JP4663634B2 - 腫瘍転移の分析のための動物モデル - Google Patents

腫瘍転移の分析のための動物モデル Download PDF

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JP4663634B2
JP4663634B2 JP2006518659A JP2006518659A JP4663634B2 JP 4663634 B2 JP4663634 B2 JP 4663634B2 JP 2006518659 A JP2006518659 A JP 2006518659A JP 2006518659 A JP2006518659 A JP 2006518659A JP 4663634 B2 JP4663634 B2 JP 4663634B2
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metastasis
cells
cancer
tumor
metastatic
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JP2007527216A (ja
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雅登 中村
保行 大西
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Central Institute for Experimental Animals
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A01K67/0276—Knock-out vertebrates
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
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    • A61K49/0008—Screening agents using (non-human) animal models or transgenic animal models or chimeric hosts, e.g. Alzheimer disease animal model, transgenic model for heart failure
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57525—Immunoassay; Biospecific binding assay; Materials therefor for cancer of the liver or pancreas
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/0331—Animal model for proliferative diseases
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    • C12N2799/00—Uses of viruses
    • C12N2799/02—Uses of viruses as vector
    • C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/136—Screening for pharmacological compounds
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Environmental Sciences (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Medicinal Chemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Hematology (AREA)
  • Animal Husbandry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Physics & Mathematics (AREA)
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JP2006518659A 2003-07-10 2004-06-18 腫瘍転移の分析のための動物モデル Expired - Fee Related JP4663634B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48704403P 2003-07-10 2003-07-10
PCT/US2004/019697 WO2005013682A2 (en) 2003-07-10 2004-06-18 Animal model for the analysis of tumor metastasis

Related Child Applications (1)

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JP2010208640A Division JP2011030570A (ja) 2003-07-10 2010-09-16 腫瘍転移の分析のための動物モデル

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JP2007527216A JP2007527216A (ja) 2007-09-27
JP4663634B2 true JP4663634B2 (ja) 2011-04-06

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JP2006518659A Expired - Fee Related JP4663634B2 (ja) 2003-07-10 2004-06-18 腫瘍転移の分析のための動物モデル
JP2010208640A Withdrawn JP2011030570A (ja) 2003-07-10 2010-09-16 腫瘍転移の分析のための動物モデル

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US (1) US20050132427A1 (https=)
EP (1) EP1644732B1 (https=)
JP (2) JP4663634B2 (https=)
AT (1) ATE458997T1 (https=)
AU (1) AU2004263079A1 (https=)
CA (1) CA2531916A1 (https=)
DE (1) DE602004025706D1 (https=)
WO (1) WO2005013682A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4356923A1 (en) 2022-10-20 2024-04-24 Universidade de Aveiro Pkmyt1 for use in regenerative medicine

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006039678A2 (en) * 2004-09-29 2006-04-13 Central Institue For Experimental Animals Establishment of highly metastatic cell lines using nog mice
CN1920564B (zh) * 2005-08-26 2011-08-24 中国科学院上海生命科学研究院 细胞转录因子ilf-1的应用
JP2007139656A (ja) * 2005-11-21 2007-06-07 Igaku Seibutsugaku Kenkyusho:Kk 食道癌診断キット
US20070283453A1 (en) * 2006-05-31 2007-12-06 Juan Carlos Rodriguez Cimadevilla Animal models of tumor metastasis and toxicity
CA2681899C (en) 2007-03-27 2018-06-19 Immunovia Ab Methods for diagnosis of pancreatic adenocarcinoma, and biomarkers and arrays for use in the same
WO2010118782A1 (en) * 2009-04-17 2010-10-21 Universite Libre De Bruxelles Methods and tools for predicting the efficiency of anthracyclines in cancer
WO2012106529A1 (en) * 2011-02-02 2012-08-09 The Trustees Of Princeton University Jagged1 as a marker and therapeutic target for breast cancer bone metastasis
ES2645366T3 (es) 2011-02-11 2017-12-05 The Rockefeller University Tratamiento de trastornos de la angiogénesis
WO2013035779A1 (ja) * 2011-09-06 2013-03-14 国立大学法人東京大学 細胞間の相互作用の解析方法
EP3310159B1 (en) 2015-06-16 2024-10-09 The Jackson Laboratory Genetically modified mice and methods relating to complement dependent cytotoxicity
KR102664078B1 (ko) 2015-06-23 2024-05-10 더 잭슨 래보라토리 환자-유래 이종이식을 가지는 hla-비매칭의 인간화된 nsg 마우스 모델
KR101992817B1 (ko) * 2016-02-15 2019-09-30 고려대학교 산학협력단 폐암 동물모델의 제조방법
WO2017142292A1 (ko) * 2016-02-15 2017-08-24 고려대학교 산학협력단 폐암 동물모델의 제조방법
RU2725273C1 (ru) * 2019-11-05 2020-06-30 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр онкологии" Министерства здравоохранения Российской Федерации Способ трансплантации фрагмента нейроэндокринной опухоли поджелудочной железы человека в поджелудочную железу иммунодефицитных мышей
GB202010970D0 (en) 2020-07-16 2020-09-02 Immunovia Ab Methods, arrays and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1338198B1 (en) * 2000-12-01 2007-11-28 Central Institute For Experimental Animals Method of constructing mouse suitable for the take, differentiation and proliferation of heterogenous cells, mouse constructed by this method and use of the mouse
US7135609B2 (en) * 2001-05-10 2006-11-14 Chugai Seiyaku Kabushiki Kaisha Non-human animal exhibiting bone metastasis of tumor cells and method of screening for bone metastasis inhibitors

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4356923A1 (en) 2022-10-20 2024-04-24 Universidade de Aveiro Pkmyt1 for use in regenerative medicine

Also Published As

Publication number Publication date
JP2007527216A (ja) 2007-09-27
WO2005013682A2 (en) 2005-02-17
US20050132427A1 (en) 2005-06-16
EP1644732A2 (en) 2006-04-12
EP1644732B1 (en) 2010-02-24
CA2531916A1 (en) 2005-02-17
JP2011030570A (ja) 2011-02-17
AU2004263079A1 (en) 2005-02-17
DE602004025706D1 (https=) 2010-04-08
WO2005013682A3 (en) 2005-07-28
ATE458997T1 (de) 2010-03-15

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