JP4559150B2 - Syringe pump - Google Patents

Description

 The present invention is for loading a detachable syringe in an immobile state, setting a syringe pusher on the slider portion of the pressing means, and moving the slider portion to accurately deliver the liquid medicine in the syringe according to the set flow rate. The present invention relates to a syringe pump and an infusion method using a syringe pump.

  Syringe pumps are devices whose main purpose is to perform high-precision infusions of chemical solutions such as nutritional supplements, blood transfusions, chemotherapeutic agents, and anesthetics in ICU, CCU, and NICU. It is particularly superior in comparison with the type pump. The method of using this syringe pump is to set the syringe whose pusher has been protruded by the insertion of the chemical solution so that it does not move relative to the loading part of the pressing means, and set the pusher to the slider part. Then, when the infusion start switch is pressed, the slider portion is moved according to the set flow rate, and the liquid medicine in the syringe is accurately delivered by the piston movement of the pusher. Thus, many models have been put into practical use because of relatively good infusion accuracy.

  On the other hand, when infusion is started after the syringe is set in the syringe pump as described above, it is known that it takes time until the chemical solution in the syringe is compressed by the movement of the pusher and actually discharged. . In particular, it is remarkable that it takes time until infusion at the set flow rate at a set flow rate of 1 ml / h or less per hour. The main cause of this seems to be that if the set flow rate is small, the gasket itself does not move due to the static friction of the gasket provided at the end of the pusher, and only the pusher side of the gasket is deformed. Yes.

Therefore, as a countermeasure, before moving the syringe pusher at the set flow rate, move the pusher at a speed greater than the set flow rate. Syringe pumps configured to move have been proposed. (Patent Document 1)
Japanese Patent No. 3203570.

  However, according to the syringe pump according to the above proposal, since the set flow rate is greatly exceeded immediately after the start of the infusion, there is a problem that the infusion accuracy is lowered when the infusion operation is performed at the set flow rate following this.

  Therefore, the present invention has been made in view of the above-described problems, and the infusion accuracy of the syringe pump and the syringe pump does not deteriorate even if an infusion operation that greatly exceeds the set flow rate is performed immediately after the start of the infusion. The purpose is to provide a method.

  In order to solve the above-described problems and achieve the object, according to the syringe pump of the present invention, the pressing means for sending the chemical solution by moving the pusher of the syringe at the set flow rate, and the elapsed time from the start of the infusion And a timer means for measuring the flow rate, and moves until a primary time elapses at a speed greater than the set flow rate, and after the primary time elapses at a speed greater than the set flow rate in a direction opposite to the delivery direction. And a control means for controlling the pressing means so as to move at a speed of the set flow rate after the secondary time elapses.

  In addition, the syringe includes a storage medium that stores individual information regarding at least one of the set flow rate, volume, chemical, and manufacturer, and the pressing unit includes a reading unit that reads the individual information of the storage medium. The control means determines the primary time or the secondary time or both according to the individual information read by the reading means.

  The syringe includes main body cylinder portions of different volumes, and the pressing means includes a loading portion for loading the main body cylinder portion in a detachable and stationary position, and the pusher in the longitudinal direction of the main body volume portion. A slider unit that is movably and detachably loaded; and a volume detection unit that detects the volume of the main body cylinder unit loaded in the loading unit to obtain a volume value and sends the volume value to the control means. The control means determines the primary time or the secondary time or both according to the volume value.

Further, the syringe pump of the present invention moves the pressing portion that comes into contact with the pusher of the syringe, so that the pressing portion presses the pusher and sends out the chemical solution in the syringe, An acquisition unit that acquires the flow rate of the chemical solution to be delivered from the syringe as a target setting flow rate, and a period until the target setting flow rate acquired by the acquisition unit is set, and the setting flow rate is set based on the target setting flow rate Setting means for controlling, a control means for controlling a moving speed when the pressing means moves the pressing portion according to a set flow rate set by the setting means, and the pressing means moves the pressing portion, Detecting means for detecting a pressing force when the pressing portion presses the pusher, and the setting means defines a timing for changing the setting of the set flow rate after the feeding of the chemical solution is started. You Until the pressing force detected by the detection means reaches the first reference value, a flow rate larger than the target set flow rate is set as the set flow rate, and the first reference value is reached. Thereafter, until the pressing force detected by the detecting means reaches the second reference value that defines the timing for changing the setting of the set flow rate again and is lower than the first reference value . During that time, a negative flow rate smaller than the target set flow rate is set as the set flow rate so that the pressing unit is moved in the reverse direction by the pressing means , and after reaching the second reference value, The target set flow rate is set.

The syringe includes a storage medium that stores at least one of the target set flow rate, the volume, the type of chemical solution , and information about the manufacturer as personal information , and the syringe pump is stored in the storage medium. And a reading unit that reads the personal information, wherein the first reference value and the second reference value are changed according to the personal information read by the reading unit .

In addition, the first reference value and the second reference value are changed according to the volume of the main body cylinder portion of the syringe .

  In addition, according to the infusion method using the syringe pump of the present invention, the step of feeding the drug solution by moving the pusher of the syringe at the set flow rate by the pressing means, and the measurement of the elapsed time from the start of the infusion by the timer means And the pressing means moves the pusher until a primary time elapses at a speed greater than the set flow rate, and after the primary time elapses, at a speed greater than the set flow rate. Moving the pusher in a direction opposite to the delivery direction until a secondary time elapses, and controlling the pressing means by the control means so as to move at the set flow rate after the secondary time elapses; It is characterized by comprising.

  In addition, a step of providing a storage medium storing individual information regarding at least one of the set flow rate, volume, chemical solution, and manufacturer in the syringe, and a reading unit provided in the pressing unit, the reading unit provided in the pressing unit, the storage medium. A step of reading individual information, and a step of determining the primary time or the secondary time or both by the control means according to the individual information read by the reading means.

  The syringe is composed of a main body cylinder portion having a different volume, a step of loading the main body cylinder portion in a detachable and immovable position on the loading portion of the pressing means, and a slider portion of the pressing means on the slider portion. A step of loading the pusher movably and detachably in the longitudinal direction of the main body volume portion, and detecting the volume of the main body cylinder portion loaded in the loading portion by a volume detection unit to obtain a volume value, A step of sending the volume value to the control means; and a step of determining the primary time or the secondary time or both by the control means according to the volume value.

  Then, the pressing force detecting means provided in the pressing means detects the pressing force when the pusher moves, and the comparing means provided in the control means detects the pressing force detecting means. Comparing the pressing force with a primary reference value and determining that the primary time has elapsed when the pressing force rises to the primary reference value, the pressing force and a secondary reference value lower than the primary reference value Comparing and determining that the secondary time has elapsed when the pressing force falls to the secondary reference value is provided.

  According to the syringe pump and the infusion method using the syringe pump of the present invention, an infusion operation that is larger than the set flow rate is performed immediately after the start of the infusion, and the infusion operation in the reverse direction is performed subsequently. Since it can transfer to operation | movement, the effect that an infusion precision does not fall can be acquired.

  Hereinafter, an embodiment of the present invention will be described with reference to the accompanying drawings.

  FIG. 1 is an external perspective view of the syringe pump 1, and is a view showing a setting dial 6 provided on the side face so that the operation panel 2f is placed in front and can be operated with the right hand.

  In this figure, the syringe pump 1 is a device called a micro continuous infusion pump mainly intended for medicinal solution infusion such as nutritional supplementation, blood transfusion, chemotherapeutic agent, and anesthetic agent in ICU, CCU and NICU. First, operability is improved by centrally arranging the operation panel 2f for displaying the flow rate as a feature on the appearance on the upper surface as shown in the figure. In addition, this operation panel 2f is basically covered with an embossed sheet cover, and has a drip-proof design that satisfies the drip-proof test of JIS 0920. For example, inadvertently spilled chemicals on the operation panel In addition to being able to be wiped off easily, it has a high drip-proof property that prevents chemicals from entering the inside.

  Further, the upper cover 2 and the lower cover 3 which are the base of the syringe pump 1 are integrally injection-molded from a chemical-resistant molding resin material, and a rubber made of, for example, a silicone elastomer is formed on the connection surfaces of the covers 2 and 3. By adopting a configuration in which the seal 4 is interposed and screwed together, it is configured to completely prevent foreign matters such as liquid from entering the inside.

  In addition, in order to improve the accuracy and operability of the infusion, precise infusion operation control by microcomputer (CPU) control can be realized. Further, as shown in the figure, the alarm lamp 7 which is an operation indicator provided to project upward at a position that is easily visible from the outside has a plurality of (four) light-emitting LED elements that are lit and blinking in red or green. These are rotated and displayed so that the operation status and alarm status of the syringe pump can be monitored even from a distance to ensure safety. Further, an alarm buzzer 7b (not shown) that synchronizes with this or sounds individually is also incorporated, and various alarm functions are provided for safety.

  In addition, since it is small and light, it can be easily carried, and it is designed to be convenient for use when a plurality of devices are used simultaneously. Furthermore, by turning the setting dial 6 on the right side surface of the apparatus, the flow rate setting, which is a numerical setting corresponding to the rotation speed and the rotation direction, can be performed within a short time, while the flow rate indicator of the display panel is obtained. The setting value can be displayed on the display unit 11 by a liquid crystal display so that the setting value can be changed in conjunction with the rotation operation of the setting dial 6 when setting or changing a numerical value such as a flow rate. I can do it.

  Furthermore, as shown in the drawing, it has a long and slender shape, so that it can be used in multiples. Specifically, the syringe pump 1 has a height dimension of 114 mm, a width dimension of 322 mm, a depth dimension of 115 mm, a weight of about 1.9 kg, and a power source of an AC commercial power source, an internal battery, Three systems of external DC power supply DC15V are provided.

  The built-in battery has a charging time of 15 hours, and is covered with a lid at the bottom of the lower cover 3 so that it can be easily exchanged from the outside. Yes. In addition, the replacement time of the battery is about 3 years or more, while the charge control is trickle charging to achieve a long life. In addition, overdischarge and prevention of charging are realized through cell damage detection / cell damage safety measures for rechargeable batteries. Then, by using a heat-resistant nickel-cadmium battery or a lithium hydrogen battery, when a new battery is used, continuous operation can be performed for 120 minutes or more until an alarm occurs and 150 minutes or more until shutdown.

  In addition, a display unit 10 for gamma infusion and display units 11 for flow rate, scheduled amount, and integrated amount are provided on the operation panel 2f, while the setting dial 6 can be easily removed for cleaning. In this way, the recess 6e is formed in a part, so that the toe can be moved to the outside while removing the tip of the recess 6e and rotated.

  In order to set the main body cylinder portion S of the syringe, the upper cover 2 has a partially recessed syringe stage 2a and a slit portion 2c in which a flange portion SF formed integrally with the syringe main body is set. And are integrally injection-molded. A clamp column 2b (shown by a broken line) for rotatably supporting the clamp 5 is provided as will be described later.

  On the other hand, the slider assembly 50, which is provided so as to be movable in the direction of the arrow A4 in the figure by driving with a stepping motor and manually, the slider assembly 50 constituting a part of the pressing means reciprocates on the recess 2d of the upper case 2. On the other hand, it is fixed so as to be connected to a slider feed mechanism described later via a pipe shaft and an inner clutch shaft described later. Further, by manually operating the slider lever 52 of the slider assembly 50, it can be freely moved to a position suitable for the pusher SP, and when the clutch lever 52 is released, the pusher SP can be automatically mounted. It is configured.

  The lower cover 3 is provided with a DC power connector 9 and an AC inlet 8 side by side. Further, an external communication connector (not shown) is disposed on the bottom of the side surface of the lower cover 3 so that an external communication function described later, for example, an external communication function connected to an external medical monitor can be performed. And remote control of motor drive. In addition, a nurse call connector (not shown) for the nurse call is arranged next to the external communication connector, and when installed in the hospital, it is connected to the nurse call connection terminal near the bed to care for abnormal conditions. I'm trying to inform women. Furthermore, a female screw portion (not shown) for fixing to the pole next to the bed with a clamp is insert-molded in the lower cover 3.

  At the left end of the operation panel 2f, a power switch 15, an AC / DC lamp 16 and a battery lamp 17 are concentrated as shown in the figure. A gamma setting display unit 10 is disposed next to these lamps. However, a model without the gamma setting display unit 10 can be used sufficiently. The gamma setting display unit 10 is provided with a display on / off switch 10a and an item changeover switch 10b.

  On the other hand, a syringe diameter detector 5K that converts the amount of movement of the clamp in the vertical direction into an electrical signal when set using the clamp 5 is provided on the display unit 10, and the syringe diameter is automatically measured. The detection result is displayed on the syringe display lamp 18 that displays the volume of the syringe S of 10 cc (ml), 20 cc (ml), 30 cc (ml), and 50 cc (ml).

  Also, an alarm lamp 7 which is an operation indicator formed so as to protrude upward from a transparent acrylic resin or the like is provided below the clamp 5 so that the built-in red and green lights appropriately. The infusion operation state can be displayed as an electric light by illuminating, flashing, or turning on the light-emitting LED so that light is scattered from the inside by rotating clockwise. Next to the clamp 5, there are provided display lamps 19a, 19b, 19c for displaying the pressing force detected by the pressing force detecting means provided in the syringe pump by three-stage switching. Next to these lamps, a remaining amount alarm lamp 20, a battery alarm lamp 22 and others are intensively arranged.

  Next to these lamps, a 7-segment LED display section 11 having flow rate / planned amount / integrated amount lamps 23, 24, 25 is provided. Further, on the right side of the display unit 11, there are provided a display changeover switch 26 and an integration clear switch 27 as flow rate setting switches. A fast forward switch 30, a start switch 29, and a stop / mute switch 28 are provided below the display unit 11.

  In the above configuration, in order to set the syringe, the clamp 5 is pulled upward as shown in the external perspective view of the clamp 5 in FIG. Then, the clamp 5 held in a spline-fitted state with respect to the vertical protrusions 2b-1, 2b-2, 2b-3 of the clamp post 2b is rotated by about 90 degrees in the direction of the arrow D1. The upper end portion is made to stay against a pulling force (not shown).

  Following this, the syringe flange SF is inserted into the slit 2c in order to set the syringe flange SF in the slit 2c. After that, after setting the main body cylinder portion S of the syringe on the syringe stage 2a, when the clamp 5 is rotated in the clockwise direction in the direction of the arrow D1, the above-described locked state is released, and in the direction of the arrow D2 in the figure. The syringe is clamped by being pulled, and the syringe diameter is automatically detected. Here, the IC tag 101k, which is a storage medium storing information on the set flow rate according to the chemical solution, the volume of the syringe, the name of the chemical solution, and the manufacturer name, is fixed to the flange SF of the syringe S, and fixed to the slit 2c. The IC tag detector 101 may be configured to read out wirelessly.

  The slit 2c and the syringe stage 2a are further formed with small-diameter arc grooves 2a-2, 2a-3, and 2a-1 as shown in the drawing, and these arcs are used for small-capacity and small-diameter syringes. It can be held in a stationary state on the groove. This completes the syringe setting.

  Subsequently, the clutch lever 52 is released and the slider assembly 50 is moved. At this time, when the clutch lever 52 of the slider assembly 50 shown in FIG. Therefore, when the clutch lever 52 is released after the syringe pusher SP contacts the slider assembly 50, the right and left hooks described later automatically hold the pusher SP of the syringe S. That is, when the clutch lever 52 is released, the hook of the slider assembly 50 sandwiches the syringe pusher. The above is the basic set operation.

  3 and 4 are external perspective views of the slider feed mechanism 33 built in the upper cover 2. In both figures, the slider feed mechanism 33 is made of aluminum die casting and has a base 34 that is excellent in rigidity and vibration proofing as a base. The base 34 is integrally formed with left and right wall surfaces 34a (one of which is not shown), and both lead screws 37 having a gear train gear 36 fixed to one end thereof are rotatable in a space between the left and right wall surfaces 34a. It is supported. Each of the inner clutch shaft 43 and the guide shaft 38 is supported by a bearing (not shown) so as to be slidable and rotatable in the longitudinal direction.

  The inner clutch shaft 43 is provided with a pipe shaft 40 that can be moved in the direction of arrow A4 shown in FIG. Further, the guide shaft 38 is fixed to the base 34 so as to be stationary. A block 41 is fixed to the end of the pipe shaft 40. The block 41 is fixed with a bush 42 made of polyacetal resin that is inserted into the guide shaft 38 to prevent rotation. Further, the inner clutch shaft 43 is always urged in the direction of the broken arrow A1 shown in the figure, and a nut holder 44 to which a half nut block 45 is fixed so that the tooth portion 45a always meshes with the tooth portion of the lead screw 37 is fixed. Thus, only when the inner clutch shaft 43 is rotated in the direction of the solid arrow A3, it is configured to be in a free state in which the meshing state is released, so that it can freely move in the direction of the arrow A5. A clutch sensor plate 39 is pivotally supported on the guide shaft 38.

  The slider feed mechanism 33 is further provided with a pressing force detector 102 as a pressing force detection means on the nut holder 44. The configuration of the slider feed mechanism 33 is such that the rotation of the motor 35 having an encoder detector 135 (not shown) fixed to its output shaft is transmitted to the final gear fixed to the lead screw 37 which is a feed screw via the gears 36 and 36. By doing so, the nut holder 44 is moved, and by pushing the pusher SP of the syringe, the medicinal solution contained therein can be infused. At this time, the nut holder 44 tries to advance in the feeding direction. However, a force acting in the opposite direction is generated by the action of resistance in the syringe and other infusion channels.

  The force generated in this way is subjected to a reaction force in the direction opposite to the feed direction by the meshing state of the half nut 45 fixed to the nut holder 44 and the lead screw 37. As a result, the entire feed screw moves in the reverse direction, and the tip portion of the feed screw is transmitted as a pressing force to the pressing force detecting means 102 via a lever (not shown).

  In this way, the transmitted pressing force is converted into, for example, a deflection of a force sensor of a piezoelectric element, and this mechanical deflection amount is converted into an electrical output and further converted into a digital signal. When the pressing force detected in this way reaches a set value, it is determined that a blockage at the time of infusion has occurred, and the alarm lamp 7 of the operation indicator is displayed as an alarm for notifying an abnormal state, and an alarm sound (buzzer) is generated. Generate (ring).

  In addition, the pressing force generated from the resistance in the syringe and other infusion channels in this manner is displayed in three steps by three display lamps 19a, 19b, 19c provided on the display panel on the upper cover 2. Furthermore, the occlusion detection mechanism also takes into account the sliding resistance of the syringe. Each manufacturer and syringe volume type (50 cc, 30 cc, 20 cc, 10 cc) is detected as described above, and the sliding resistance of the syringe is detected. Automatic correction is made. In the primary storage memory inside the CPU, for example, sliding resistance data related to syringes for 10 companies is stored in advance, and an arbitrary manufacturer can be set. Here, the pressing force detector 102 may be provided anywhere as long as the pressing force can be detected. For example, the pressing force detector 102 may be provided on one shaft support portion of the lead screw 37.

  On the other hand, the remaining amount detection mechanism is an important function when the remaining amount becomes low during the operation, and the pump continues to operate, the block 41 and the nut holder 44 are moved, and the pusher SP of the syringe is moved. When a predetermined position is reached, a metal fitting (not shown) fixed to the block 41 fixed to the pipe shaft 40 comes into contact with a lever of a potentiometer (not shown) fixed inside the upper cover 2 of the main body. . When the movement is further continued from the contact state, the value of the potentiometer reaches a predetermined value stored in advance. At this time, it is displayed on the alarm lamp 7 as an operation indicator as an alarm for notifying an abnormal state, and an alarm sound is generated to display a remaining amount alarm.

  As described above, when the operation of the chemical solution infusion of the pump is completed, the slider assembly 50 is returned to the initial position by moving in the direction opposite to the feeding direction, and the lever of the potentiometer is pulled by the tension connected to the lever. It is configured to return to the initial position by the force of the spring. Further, a clutch disengagement detection mechanism is provided, and the clutch lever 52 is accidentally gripped during the infusion operation of the pump, and the meshing state of the half nut 45 and the lead screw 37 constituting the clutch is cut, or When the same thing occurs due to the action of some load or the like, an alarm sound is generated and an abnormality is notified by an operation indicator.

  For this purpose, when the clutch lever 52 of the slider assembly 50 is gripped, the half nut 45 is rotated through the pipe shaft 40 in the direction opposite to the broken line arrow A1 shown in FIG. As a result, the engagement state between the thread portion 37a of the lead screw 37 and the thread portion 45a of the half nut 45 is configured to be released.

  In addition, when the half nut 45 is rotated in this way, a clutch sensor is receiving a biasing force by a biasing means (not shown) so that the sliding surface 39c always contacts the sliding surface 45c of the half nut 45. A photosensor (transmission type) 46 in which the plate 39 is rotated at the same time and the lever portion 39b at one end of the clutch sensor plate 39 is fixed inside the upper cover, and is normally shielded from the sensor. By rotating the plate 39, light is transmitted, and an alarm is displayed by detecting this.

  In FIG. 4, when the stepping motor 35 is driven to move the pusher SP, the lead screw 37 is driven to rotate, and the nut holder 44 that fixes the half nut 45 that meshes with the lead screw 37 moves in the direction of arrow B1. Therefore, the pipe shaft 40 is also moved in the arrow B2 direction, and the slider assembly 50 is moved. At this time, the lever portion 39b at one end of the clutch sensor plate 39 shields the photosensor (transmission type) 46 from light.

  In the battery remaining amount display, the battery remaining amount is displayed on the battery lamp 17 in three stages. Conventionally, the remaining battery level is detected based on the battery voltage. However, this apparatus detects the remaining battery level with higher accuracy by integrating the current.

  Again, in FIG. 1, the setting dial 6 is a so-called jog type in which three concave portions 6a are provided on the side surface, and the fingertip is inserted into the concave portions 6a and then rotated. The setting dial 6 is a non-contact type and is an endless encoder type that detects the rotation of the dial. The setting dial 6 can be rotated at a high speed after putting a fingertip into the recess 6a, and according to the rotation angle. While it is considered that it can be set, it can be easily attached and detached as necessary, and when the liquid in the syringe leaks onto the pump device, it is washed with water in the same way as an operation panel with other drip-proof measures. I can do it.

  When the setting dial 6 is rotated clockwise, various setting values are increased and displayed on the display unit 11. Similarly, when the setting dial 6 is rotated counterclockwise, the setting value is displayed on the display unit 11 so as to decrease. Specifically, when the display changeover switch 26 provided on the display panel of FIG. 1 is pressed, the flow rate lamp 23, the scheduled amount lamp 24, and the integrated amount lamp 25 are sequentially turned on so that each setting can be performed. It has become.

  Therefore, when setting the flow rate, the display changeover switch 26, which is a flow rate setting switch, is pressed to turn on the flow rate lamp 23, and then the setting dial 6 is rotated to set the flow rate. 11 shows the set value. The display range is 0.0 to 1200 ml / h (up to 999.9: 0.1 ml / h step) (1000 to 1 ml / h step). The range can be set. In addition, each type of syringe from each manufacturer can be guaranteed. In addition, when the flow rate setting value is “0”, the buzzer issues a one-shot notification so that it cannot start. Further, even when the flow rate set value exceeds the drivable flow range, the buzzer issues a one-shot alarm so that the start cannot be started.

  In order to set the integrated amount, the display changeover switch 26 is pressed so that the integrated lamp 25 is turned on, and then the setting dial 6 is rotated and set while viewing the display unit 11. The display range of the integrated amount at this time is 0.0 to 999.9 ml (0.1 ml step), the minimum flow rate → 0.0, and the encoder fixed to the output shaft of the stepping motor 35. While adding up from the pulse count value, the fast-forwarding amount that is fast-forwarded after the fast-forward switch 30 is pressed is added.

  The infusion volume is set to body weight; 0.0 to 300.0 kg (0.1 kg step), drug amount; 0.0 to 300.0 mg (0.1 mg step), solution amount; 0.0 to 300. 0 ml (0.1 ml step), γ amount; 0.00 to 50.00γ (μg / Kg / min) (0.01 γ step).

  The minimum flow rate is displayed from 0.0, and when the body weight, drug amount, solution amount, and γ amount are entered, the flow rate is automatically calculated and displayed, and infusion starts at the displayed flow rate. It can be done. When this calculation result deviates from the settable flow rate (0.1 ml / h or more, 1200 ml / h or less), the display of the flow rate on the display unit 11 is “−−−−” other than a number. Before and after this, the buzzer issues a one-shot alert so that the infusion operation cannot be started.

  On the other hand, when the calculation result is within 1200 ml / h, the calculation result is displayed, but when the calculation result is 300.1 ml / h or more and the type of syringe is 10 to 30 cc automatically detected. The alarm buzzer issues a one-shot alarm so that the start cannot be started even when the start switch 29 is pressed.

  Next, when the fast-forward switch 30 is pressed, the infusion flow rate is increased. When the syringe is 50 cc, 1200 ml / h, 30 cc is 500 ml / h, 20 cc is 400 ml / h, and the syringe is 10 cc. Infusion is performed at 300 ml / h.

  Further, the display range of the scheduled amount setting is 0.0 to 999.9 ml (0.1 ml step), and the minimum flow rate → 0.0, and the operation can be selected by an internal selection switch. When the scheduled amount = 0.0, when the start switch 29 is pressed, the buzzer issues a one-shot and the scheduled amount lamp 24 of the scheduled amount LED blinks so that the start cannot be started. In addition, when the planned amount is less than the integrated amount, the LED of the planned amount lamp 24 blinks to generate a buzzer so that it cannot be continued. In addition, when the planned amount <= integrated amount in the infusion, the LED of the planned amount lamp 24 blinks and a buzzer is issued to automatically switch to the KVO operation. At this time, since the flow rate is displayed as KVO (0.1 ml / h), the sound is muted when the stop / mute switch 28 is pressed once. There is a re-alarm while the KVO operation continues, and the operation stops when the stop switch 28 is pressed again. On the other hand, the initial display upon power-on of the device is “0” ml when in a mode other than the memory mode.

  Next, FIG. 5A is an external perspective view of the slider assembly 50, and FIG. 5B is an external perspective view with the cover 55 removed. In FIG. 5, the slider assembly 50 is fixed at the ends of the inner clutch shaft 43 and the pipe shaft 40 of the slider feed mechanism 33, and holds various different syringes in an immovable state in a detachable manner. It has an important function for accurately delivering the syringe contents by driving. A boot 51 is put on the pipe shaft 40. In FIG. 5A, left and right hook members 53 and 54 are provided. As shown in FIG. 5B, these hook members are operated so as to be freely opened and closed in synchronization with the directions of the arrows B3 and B4 in order to grip the pusher when the clutch lever 52 is grasped. For this purpose, each hook member is formed in a substantially L-shape and an inverted L-shape, and is rotatably supported by rotation portions 53k and 54k on the side surface of the base on which the pusher is gripped. .

  These left and right hook members are formed with first arm portions 53-1 and 54-1 and second arm portions 53-2 and 54-2 as shown in the figure, and second arm portions 53-2 and 54-2 are formed. -2 is provided so as to be inserted into the pin 61. When the pin 61 is moved in the arrow B2 direction by the pressing operation of the clutch lever 52 in the arrow B1 direction, the left and right hook members 53 and 54 are moved to the arrow B3, It is configured to open in synchronization with the B4 direction. From the above, it will be understood that the left and right hook members 53 and 54 are opened by the operation of the clutch lever 52.

  Further, a protrusion 55a for placing the pusher SP on the side surface portion of the cover 55 is provided so as to form at least one step, and it is possible to place a pusher having a different size, and pushes the pusher downward. Prevents falling.

  FIG. 6 is a side view of the slider assembly 50 with the clutch lever 52 removed. If the same reference numerals are given to the components already described and the description is omitted, the slider base 60 is slidably provided. A tension spring 63 is stretched between the slider part 65 to be applied and the hook part 52d of the clutch lever 52, and the right and left hook members 53, 54 are always closed by the action of the pin 61 implanted in the slider part 65. Is being energized.

  Further, a cam groove 52a into which a projection 64a of a plate cam part 64 provided slidably in the slider part 65 enters is formed in the clutch lever 52, and the clutch lever 52 is manually rotated in the direction of arrow B1. Thus, the plate cam part 64 is moved in the direction of arrow B9. Further, a stopper part 57 urged so that one end always protrudes by the action of a torsion spring, and a pin 58 that slides on the sliding surface 64g of the plate cam part 64 is press-fitted into the side surface portion of the base 60. A part 57 is provided so as to penetrate the plate cam part 64.

  On the other hand, an end portion of the inner clutch shaft 43 is formed with a locking portion 43e cut in parallel, and a plate 67 made of a thick stainless steel plate is fixed to the locking portion 43e by a screw 66. The adjustment bolt 77 fixed to the plate 67 is configured to come into contact with the rotation of the clutch lever 57. The clutch lever 52 is rotatably supported around the pipe shaft, and a screw 66 is set in the long groove portion 52c.

  With the above configuration, the slider component 65 is built in the slider base 60 so as to be movable in the vertical direction, while the pin 61 is insert-molded and is urged to move by the tension spring 63, so that no external force acts. In this case, the left and right hook members 53 and 54 engaged with the pin 61 are moved so as to be closed.

  Further, when the protrusion 64 a is moved by the movement of the clutch lever 52, the plate cam component 64 comes into contact with the contact surface 65 a of the slider component 65 and is moved together with the slider component 65. Thus, the left and right hook members 53 and 54 are opened by the action of the pin 61.

  Next, FIG. 7 is a schematic view showing a slider feed mechanism 33 which is a pressing means of the syringe pump. In the figure, the same reference numerals are given to the components already described, and the description is omitted, and the operation will be described. When the hook members 53 and 54 are opened by operating the clutch lever 52 after the syringe body S is set in the non-moving state as described above, the movement of the clutch lever 52 moves to the inner clutch shaft 43 via the plate 67. Then, the slider assembly 50 is disengaged from the slider feed mechanism 33, so that it can move in the longitudinal direction of the arrow A4. Therefore, the pusher is set.

  On the other hand, when the pusher SP of the syringe body S is set on the slider assembly 50, the press-fitting pin of the stopper component 57 falls into the stepped portion, and the clutch lever 52 cannot be operated and the hook member 53 is placed. , 54 are automatically moved to the closed state. At this time, the slider assembly 50 is in mesh with the slider feed mechanism 33 (see FIG. 4).

  In this state, the stepping motor 35 is energized, and the slider assembly 50 is moved to the position indicated by the broken line, whereby the pusher SP is pressed and infusion is performed. The above pressing means is connected to the control board 100 which is a control means, and drive control is performed.

  The use explanation of the syringe pump of the above description is given. As a preparatory preparation, first, the tool is checked, and it is confirmed that the syringe pump 1, the attached pole clamp, the AC power cable, the infusion stand, the syringe containing the medicinal solution, and the indwelling needle are prepared. After this, the pole clamp is fixed to the infusion stand, and the pole clamp is firmly fixed to the infusion stand. For this purpose, a pole clamp mounting screw is inserted into the screw hole at the bottom of the syringe pump and fixed. Next, an AC power cable is connected to the AC inlet on the right side of the main body, and the plug is connected to an AC 100V outlet with a ground terminal.

  When the AC power source is connected, the battery lamp 17 is turned on to indicate that the built-in battery is being charged.

  Therefore, when the power is turned on by pressing the power switch 15 for about 1 second to turn on the power, all the lamps flash three times, and a buzzer sounds again to perform a self-check automatically. At this time, the AC / DC lamp 16 is turned on, while the display lamps 23, 24, and 25 for the flow rate, the predetermined amount, and the integrated amount are turned on. In addition, a preset syringe maker is displayed as a number for about 3 seconds on the flow rate / scheduled amount / integrated amount display unit 11. Since the syringe manufacturer setting label is affixed to the syringe pump to be used, make sure that the syringe manufacturer setting label matches the syringe manufacturer set on the main unit.

  After the predetermined time has elapsed, the number of the syringe manufacturer in the flow rate / scheduled amount / integrated amount display unit 11 disappears and “0.0” is displayed on the display unit 11. At this time, the operation indicator 7 is turned off.

  On the other hand, the syringe type display lamp 18 prompts the user to set the syringe by displaying that all the four built-in display lamps are blinking and indicating that no syringe is mounted.

  The syringe S is set when all of the above indications are confirmed. After the syringe is connected to the infusion line (tube) and the syringe filled with the chemical solution in an aseptic environment, the syringe body S is set on the stage 2a and the clamp 5 is fully pulled up, and then the arrow D1 direction Turn to. That is, as described above, since the clamp 5 is pulled upward to set the syringe body S and rotated about 90 degrees, the clamp 5 can be pulled upward. Turn in the direction of arrow D1.

  Subsequently, the syringe flange SF is inserted into the slit 2c in order to set the syringe flange SF in the slit 2c. After that, when the syringe body S is set on the syringe stage 2a and then the clamp 5 is rotated in the direction of the arrow D1, the locked state is released and the syringe 5 is moved in the direction of the arrow D2 to perform the syringe clamp.

  Subsequently, the clutch lever 52 of the slider assembly 50 is pushed to release the clutch and move the slider assembly 50. At this time, when the clutch lever 52 of the slider assembly 50 is pushed, the hand is freely moved as described above. You can move.

  Therefore, when the pusher SP of the syringe is brought into contact with the slider assembly 50 and then the clutch lever 52 is released, the left and right hooks 53 and 54 automatically hold the pusher SP. That is, when the clutch lever 52 is released, the hook of the slider sandwiches the pusher of the syringe.

  Thereafter, the clamp 5 is rotated in the direction of the arrow D1 as described above, and is lowered in the direction of the arrow D2, and the syringe S is fixed. When the syringe is set as described above, priming is performed. This priming must be performed before the patient is punctured. When the fast-forward switch 30 is pressed, the alarm lamp 7 of the operation indicator is rotated, the infusion operation is started, and the drug solution comes out from the tip of the indwelling needle. When the fast-forward switch 30 is continuously pressed and the chemical solution is sent to the tip of the indwelling needle, the integrated amount lamp 25 blinks. Further, during the fast-forwarding of the flow rate / scheduled amount / integrated amount display unit 11, the integrated amount lamp 25 blinks, and the priming amount is displayed on the flow rate / scheduled amount / integrated amount display unit 11.

  This priming amount is added to the integrated amount in steps of 0.1 ml. Here, the integration amount can be cleared to “0” by pressing the integration clear switch 27.

  This priming is important in order to make the working surface of the slider assembly 50 of the main body contact with the pusher SP of the syringe without any gap by eliminating the gap between the syringe and the main body.

  When the above priming is completed, the flow rate is set. At this time, it is first confirmed that the flow rate lamp 23 is lit. When the flow rate lamp 23 is not lit, the display changeover switch 26 is pressed to turn on the flow rate lamp 23.

  After this, the setting dial 6 is turned to set the flow rate per hour. At this time, in order to prevent malfunction of the setting dial operation and to ensure safety, the numerical value does not change for half a half after turning. It has become. If it exceeds half a circle, the buzzer will sound and the value will change.

  The numerical value decreases or decreases when the setting dial 6 is turned forward, and increases when the setting dial 6 is rotated backward. Further, when the setting dial 6 is turned with the stop / mute switch 28 being pressed, the numerical value rapidly changes at the upper digit.

  About the syringe type and the maximum flow rate, the maximum flow rate that can be set is set according to the type of the syringe. For example, the maximum flow rate is 300 ml with a 30 ml syringe. Therefore, when a numerical value larger than the maximum flow rate is set and the start switch 29 is pressed, the flow rate setting value blinks and infusion is not started, so it is set again.

  After setting the flow rate as described above, confirm that the syringe pump 1 is in the stopped state, puncture the indwelling needle into the patient's arm, etc. Do. Following this, infusion is started when the start switch 29 is pressed. At this time, since the alarm lamp 7 of the operation indicator is turned on, the infusion operation of the chemical solution can be confirmed from a distance.

  If the infusion is not started even after about 2 minutes have passed since the setting of the flow rate was completed after the syringe was set in the syringe pump 1, a buzzer sounds to inform the user of forgetting to start. Therefore, when the stop / mute switch 28 is pressed, the buzzer stops sounding.

  When changing the flow rate during infusion, the infusion is temporarily stopped to stop the infusion. Therefore, when the stop / mute switch 28 is pressed, the operation indicator 7 is turned off.

  In order to check the integrated amount after the infusion is started, when the display changeover switch 26 is pressed, the integrated amount lamp 25 is turned on. Then, the integrated amount from the start of the infusion is displayed on the flow rate / scheduled amount / integrated amount display unit 11 for about 15 seconds in 0.1 ml steps.

  To clear the accumulated amount, press the stop / mute switch 28 to stop the main body 1 and then press the display changeover switch 26 to display the accumulated amount. Then, clear the accumulated clear switch 27 for about 1.5 seconds. When the button is pressed, a buzzer sounds and the integrated amount on the flow rate / scheduled amount / integrated amount display unit 11 is cleared to “0.0 ml”.

  When a predetermined amount of medicinal solution is infused, the stopped state is confirmed, and the syringe is removed. For this purpose, the clamp 5 is pulled upward and then held in a state of turning about 90 degrees. Subsequently, the clutch lever 52 of the slider assembly 50 is pushed, and the left and right hook members 53 and 54 are opened to remove the syringe. After that, when not using again, the power switch 15 is kept pressed for about 2 seconds or more.

  Although the desired function can be sufficiently achieved by the syringe pump 1 having the above function, the gamma infusion setting function enables more effective medicinal solution infusion.

  For this reason, when the display ON / OFF switch 10a is first pressed for about 2 seconds or longer, the gamma infusion setting screen 10 is turned on and gamma infusion is enabled. Subsequently, when the item changeover switch 10b is pressed, the gamma setting screen is changed, and each time the item changeover switch 10b is pressed, the gamma amount, the body weight, the drug amount, and the solution amount are displayed blinking. Since the location where the display is flashing is an item whose setting can be changed, the numerical value on the gamma setting setting screen 10 is changed by turning the setting dial 6 while the desired item is displayed. . When the setting dial 6 is turned while pressing the stop / mute switch 28, each step value can be rapidly changed. This gamma infusion setting screen 10 is displayed by automatically calculating the flow rate according to the set gamma amount, body weight, drug amount, and solvent amount.

  The external communication connection connector is provided for monitoring the state of the syringe pump with an external medical monitor. The nurse call connector can be connected to a nurse call using an optional nurse call cable.

  As a special function setting, the setting of each mode can be changed as needed by operating the switch inside the main body. As these special functions, the scheduled amount of the flow rate / scheduled amount / integrated amount display unit 11 can be changed between the standard mode and the scheduled amount mode. In the standard mode, every time the display changeover switch 26 is pressed, the flow rate and the integrated amount are displayed in this order, and the scheduled amount cannot be set. Further, when switching to the scheduled amount mode by operating the changeover switch inside the main body, the display on the display unit 11 is in the order of flow rate, scheduled amount, and integrated amount, and the scheduled amount can be set. In order to set the predetermined amount, the display changeover switch 26 is pressed so that the predetermined amount lamp 24 is turned on, and then the setting dial 6 is turned to set the predetermined amount. This setting can be changed in 0.1 ml steps. When the scheduled amount is set and the injection is started, when the integrated amount reaches the scheduled amount, the scheduled amount lamp 24 blinks and a buzzer sounds.

  When the predetermined amount is set in this way, the KVO (keep-vain open) function is continued at a flow rate of 0.1 ml for the infusion of the chemical solution. If it is desired to check the operation halfway, when the stop / mute switch 28 is pressed, the alarm lamp 7 of the operation indicator is turned on and the buzzer stops. At this time, the keep vane open function continues, and when the stop / mute switch 28 is pressed again, the alarm lamp 7 is turned off, the keep vane open function is canceled and the stop state is entered, and the infusion in the scheduled amount mode is performed. end.

  The re-alarm can be changed between the standard mode and the mute mode. When the alarm lamp 7 blinks in red and the buzzer sounds, and the buzzer is muted and the alarm state is not canceled for 2 minutes or more, the buzzer sounds again. The standard mode and the mute mode can be set so that the re-alarm function does not operate even if the alarm state continues for 2 minutes or longer.

  The forgetting to start warning can be changed between the standard mode and the mute mode, the operation indicator 7 blinks red, and the buzzer sounds. It is possible to set a mode for notifying forgetting to start and a mute mode in which the forgetting to start alarm function does not operate even if the stop state continues for 2 minutes or more.

  The syringe manufacturer can be changed with the internal changeover switch, but this special function setting can cause an accident if done carelessly. May be.

  The setting of the blockage detection pressure level and the setting of the buzzer volume are performed by pressing the stop / mute switch 28 and pressing the display changeover switch 26. First, to change the setting of the occlusion detection pressure level, when the display changeover switch 26 is pressed simultaneously while pressing the stop / mute switch 28, “PrES” is displayed on the flow rate / scheduled amount / integrated amount display unit 11, and the setting mode become. While pressing the stop / mute switch 28 as it is, releasing and pressing the display changeover switch 26, the print characters “L”, “M”, and “H” in the vicinity of the blocking pressure setting value lamps 19a, 19b, and 19c are sequentially displayed. Since it lights up, when the desired setting is reached, the finger can be released from all the switches, the stop / mute switch 28 is pressed, and the integrated clear switch 27 is pressed to set the blockage detection pressure level.

  To change the buzzer volume setting, hold down the stop / mute switch 28 and simultaneously press the integration clear switch 27. “bEL * 2” is displayed on the flow rate / scheduled amount / integrated amount display unit 11 and is set. Become a mode. While holding down the stop / mute switch 28 as it is, releasing and clearing the integration clear switch 27, the display is “bEL: 1”, “bEL: 2”. When the desired volume is reached, release your finger from all switches to set the buzzer volume.

  It can also be used with a DC power supply due to the power concentration box. In this case, it is confirmed that the AC power cable is disconnected from the main body 1, and the DC cable is connected to the DC connector 9 on the right side of the main body. Subsequently, when the power switch 15 is turned on, the AC / DC lamp 16 is lit and DC power is supplied.

  When neither AC power nor DC power is supplied, the built-in battery is automatically switched, the AC / DC lamp 16 is turned off, and the built-in battery can be used continuously for about 2 hours. The built-in battery is charged when an AC power source or a DC power source is connected regardless of whether the power source is on or off. During this charging, the battery lamp 17 is lit and the remaining battery level is displayed in three levels. As a guideline for this battery level, when all three lamps are lit, it can be used for about 80 minutes or more, and when two lamps are lit, there is an operating time of about 30 minutes or more. When only one is lit, it can be used for about 15 minutes or more. If all three are blinking, only two or one is lit, indicating that the battery is degraded.

  Further, when the remaining amount of the built-in battery further decreases, the battery alarm lamp 22 blinks and a buzzer sounds. Therefore, an AC power source is connected and quickly connected to an AC or DC power source for use.

  Summarizing the above specifications, the operation sound of the syringe pump was quiet, and it was 55 dB or less even under the worst conditions. Under normal conditions (0.1 to 150 ml / h), 47 dB or less was achieved at a position 10 mm from the main body. In addition, it was easy to clean, the outer layer was easy to clean, it could be cleaned with gauze and cotton swabs, and the user could disassemble and clean to some extent without using tools. Also, maintenance is easy, no special tools are required, and each component is unitized, so supply is easy, adjustment is simple, and A / D values are displayed by internal switches. It is configured so that adjustment can be confirmed.

  In addition, assuming that the electric margin is used in the vicinity of the electric knife, for example, the power supply impulse; 2 KV, 500 nSec, radiation; 1 KV, 3 directions are satisfied. Furthermore, even if a cellular phone (5 W) is used in the vicinity, it can withstand. In addition, the static noise margin does not malfunction at 10 KV and does not break at 15 KV, so that noise standards in Japan; VCIM Group 1 Class A and overseas; FCC Prat. 18, CISPR 11 (IEC601-1-2) and VDEDIN 57871 were satisfied.

  The electric shock protection type is CLASS * I (3 KV or more) and TYPE CF (ground leakage: 0.5 mA or less) in Japan; JIS T1001, T1002 and overseas; IEC 601-1.

  The chemical resistance was not wiped with alcohol, but the outer layer was made ABS grade V0 so as to have chemical resistance equivalent to alcohol, and the back side was printed so that the nameplate, printed characters, display, etc. would not disappear. Dealed with.

  The drive thrust (force to push the pusher) is about 15 kg / f and can withstand about 20 kg / f, and the actual machine (feed) accuracy can be as high as ± 1%. I was able to guarantee each type of each manufacturer.

  Further, the guideline for occurrence of the remaining amount alarm is 10 cc: 0.5 ml, 20 cc: 1.0 ml, 30 cc: 1.0 ml, 50 cc: 1.0 ml.

  The γ amount display unit 10 is a liquid crystal with a backlight (yellow or green). It is a numerical display consisting of 7 segments each. Weight, Kg, drug amount, mg, solution volume ml, γ amount, μg / Kg / min can be displayed, body weight; 7 SEG 4 digits + decimal point 1 SEG, drug amount; 1 SEG, γ amount; 7 SEG 4 digits + decimal point 1 SEG. When the normal infusion mode is selected, the entire screen is turned off.

  The flow rate / integrated amount / scheduled amount display unit 11 is an easy-to-read LED display, and automatically switches to the flow rate display when 7 SEG 4 digits + decimal point 1 SEG and the γ mode is set. In addition, the flow rate display is switched sequentially corresponding to the set value during the setting of the γ mode. When the integrated amount or the planned amount is displayed, the flow rate display is automatically switched if left for about 15 seconds.

  An alarm is generated during Er *, CPU runaway, switch operation, and self-check, but it has an easy-to-understand tone and no discomfort, and is compatible with overseas standards and can be switched in three levels (panel operation). It enables memorizing the set volume and displaying the volume level at the time of setting. The maximum volume is set to 65 dB or more at a distance of 1 m, and is further self-excited (so as to be notified when the CPU runs away).

  The timbre has three frequencies (about 2 to 4 KHz) and is capable of PWM output from the CPU (alarm → PWM output, watchdog → hard oscillation). This volume switching procedure is not possible in the alarm state (excluding voltage drop and remaining amount), press the total clear, hold down the stop switch, and press the switch, then medium → large → small → medium → (The buzzer sounds for 1.5 seconds) and the flow rate display unit is synchronized with the buzzer at 7 Seg. Medium = "b-2", Large = "b-3", Small = "b -1 "is displayed and the result is written to the EEPROM.

  Next, FIG. 8 is a block diagram of the syringe pump 1.

  In this figure, components that have already been described are denoted by the same reference numerals and description thereof is omitted. The control means 100 is surrounded by a broken line, and is configured so that the CPU 110 of the microprocessor performs overall control. Has been. A data bus 115 and an address bus 114 are connected to the CPU 110, and digital data and digital data are exchanged with the CPU 110 via these bus lines. The CPU 110 is connected to a clock circuit 111 connected to a crystal 112 that generates a clock signal, and operates at a predetermined speed by obtaining the clock signal. A timer circuit 113 as a timer means is connected to the data bus 115, and the elapsed time is sent to the CPU 110 by measuring time. The data bus 115 is connected to a RAM 116 that also functions as an integrated amount storage unit, while the address bus 114 is connected to a ROM 117 including a nonvolatile memory. The ROM 117 and RAM 116 together with the CPU 110 constitute a comparison unit.

  The input / output interface 118 connected to the data bus 115 includes a power switch 15 for turning on / off the three systems described with reference to FIG. 1, a start switch 29 that is pressed when infusion is started, and a syringe. IC tag for detecting the syringe diameter detector 5K as the volume detector, the flow rate setting dial 6, the pressing force detector 102 as the pressing force detection means, and the IC tag 101K in a non-contact manner and rewriting the stored contents as necessary. An encoder 135 (see FIG. 7) for detecting the rotation amount of the detector 101 and the stepping motor 35 and mainly detecting the integrated amount, the nurse call circuit 12 and others are connected as shown.

  On the other hand, the output interface 119 connected to the address bus 114 includes the blockage indicators 19a, 19b, 19c, the flow rate indicator 11, the alarm lamp 7, and the alarm buzzer 7b described with reference to FIG. A motor driving circuit 35k and the like for driving the stepping motor 35 described above are connected. When infusion is started with the above configuration, infusion in the following basic operation is executed.

  FIG. 9 is a flowchart illustrating the basic operation of the syringe pump 1.

  In this figure, after the syringe is set in the pressing means as described above and the pusher is set in the slider assembly 50 and the syringe volume is displayed and confirmed, when the start switch 29 is pressed, infusion is performed in step S1. In step S2, the set flow rate set using the setting dial 6 is read. Alternatively, the IC tag 101K, which is a storage medium for wirelessly exchanging data, is detected by the IC tag detector 101, and not only the set flow rate but also the syringe volume, the chemical solution, and the individual information of the manufacturer are read.

  In the subsequent step S3, the drive pulse rate of the stepping motor 35 is set to be larger than the set flow rate based on the read set flow rate. This setting may be performed by reading from a data table stored in advance in the ROM 117, or may be obtained from an arithmetic expression, or may be automatically set based on a large set flow rate immediately after the start of infusion stored in the IC tag 101K. it can. Subsequently to step S4, the stepping motor 35 is driven in the forward direction to start the infusion, and the elapsed time is measured by the timer means.

  As a result, infusion of a larger amount than the set flow rate is started, and the chemical solution in the syringe starts to be compressed by the movement of the pusher. In this way, particularly when the set flow rate is set to 1 ml / h or less per hour, the time until infusion at the set flow rate is shortened. That is, even when the set flow rate is small as described above, the gasket provided at the end of the pusher is moved in the infusion direction against static friction.

  Following this step S4, the process proceeds to step S5, where it is determined whether or not a predetermined primary time (seconds) stored in advance in the ROM 117 or the IC tag has elapsed, and step S4 is executed until the primary time elapses. When the primary time elapses, the process proceeds to step S6, and the stepping motor 35 is driven in the reverse direction so that the setting of the drive pulse rate is larger than the set flow rate, thereby moving the presser in the direction opposite to the infusion direction. At the same time, time is measured by the timer means. The reverse driving pulse rate is also automatically set based on the read set flow rate. Following this, the process proceeds to step S7, where the elapsed time is measured by the timer means to determine whether or not a predetermined secondary time (seconds) has elapsed. When the secondary time has elapsed, the process proceeds to step S8. The drive pulse rate of the stepping motor 35 is set to the set flow rate. The preparation for the normal infusion start operation is now complete, and in step S9, the stepping motor 35 is driven in the forward direction to execute the normal infusion operation, and the infusion is terminated in step S10.

  As described above, immediately after the start of the infusion, an infusion operation that becomes larger than the set flow rate is performed, and then the infusion operation in the reverse direction is performed. The accuracy can be prevented from decreasing.

  Next, FIG. 10 is a flowchart for explaining the operation of the syringe pump 1 of another embodiment. In the figure, when the infusion is started in step S100, the set flow rate is read in step S101. Following this, in step S102, the drive pulse rate of the stepping motor 35 is set larger than the set flow rate. Infusion is thus started, and the stepping motor 35 is driven in the forward direction in step S103. In step S105, the pressing force detector 102 detects the pressing force of the presser SP, and in step S105, a determination is made as to whether or not a predetermined primary reference value (threshold value) is exceeded. The operations in steps S103 and S104 are executed until the reference value or more is reached. When the operation exceeds the primary reference value, the process proceeds to step S106, and the stepping motor 35 is driven in the reverse direction. Next, in step S107, the pressing force of the presser SP is detected by the pressing force detector 102, and the operations in steps S106 and 107 are executed until the pressure becomes equal to or less than a predetermined secondary reference value (threshold value). If the value is less than the value, the process proceeds to step S109, and the drive pulse rate of the stepping motor 35 is set to the set flow rate. In step S110, the stepping motor is driven in the forward direction to shift to the normal infusion operation in step S111. In step S112, the infusion operation is terminated.

  As described above, not only the control based on the passage of time as described in FIG. 9 but also the control at the start of the infusion may be performed based on the pressing force of the actual pressing means, or the passage of time as described later. It is also possible to perform control at the start of infusion based on both the pressure and the pressing force. The processing flow of steps S5 to S7 is performed based on the primary time, the secondary time, the primary reference value, and the secondary reference value stored in a table in a storage memory such as the CPU 110 according to each manufacturer and syringe volume type. Anyway.

  FIG. 11 is a relationship diagram of the flow rate, the infusion time, and the pressing force based on the infusion operation described in FIGS. 9 and 10, and the right vertical axis is detected by the pressing force detector 102 and converted into a voltage value. The detected value (V) is shown, the left vertical axis shows the flow rate (Q), and the horizontal axis shows the time elapsed (T) from the start of infusion.

  In this figure, when the set flow rate is 0.1 ml / h per hour, the flow rate is set to 50 ml / h, which is 500 times immediately after the start of infusion, and the elapsed time of 500 msec, which is the primary time, is measured by the timer means. The pusher is moved in the infusion direction until After the elapse of the primary time, the pusher is moved in the direction opposite to the infusion direction until the elapse of 500 msec, which is the secondary time, is set to 50 ml / h which is 500 times the set flow rate. Then, after the secondary time has elapsed, the pusher is moved so as to move at a set flow rate of 0.1 ml / h, and a normal infusion operation is performed.

  In addition, since the syringe is fixed with an IC tag that is a storage medium storing individual information regarding at least one of its volume, chemical solution, and manufacturer, primary time and secondary time are determined according to the individual information. Is determined. Alternatively, when the syringe is loaded in the stationary position, the volume is automatically detected to obtain a volume value, and the primary time and the secondary time are determined according to the volume value.

  On the other hand, the pressing force detector 102 can detect the primary reference value of 0.64 V and the secondary reference value of 0.3 V from the pressing force of the presser, so that the comparison is made and the pressing force increases to the primary reference value. While determining that the primary time has elapsed, compare the pressing force with the secondary reference value that is lower than the primary reference value, and determine that the secondary time has elapsed when the pressing force falls to the secondary reference value. It may be controlled by the comparison means stored in the ROM.

  Next, FIG. 12 is a flowchart for explaining the basic operation of the syringe pump 1 according to the embodiment. In this figure, in step S200, the syringe is set in the pressing means as described above, and the pusher is set in the slider assembly 50, and the syringe volume is displayed and confirmed. In step S201, the flow rate for infusion is set automatically or manually as described above and set to 0.1 ml / h. Subsequently, the start switch 29 is pressed in step S202, and the process proceeds to step S203.

  In this step S203, the setting of the drive pulse rate of the stepping motor 35 is set larger than the set flow rate based on the set flow rate, and is automatically set to 50 ml / h. Subsequently to step S204, the stepping motor 35 is driven in the forward direction to start rapid infusion, and the elapsed time is measured by the timer means. As a result, a rapid infusion larger than the set flow rate is started, and the chemical solution in the syringe starts to be compressed by the movement of the pusher. In this way, in particular, when the set flow rate is set to 1 ml or less per hour, the time until infusion at the set flow rate is shortened. That is, even when the set flow rate is small as described above, the gasket provided at the end of the pusher is moved in the infusion direction against static friction.

  Following this step S204, the process proceeds to step S205, where it is determined whether or not the detection value of the pressing force by the pressing force detector 102 is equal to or higher than the reference value of 0.64 V (volts), and the step is continued until the reference value is reached. When S204 is executed and the reference value is reached, the process proceeds to step S206, and the driving of the stepping motor 35 is stopped. Subsequently, in step S207, the setting of the drive pulse rate of the stepping motor 35 is set to, for example, 50 ml / h so as to be larger than the set flow rate. In step S208, the pusher is driven in the reverse direction to move the pusher in the direction opposite to the infusion direction. Move.

  Subsequently, in step S209, it is determined whether or not the secondary time of 0.5 seconds has elapsed in the time measurement by the timer means. When this secondary time has elapsed, the process proceeds to step S210 and the driving of the stepping motor 35 is stopped. Next, in step S211, the pulse rate of the stepping motor is set to a set flow rate of 0.1 ml / h. The preparation for the normal infusion start operation is now complete, and in step S212, the stepping motor 35 is driven in the forward direction to execute the normal infusion operation. In step S213, the infusion is terminated in step S214 after the longest time of 2 hours has elapsed. In step S215, the work is finished.

  As described above, immediately after the start of the infusion, the infusion operation that becomes larger than the set flow rate is performed, and the pressing force is monitored.When the predetermined pressing force is reached, the infusion operation in the reverse direction is performed until the secondary time is reached. It is possible to shift to the infusion operation at the set flow rate subsequent to, within a short time, so that the infusion accuracy is not lowered.

  FIG. 13 is a correlation diagram of the integrated amount theoretical value X, the integrated amount actual measurement value Y, and the pressing force actual measurement value Z obtained within 30 seconds from the start of the infusion by the above infusion operation. FIG. 14 shows the correlation between the integrated amount theoretical value x, the integrated amount actual measurement value y, and the pressing force actual measurement value z obtained during the period from the start of the infusion to 30 seconds by the conventional infusion operation disclosed in Patent Document 1 above. It is a figure, Comprising: It is the correlation figure shown on the same scale as the correlation figure of this invention for the comparison.

  As can be seen from FIG. 13, when a predetermined second (about 3 seconds) elapses from the start of the infusion, the actually measured pressing force value Z temporarily rises to 0.65 V, but decreases to 0.5 V after about 5 seconds and then 30 Stable until seconds have passed. The accumulated amount actual measurement value Y approximates to the accumulated amount theoretical value X without increasing the accumulated amount after rapidly rising to about 0.0012 ml after about 5 seconds. In this way, immediately after the start of the infusion, an infusion operation that exceeds the set flow rate is performed, followed by the infusion operation in the reverse direction, so that the pressing force is forcibly released more than necessary. By moving closer to the integrated amount theoretical value, it becomes possible to shift to the infusion operation at the set flow rate within a short time, and the infusion accuracy of the infusion accuracy with little error between the integrated amount theoretical value X and the integrated amount actual measurement value Y can be achieved. Improvement was confirmed. Specifically, the infusion accuracy was + 32% for 30 seconds from the start of the infusion, and it was confirmed that infusion with high transfer accuracy was possible.

  On the other hand, according to the correlation diagram of the conventional infusion operation of FIG. 14, as can be seen from this figure, when about 3 seconds have elapsed from the start of the infusion, the actually measured pressing force z rises temporarily to 0.65 V Thereafter, until 30 seconds elapses, the pressing force gradually decreases to release the pressing force more than necessary. Further, the accumulated amount actual value y gradually rises after about 8 seconds have elapsed, and the accumulated amount exceeds 0.006 ml after 30 seconds have elapsed. This is a numerical value 10 times the integrated amount theoretical value x. As described above, in the conventional infusion method, an infusion operation that becomes larger than the set flow rate is performed immediately after the start of infusion, and if the infusion operation is performed as it is, the infusion operation at the set flow rate cannot be transferred within a short time, but the integrated amount theory It was confirmed that a large error appears between the value x and the integrated amount actual measurement value y. Specifically, it was confirmed that the infusion accuracy was + 632% for 30 seconds from the start of the infusion.

  As described above, immediately after the start of the infusion operation, an infusion operation that becomes larger than the set flow rate is performed, and then the infusion operation in the reverse direction is performed, so that the infusion operation at the set flow rate that follows can be shifted within a short time. As described above, this is particularly effective when the set flow rate is small. Here, it goes without saying that even when the set flow rate is set to a large value, the accuracy of infusion can be prevented from being lowered. For example, it is particularly effective when the viscosity of the infused chemical solution is high and the sliding resistance of the pusher is increased. It becomes.

FIG. 2 is an external perspective view of a syringe and a syringe pump 1. (A) is a principal part external appearance perspective view of the upper cover 2 of the main body 1, (b) is principal part sectional drawing of the clamp 5. FIG. These are the external appearance perspective views which showed a mode that the slider feed mechanism 33 was in the non-locking state. These are the external appearance perspective views which showed a mode that the slider feed mechanism 33 was a latching state. (A) is the external appearance perspective view of the slider assembly 50, (b) is the external appearance perspective view which removed and showed the cover 55 of the slider assembly. FIG. 4 is a front view of the slider assembly 50. These are the schematic diagrams of a press means. FIG. 3 is a block diagram of a syringe pump. These are flowcharts for operation | movement description which shows the basic operation | movement of the syringe pump 1 of a syringe pump. These are the flowcharts for operation | movement description of the syringe pump 1 of 1st Embodiment. FIG. 11 is a relationship diagram of flow rate, infusion time, and pressing force based on the infusion operation described in FIGS. 9 and 10. These are flowcharts of operation | movement description of the syringe pump 1 of an Example. These are the correlation diagrams of the integrated amount theoretical value X, the integrated amount actual measurement value Y, and the pressing force actual measurement value Z obtained from the start of the infusion to 30 seconds. These are the correlation diagrams of the integrated amount theoretical value x, the integrated amount actual measurement value y, and the pressing force actual measurement value z obtained from the start of the infusion to 30 seconds by the conventional infusion operation.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Syringe pump 2 ... Upper cover 3 ... Lower cover 5 ... Clamp,
6 ... Setting dial 7 ... Alarm lamp 11 ... Flow rate / scheduled amount / integrated amount display unit 15 ... Power switch 16 ... AC / DC lamps 19a to 19c ... Blocking lamp 25 ... Integrated amount lamp 26 ... Changeover switch 27 ... Integrated clear switch 33 ... Slider feed mechanism 34 ... Base 35 ... Stepping motor (with encoder)
36 ... Gear 37 ... Lead screw 38 ... Guide shaft,
40 ... Pipe shaft 43 ... Inner clutch shaft 44 ... Nut holder 45 ... Half nut 50 ... Slider assembly 51 ... Boot 52 ... Clutch lever 53 ... Right hook 54 ... Left hook 100 ... Control unit 101 ... IC tag detector 102 ... Push Pressure detector

Claims (3)

A syringe pump,
A pressing unit that moves the pressing unit that is in contact with the pusher of the syringe so that the pressing unit presses the pusher and sends out the chemical solution in the syringe;
An acquisition means for acquiring a flow rate of the chemical solution to be delivered from the syringe as a target set flow rate;
A setting means for setting a set flow rate based on the target set flow rate for a period until the target set flow rate obtained by the obtaining means is set;
Control means for controlling the moving speed when the pressing means moves the pressing portion according to the set flow rate set by the setting means;
Detecting means for detecting a pressing force when the pressing means moves the pressing portion and the pressing portion presses the pusher;
The setting means includes
The target set flow rate is maintained until the pressing force detected by the detection means reaches the first reference value that defines the timing for changing the setting of the set flow rate after the delivery of the chemical solution is started. Larger flow rate is set as the set flow rate,
After reaching the first reference value, a reference value that defines the timing for changing the setting of the set flow rate again is set to a second reference value that is lower than the first reference value by the detecting means. Until the detected pressing force reaches, a negative flow rate smaller than the target set flow rate is set as the set flow rate so that the pressing unit is moved in the reverse direction by the pressing means ,
A syringe pump, wherein the target set flow rate is set after reaching the second reference value. The syringe includes a storage medium that stores at least one of the target setting flow rate, volume, type of chemical solution, and information on the manufacturer as personal information,
The syringe pump includes a reading unit that reads the personal information stored in the storage medium,
The syringe pump according to claim 1, wherein the first reference value and the second reference value are changed according to the personal information read by the reading unit.   2. The syringe pump according to claim 1, wherein the first reference value and the second reference value are changed according to a volume of a main body cylinder portion of the syringe.

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