JP4683682B2 - 平滑筋細胞および/または内皮細胞への組織向性を与えられた遺伝子送達ベクター - Google Patents
平滑筋細胞および/または内皮細胞への組織向性を与えられた遺伝子送達ベクター Download PDFInfo
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C12N2710/00011—Details
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- C12N2710/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
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- C12N2710/10341—Use of virus, viral particle or viral elements as a vector
- C12N2710/10345—Special targeting system for viral vectors
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- C12N2810/00—Vectors comprising a targeting moiety
- C12N2810/50—Vectors comprising as targeting moiety peptide derived from defined protein
- C12N2810/60—Vectors comprising as targeting moiety peptide derived from defined protein from viruses
- C12N2810/6009—Vectors comprising as targeting moiety peptide derived from defined protein from viruses dsDNA viruses
- C12N2810/6018—Adenoviridae
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EP98203921 | 1998-11-20 | ||
EP98203921:6 | 1998-11-20 |
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JP2000157289A JP2000157289A (ja) | 2000-06-13 |
JP2000157289A5 JP2000157289A5 (fr) | 2009-10-22 |
JP4683682B2 true JP4683682B2 (ja) | 2011-05-18 |
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JP (1) | JP4683682B2 (fr) |
AT (1) | ATE296894T1 (fr) |
AU (1) | AU770780B2 (fr) |
CA (1) | CA2318492C (fr) |
DE (1) | DE69925567T2 (fr) |
ES (1) | ES2244145T3 (fr) |
IL (1) | IL133032A (fr) |
MX (1) | MXPA99010682A (fr) |
NO (1) | NO995697L (fr) |
NZ (1) | NZ501214A (fr) |
WO (1) | WO2000031285A1 (fr) |
ZA (1) | ZA997213B (fr) |
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US6929946B1 (en) | 1998-11-20 | 2005-08-16 | Crucell Holland B.V. | Gene delivery vectors provided with a tissue tropism for smooth muscle cells, and/or endothelial cells |
AU776067B2 (en) * | 1999-03-04 | 2004-08-26 | Crucell Holland B.V. | Means and methods for fibroblast-like or macrophage-like cell transduction |
US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
EP1285079A2 (fr) | 2000-05-31 | 2003-02-26 | University of Saskatchewan | Adenovirus bovin modifie avec modification du tropisme |
CA2421864A1 (fr) * | 2000-09-20 | 2002-03-28 | Crucell Holland B.V. | Vecteurs de transfert de genes munis d'un tropisme tissulaire pour des cellules dendritiques |
US6905678B2 (en) * | 2001-07-07 | 2005-06-14 | Crucell Holland B.V. | Gene delivery vectors with cell type specificity for mesenchymal stem cells |
EP1482052A1 (fr) * | 2003-05-27 | 2004-12-01 | Cytos Biotechnology AG | Polypeptides modifiées pour cibler l'entrée des Adenovirus de sous-typ B dans une cellule |
US11253608B2 (en) | 2017-05-26 | 2022-02-22 | Epicentrx, Inc. | Recombinant adenoviruses carrying transgenes |
Citations (1)
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WO1997000326A1 (fr) * | 1995-06-15 | 1997-01-03 | Introgene B.V. | Systemes d'empaquetage pour adenovirus recombinant chez l'homme, destine a la therapie genique |
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US5770442A (en) * | 1995-02-21 | 1998-06-23 | Cornell Research Foundation, Inc. | Chimeric adenoviral fiber protein and methods of using same |
IL124654A0 (en) * | 1995-11-28 | 1998-12-06 | Genvec Inc | Vectors and method for gene transfer to cells |
US5877011A (en) * | 1996-11-20 | 1999-03-02 | Genzyme Corporation | Chimeric adenoviral vectors |
FR2758822B1 (fr) * | 1997-01-30 | 1999-07-02 | Centre Nat Rech Scient | Utilisation d'un polypeptide a titre de recepteur cellulaire des adenovirus |
FR2761689B1 (fr) * | 1997-04-02 | 1999-06-25 | Transgene Sa | Fibre adenovirale modifiee et adenovirus cibles |
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- 1999-11-19 ZA ZA9907213A patent/ZA997213B/xx unknown
- 1999-11-22 WO PCT/NL1999/000717 patent/WO2000031285A1/fr unknown
- 1999-11-22 JP JP33203399A patent/JP4683682B2/ja not_active Expired - Fee Related
- 1999-11-22 AU AU59600/99A patent/AU770780B2/en not_active Ceased
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WO1997000326A1 (fr) * | 1995-06-15 | 1997-01-03 | Introgene B.V. | Systemes d'empaquetage pour adenovirus recombinant chez l'homme, destine a la therapie genique |
Also Published As
Publication number | Publication date |
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AU5960099A (en) | 2000-05-25 |
MXPA99010682A (es) | 2002-03-08 |
NZ501214A (en) | 2002-02-01 |
IL133032A (en) | 2007-06-03 |
CA2318492C (fr) | 2010-05-11 |
NO995697L (no) | 2000-05-22 |
ATE296894T1 (de) | 2005-06-15 |
IL133032A0 (en) | 2001-03-19 |
ES2244145T3 (es) | 2005-12-01 |
ZA997213B (en) | 2000-05-22 |
JP2000157289A (ja) | 2000-06-13 |
DE69925567T2 (de) | 2006-05-04 |
DE69925567D1 (de) | 2005-07-07 |
NO995697D0 (no) | 1999-11-19 |
AU770780B2 (en) | 2004-03-04 |
WO2000031285A1 (fr) | 2000-06-02 |
CA2318492A1 (fr) | 2000-06-02 |
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LAPS | Cancellation because of no payment of annual fees |