophion Bioscience As A substrate and a method for determining and/or monitoring electrophysiological properties of ion channels
JP2004514417A (ja) * 2000-07-07 2004-05-20 ブリストル−マイヤーズ　スクイブ　カンパニー 薬品発見用化合物の高速処理スクリーニングに適した電気生理学的配置
US6465331B1 (en) * 2000-08-31 2002-10-15 Micron Technology, Inc. DRAM fabricated on a silicon-on-insulator (SOI) substrate having bi-level digit lines
AU2003240561A1 (en) 2002-06-06 2003-12-22 Rutgers, The State University Of New Jersey MULTIFUNCTIONAL BIOSENSOR BASED ON ZnO NANOSTRUCTURES
IL152746A0 (en) 2002-11-11 2003-06-24 Yissum Res Dev Co Biosensor for molecules
EP1634075B1 (en) 2003-06-10 2015-01-14 Yissum Research Development Company Of The Hebrew University Of Jerusalem Electronic device for communication with living cells
US7270973B2 (en) * 2003-12-23 2007-09-18 The United States Of America As Represented By The Secretary Of The Navy Catalytic enzyme-modified textiles for active protection from toxins

Also Published As

Publication number Publication date
US7795039B2 (en) 2010-09-14
WO2004109282A1 (en) 2004-12-16
US20070099173A1 (en) 2007-05-03
EP1634075A1 (en) 2006-03-15
EP1634075B1 (en) 2015-01-14
JP2006527380A (ja) 2006-11-30

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