JPH07116049B2 - Easy-to-use Kampo formulation - Google Patents
Easy-to-use Kampo formulationInfo
- Publication number
- JPH07116049B2 JPH07116049B2 JP3165157A JP16515791A JPH07116049B2 JP H07116049 B2 JPH07116049 B2 JP H07116049B2 JP 3165157 A JP3165157 A JP 3165157A JP 16515791 A JP16515791 A JP 16515791A JP H07116049 B2 JPH07116049 B2 JP H07116049B2
- Authority
- JP
- Japan
- Prior art keywords
- kampo
- easy
- preparation
- composition
- gelatin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Description
【0001】[0001]
【産業上の利用分野】本発明は、漢方製剤の服用が容易
な易服用性漢方製剤組成物に関し、更に詳細には、老
人、幼児や、水の摂取が制限されている患者でも困難を
感じることなく漢方製剤を服用することのできる易服用
性漢方製剤組成物に関する。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an easy-to-dose Kampo preparation composition which allows easy administration of Kampo preparations. More specifically, it is difficult for elderly people, infants and patients with restricted water intake. The present invention relates to an easily-administered Kampo preparation composition that can be taken without any Kampo preparation.
【0002】[0002]
【従来の技術】従来より、漢方製剤は乾燥エキスをその
まま、もしくは湯や水に溶かして服用するのが一般的で
ある。 しかし、漢方製剤には、苦味や独特な味や臭い
を有するものが多く、老人や幼児にとってこの服用は苦
痛となることも多かった。 また、漢方薬を服用する患
者が、同時に水分の摂取量を制限されている場合もある
が、限られた量の水で漢方製剤を摂取する場合、漢方製
剤が口中に残り、強い不快感を与えることもあった。2. Description of the Related Art Conventionally, it has been general practice to take dried extracts of Kampo preparations as they are or by dissolving them in hot water or water. However, many Kampo preparations have a bitter taste, a unique taste and smell, and it was often a pain for old people and young children to take this medicine. Also, patients who take Kampo medicines may be restricted in water intake at the same time, but when Kampo preparations are taken with a limited amount of water, the Kampo preparations remain in the mouth and cause strong discomfort. There were things.
【0003】[0003]
【発明が解決しようとする課題】したがって、老人や幼
児、また水分の摂取を制限されている患者であっても容
易に服用できる漢方製剤の開発が望まれていた。Therefore, there has been a demand for the development of a Kampo preparation which can be taken easily even by elderly people, infants, and patients with restricted water intake.
【0004】[0004]
【課題を解決するための手段】上記実情に鑑み、本発明
者らは何の困難性も感じず服用することのできる漢方製
剤組成物を得べく鋭意研究を行なった結果、漢方製剤を
半固体のゼリー状に成型することによりその目的が達成
されることを見出した。[Means for Solving the Problems] In view of the above circumstances, the present inventors have conducted diligent research to obtain a Kampo preparation composition that can be taken without feeling any difficulty. As a result, the Kampo preparation is semisolid. It was found that the object can be achieved by molding into a jelly form.
【0005】すなわち本発明は、漢方製剤をゼラチンを
用いて半固形状に成型したことを特徴とする易服用性漢
方製剤組成物を提供するものである。That is, the present invention provides an easy-to-dose Chinese herbal medicine composition characterized by molding a Chinese herb medicine into a semi-solid state using gelatin.
【0006】本発明の易服用性漢方製剤組成物(以下、
「易服用性組成物」という)は、漢方製剤を水に溶解若
しくは懸濁させ、これに溶解させたゼラチンを加えて均
一になるまで撹拌し、得られた混合物を所定の容器に注
入し、固化せしめることにより得られる。[0006] The easy-to-administer Chinese medicine preparation composition of the present invention (hereinafter,
"Easy-to-dosage composition") is a Chinese herb formulation dissolved or suspended in water, the dissolved gelatin is added and stirred until uniform, and the resulting mixture is poured into a predetermined container, It is obtained by solidifying.
【0007】本発明の易服用性組成物調製のためのゼラ
チン量は、最終組成物量に対して3.5〜5.5W/W%と
することが好ましく、特に、4.5W/W%であることが好
ましい。 本発明の易服用性組成物で用いるゼラチンの
好ましい条件は、ゼラチン特有の臭いがないこと、室温
程度の温度条件下でも固体状態を維持していることおよ
び間欠滅菌を行っても固体状態が変化しないことであ
り、このような条件を満たすゼラチンは全て好適に利用
することができる。 特に好ましいゼラチンとしては、
等電点が4.5〜5程度のアルカリ処理ゼラチンが挙げ
られる。The amount of gelatin for preparing the easy-to-dose composition of the present invention is preferably 3.5 to 5.5 W / W% with respect to the final composition amount, and particularly 4.5 W / W%. Preferably there is. Preferred conditions of gelatin used in the ingestible composition of the present invention are that there is no odor peculiar to gelatin, that the solid state is maintained even under temperature conditions of room temperature, and that the solid state changes even after intermittent sterilization. That is not the case, and any gelatin that satisfies such conditions can be preferably used. Particularly preferred gelatin is
Alkali-processed gelatin having an isoelectric point of about 4.5 to 5 can be used.
【0008】ゼラチンを用いるのは、組成物の粘度の調
製が容易であり、また服用するときに口の中に残らず、
喉に詰まることもないためである。 これに対し、ゼリ
ー調製のために広く使用されている寒天は、小片が口の
中に残り、苦味が消えにくいという問題があるので、そ
の使用は好ましくない。The use of gelatin makes it easy to adjust the viscosity of the composition, and does not remain in the mouth when taken,
This is because it does not clog the throat. On the other hand, agar, which is widely used for preparing jelly, has a problem that small pieces remain in the mouth and bitterness is hard to disappear, and therefore its use is not preferable.
【0009】本発明の易服用性組成物には、更に任意成
分としてフレーバー、甘味料、クエン酸またはその塩、
香料、色素等を加えることもできる。 フレーバーとし
ては、例えばフレーバーミックス(アップル味、パイン
味;大塚製薬(株)製)等を利用することができ、酸味が
あり、匂いの強いものが好ましい。The easily ingestible composition of the present invention further comprises a flavor, a sweetener, citric acid or a salt thereof, as an optional component,
Fragrances, pigments, etc. can also be added. As the flavor, for example, a flavor mix (apple taste, pine taste; manufactured by Otsuka Pharmaceutical Co., Ltd.) and the like can be used, and those having acidity and strong odor are preferable.
【0010】本発明の易服用性組成物を注入する容器と
しては、その容積が10〜20ml、特に好ましくは1
3〜15mlのカップ型のものが好ましく、これに注入
したものが製造しやすく、また服用しやすい。 更に、
このものは、製造後冷蔵庫等で冷蔵(4℃程度)すれ
ば、安定に貯蔵することができ、更に食感もよく摂取し
易くなるので、より有利である。The container for injecting the easy-to-dose composition of the present invention has a volume of 10 to 20 ml, particularly preferably 1
A cup type of 3 to 15 ml is preferable, and the one injected into this is easy to manufacture and easy to take. Furthermore,
This product is more advantageous because it can be stably stored if it is refrigerated (about 4 ° C.) in a refrigerator or the like after the production, and the texture is easy to ingest.
【0011】本発明の易服用性組成物にすることが特に
有利な漢方製剤としては、柴苓湯、小柴胡湯、柴朴湯、
五苓散、防巳黄耆湯、木防巳湯、猪苓湯、防風通聖散、
六味丸、牛車腎気丸、茵ちん五苓散、当帰芍薬散、八味
地黄丸、緒苓湯合四物湯、五淋散、竜胆瀉肝湯、清心蓮
子飲、柴胡加竜骨牡蠣湯、桂枝加竜骨牡蠣湯、補中益気
湯、十味敗毒湯等が例示されるが、これのみに限られ
ず、種々の漢方薬剤を本発明の易服用性組成物とするこ
とができる。The Kampo preparations for which it is particularly advantageous to use the easy-to-dose composition of the present invention include Sairei-to, Shosaiko-to, Saiboku-to,
Goreisan, Hoomi Yakiyu, Kihomiyu, Inoriyu, Bofutsu Seisan,
Rokumi Maru, Gyokujinki Maru, Aochin Goryo San, Toki Shakuyaku San, Hami Ji O Maru, Oreiyu Goshishinto, Goshoku San, Ryugareikanto, Seishin Renko Drink, Saiko Karyukotsu Oyster Examples include, but are not limited to, Keishi-karyukotsu oyster hot water, Hochuekkito hot water, and Jumi-seidoto hot water, and various Kampo medicines can be used as the ingestible composition of the present invention. .
【0012】[0012]
【発明の効果】本発明の易服用性組成物を利用すること
により、漢方製剤の有する苦味等を気にすることなく漢
方製剤を服用することが可能となる。 また、水分摂取
量を制約されている患者も容易に漢方製剤を服用するこ
とが可能となる。更に、フレーバー、甘味料等の配合を
変更することにより、より患者の好みに適応した漢方製
剤組成物を提供することが可能となる。EFFECTS OF THE INVENTION By using the easy-to-dose composition of the present invention, it is possible to take a Kampo preparation without worrying about the bitterness and the like of the Kampo preparation. In addition, patients with restricted water intake can easily take Kampo preparations. Furthermore, by changing the blending of flavors, sweeteners, etc., it becomes possible to provide a Kampo preparation composition more suited to the taste of the patient.
【0013】[0013]
【実施例】次に実施例を挙げ、本発明を更に詳しく説明
するが、本発明はなんらこれら実施例に制約されるもの
ではない。The present invention will be described in more detail with reference to the following examples, but the present invention is not limited to these examples.
【0014】実 施 例 1 紫苓湯ゼリー:( 組 成;100個分 ) 紫苓湯エキス((株)ツムラ製) 300 g フレーバーミックス 33g (パイナップル味;大塚製薬(株)製) 菓子用ゼラチン 77 g 水 1300 mlExample 1 Shionto Jelly: (Composition: 100) Shionto Extract (Tsumura Co., Ltd.) 300 g Flavor Mix 33 g (Pineapple Flavor; Otsuka Pharmaceutical Co., Ltd.) Gelatin for confectionery 77 g water 1300 ml
【0015】( 製 法 ) A. 紫苓湯エキスとフレーバーを1000mlの熱湯で
溶解する。 B. 菓子用ゼラチンを水300mlで約10分ほどふや
かし、これを湯せんで溶かす。 C. AとBを混ぜ合わせ、これを15ml用プチカップ
100個に分配する。 D. ハンドシーラーでシールし、90℃1時間の滅菌を
3回、間欠的に行ない、滅菌を行なって製品を得る。 得られた紫苓湯ゼリーは、匂いが気にならず、水なしで
も服用することができた。(Production Method) A. Shionto extract and flavor are dissolved in 1000 ml of boiling water. B. Soften the confectionery gelatin with 300 ml of water for about 10 minutes and dissolve it in a water bath. C. Mix A and B and dispense into 100 15 ml petit cups. D. Seal with a hand sealer and sterilize at 90 ° C. for 1 hour three times intermittently to obtain a product. The obtained Shirei-to jelly did not care about the smell and could be taken without water.
【0016】実 施 例 2 紫苓湯ゼリーをいろいろな条件で間欠滅菌し、日本薬局
方に準拠して無菌試験を行なった。 この結果を表1に
示す。Example 2 Shion-tou jelly was intermittently sterilized under various conditions, and a sterility test was conducted according to the Japanese Pharmacopoeia. The results are shown in Table 1.
【0017】 [0017]
【0018】実施例3 また、間欠滅菌した紫苓湯ゼリーについて、製造直後お
よび室温で3週間放置後に、下記方法でその有効成分量
を測定し、安定性を調べた。 この結果を図1および図
2に示す。Example 3 The stability of Shirei-to jelly that had been intermittently sterilized was measured by the following method immediately after production and after being left at room temperature for 3 weeks. The results are shown in FIGS. 1 and 2.
【0019】測 定 成 分 : グリチルリチンおよびバ
イカリン 測 定 方 法 : 試料を0.1M H3PO4・CH3CN
(72:28)で抽出し、遠心分離後HPLCに注入し
た。 HPLC条件: グリチルリチン カ ラ ム ; Finepak SIL C18S 移 動 相 ; MeOH・0.05M りん酸塩溶液(5:2) 測定波長 ; 254nm バイカリン カ ラ ム ; Finepak SIL C18S 移 動 相 ; 0.1M H3PO4・CH3CN(72:28) 測定波長 ; 280nmMeasurement component: Glycyrrhizin and baicalin Measurement method: Sample was 0.1MH 3 PO 4 · CH 3 CN
It was extracted at (72:28), centrifuged, and then injected into HPLC. HPLC conditions: Glycyrrhizin column; Finepak SIL C18S mobile phase; MeOH / 0.05M phosphate solution (5: 2) Measurement wavelength; 254 nm baicalin column; Finepak SIL C18S mobile phase; 0.1MH 3 PO 4 CH 3 CN (72:28) Measurement wavelength 280nm
【0020】図1および図2に示すように、間欠滅菌し
た紫苓湯ゼリーの有効成分含量は、紫苓湯エキス顆粒
や、間欠滅菌しないものと比べなんら変化はなく、また
3週間保存後もほとんど変わりなかった。As shown in FIGS. 1 and 2, the active ingredient content of intermittently sterilized Sairei-to jelly did not change at all compared to that of Shirei-to extract granules and those without intermittent sterilization, and even after storage for 3 weeks. It hardly changed.
【図1】 紫苓湯製剤中のグリチルリチン含量Fig. 1 Glycyrrhizin content in Sairei-to preparation
【図2】 紫苓湯製剤中のバイカリン含量 以 上Fig. 2 Baicalin content in Sairei-to preparation
───────────────────────────────────────────────────── フロントページの続き (72)発明者 松本 有右 東京都八王子市館町1097 株式会社八王子 薬剤センター内 (72)発明者 下平 秀夫 東京都八王子市館町1097 株式会社八王子 薬剤センター内 (72)発明者 内田 寛 東京都八王子市館町1097 株式会社八王子 薬剤センター内 ─────────────────────────────────────────────────── ─── Continuation of the front page (72) Inventor Yusuke Matsumoto 1097 Hachioji Tatemachi, Hachioji, Tokyo (72) Inventor Hideo Shimohira 1097 Hachioji Tatemachi, Hachioji, Tokyo (72) ) Inventor Hiroshi Uchida 1097 Tatemachi, Hachioji City, Tokyo Hachioji Pharmaceutical Center Co., Ltd.
Claims (4)
成型したことを特徴とする易服用性漢方製剤組成物。1. An ingestible Kampo preparation composition, characterized in that the Kampo preparation is molded into a semi-solid state using gelatin.
および五苓散から選ばれたものである請求項第1項記載
の易服用性漢方製剤組成物。2. The easy-to-administer Chinese medicine composition according to claim 1, wherein the Chinese medicine preparation is selected from Sairei-to, Shosaiko-to, Saiboku-to and Goreisan.
の易服用性漢方製剤組成物。3. The ingestible Kampo pharmaceutical composition according to claim 1, which has a jelly shape.
加えたものである請求項第1項記載の易服用性漢方製剤
組成物。4. The ingestible Kampo pharmaceutical composition according to claim 1, which further contains flavor mix and sugar.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP3165157A JPH07116049B2 (en) | 1991-06-05 | 1991-06-11 | Easy-to-use Kampo formulation |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15986191 | 1991-06-05 | ||
JP3-159861 | 1991-06-05 | ||
JP3165157A JPH07116049B2 (en) | 1991-06-05 | 1991-06-11 | Easy-to-use Kampo formulation |
Publications (2)
Publication Number | Publication Date |
---|---|
JPH0543474A JPH0543474A (en) | 1993-02-23 |
JPH07116049B2 true JPH07116049B2 (en) | 1995-12-13 |
Family
ID=26486533
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP3165157A Expired - Fee Related JPH07116049B2 (en) | 1991-06-05 | 1991-06-11 | Easy-to-use Kampo formulation |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH07116049B2 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11322624A (en) * | 1998-05-06 | 1999-11-24 | Ina Food Ind Co Ltd | Chinese medicine/crude medicine preparation to be prepared in time of use |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5241978B2 (en) * | 1999-10-13 | 2013-07-17 | 帝國製薬株式会社 | Kampo jelly pharmaceutical composition |
JP2001226293A (en) * | 2000-02-17 | 2001-08-21 | Kotaro Kanpo Seiyaku Kk | Taking assisting agent |
KR20030012714A (en) * | 2001-08-04 | 2003-02-12 | 양상철 | a making method for growth food |
KR20030060124A (en) * | 2002-01-07 | 2003-07-16 | 김준원 | Manufacturing method of herb remedy |
KR100398470B1 (en) * | 2002-10-30 | 2003-09-19 | 충청북도 | Swallwing food and method for manufacturing it |
KR100578278B1 (en) * | 2005-01-05 | 2006-05-11 | 이부용 | Swallowing aid comprising korean yam powder |
JP4955287B2 (en) * | 2006-03-10 | 2012-06-20 | 大鵬薬品工業株式会社 | Paeoniflorin-containing jelly preparation |
WO2009139167A1 (en) * | 2008-05-15 | 2009-11-19 | 明治乳業株式会社 | Nutrient composition capable of adjusting energy amount, water amount and salt equivalent |
JP5763994B2 (en) * | 2011-07-13 | 2015-08-12 | 日東電工株式会社 | Jelly-form preparation and method for producing the jelly-form preparation |
JP6088044B2 (en) * | 2013-04-01 | 2017-03-01 | 国立大学法人大阪大学 | Composition for preventing muscle aging |
US20220386668A1 (en) | 2019-10-25 | 2022-12-08 | Sumitomo Chemical Company, Limited | Food composition |
-
1991
- 1991-06-11 JP JP3165157A patent/JPH07116049B2/en not_active Expired - Fee Related
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH11322624A (en) * | 1998-05-06 | 1999-11-24 | Ina Food Ind Co Ltd | Chinese medicine/crude medicine preparation to be prepared in time of use |
Also Published As
Publication number | Publication date |
---|---|
JPH0543474A (en) | 1993-02-23 |
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