JPH05339162A - Chinese medicinal formulation for treating common cold - Google Patents

Abstract

PURPOSE: To obtain a chinese medicinal formulation capable of manifesting a general treating effect suitable to all of the various common colds developing based on a unique climate and a living environment in Peaple's Republie of China, and also having a potent curing effect on an initial period of the cold, further on exacerbated symptoms and multiple symptoms accompanying with the cold. CONSTITUTION: This chinese medicinal formulation for a common cold consists of major ingredient of an antipyretic detoxifying agent, a sub-ingredient consisting of A, B and C, a supporting ingredient consisting of D, E, F, G and H and minor ingredient of I. To the above formulation, >=1 kind selected from eight Chinese expectoratic and antipyretic medicines is added thereto, A: Mentha arvensis L., B: Schizonepeta tenuifolia (Benth), C: Dendrobium moniliforme (L), D: Arctium lappe L., E: Chrysanthemum morifolium Ramat., F: Scutellaria amoeana C, H, Wright, G: Prunus amygdalus Batsch., H: Angelica decursive (Miq.), I: Platycodon grandiflorum (Jacq.).

Description

Detailed Description of the Invention

[0001]

[Field of Industrial Application] The present invention is suitable for all kinds of common colds caused by the climate and living environment peculiar to Japan, and the initial and one-step deepening of the common colds and the frequent occurrence of common colds. The present invention relates to a Kampo medicine for treating colds, which has a great healing effect on all evidences.

[0002]

2. Description of the Related Art The common cold is one of the most frequently seen diseases, but there is no perfect cure for it and there are many points that need improvement.

In other words, Western medical treatment is limited to the administration of symptomatic therapeutic agents for temporarily relieving superficial symptoms such as fever and cough, or the administration of antibiotics for preventing secondary infections such as pneumonia. However, the development and practical application of a cold remedy that exhibits a reliable therapeutic effect has not succeeded even now.

On the other hand, a medicine for treating colds by Kampo medicine utilizes a Kampo medicine which is composed by combining a plurality of drugs, and in China, it is a prescription for Chinese medicine (Kakkonto, Keishito, It has also been used in Japanese Kampo, as it has been used in many ways, but it is occurring in Japan where the climate and living environment are significantly different from China, as described below. Due to its poor healing effect against many types of common cold, recently Tianjin common cold pieces, silver boiled detoxification pieces, etc., which belong to different hot-drying agents, have come to be used. However, these drug effects are also limited to the early stage of common cold or common cold symptoms or common cold with few comorbidities.

[0005]

[Problems to be Solved by the Invention] The climate of Japan is clearly warmer than that of China, the humidity is extremely high, and the difference in temperature and humidity inside and outside is large due to the spread of cooling and heating equipment. During this period, people will be exposed to extremely large changes in temperature and humidity, which will cause new colds due to this environmental change, and the physical constitution of modern people due to lack of exercise and changes in diet due to the use of cars. Is becoming vulnerable,
Treatment of common cold syndrome with multiple and multiple etiologies, which is often associated with a highly common epidemic cold due to viral infection or complicated evidence (persistent fever, sore throat, swollen tonsils, cough, phlegm, etc.) However, it is difficult to prevent the disease from progressing with conventional Western medicine treatments and Chinese medicine treatments because colds at each stage are difficult to prevent.

[0006]

SUMMARY OF THE INVENTION The present invention provides a complex drug, which is commonly referred to as a Chinese medicine in ancient Chinese medicine, and this Chinese medicine is used for the treatment of a single medical illness and for the treatment of multiple drugs (Chinese medicine). It is possible to enhance the effect of the drug by synthesizing and strengthening the characteristics of each drug by a combination of drugs, or eliciting the overall effect such as offsetting and adjusting side effects and defects of each drug.
Furthermore, since each of these individual drugs is rich in a wide variety of active ingredients, the formulation of the complex as a complex contains a great variety of components.・ Because it can have various effects,
Focusing on the fact that if this medicine is used, a comprehensive cold remedy by Chinese medicine can be obtained, and the composition drug of the medicine was specified based on the development principle described below, and the present invention was completed. ..

[0007] That is, the medicine for detoxification of clean heat, the subject of divergent fever / departure solution, and the table of clear heat agar, and the agent of clear heat detoxification / abrasion heat / blanket / dry / wet pneumonia / cough cough. By using the drug and an antitussive drug, we provide a comprehensive Kampo medicine for the treatment of common colds that has remarkable efficacy against all common colds currently clinically seen in Japan. This is to solve the problem.

[0008] As for the details of the representative example of this basic formula, Kimiyaku is a heat-detoxifying toxin, Forsythia japonica, and the subject drug is a mint of divergent fever, a kaigai of a blast-air solution, and a gypsum of fresh-heat fire. The medicines are Sanzcon goboushi for detoxification and Kikuka for scabbing heat, Ogon for dry heat and dryness, Kyounin for pneumoconiosis and Zenko for coughing cough, and the medicine for use is Kikiou for coughing. And the preferred adult 100 of these drugs
The blending ratio for the day is Kingfinka 250 / Forsythia 20
0 / Mentha 80 / Kay Guy 100 / Gypsum 180 / Sandscon 100 / Goboushi 100 / Kikuka 180 / Ougon 100 / Kyonin 120 / Zenko 80 / Kyoko 100 (unit is grams), but according to symptoms and target age, etc. ~ 50 · Forsythia 10
00-40 ・ Mentha 600〜40 ・ Kayguy 1000〜
50 / Gypsum 2500 ~ 50 / Sandscon 1000 ~
50 ・ Goboushi 1000-50 ・ Kikuka 1500-50
・ Ou Gon 1000-50 ・ Kyounin 1000-40
-The dose can be adjusted within the range of Zenko 1000-50 and Kyoukyo 1000-50.

The above-mentioned development principles of the Kampo medicine for treating colds are established as follows.

(1) Main symptoms of the common cold in Japan In the common cold of Japan, there are many kinds of common cold symptoms based on the difference in etiology, and the main symptoms in modern times are classified into the following two categories. (Category 1st category) chills, mild fever, no sweat, headache, nasal obstruction, swelling, sore throat, cough, limb pain, moss whiteness, pulse swelling. (Certificate 2nd category) Fever, chills and mildness, sore throat, coughing, phlegm, dry mouth, white moss, and pulse number. The main complications (concurrent evidence) are as follows. (Major complications) Persistent fever, erythema pain, pharyngitis (voicing), swelling of the throat (swelling or purulence; tonsillitis), cough (cough and sputum production).

Comprehending both types and major complications of the above evidence, it is possible to cover most of the early symptoms of the common cold encountered in modern Japan.

(2) Treatment policy Since most of the common colds in Japan show such complicated medical evidences, regardless of the type of clinical evidence, treatments such as tabulation, fever and detoxification are used. There must be. Furthermore,
It is necessary to mix a drug that corresponds to the common evidence (complication) of the cold. Here, detoxification is to release heat poison (a lesion that shows intense heat due to infection with bacteria, viruses, etc.).

(3) Selection and Mixing of Drugs Many drugs (Chinese drugs) useful for treating the common cold are selected. From among these, drugs suitable for different types of clinical evidence are selected, and these are mixed based on the composition theory. To use. For this reason, if a prescription for the common cold disease symptom in Japan is established as the basic drug, it will be possible to appropriately mix and adapt drugs that are suitable for different medical illnesses. .. Based on this principle, we can reach the following conclusions by examining the clinical picture of Japanese common cold. That is, in addition to the effect of the screen for scabbing by the hot and cold temperature table, strengthening the clear heat and detoxification to deal with the main evidence of the common cold, and further the effects of pneumoconiosis, coughing, expectoration, and sore throat. The composition of a comprehensive cold remedy in modern Japan can be determined by adding and preparing for evidence.

(4) Effectiveness of the Kampo medicines of the present invention, as described in the preceding paragraph, there is a list of screens for defecation, detoxification of heat of fever, cough of pneumoconiosis, and phlegm.

(5) Kampo medicine prescribing principle of the inventive medicine The present invention (reason for selecting medicines constituting the medicine and theoretical basis of composition of the medicine) is shown simply in FIG. Is a map
This figure was created by the inventors in the process of development of the formula of the present invention. From the left, the first column shows the first drug, the second column shows the first drug, and the second drug shows the third drug. The columns are divided into adjuvants and the fourth column is classified as emissary, and the major effects of each drug in the drug and the relationship between the drugs are clearly stated. Kingginka, your medicine in medicine
Forsythia is detoxified with clear heat. Minakami of the subject medicine is divergent heat, Kaigai is a deflagration solution table, Gypsum is a clean fire, and it is excluded together with Kimiyaku. Sayaku's Sandscon Goboushi is a clear heat detoxification,
Together with your medicine, Kyou, detoxification with your medicine, Kikuka helped mint and keikai, heat removal table and levitating heat, Ougon is dry and dry, Kyounin is pneumocystic, and Zenko is helped with Zenko. Pulmonary table / cough. Kikyou, a drug, helps Sanzcon Goboushi to detoxify the heat of detoxification, detoxifies it with your medicine, helps to prevent coughing phlegm of Kyounin Zenko, and also works with gypsum, kikuka, and ogon to stop pneumoconiosis. Fulfill

[0016] With all of the above drugs
Co-deliver the effects of pneumoconiosis cough and expectoration.

(6) Ingredients and drug efficacy of typical drugs composing the pharmaceutical composition of the present invention Kingfish, which is a drug, contains flavonoid glycosides such as luteolin and saponin and tannin, and forsythia is phenol compounds such as forsytin and sterol derivatives. -Contains saponins, flavonoid glycosides, alkaloids, etc., sharing both with strong antibacterial and antiviral (antiviral) effects, and becoming a representative drug for detoxification.

Mint of menthol and ment
Contains volatile oils of terpenes such as hone and camphene / limonene
Gypsum contains calcium sulfate as a main component and eliminates the cause of fever by excluding cold and heat both in the table and excluding the cause of fever, and contains volatile oils such as enthone and limonene. It is a representative drug.

[0019] Sanzcon, which is an adjuvant, contains alkaneloids such as matrine and flavonoid glycosides / steroids and exhibits an anti-tumor effect, and enhances the effect of clear heat detoxification in combination with clear heat detoxification, goldfish / Forsythia. Burdock is a
Containing glycosides such as rctiin and fatty oils and exhibiting antibacterial action, debris fever / antitumor detoxification. Kikuka is borneol
-Containing terpene essential oils such as camphor and chrysanthone, and furanovoid glycosides, etc., and exhibiting an anti-pathogenic effect, scabbing heat. Ougon is baical
Containing glycosides with flavonoids such as ein and wogonin as aglycones, it has a wide range of medicinal properties such as anti-inflammatory, antibacterial, antipyretic, diuretic, and sedative. Ougong often performs coughing and expectoration together with Kyounin Zenko, who is a pneumocongestive phlegm, in combination with gypsum, which is a hot-spotted fire. Kyounin is amyg
With dalin as the main component, it calms the respiratory center and exerts the effect of pneumoconiosis cough well with antitussive palsy and kyoko zenko. Zenko contains phlocoumarin glycosides mainly consisting of nodakenin and volatile oil to promote secretion of tracheal mucus, and both Kikyo and Zenko perform expectoration and drainage.

Kyokyo, the drug, is a platycodige
Containing triterpenes such as nin and steroid glycoside saponin, the secretion of tracheal mucus is markedly increased and the effect of expectoration is exhibited.

Therefore, the ingredients and efficacy of each of the above-mentioned drugs of Kimi, Shou, Sa, and Shishi are the same as those of the Kampo medicine for treating colds of the present invention.

(7) Addition and Degradation of the Formulation of the Present Invention The basic formulation of the present invention is used as a substitute or an additional drug for the above-mentioned drug according to its efficacy classification, depending on the clinical treatment needs and the circumstances of the manufacturing raw material. The following exemplified drugs can be used. However, because one drug has multiple effects, some may be listed redundantly. 1. Seito Detoxification: Daisei, Banrankon, etc. 2. Divergent fever: Soyo, Koboushi, Psycho, Cuckon, Tantoushi, etc. 3. Gust Wind Solution Table: Shisoyou, Maou, Keishi, Saishin
Bow-fu, juniper, ginger, ginger, etc. 4. Kiyo hot fire: chimo, sushi, chikuyo, locon, etc. 5. Convection heat: Soyo, burdock, sentai, etc. 6. Fire and dryness: Ouren, Ryutan, etc. 7. Pneumoconiosis cough: Maoh, Hakuzen, Sohakuhi, etc. 8. Antitussive sputum: Fritillaria, Taerexi, Hyakubu, Biwayou, Zion, Shiso, Kanzo, etc. 9. Cough throat: Genjin, Bakumondou, Tenmondou, Kanzo, etc.

Further, in the treatment of complex cold syndrome, when a special symptom appears, a drug having the following efficacy can be added to the basic preparation of the present invention. However, because one drug has multiple effects, some may be listed redundantly. 1. Cough flat stomach: Maou, Hakubu, Hakuzen, etc. 2. Dehumidification Table: Cuckoo, Koju, Sojutsu, Kyoukatsu, etc. 3. Phylogenetic phlegm: chimp, karou, kyokyo, etc. 4. Yoinsei heat: Tenmondou, Bakumondou, Shojiou, Genjin, Seiko, Chinese cabbage, etc. 5. Dry-wet turbidity: Sojutsu, Koboku, etc. 6. Under guidance: Hawthorn, Bakuga, Shinkiku, Chinpi, etc. 7. Kiyoshi Shinkai: Gooh, Jako, etc. 8. Wanaka Nakamiso: Ginger, chimpi, tanso, etc.

When preparing or adding the Kampo medicine of the present invention using these drugs, the above-mentioned composition principle of the Kampo medicine must be observed.

[0025]

[Action]

(1) Action of the present invention The above-mentioned Kampo medicine for treating colds according to the present invention is a cold showing excellent therapeutic effects against various common cold clinical symptoms commonly encountered in Japan. Therapeutic agents can be formulated, thus establishing a complete treatment method for treating the common cold.

[0026] For example, in the early stage of the common four-year cold, which shows fever, slight chills, coldness, sweatlessness, headache, nasal obstruction, etc., the effects of leprosy table, clear heat detoxification, pneumoconiosis cough, and expectorant phlegm are effective. The Kampo medicine of the present invention having the following is applied, but in the case of severe cold and influenza at each stage with further progress from the initial disease,
That is, persistent high fever, chills, headache, bodyache, limb pain,
Even when symptoms such as swelling of the pharynx (swelling of the throat) are observed, treatment can be performed by the compounding characteristics of this medicine. For example, the clear heat from gypsum, sandscon, etc.
Detoxification, fresh heat, dryness, and wetness due to addition of syrup, etc. are unique compounding characteristics, and by combining these effects, an extremely excellent effect can be obtained.

Further, even in the case of bronchitis accompanied by severe cough and sore throat, excellent therapeutic effects can be obtained by applying the present preparation. This is because the medicinal effects of cough and expectorant, such as Zenko and Kyou, are combined with the pneumoconiosis fever caused by gypsum and oogon in this formulation, and an excellent therapeutic effect for pneumoconiosis cough is obtained.

(2) Characteristics of action of the present Chinese medicine Summarizing the above, the Chinese herbal medicine of the present invention is a newly created preparation by analyzing the pathological characteristics of the common cold caused by the living environment in Japan. The composition has the following characteristics that are unprecedented. 1. Strengthen the efficacy of detoxification by adding supplements such as Sandscon to your medicines such as goldfish and forsythia. Addition of the effect of clear heat embers by the addition of a subject such as gypsum. 3. Add the effect of fire, dryness, and wetness by adding a supplement such as sardine. 4. Prepare preparations for cold and heat illness by arranging subjects such as kayga on subjects such as mint and goshes and chrysanthemums. Strengthening the effect of cough and expectoration by adding supplements such as Kyounin and Zenko, and chemotherapeutics such as Kyoukyo

These drugs produce a total effect in relation to each other, remarkably enhance the efficacy of the Chinese medicine, and are effective for the common cold disease certificate in Japan. That is, a. Common cold / influenza that causes symptoms at each stage from the beginning, b. Common cold / influenza with many complex evidences, c. It has been confirmed by many clinical trials that it has an excellent therapeutic effect on many types of influenza, that is, common cold syndrome caused by infection with common cold virus.

[0030]

Example 1 180 g of gypsum was pre-roasted with water. on the other hand,
Essential oil is collected by steam-distilling 100 g of kayigai, 80 g of mint, 120 g of Kyounin, 180 g of Kikuka, and 80 g of Zenko. The steam distillation residue is added to the gypsum decoction together with the decoction, and 250 g of other gold ginkgo, 200 g of forsythia, 100 g of sandscon, 100 g of burdock, 100 g of sardine.
Add 100g of gram and 100g of kyokyo, water-boil, collect the decoction, and then re-hydrolyze. The first and second decoctions are combined and concentrated under reduced pressure to obtain a crude extract. To the crude extract, sucrose as a flavoring agent and starch as an excipient were added, and essential oil obtained by steam distillation was added to the mixture to homogenize the mixture, and the mixture was sealed in 300 packets and stored as a dry syrup. As a result of taking 1 packet of this in hot water 3 times a day, the initial symptoms of the common cold were completely healed in 1-2 days,
If there is a complication, the various symptoms disappear within 1 to 3 days, and
No side effects were observed.

[0031]

[Example 2] A crude extract and clean oil were collected by the prescription amount and the brewing method of Example 1. Excipient starch was added to the crude extract to granulate it, and then impregnated with clean oil to homogenize it. Take 1 capsule of this granular preparation in warm water and take 3 times a day
Times. Regarding the therapeutic effect and side effects, the same excellent results as in Example 1 were obtained.

[0032]

[Example 3] A crude extract and a clean oil were collected by the prescription amount and the brewing method of Example 1. Excipient powder is obtained by adding starch as an excipient to the crude extract, impregnating it with pure oil, and homogenizing with stirring. This 3
Store in a 00-pack in a sealed package. Take 1 pack of this extract powder in warm water and take 3 times a day. Regarding the therapeutic effect and side effects, the same excellent results as in Example 1 were obtained.

The same excellent results were obtained even when this drug was changed to a capsule form.

[0034]

[Example 4] A crude extract and a clean oil were collected by the prescription amount and the brewing method of Example 1. Excipient starch is added to the crude extract for granulation, impregnated with clean oil to homogenize, and compressed into tablets, which are then sealed and stored in the form of tablets. As a result of taking this drug, the same excellent results as in Example 1 were obtained.

[0035]

[Example 5] A crude extract and clean oil were collected by the prescription amount and the brewing method of Example 1. Add honey and pure oil to the crude extract, and make it into a circle and make a pill, and store it in a sealed container as a pill. The results of taking this drug were as excellent as in Example 1.

[0036]

[Example 6] A crude extract and fresh oil were collected by the prescription amount and the brewing method of Example 1. However, the concentration of the crude extract under reduced pressure is limited to the intermediate stage, and fresh oil is added to the crude extract, the mixture is dispensed and sealed in ampoules, and stored as a liquid agent in a cool and dark place. When taking, open the ampoule and pour it into warm water to warm it. The same excellent results as in Example 1 were obtained as a result of taking this drug.

In the above examples, it was proved that the single dose was used in the same amount as the raw drug, and the therapeutic effect did not depend on the dosage form.

[0038]

[Example 7] The raw material formulation mixed in the mixing ratio of Example 1 was wrapped in a tea bag type using a double daily dose, and 400 ml of water was added to this one package, and the lid was placed in a enamel container. Close and brew for 30 minutes with low heat to collect the first brew, mix the re-brewed brewing residue with the first brew, and divide it into 3 minutes and take 3 times a day. The same excellent results as in Example 1 were obtained as a result of taking this drug.

[0039]

[Embodiment 8] Cold disease progresses one step and is accompanied by upper respiratory tract infection, bronchitis, etc., and fever is not high (fever is not high), nasal obstruction (nasal congestion), swelling (severe eyes), cough and cough (cough). For those who see the evidence of sputum, phlegm, sore throat, dry mouth, lichen yellow, and pulse rate, the basic formulation of the present invention shown in Example 1 is unsuitable. Change the part.

That is, Kaigai-Sandscon-Goboushi-Kikuka was removed from the basic agent for treating colds of Example 1, and 100 g of Shiso, 100 g of Bimo, 100 g of Sohakuhi, and 80 g of licorice were added. Due to this change in prescription, the efficacy of tabulation is weaker than that of the basic formulation, and the efficacy of coughing phlegm is strengthened, and it becomes a formulation having the efficacy of clearing fever and coughing phlegm, which is suitable for the above-mentioned diseases.

Using this formulation as a dry syrup formulation in the same manner as in Example 1, an excellent healing effect was obtained for persons with the above-mentioned diseases.

[0042]

[Example 9] Fever, chills (sause), nasal obstruction, inadequate stomach (bad gastrointestinal condition), pain, nausea (drowsiness), vomiting, stool softness, and swelling (sickness) due to summer colds, moderate heat, gastroenteritis, etc. For those who see evidence of loss of appetite, white tongue coating, moisturization and pulse wetness, the basic formulation of Example 1 is modified as follows.

That is, Kaigai, Gypsum, Sandscon, Goboushi, Kikuka, Zenko were removed from the basic agent for treating colds of Example 1, and 100 g of Cuckoo, 100 g of Kouji, 80 g of Chimo, 80 g of Komoku, 120 g of Chinpi, 60 g of ginger were added. In addition, the efficacy of dehumidification / decomposition table is enhanced and the efficacy of reasonably stomach / falling back emesis is exhibited, and thus the above medical certificate can be satisfied.

This formulation was used as a dry syrup in the same manner as in Example 1, and an excellent effect on summer cold, mid-heat, gastroenteritis, etc. was observed.

[0045]

The method of the present invention having the composition as described above is
For the common colds of various illnesses commonly encountered in Japanese clinical practice,
The common cold, which completely eliminates various deficiencies found in conventional cold remedies and is an ideal therapeutic agent with excellent therapeutic effect,
As a result of administration test to patients with epidemic cold, various influenza colds, and common cold syndrome, it is extremely effective for early common cold symptoms, improvement of symptoms of the common cold, and severe pharyngitis associated with common cold. It was also found to be completely effective for complications such as tonsillitis and bronchitis.

[Brief description of drawings]

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a diagram showing the disjunctive position of the cold treatment drug of the present invention.

─────────────────────────────────────────────────── ─── Continuation of the front page (51) Int.Cl. ⁵ Identification code Internal reference number FI technical display location A61K 35/78 ABM W 7167-4C

Claims (2)

[Claims] 1. A medicine for cleansing detoxification, and a subject for divergent fever / gust removal / seal heat and exhalation heat and exothermic detoxification, shaving heat, exhalation heat
A Chinese herbal medicine for the treatment of common colds for leprosy fever, clear heat detoxification, pneumoconiosis cough, and expectorant phlegm, which is characterized by using a drug for pneumoconiosis and coughing phlegm and a drug for coughing and sore throat. 2. A drug according to claim 1, which is a drug for cough flatulence, chemotherapeutic dissociation table, phlegm-induced phlegm, yo-injyo heat, dry moisturizing turbidity, induction treatment, Seishin open sword, Wanaka stomach. A Chinese herbal medicine for treating the common cold, which is characterized by adding one or more to treat special symptoms.