JP4555407B2 - Kampo medicines and herbal medicines - Google Patents
Kampo medicines and herbal medicines Download PDFInfo
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Description
【０００１】
【発明の属する技術分野】
この発明は、熱水又は水に分散させて用時調製する医薬用或いは健康食品用の漢方・生薬の製剤に関する。
【０００２】
【従来の技術】
経口より服用する医薬製剤は通常、粉末剤、顆粒剤、錠剤、カプセル剤等の形態に加工される。シロップ剤やドリンク剤等の液剤は、医薬品の安定性確保が難しいため、経口医薬製剤としては限られている。
漢方や生薬は、元来、熱湯により煎じた液を服用するものや、お湯と共に服用することが有効であるとされているもの等、暖めて服用することの有用性は広く知られている。しかしながら、煎じる方法は、特殊な装置を必要とする等、煩雑で服用の利便性の面で問題がある。
これを改良するため、漢方・生薬のエキス剤を利用して製剤化された顆粒が知られているが、これをお湯のなかに溶解（若しくは分散）させて服用しようとしても、漢方・生薬のエキス粉末の多くは、軽くて浮き易く、表面だけ溶けてダマになって分散溶解ができない、更にエキス粉末のなかには低温で溶解が悪い成分も含まれており、容器底部に沈殿してしまい、一様に分散しにくい、といった問題がある。また漢方や生薬は、独特の苦みや臭い、味がある場合が多く、単に熱水又は水に分散させて服用する方法では、幼児や老人には服用が苦痛となることが多い。高齢等により咀嚼・嚥下困難になると、粉末剤、顆粒剤、錠剤、カプセル剤をそのまま服用することが困難になり、新しい服用形態が望まれている。
【０００３】
しかし、薬剤を粉末剤、顆粒剤、錠剤、カプセル剤等として加工し、熱水又は水に分散させて服用する形態とした場合、薬剤が不溶性の成分を含むと均質に分散させることができず、また成分によってはダマになりやすいといった問題がある。更に、不溶成分が容器の底部に沈降すると、飲み残しが生じ、一定の服用量を定めた医薬品としては不適である。更に、独特の苦みや味のある成分が底の部分に凝集するとこの部分を服用することに大きな苦痛を伴うことになる。
【０００４】
【発明が解決しようとする課題】
この発明は、上記事情を考慮してなされたもので、服用時、熱水又は水に均質に分散させて飲み残しを防ぐことができ、またマスキング効果により服用を容易にすると共に、特に咀嚼・嚥下困難者等の服用を可能とした医薬用或いは健康食品用の用時調製漢方・生薬製剤を提供することを目的としている。
【０００５】
【課題を解決するための手段】
この発明に係る用時調製漢方・生薬製剤は、熱水又は水に分散させて用時調製する医薬用或いは健康食品用の漢方・生薬の製剤であって、漢方・生薬のエキス粉末を、増粘剤，ゲル化剤の少なくとも一方を混合して粉末剤、顆粒剤、錠剤、塊状剤、カプセル剤のいずれかの形態に加工してなることを特徴とする。
この発明による漢方・生薬製剤は例えば、漢方・生薬のエキス粉末を増粘剤やゲル化剤と混合して造粒機により造粒し、乾燥させて顆粒剤とし、或いはこれを打錠して錠剤、塊状剤とし、或いは粉砕して粉末剤とする。
【０００６】
この発明において、増粘剤やゲル化剤を混合する目的は、服用時に漢方や生薬を熱水や水に均質に分散させて沈降を起こさせず、飲み残しを防ぐこと、漢方や生薬の苦み、独特のにおいや味を粘性物やゲル化物の形態によりマスキングすること、咀嚼・嚥下困難者の服用を可能にすること、等にある。
この様な目的のために、増粘剤又はゲル化剤として、寒天、キサンタンガム、結晶化セルロース、カルボキシルメチルセルロース、カルボキシルメチルセルロースナトリウム、カルボキシルメチルセルロースカルシウム、カルボキシルメチルスターチナトリウム、カラギナン、ファーセレラン、アルギン酸、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル、ゼラチン、グアーガム、ローカストビーンガム、ペクチン、トラガントガム、タラガム、アラビアガム、カラヤガム、デンプン、デンプン誘導体、脱アシル型ジェランガム、ネイティブ型ジェランガム、カードラン、アゾトバクタービネランジーガム、プルラン、アラビノガラクタン、デキストリン、ヒドロキシエチルメチルセルロース、ヒドロキシエチルセルロース、ヒドロキシプロピルセルロース、ヒドロキシプロピルメチルセルロース、ポリビニルアルコール、ポリビニルピロリドン、コンドロイチン硫酸ナトリウム、ケイ酸アルミニウムマグネシウムの中から１種以上選択された素材が用いられる。
【０００７】
上述した増粘剤の目的から、増粘剤を加えた製剤１０ｇを１００ｃｃの熱水又は水に分散させて服用，飲用する際の粘度は、６．０〜３，０００ｃＰ程度が好ましく、更に望ましくは、１５．０〜５００ｃＰの範囲とする。６．０ｃＰ未満の粘度では、薬剤の均質分散の効果が得られず、また３，０００ｃＰを超える粘度では、用時調製が難しく、増粘剤によっては糊状感が強くなって飲用に耐えなくなる。
またゲル化剤を加えた製剤１０ｇを１００ｃｃの熱水又は水に分散させて服用，飲用する際のゼリー強度は、５〜１００ｇ／ｃｍ2の範囲が適当であり、より望ましくは、１０〜５０ｇ／ｃｍ2の範囲とする。ゼリー強度が５ｇ／ｃｍ2未満では、ゲル化までに薬剤が沈降してしまい、均質分散が難しくなり、味のマスキング効果も得られない。ゼリー強度が１００ｇ／ｃｍ2を超えると、ゲル化が強くなりすぎ、咀嚼・嚥下困難者の服用，飲用が困難になる。
【０００８】
熱水又は水に入れて服用，飲用する場合の温度は、熱水では７０℃以下が目安となり、水の場合は冷蔵された水を考慮して５℃以上が目安となる。従って、この温度範囲における物性が上述の粘性及び強度の範囲に入るように調製される。用時調製して服用するためには、調製から服用まで１時間以内であること、望ましくは１０分以内であることがよい。しかし例えば、冷蔵保存することにより、服用までの時間は延ばすことができる。
【０００９】
この発明において、増粘剤やゲル化剤に加えて、均質分散性を更に良好にするために分散剤を添加することができる。分散剤としては、ブドウ糖、ショ糖、果糖、乳糖、マンニトール、ソルビトール、キシリトール、マルチトール、フラクトオリゴ糖、乳果オリゴ糖、キシロオリゴ糖、デキストリン等の糖や糖アルコール、デンプン化工品の中から１種以上が選ばれる。錠剤の場合には更に、結晶セルロース、カルボキシルメチルセルロース、クロスカルメロースナトリウム、崩壊用寒天等の崩壊剤、デキストリン等の結合剤を加えることができる。顆粒剤の場合には、接着剤としてアラビアガム、プルラン、乳糖、ショ糖等を加えることができる。
【００１０】
この発明において更に、甘味料、香料、酸味料、調味料の少なくとも１種を加えることができる。甘味料としては、分散剤を兼ねてブドウ糖、ショ糖、乳糖、ソルビトール等の糖や糖アルコールが、また製剤用量やカロリーを考慮してステビアやアスパルテーム等のダイエット甘味料が用いられる。クエン酸、リンゴ酸、乳酸等の酸味料や香料、調味料は、漢方や生薬の味を考慮して選択される。
【００１１】
この発明における用時調製漢方・生薬製剤の対象となる有効成分としては、漢方薬や生薬のエキスが用いられる。具体的に漢方薬としては、小柴胡湯、柴苓湯、補中益気湯、柴朴湯、牛車賢気丸、加味逍遥散、麦門冬湯、八味地黄丸、大建中湯、小青竜湯、六君子湯、当帰芍薬散、十全大補湯、葛根湯、柴胡桂枝湯、桂枝茯苓丸、釣藤散、大柴胡湯、柴胡加竜骨牡蛎湯、猪苓湯、温経湯、黄連解毒湯、防巳黄耆湯、五苓散、白虎加人参湯、芍薬甘草湯、半夏白朮天麻湯、人参養栄湯、防風通聖散、半夏瀉心湯、小柴胡湯加桔梗石膏、桂枝加朮附湯、荊芥連翹湯、半夏厚朴湯、加味帰脾湯、温清飲、清肺湯、大黄甘草湯、十味敗毒湯、当帰飲子、辛夷清肺湯、当帰四逆加呉茱萸生姜湯、麻黄附子細辛湯、乙字湯、安中散、葛根湯加川キュウ辛夷、桔梗湯、桂枝湯、桂枝加芍薬湯、小建中湯、消風散、清上防風湯、治頭瘡一方、桃核承気湯、人参湯、麻黄湯、麻杏甘石湯、苓桂尤甘湯等のエキスが用いられる。
また生薬としては、アロエ、オオバコ、ドクダミ、ハトムギ、ギムネマ、シャクヤク、トウキ、ケイヒ、センキュウ、ソウジュツ、ブクリョウ、ボタンピ、トウヒ、コウブシ、ジオウ、カンゾウ、トウニン、オウレン、ショウキョウ、チョウジ、ニンジン、チンピ、エンゴサク、カノコソウ、キジツ、オウゴン等のエキスが用いられる。
これらの漢方、生薬の配合量は、薬効や効果を示す１日の服用量から、服用回数を考慮して決定される。
【００１２】
【発明の実施の形態】
以下、この発明の実施例をいくつか説明するが、この発明はこれらの実施例に限られるわけではない。
【００１３】
［実施例１］
葛根湯のエキス粉末１４重量部、キサンタンガム２重量部、ブドウ糖３０重量部、デキストリン５２．４重量部、珪酸カルシウム１重量部、アスパルテーム０．２重量部、レモン及び蜂蜜香料０．１重量部を混合し、流動層造粒機（大川原製作所製）で１．０％キサンタンガム水溶液を上記混合粉末に対して３０重量部噴霧しながら、６０℃で２０分造粒した。
造粒された漢方製剤を整粒の後、見かけ比重を測定したところ、０．３７ｇ／ｃｃであった。造粒された漢方製剤を、１回の服用量である１０ｇ（葛根湯０．６２５ｇ；１日分の１／３量相当）に分包し、１分包量をカップに入れ、１００ｃｃの湯（８０℃）を加えて分散させた。漢方薬は均一に分散溶解され沈殿を起こすことはなかった。１０分後にＢ型回転粘度計（芝浦システム（株）製，ビスメトロンＶＳ−Ａ）にて粘度を測定したところ、７２．５ｃＰであった。このとき温度は６０．５℃であり、飲用に適した温度であった。
【００１４】
［実施例２］
小青竜湯のエキス粉末９．２重量部、グアーガム６重量部、ステビア０．１重量部、ブドウ糖３０重量部、デキストリン５２．６重量部、オレンジ香料０．１重量部を混合し、流動層造粒機で８．０％プルラン水溶液を上記混合末に対して２５重量部噴霧しながら造粒した。
造粒された漢方製剤を整粒の後、１回の服用量である９．０ｇ（小青竜湯０．８３ｇ；１日分の１／３量相当）に分包し、１分包量をカップに入れ、１００ｃｃの湯（８０℃）を加えて分散させた。漢方薬は均一に分散溶解され沈殿を起こすことはなかった。１０分後にＢ型粘度計にて粘度を測定したところ、１４６．７ｃＰであった。このとき温度は６３℃であり、飲用に適した温度であった。
【００１５】
［実施例３］
防風通聖散のエキス粉末１０重量部、アセチル化タピオカデンプン３２重量部、アスパルテーム０．２重量部、ブドウ糖３０重量部、デキストリン２３．５重量部、パイナップル香料１．３重量部を混合し、流動層造粒機で１０％乳糖水溶液を上記混合末に対して３０重量部噴霧しながら造粒した。
造粒された漢方製剤を、１回の服用量である７．５ｇ（防風通聖散０．７５ｇ；１日分の１／３量相当）に分包し、１分包量をカップに入れ、１００ｃｃの湯（８０℃）を加えて分散させた。漢方薬は均一に分散溶解され沈殿を起こすことはなかった。１０分後にＢ型粘度計にて粘度を測定したところ、６１．６ｃＰであった。このとき温度は６２℃であり、飲用に適した温度であった。
【００１６】
［実施例４］
人参養栄湯のエキス粉末１０重量部、カルボキシメチルセルロースナトリウム３重量部、アスパルテーム０．２重量部、ブドウ糖３０重量部、デキストリン５５．９重量部、紅茶香料０．６重量部を混合し、流動層造粒機で１．０％カルボキシメチルセルロースナトリウム水溶液を上記混合末に対して３０重量部噴霧しながら造粒した。
造粒された漢方製剤を、１回の服用量である１０ｇ（人参養栄湯１ｇ；１日分の１／３量相当）に分包し、１分包量をカップに入れ、１００ｃｃの湯（８０℃）を加えて分散させた。漢方薬は均一に分散溶解され沈殿を起こすことはなかった。１０分後にＢ型粘度計にて粘度を測定したところ、１７１．２ｃＰであった。このとき温度は６３．２℃であり、飲用に適した温度であった。
【００１７】
［実施例５］
アロエ、オオバコ、ドクダミ、ハトムギ及びギムネマからなる生薬配合エキス粉末４重量部、緑茶エキスパウダー７重量部、グアーガム３重量部、乳糖６４重量部、微結晶セルロース１０重量部、崩壊寒天５重量部、コーンスターチ３重量部、ショ糖脂肪酸エステル２重量部、合成珪酸アルミニウム２重量部を混合して造粒した。造粒後、乾燥させて顆粒とし、これを打錠機にて１錠１０ｇに変形打錠した。水１００ｃｃにこの錠剤１錠を加えたところ、約２分で崩壊し、均一分散した。１０分後にＢ型粘度計にて粘度を測定したところ、１７．３ｃＰであった。
【００１８】
［実施例６］
大黄甘草湯２．５重量部、ショ糖２０重量部、ブドウ糖５８．５重量部、アルギン酸ナトリウム５重量部、リン酸ー水素カルシウム２重量部、クエン酸１重量部、レモン香料１重量部、粉末ハチミツ１０重量部を混合した。粉末の漢方製剤を、１回の服用量である１０ｇ（大黄甘草湯０．２５ｇ；１日分の１／３量相当）に分包し、１分包量をカップに入れ１００ｃｃの水を加えて分散させた。漢方薬は均一に分散溶解され、５分後にはアルギン酸ナトリウムとカルシウムイオンが反応してゼリーを形成した。１０分後にレオメーターMODEL COMPAC-10（サン科学にてゼリー強度を測定したところ、３５ｇ／ｃｍ2であり、服用に適していた。
【００１９】
実施例１〜６の配合の漢方・生薬製剤を、配合前の漢方・生薬のみの場合のそれぞれ比較例１〜６と対照させて、それぞれ実施例１〜６と同様の条件で分散させて１０人のパネラーに飲食させた。二点比較法による官能検査の結果、以下に示すように、実施例１〜６の場合にそれぞれ比較例１〜６に比べて飲食し易い（有意差１％で有意差あり）との評価を得た。
【００２０】
【表１】
【発明の効果】
以上述べたようにこの発明によれば、漢方や生薬を増粘剤やゲル化剤と混合して製剤化することにより、用時調製時に沈降を起こすことなく均質に分散させて薬剤の飲み残しを防ぐことができ、苦みや臭い、味をマスキングして飲みやすくすると共に、咀嚼・嚥下困難者に服用を可能とする医薬或いは健康食品用の製剤を提供することができる。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a preparation of a traditional Chinese medicine / herbal medicine for use in medicine or health food prepared by dispersing in hot water or water.
[0002]
[Prior art]
Pharmaceutical preparations to be taken orally are usually processed into powders, granules, tablets, capsules and the like. Liquid preparations such as syrups and drinks are limited as oral pharmaceutical preparations because it is difficult to ensure the stability of pharmaceuticals.
Traditionally, Kampo and herbal medicines are widely known for their usefulness when warmed, such as those that take a liquid decocted with hot water and those that are considered to be effective when taken with hot water. However, the roasting method is troublesome and requires a special device, and is problematic in terms of convenience of taking.
In order to improve this, granules formulated using Kampo and herbal extracts are known, but even if you try to dissolve (or disperse) them in hot water, Many of the extract powders are light and easy to float, melt only on the surface, become lumpy and cannot be dispersed and dissolved, and some extract powders also contain components that are poorly dissolved at low temperatures and settle to the bottom of the container. It is difficult to disperse like. In addition, Kampo and herbal medicines often have unique bitterness, smell, and taste, and in the case of taking the medicine by simply dispersing it in hot water or water, it is often painful for infants and the elderly. If chewing / swallowing becomes difficult due to aging, etc., it becomes difficult to take powders, granules, tablets, and capsules as they are, and new dosage forms are desired.
[0003]
However, if the drug is processed as a powder, granule, tablet, capsule, etc. and is taken in hot water or dispersed in water, it cannot be uniformly dispersed if the drug contains insoluble ingredients. Also, depending on the component, there is a problem that it is easy to get rid of. Furthermore, if the insoluble component settles on the bottom of the container, it causes unreasonableness and is unsuitable as a pharmaceutical product with a fixed dose. In addition, when unique bitterness and tasting ingredients are aggregated in the bottom part, taking this part is very painful.
[0004]
[Problems to be solved by the invention]
The present invention has been made in consideration of the above circumstances, and can be uniformly dispersed in hot water or water at the time of taking, and can prevent leftovers. In addition, the masking effect facilitates taking, The purpose of the present invention is to provide a herbal medicine / herbal preparation prepared for use in medicine or health food that can be taken by persons with difficulty in swallowing.
[0005]
[Means for Solving the Problems]
The herbal medicine / herbal preparation prepared at the time of use according to the present invention is a herbal medicine / herbal medicine preparation for use in medicine or health food prepared by dispersing in hot water or water, and the extract powder of herbal medicine / herbal medicine is increased. It is characterized in that at least one of a sticking agent and a gelling agent is mixed and processed into a powder, granule, tablet, block, or capsule.
The herbal medicine / herbal medicine preparation according to the present invention is prepared, for example, by mixing a herbal medicine / herbal medicine extract powder with a thickener or a gelling agent, granulating it with a granulator, and drying it to form a granule or compressing it. Tablets, lumps, or pulverized powders.
[0006]
In this invention, the purpose of mixing thickeners and gelling agents is to prevent Chinese medicine and herbal medicines from being left un-drinked by uniformly dispersing herbal medicine and herbal medicines in hot water or water at the time of taking. These include masking unique odors and tastes in the form of viscous or gelled substances, enabling the use of persons with difficulty in chewing and swallowing, and the like.
For this purpose, as a thickener or gelling agent, agar, xanthan gum, crystallized cellulose, carboxymethylcellulose, sodium carboxymethylcellulose, carboxymethylcellulose calcium, sodium carboxymethyl starch, carrageenan, farselerane, alginic acid, sodium alginate, Propylene glycol alginate, gelatin, guar gum, locust bean gum, pectin, tragacanth gum, tara gum, gum arabic, karaya gum, starch, starch derivatives, deacylated gellan gum, native gellan gum, curdlan, Azotobacter vinegar gum, pullulan , Arabinogalactan, dextrin, hydroxyethylmethylcellulose, hydroxyethylcellulose , Hydroxypropyl cellulose, hydroxypropylmethyl cellulose, polyvinyl alcohol, polyvinyl pyrrolidone, sodium chondroitin sulfate, is selected material one or more of the magnesium aluminum silicate is used.
[0007]
For the purpose of the thickener described above, the viscosity when taking and drinking 10 g of the preparation containing the thickener dispersed in 100 cc of hot water or water is preferably about 6.0 to 3,000 cP, and more preferably Is in the range of 15.0 to 500 cP. If the viscosity is less than 6.0 cP, the effect of homogeneous dispersion of the drug cannot be obtained. If the viscosity exceeds 3,000 cP, it is difficult to prepare at the time of use, and depending on the thickener, the pasty feeling becomes strong and cannot be taken. .
In addition, the jelly strength when taking and drinking 10 g of a preparation containing a gelling agent dispersed in 100 cc of hot water or water is suitably in the range of 5 to 100 g / cm 2 , more preferably 10 to 50 g. / Cm 2 range. When the jelly strength is less than 5 g / cm 2 , the drug settles before gelation, and it becomes difficult to uniformly disperse, and the taste masking effect cannot be obtained. When the jelly strength exceeds 100 g / cm 2 , gelation becomes too strong, making it difficult for a person with difficulty in chewing or swallowing to take or drink.
[0008]
The temperature when taking or drinking in hot water or water is 70 ° C. or lower for hot water, and 5 ° C. or higher for water in consideration of refrigerated water. Accordingly, the physical properties in this temperature range are adjusted so as to fall within the above viscosity and strength ranges. In order to prepare and take at the time of use, the time from preparation to taking is within 1 hour, preferably within 10 minutes. However, for example, the time until taking can be extended by refrigeration storage.
[0009]
In this invention, in addition to the thickener and the gelling agent, a dispersant can be added in order to further improve the homogeneous dispersibility. Dispersing agents include glucose, sucrose, fructose, lactose, mannitol, sorbitol, xylitol, maltitol, fructooligosaccharides, whey oligosaccharides, xylooligosaccharides, dextrin sugars, sugar alcohols, and starch products. The above is selected. In the case of tablets, a disintegrating agent such as crystalline cellulose, carboxymethyl cellulose, croscarmellose sodium, disintegrating agar, and a binder such as dextrin can be added. In the case of granules, gum arabic, pullulan, lactose, sucrose and the like can be added as an adhesive.
[0010]
In the present invention, at least one of a sweetener, a flavor, a sour agent, and a seasoning can be added. As sweeteners, sugars and sugar alcohols such as glucose, sucrose, lactose and sorbitol are used as a dispersant, and diet sweeteners such as stevia and aspartame are used in consideration of the dosage and calories. Acidic, flavoring and seasonings such as citric acid, malic acid and lactic acid are selected in consideration of the taste of Chinese medicine and herbal medicine.
[0011]
As an active ingredient which is a target of the Chinese medicine / herbal preparation prepared at the time of use in the present invention, herbal medicine or herbal extract is used. Specifically, herbal medicines include Sho-saiko-to, Sai-sai-yu, Hochuekki-to, Sai-boku-yu, Ushizuru Ken-ki-maru, Kamizo Harukasan, Mumon Fuyu-yu, Hachimi-jio-maru, Daikenchu-to, small Seiryu-yu, Rikkunshi-yu, Tokiki Yakusan, Juzen Daiyu-yu, Kakkon-yu, Saiko-Katsura-yu, Katsura-Karasuma, Cho-to-san, Dai-saiko-to, Saiko-ka-ryu-bon-oyster-yu, Tsukuyu, Onkei-yu, Huangren detoxification hot water, Fenghuang Huangpu-yu, Gojosan, Shirakaka Ginseng-yu, Shakuyaku kanso-yu, Hankaba Hakuto Tenma-yu, Ginseng Yoei-san, Fufutsu Seisan, Hankatsushinshin-yu, Koshiba Pepper gypsum plaster, Katsueka Kakitsuyu, Kureren Kouyu, Semi-Summer Koboku-yu, Kamiki-spa-yu, Onsen, Seiroku-yu, Daio-kanzo-to, Tomi-jinku-to, Toki-Dinshi Lung hot water, Toki four reverse Kagyu ginger hot spring, Mao-bushi-ko hot water, Otsuji hot water, Annakasan, Kakkon Yukagawa cucumber hot water, Kikyo hot water, Keieda hot water, Keieda hot water medicinal hot water, Kokenchu hot water, Soufusan, Kiyokami Fudo-to, Jiyu-wanu, Peach Nucleus, Ginseng, Mao-to, Apricot sweet stone hot water, extract, such as 苓桂 likelihood sweet hot water is used.
Herbal medicines include aloe, psyllium, dokudami, pearl barley, gymnema, peonies, touki, keihi, senkyu, sojutsu, bukuryo, buttonpi, spruce, kobushi, elephant, licorice, tonin, ouren, ginger, clove, carrot, chimpi, Extracts such as engosaku, valerian, pheasant, and ogon are used.
The amount of these herbal medicines and herbal medicines is determined in consideration of the number of doses based on the daily dose showing the medicinal effects and effects.
[0012]
DETAILED DESCRIPTION OF THE INVENTION
Several embodiments of the present invention will be described below, but the present invention is not limited to these embodiments.
[0013]
[Example 1]
14 parts by weight of Kakkonto extract powder, 2 parts by weight of xanthan gum, 30 parts by weight of glucose, 52.4 parts by weight of dextrin, 1 part by weight of calcium silicate, 0.2 parts by weight of aspartame, 0.1 parts by weight of lemon and honey flavor The mixture was granulated at 60 ° C. for 20 minutes while spraying 30 parts by weight of a 1.0% xanthan gum aqueous solution onto the mixed powder with a fluidized bed granulator (manufactured by Okawara Seisakusho).
After granulating the granulated Chinese medicine preparation, the apparent specific gravity was measured and found to be 0.37 g / cc. The granulated Chinese medicine preparation is packaged into 10g (0.625g of Kakkonto, equivalent to 1/3 of the daily dose) which is a single dose. (80 ° C.) was added and dispersed. Herbal medicine was uniformly dispersed and dissolved, and no precipitation occurred. Ten minutes later, when the viscosity was measured with a B-type rotational viscometer (Bismometron VS-A, manufactured by Shibaura System Co., Ltd.), it was 72.5 cP. At this time, the temperature was 60.5 ° C., which was suitable for drinking.
[0014]
[Example 2]
9.2 parts by weight of Shoseiryu extract powder, 6 parts by weight of guar gum, 0.1 part by weight of stevia, 30 parts by weight of glucose, 52.6 parts by weight of dextrin and 0.1 part by weight of orange flavor are mixed and fluidized bed. Granulation was carried out while spraying 25 parts by weight of an aqueous 8.0% pullulan solution with respect to the mixed powder using a granulator.
After the granulated Chinese medicine preparation is sized, it is packaged into a single dose of 9.0 g (0.83 g of Shosei Ryuto; equivalent to 1/3 of the daily dose). Was added to a cup and 100 cc of hot water (80 ° C.) was added and dispersed. Herbal medicine was uniformly dispersed and dissolved, and no precipitation occurred. Ten minutes later, when the viscosity was measured with a B-type viscometer, it was 146.7 cP. At this time, the temperature was 63 ° C., which was suitable for drinking.
[0015]
[Example 3]
10 parts by weight of Fufutsu Seisaku extract powder, 32 parts by weight of acetylated tapioca starch, 0.2 parts by weight of aspartame, 30 parts by weight of glucose, 23.5 parts by weight of dextrin, 1.3 parts by weight of pineapple flavor are mixed and flowed Granulation was carried out with a layer granulator while spraying 30 parts by weight of a 10% aqueous lactose solution onto the mixed powder.
The granulated Kampo preparation is packaged into 7.5g, which is a single dose (Fukatsutsu Seisaku 0.75g; equivalent to 1/3 of the daily dose), and the 1-packed amount is put into a cup. 100 cc of hot water (80 ° C.) was added and dispersed. Herbal medicine was uniformly dispersed and dissolved, and no precipitation occurred. Ten minutes later, when the viscosity was measured with a B-type viscometer, it was 61.6 cP. At this time, the temperature was 62 ° C., which was suitable for drinking.
[0016]
[Example 4]
Mixing 10 parts by weight of extract powder of carrot ginseng, 3 parts by weight of sodium carboxymethyl cellulose, 0.2 parts by weight of aspartame, 30 parts by weight of dextrose, 55.9 parts by weight of dextrin, and 0.6 parts by weight of tea flavor, Granulation was carried out with a granulator while spraying 30 parts by weight of a 1.0% sodium carboxymethylcellulose aqueous solution on the mixed powder.
The granulated Kampo preparation is packaged into 10g (1 g of ginseng Yoei-to, equivalent to 1/3 of the daily dose) which is a single dose, and the 1-packed amount is put into a cup and 100cc of hot water (80 ° C.) was added and dispersed. Herbal medicine was uniformly dispersed and dissolved, and no precipitation occurred. Ten minutes later, the viscosity was 171.2 cP when measured with a B-type viscometer. At this time, the temperature was 63.2 ° C., which was suitable for drinking.
[0017]
[Example 5]
Herbal medicine extract powder consisting of aloe, plantain, dokudami, pearl barley and gymnema 4 parts by weight, green tea extract powder 7 parts by weight, guar gum 3 parts by weight, lactose 64 parts by weight, microcrystalline cellulose 10 parts by weight, disintegrated agar 5 parts by weight, corn starch 3 parts by weight, 2 parts by weight of sucrose fatty acid ester and 2 parts by weight of synthetic aluminum silicate were mixed and granulated. After granulation, it was dried to give granules, which were deformed into tablets of 10 g using a tableting machine. When 1 tablet was added to 100 cc of water, it disintegrated in about 2 minutes and uniformly dispersed. Ten minutes later, when the viscosity was measured with a B-type viscometer, it was 17.3 cP.
[0018]
[Example 6]
Daikokanzoto 2.5 parts by weight, sucrose 20 parts by weight, glucose 58.5 parts by weight, sodium alginate 5 parts by weight, phosphate-calcium hydrogen 2 parts by weight, citric acid 1 part by weight, lemon flavor 1 part by weight, powder 10 parts by weight of honey were mixed. The powdered Chinese medicine preparation is packaged into 10 g (Daikankanzoto 0.25 g; equivalent to 1/3 of the daily dose), and the 1-minute package amount is put into a cup and 100 cc of water is added. And dispersed. The herbal medicine was uniformly dispersed and dissolved, and after 5 minutes, sodium alginate and calcium ions reacted to form a jelly. After 10 minutes, the rheometer MODEL COMPAC-10 (when the jelly strength was measured by Sun Science, it was 35 g / cm 2 and was suitable for taking.
[0019]
In contrast to the comparative examples 1 to 6 in the case of using only the traditional Chinese medicines and herbal medicines of the blends of Examples 1 to 6, respectively, 10 A human panel was allowed to eat and drink. As a result of the sensory test by the two-point comparison method, as shown below, in the case of Examples 1 to 6, it was evaluated that it was easier to eat and drink compared to Comparative Examples 1 to 6 (significant difference was 1%). Obtained.
[0020]
[Table 1]
【The invention's effect】
As described above, according to the present invention, by mixing a Chinese medicine or herbal medicine with a thickener or gelling agent to prepare a preparation, it is uniformly dispersed without causing sedimentation during preparation at the time of use. It is possible to provide a pharmaceutical or health food preparation that can be easily taken by masking bitterness, odor, and taste, and that can be taken by persons with difficulty in chewing or swallowing.
Claims (2)
漢方・生薬のエキス粉末を、増粘剤、及び分散剤を混合して粉末剤、顆粒剤、錠剤、塊状剤、カプセル剤のいずれかの形態に加工してなり、１００ｃｃの熱水又は水に１０ｇを分散させた用時調製時、温度１０〜８０℃の範囲で粘度が６．０〜３，０００ｃＰの範囲に調製されており、
前記増粘剤は、キサンタンガム、グアーガム、アセチル化タピオカデンプン、及びカルボキシメチルセルロースナトリウムの中から１種以上選択され、
前記分散剤は、ブドウ糖、ショ糖、果糖、乳糖、マンニトール、ソルビトール、キシリトール、マルチトール、フラクトオリゴ糖、乳果オリゴ糖、キシロオリゴ糖、デキストリン、及びデンプン加工品の中から１種以上選択されることを特徴とする用時調製漢方・生薬製剤。A preparation of herbal medicine or herbal medicine for medical or health food that is prepared in use within 1 hour from preparation to administration by dispersing in hot water or water,
Chinese herbal medicine extract powder is mixed with thickener and dispersing agent and processed into powder, granule, tablet, block, capsule, 100cc hot water or water At the time of preparation in which 10 g is dispersed, the viscosity is adjusted in the range of 6.0 to 3,000 cP in the temperature range of 10 to 80 ° C.,
The thickener is at least one selected from xanthan gum, guar gum, acetylated tapioca starch, and sodium carboxymethylcellulose;
The dispersant is selected from at least one selected from glucose, sucrose, fructose, lactose, mannitol, sorbitol, xylitol, maltitol, fructooligosaccharides, whey oligosaccharides, xylooligosaccharides, dextrin, and processed starch products. Chinese medicine and herbal medicine preparations prepared at the time of use.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12336698A JP4555407B2 (en) | 1998-05-06 | 1998-05-06 | Kampo medicines and herbal medicines |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP12336698A JP4555407B2 (en) | 1998-05-06 | 1998-05-06 | Kampo medicines and herbal medicines |
Publications (2)
| Publication Number | Publication Date |
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| JPH11322624A JPH11322624A (en) | 1999-11-24 |
| JP4555407B2 true JP4555407B2 (en) | 2010-09-29 |
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| JP12336698A Expired - Lifetime JP4555407B2 (en) | 1998-05-06 | 1998-05-06 | Kampo medicines and herbal medicines |
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| JP2001226293A (en) * | 2000-02-17 | 2001-08-21 | Kotaro Kanpo Seiyaku Kk | Taking assisting agent |
| KR100441629B1 (en) * | 2001-03-20 | 2004-07-27 | 오성천 | Functional Yanggaeng Composition Containing Herbal Extracts |
| TWI327474B (en) * | 2001-04-06 | 2010-07-21 | Neochemir Inc | Kit for preparation of carbon dioxide agent for external use. |
| JP2003079325A (en) * | 2001-06-28 | 2003-03-18 | Kanebo Ltd | Gelling powder |
| JP2003137726A (en) * | 2001-10-31 | 2003-05-14 | Ichimaru Pharcos Co Ltd | Hyaluronidase activity inhibitor |
| JP4263513B2 (en) * | 2003-03-20 | 2009-05-13 | 三栄源エフ・エフ・アイ株式会社 | Mastication / swallowing foods and chewing / swallowing assist compositions |
| JP2004345999A (en) * | 2003-05-21 | 2004-12-09 | Taiko Pharmaceutical Co Ltd | Bacterial cell preparation composition |
| US7494667B2 (en) * | 2004-03-02 | 2009-02-24 | Brunob Ii B.V. | Blends of different acyl gellan gums and starch |
| JP4955287B2 (en) * | 2006-03-10 | 2012-06-20 | 大鵬薬品工業株式会社 | Paeoniflorin-containing jelly preparation |
| JP2008000005A (en) * | 2006-06-20 | 2008-01-10 | Shizuoka Prefecture | Agent for ameliorating dysphagia and food for ameliorating dysphagia |
| EP2039362A4 (en) * | 2006-06-28 | 2011-06-29 | Otsuka Pharma Co Ltd | Tooth enamel dissolution inhibitor |
| JP5414966B2 (en) * | 2006-08-07 | 2014-02-12 | 大蔵製薬株式会社 | Jelly-like medicine that can be prepared at the time of use |
| US9084741B2 (en) | 2007-10-12 | 2015-07-21 | Ryukakusan Co., Ltd. | Granular jelly beverage for medication and process for producing the same |
| JP5433295B2 (en) * | 2009-05-01 | 2014-03-05 | 高田製薬株式会社 | Xanthan gum-coated water-soluble saccharide and compression-molded preparation |
| JP6042696B2 (en) * | 2011-10-31 | 2016-12-14 | 興和株式会社 | Anti-containing composition |
| JP6045238B2 (en) * | 2012-07-27 | 2016-12-14 | 旭化成株式会社 | Tablet containing thickening polysaccharide |
| JP6045237B2 (en) * | 2012-07-27 | 2016-12-14 | 旭化成株式会社 | Tablet-type thickener |
| JP6196847B2 (en) * | 2012-08-30 | 2017-09-13 | 興和株式会社 | Anti-containing composition |
| KR101436784B1 (en) * | 2012-11-30 | 2014-09-01 | 코스맥스바이오 주식회사 | Stick gel composition of red ginseng reduced bitterness and improved intake and manufacturing method thereof |
| JP2014214141A (en) * | 2013-04-30 | 2014-11-17 | 興和株式会社 | Sinomenium stem-containing composition |
| CN103783521B (en) * | 2013-12-31 | 2015-12-09 | 陈慧婷 | A kind of Fructus Jujubae Rhizoma Dioscoreae Semen Tritici aestivi dispersible tablet and preparation method |
| CN103783517B (en) * | 2013-12-31 | 2016-01-20 | 陈慧珊 | A kind of Rhizoma Dioscoreae Rhizoma Polygonati dispersible tablet and preparation method |
| JP2019069914A (en) * | 2017-10-06 | 2019-05-09 | 松浦薬業株式会社 | Chinese medicine pharmaceutical composition and chinese medicine preparation |
| WO2019202968A1 (en) * | 2018-04-17 | 2019-10-24 | 株式会社ダイセル | Easy-to-take granular preparation, and method for producing same |
| KR20220086643A (en) * | 2019-10-25 | 2022-06-23 | 스미또모 가가꾸 가부시키가이샤 | food composition |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH01165527A (en) * | 1987-12-23 | 1989-06-29 | Tsumura & Co | Preparation of extract of chinese medicine |
| JPH0372428A (en) * | 1989-05-31 | 1991-03-27 | Eiko Hatakeyama | Preparation of chinese herbal medicine derived from basidiomycetes |
| JP2508555B2 (en) * | 1991-05-24 | 1996-06-19 | 株式会社紀文食品 | Bitterness reduction method |
| JPH07116049B2 (en) * | 1991-06-05 | 1995-12-13 | 株式会社ツムラ | Easy-to-use Kampo formulation |
| JPH05339162A (en) * | 1992-06-04 | 1993-12-21 | Genbu O | Chinese medicinal formulation for treating common cold |
| JPH07115942A (en) * | 1993-08-09 | 1995-05-09 | Sanji Kumai | Production of oligo drink and oligo jelly of herb medicine |
| JPH08116881A (en) * | 1994-10-26 | 1996-05-14 | Yutaka Koizumi | Method for pulverizing tea leaf, ultrafine powder tea obtained therefrom and tea drink and food and drink using the same |
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1998
- 1998-05-06 JP JP12336698A patent/JP4555407B2/en not_active Expired - Lifetime
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