JP4613279B2 - 高スループットオートサンプラー - Google Patents
高スループットオートサンプラー Download PDFInfo
- Publication number
- JP4613279B2 JP4613279B2 JP2006539662A JP2006539662A JP4613279B2 JP 4613279 B2 JP4613279 B2 JP 4613279B2 JP 2006539662 A JP2006539662 A JP 2006539662A JP 2006539662 A JP2006539662 A JP 2006539662A JP 4613279 B2 JP4613279 B2 JP 4613279B2
- Authority
- JP
- Japan
- Prior art keywords
- sample
- mass spectrometer
- valve
- fluid
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012530 fluid Substances 0.000 abstract description 133
- 239000011159 matrix material Substances 0.000 abstract description 111
- 239000012491 analyte Substances 0.000 abstract description 68
- 238000004458 analytical method Methods 0.000 abstract description 31
- 238000004587 chromatography analysis Methods 0.000 abstract description 27
- 238000010828 elution Methods 0.000 abstract description 19
- 238000002360 preparation method Methods 0.000 abstract description 12
- 230000000737 periodic effect Effects 0.000 abstract description 8
- 239000000523 sample Substances 0.000 description 244
- 238000002347 injection Methods 0.000 description 86
- 239000007924 injection Substances 0.000 description 86
- 239000000203 mixture Substances 0.000 description 41
- 238000004949 mass spectrometry Methods 0.000 description 32
- 238000000034 method Methods 0.000 description 32
- 150000001875 compounds Chemical class 0.000 description 31
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 24
- 238000004891 communication Methods 0.000 description 24
- 239000000243 solution Substances 0.000 description 22
- 238000003556 assay Methods 0.000 description 20
- 230000002829 reductive effect Effects 0.000 description 20
- 239000007788 liquid Substances 0.000 description 17
- 238000004140 cleaning Methods 0.000 description 16
- 239000000872 buffer Substances 0.000 description 14
- 239000002904 solvent Substances 0.000 description 14
- 230000008569 process Effects 0.000 description 13
- 238000012360 testing method Methods 0.000 description 13
- 238000010586 diagram Methods 0.000 description 11
- 230000002441 reversible effect Effects 0.000 description 11
- 238000009792 diffusion process Methods 0.000 description 10
- 238000000132 electrospray ionisation Methods 0.000 description 10
- 239000000126 substance Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 230000008406 drug-drug interaction Effects 0.000 description 9
- 239000000463 material Substances 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- 239000002699 waste material Substances 0.000 description 9
- 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 8
- 230000002503 metabolic effect Effects 0.000 description 8
- 238000011002 quantification Methods 0.000 description 8
- 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 7
- 238000013459 approach Methods 0.000 description 7
- 239000012504 chromatography matrix Substances 0.000 description 7
- 239000003814 drug Substances 0.000 description 7
- 238000013537 high throughput screening Methods 0.000 description 7
- 238000004811 liquid chromatography Methods 0.000 description 7
- 230000003287 optical effect Effects 0.000 description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 108090000790 Enzymes Proteins 0.000 description 6
- 102000004190 Enzymes Human genes 0.000 description 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
- 238000000065 atmospheric pressure chemical ionisation Methods 0.000 description 6
- 239000011324 bead Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 6
- 229940088598 enzyme Drugs 0.000 description 6
- 238000005086 pumping Methods 0.000 description 6
- 239000010935 stainless steel Substances 0.000 description 6
- 229910001220 stainless steel Inorganic materials 0.000 description 6
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 5
- XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 5
- 238000004590 computer program Methods 0.000 description 5
- 229960001985 dextromethorphan Drugs 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 230000007613 environmental effect Effects 0.000 description 5
- 230000002209 hydrophobic effect Effects 0.000 description 5
- 210000004185 liver Anatomy 0.000 description 5
- 239000000550 preparative sample Substances 0.000 description 5
- 229920005989 resin Polymers 0.000 description 5
- 239000011347 resin Substances 0.000 description 5
- 239000007921 spray Substances 0.000 description 5
- 239000000758 substrate Substances 0.000 description 5
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 4
- 239000004696 Poly ether ether ketone Substances 0.000 description 4
- 239000004642 Polyimide Substances 0.000 description 4
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 4
- 229940090047 auto-injector Drugs 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- 230000001276 controlling effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 230000033001 locomotion Effects 0.000 description 4
- 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 4
- 229920002530 polyetherether ketone Polymers 0.000 description 4
- 229920001721 polyimide Polymers 0.000 description 4
- 108010001237 Cytochrome P-450 CYP2D6 Proteins 0.000 description 3
- 102100021704 Cytochrome P450 2D6 Human genes 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- 239000007853 buffer solution Substances 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000011109 contamination Methods 0.000 description 3
- 230000006837 decompression Effects 0.000 description 3
- 239000012156 elution solvent Substances 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 238000005070 sampling Methods 0.000 description 3
- 239000004094 surface-active agent Substances 0.000 description 3
- 239000002202 Polyethylene glycol Substances 0.000 description 2
- 229920006362 Teflon® Polymers 0.000 description 2
- 229910001069 Ti alloy Inorganic materials 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 238000009825 accumulation Methods 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 230000015556 catabolic process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000006731 degradation reaction Methods 0.000 description 2
- 238000002724 drug interaction assay Methods 0.000 description 2
- 238000011067 equilibration Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 239000012535 impurity Substances 0.000 description 2
- 238000001727 in vivo Methods 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 230000003993 interaction Effects 0.000 description 2
- 238000005040 ion trap Methods 0.000 description 2
- 150000002634 lipophilic molecules Chemical class 0.000 description 2
- 210000001853 liver microsome Anatomy 0.000 description 2
- 210000005228 liver tissue Anatomy 0.000 description 2
- 229910001629 magnesium chloride Inorganic materials 0.000 description 2
- 230000007257 malfunction Effects 0.000 description 2
- 230000004060 metabolic process Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000002414 normal-phase solid-phase extraction Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001223 polyethylene glycol Polymers 0.000 description 2
- 239000011535 reaction buffer Substances 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 230000035945 sensitivity Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000001179 sorption measurement Methods 0.000 description 2
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- USFZMSVCRYTOJT-UHFFFAOYSA-N Ammonium acetate Chemical compound N.CC(O)=O USFZMSVCRYTOJT-UHFFFAOYSA-N 0.000 description 1
- 239000005695 Ammonium acetate Substances 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 102000003849 Cytochrome P450 Human genes 0.000 description 1
- 238000000018 DNA microarray Methods 0.000 description 1
- 101150053185 P450 gene Proteins 0.000 description 1
- 102000001708 Protein Isoforms Human genes 0.000 description 1
- 108010029485 Protein Isoforms Proteins 0.000 description 1
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 description 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 239000004809 Teflon Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000012190 activator Substances 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 150000001335 aliphatic alkanes Chemical group 0.000 description 1
- 235000019257 ammonium acetate Nutrition 0.000 description 1
- 229940043376 ammonium acetate Drugs 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 235000012501 ammonium carbonate Nutrition 0.000 description 1
- 239000012131 assay buffer Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000004440 column chromatography Methods 0.000 description 1
- 239000012468 concentrated sample Substances 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 229940079919 digestives enzyme preparation Drugs 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000009509 drug development Methods 0.000 description 1
- 238000007876 drug discovery Methods 0.000 description 1
- 230000009977 dual effect Effects 0.000 description 1
- 230000004064 dysfunction Effects 0.000 description 1
- 239000003480 eluent Substances 0.000 description 1
- 239000012149 elution buffer Substances 0.000 description 1
- 238000003891 environmental analysis Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 238000004374 forensic analysis Methods 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- 239000005350 fused silica glass Substances 0.000 description 1
- 238000007429 general method Methods 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 238000000099 in vitro assay Methods 0.000 description 1
- 238000005462 in vivo assay Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 230000002452 interceptive effect Effects 0.000 description 1
- 239000002563 ionic surfactant Substances 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003228 microsomal effect Effects 0.000 description 1
- 210000001589 microsome Anatomy 0.000 description 1
- 230000003278 mimic effect Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000007837 multiplex assay Methods 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 238000011017 operating method Methods 0.000 description 1
- 238000005457 optimization Methods 0.000 description 1
- 239000002985 plastic film Substances 0.000 description 1
- 229920006255 plastic film Polymers 0.000 description 1
- -1 polytetrafluoroethylene Polymers 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229910000160 potassium phosphate Inorganic materials 0.000 description 1
- 235000011009 potassium phosphates Nutrition 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000013094 purity test Methods 0.000 description 1
- 238000003908 quality control method Methods 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 230000000171 quenching effect Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 239000012488 sample solution Substances 0.000 description 1
- 239000004065 semiconductor Substances 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 150000003384 small molecules Chemical class 0.000 description 1
- 239000012064 sodium phosphate buffer Substances 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 239000002676 xenobiotic agent Substances 0.000 description 1
- 230000002034 xenobiotic effect Effects 0.000 description 1
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/40—Flow patterns using back flushing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/28—Control of physical parameters of the fluid carrier
- G01N30/32—Control of physical parameters of the fluid carrier of pressure or speed
- G01N2030/324—Control of physical parameters of the fluid carrier of pressure or speed speed, flow rate
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/40—Flow patterns using back flushing
- G01N2030/405—Flow patterns using back flushing re-concentrating or inverting previous separation
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N2030/626—Detectors specially adapted therefor calibration, baseline
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/24—Automatic injection systems
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/466—Flow patterns using more than one column with separation columns in parallel
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
- G01N30/7233—Mass spectrometers interfaced to liquid or supercritical fluid chromatograph
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1095—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers
- G01N35/1097—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices for supplying the samples to flow-through analysers characterised by the valves
Landscapes
- Immunology (AREA)
- Pathology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
- Sampling And Sample Adjustment (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Threshing Machine Elements (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51824003P | 2003-11-07 | 2003-11-07 | |
| PCT/US2004/036885 WO2005048126A2 (en) | 2003-11-07 | 2004-11-08 | High throughput autosampler |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007512515A JP2007512515A (ja) | 2007-05-17 |
| JP2007512515A5 JP2007512515A5 (https=) | 2009-11-12 |
| JP4613279B2 true JP4613279B2 (ja) | 2011-01-12 |
Family
ID=34590239
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006539662A Expired - Lifetime JP4613279B2 (ja) | 2003-11-07 | 2004-11-08 | 高スループットオートサンプラー |
Country Status (6)
| Country | Link |
|---|---|
| EP (2) | EP1685397B1 (https=) |
| JP (1) | JP4613279B2 (https=) |
| AT (1) | ATE494547T1 (https=) |
| CA (1) | CA2548073A1 (https=) |
| DE (1) | DE602004030938D1 (https=) |
| WO (1) | WO2005048126A2 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017154083A1 (ja) | 2016-03-07 | 2017-09-14 | 株式会社日立ハイテクノロジーズ | 分析装置 |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8414774B2 (en) | 2001-04-25 | 2013-04-09 | Agilent Technologies, Inc. | Systems and methods for high-throughput screening of fluidic samples |
| WO2009059286A1 (en) * | 2007-11-02 | 2009-05-07 | Biotrove, Inc. | Devices and methods for coupling mass spectrometry devices with chromatography systems |
| WO2009111228A2 (en) * | 2008-02-29 | 2009-09-11 | Waters Technologies Corporation | Chromatography-based monitoring and control of multiple process streams |
| EP2343549B1 (en) * | 2008-10-03 | 2020-08-19 | ARKRAY, Inc. | Analyzing device and method for controlling same |
| GB0917735D0 (en) | 2009-10-09 | 2009-11-25 | Sphere Medical Ltd | Sensor |
| GB201017256D0 (en) | 2010-10-13 | 2010-11-24 | Sphere Medical Ltd | Sensor and method |
| GB201017479D0 (en) | 2010-10-15 | 2010-12-01 | Sphere Medical Ltd | Analyte Extraction apparatus and method |
| CN105408735A (zh) * | 2013-07-03 | 2016-03-16 | 怀亚特技术公司 | 控制分析仪器中样品污染的方法和设备 |
| KR102308590B1 (ko) | 2014-02-27 | 2021-10-01 | 엘리멘탈 사이언티픽, 인코포레이티드 | 원거리에서 액체 샘플을 수집하기 위한 시스템 |
| US10585075B2 (en) | 2014-02-27 | 2020-03-10 | Elemental Scientific, Inc. | System for collecting liquid samples |
| CN107850514B (zh) | 2015-06-26 | 2021-06-08 | 基础科学公司 | 用于采集液体样品的系统 |
| DE102016121515A1 (de) * | 2016-11-10 | 2018-05-17 | Dionex Softron Gmbh | Verfahren zum Einführen einer Probe in eine Trennsäule und entsprechendes System |
| US11298701B2 (en) | 2018-11-26 | 2022-04-12 | King Instrumentation Technologies | Microtiter plate mixing control system |
| EP3896443B1 (en) * | 2020-04-15 | 2024-05-01 | F. Hoffmann-La Roche AG | Analytical system and method including switching between liquid chromatography fluidic streams |
| JP7357787B2 (ja) * | 2020-05-29 | 2023-10-06 | 株式会社日立ハイテク | 自動分析装置の制御方法 |
| CN113075339A (zh) * | 2021-04-28 | 2021-07-06 | 大庆东鼎仪器制造有限公司 | 轻烃减压等组成转化装置及方法 |
| CN116973517B (zh) * | 2023-08-08 | 2024-03-26 | 中国科学院大气物理研究所 | 一种大气痕量气体排放与沉降通量测量装置 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3524305A (en) * | 1967-12-26 | 1970-08-18 | Phillips Petroleum Co | Minimizing switching transients in multiple column chromatography |
| US4913821A (en) * | 1989-04-27 | 1990-04-03 | The Dow Chemical Company | Method for the determination of phenols in water |
| US5814742A (en) | 1996-10-11 | 1998-09-29 | L C Packings, Nederland B.V. | Fully automated micro-autosampler for micro, capillary and nano high performance liquid chromatography |
| JP3192401B2 (ja) * | 1997-04-01 | 2001-07-30 | 和光純薬工業株式会社 | 液体試料成分の分離方法及び該方法に使用する装置 |
| TW422712B (en) * | 1997-04-01 | 2001-02-21 | Wako Pure Chem Ind Ltd | Liquid test components separation method and equipment thereof |
| JP2000123784A (ja) * | 1998-10-15 | 2000-04-28 | Hitachi Ltd | 四重極質量分析装置 |
-
2004
- 2004-11-08 JP JP2006539662A patent/JP4613279B2/ja not_active Expired - Lifetime
- 2004-11-08 CA CA002548073A patent/CA2548073A1/en not_active Abandoned
- 2004-11-08 EP EP04800778A patent/EP1685397B1/en not_active Expired - Lifetime
- 2004-11-08 EP EP10160627.5A patent/EP2214010B1/en not_active Expired - Lifetime
- 2004-11-08 DE DE602004030938T patent/DE602004030938D1/de not_active Expired - Lifetime
- 2004-11-08 WO PCT/US2004/036885 patent/WO2005048126A2/en not_active Ceased
- 2004-11-08 AT AT04800778T patent/ATE494547T1/de not_active IP Right Cessation
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017154083A1 (ja) | 2016-03-07 | 2017-09-14 | 株式会社日立ハイテクノロジーズ | 分析装置 |
| US11385208B2 (en) | 2016-03-07 | 2022-07-12 | Hitachi High-Tech Corporation | Analysis device |
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004030938D1 (de) | 2011-02-17 |
| WO2005048126A2 (en) | 2005-05-26 |
| JP2007512515A (ja) | 2007-05-17 |
| EP2214010A3 (en) | 2011-03-30 |
| EP2214010B1 (en) | 2017-07-19 |
| CA2548073A1 (en) | 2005-05-26 |
| EP1685397B1 (en) | 2011-01-05 |
| EP2214010A2 (en) | 2010-08-04 |
| EP1685397A2 (en) | 2006-08-02 |
| WO2005048126A3 (en) | 2005-12-22 |
| ATE494547T1 (de) | 2011-01-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US7588725B2 (en) | High throughput autosampler | |
| JP5433580B2 (ja) | 試料注入システム | |
| JP4613279B2 (ja) | 高スループットオートサンプラー | |
| US8414774B2 (en) | Systems and methods for high-throughput screening of fluidic samples | |
| US20050123970A1 (en) | High throughput autosampler | |
| JP2007512515A5 (https=) | ||
| US5814742A (en) | Fully automated micro-autosampler for micro, capillary and nano high performance liquid chromatography | |
| Tan et al. | Chip-based solid-phase extraction pretreatment for direct electrospray mass spectrometry analysis using an array of monolithic columns in a polymeric substrate | |
| CN115398222B (zh) | 包括液相色谱流体物流之间的切换的分析系统和方法 | |
| US20070134808A1 (en) | Simultaneous multi-column liquid chromatograph for direct sampling of an array of liquid samples | |
| CN108780064B (zh) | 分析装置 | |
| Rule et al. | High-throughput sample preparation and analysis using 96-well membrane solid-phase extraction and liquid chromatography-tandem mass spectrometry for the determination of steroids in human urine | |
| CN116583732A (zh) | 自动取样器的流路清洗方法和自动取样器的流路清洗装置 | |
| Plumb et al. | The application of fast gradient capillary liquid chromatography/mass spectrometry to the analysis of pharmaceuticals in biofluids | |
| Chou et al. | A simple and high throughput parallel dual immunoaffinity liquid chromatography-mass spectrometry system for urine drug testing | |
| Majumdar | Commonly encountered analytical problems and their solutions in liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods used in drug development |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20071106 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20071106 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20090324 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20090622 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20090629 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20090918 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20091118 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20100217 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20100224 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100303 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100304 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100304 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20100812 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A711 | Notification of change in applicant |
Free format text: JAPANESE INTERMEDIATE CODE: A711 Effective date: 20100910 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20100910 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20100915 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4613279 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131029 Year of fee payment: 3 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131029 Year of fee payment: 3 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20131029 Year of fee payment: 3 |
|
| RD02 | Notification of acceptance of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D02 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313111 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| EXPY | Cancellation because of completion of term |