JP4543187B2 - 薬物候補物に関連する薬物動態パラメータ推定のための薬物候補物のアッセイのための方法および装置 - Google Patents

薬物候補物に関連する薬物動態パラメータ推定のための薬物候補物のアッセイのための方法および装置 Download PDF

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JP4543187B2
JP4543187B2 JP2001505186A JP2001505186A JP4543187B2 JP 4543187 B2 JP4543187 B2 JP 4543187B2 JP 2001505186 A JP2001505186 A JP 2001505186A JP 2001505186 A JP2001505186 A JP 2001505186A JP 4543187 B2 JP4543187 B2 JP 4543187B2
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drug
binding
drug candidate
biosensor
parameter
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JP2003502668A (ja
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マイク ヘメレイネン,
ロベルト カルルソン,
ステファン レフォス,
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Cytiva Sweden AB
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Amersham Bioscience AB
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366Apparatus specially adapted for solid-phase testing
    • G01N33/54373Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00Chemistry: analytical and immunological testing
    • Y10S436/805Optical property

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  • Urology & Nephrology (AREA)
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  • Biomedical Technology (AREA)
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  • Food Science & Technology (AREA)
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  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Optical Measuring Cells (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2001505186A 1999-06-18 2000-06-19 薬物候補物に関連する薬物動態パラメータ推定のための薬物候補物のアッセイのための方法および装置 Expired - Fee Related JP4543187B2 (ja)

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US33686599A 1999-06-18 1999-06-18
US09/336,865 1999-06-18
PCT/SE2000/001297 WO2000079268A2 (fr) 1999-06-18 2000-06-19 Procede et appareil de dosage biologique d'une drogue candidate destines a evaluer un parametre pharmacocinetique associe

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JP2003502668A JP2003502668A (ja) 2003-01-21
JP4543187B2 true JP4543187B2 (ja) 2010-09-15

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US (2) US6808938B2 (fr)
EP (1) EP1188058B1 (fr)
JP (1) JP4543187B2 (fr)
AT (1) ATE295541T1 (fr)
AU (1) AU775060B2 (fr)
DE (1) DE60020119T2 (fr)
WO (1) WO2000079268A2 (fr)

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7518724B2 (en) * 2000-07-11 2009-04-14 Maven Technologies Image acquisition, processing, and display
US20020093654A1 (en) * 2000-07-11 2002-07-18 Lieberman Robert A. Apparatus and method for imaging
US7023547B2 (en) * 2000-07-11 2006-04-04 Maven Technologies, Llc Apparatus including a biochip for imaging of biological samples and method
US6833920B2 (en) 2000-07-11 2004-12-21 Maven Technologies Llc Apparatus and method for imaging
US7193711B2 (en) * 2000-07-11 2007-03-20 Maven Technologies, Llc Imaging method and apparatus
US7126688B2 (en) * 2000-07-11 2006-10-24 Maven Technologies, Llc Microarray scanning
US6594011B1 (en) 2000-07-11 2003-07-15 Maven Technologies, Llc Imaging apparatus and method
AU2001279068A1 (en) * 2000-07-28 2002-02-13 Lion Bioscience Ag Regional intestinal permeability model
EP1358611A2 (fr) * 2000-07-28 2003-11-05 LION Bioscience AG Systeme et procede servant a predire les caracteristiques adme d'un compose en fonction de sa structure
JP4027048B2 (ja) * 2001-02-23 2007-12-26 富士フイルム株式会社 全反射減衰を利用した測定方法および測定装置
CA2455793A1 (fr) * 2001-07-25 2003-02-27 University Of North Carolina At Chapel Hill Procede de appareil pour determiner rapidement la fixation d'un ligand et d'une proteine au moyen de l'adsorption de charbon de bois
US20030044992A1 (en) * 2001-08-31 2003-03-06 Chao Anthony C. Cell-based multiplexing ADME analysis using focused fluid flow
GB2384239A (en) * 2001-12-05 2003-07-23 Sense Proteomic Ltd Arrays of protein variants
DE10160270A1 (de) 2001-12-07 2003-06-26 Bayer Ag Computersystem und Verfahren zur Berechnung von ADME-Eigenschaften
EP1469309A4 (fr) * 2001-12-27 2007-11-21 Japan Science & Tech Agency Methode d'evaluation de l'activite cellulaire
KR100555793B1 (ko) * 2002-06-25 2006-03-03 주식회사 마크로젠 고분자 그래프팅에 의해 표면이 개질된 바이오 지지체 및 그 제조방법
JP2006517397A (ja) * 2002-09-16 2006-07-27 センス プロテオミック リミテッド タンパク質アレイ、及びその使用方法
EP1439394A1 (fr) * 2002-12-20 2004-07-21 Graffinity Pharmaceuticals Aktiengesellschaft Procédé et appareil pour l'établissement de profiles ADME dans le developpement précoce des substances actives
US8741577B2 (en) * 2003-04-07 2014-06-03 Bio-Rad Laboratories Inc. Surface immobilised multilayer structure of vesicles
JP2007506967A (ja) * 2003-09-24 2007-03-22 ビアコーレ・アー・ベー 分子相互作用分析の方法及びシステム
US7470549B2 (en) * 2004-05-26 2008-12-30 Fujifilm Corporation Measurement method using biosensor
SE0401633D0 (sv) * 2004-06-24 2004-06-24 Biacore Ab Method for detecting molecular surface interactions
WO2006001749A1 (fr) * 2004-06-24 2006-01-05 Biacore Ab Detection des interactions superficielles moleculaires
JP4371954B2 (ja) 2004-08-31 2009-11-25 富士フイルム株式会社 表面プラズモン共鳴分析による被験物質の解析方法
JP4580291B2 (ja) * 2005-06-30 2010-11-10 富士フイルム株式会社 バイオセンサーを用いた測定方法
US20070003559A1 (en) * 2005-07-01 2007-01-04 Wyeth Methods of determining pharmacokinetics of targeted therapies
EP2083081A1 (fr) 2005-07-22 2009-07-29 Five Prime Therapeutics, Inc. Compositions et procédés pour traiter une maladie avec des protéines de fusion FGFR
US7700300B2 (en) * 2005-07-29 2010-04-20 Xenoport, Inc. Screening of compounds for GAT2 transporter activity
US7704695B2 (en) * 2005-07-29 2010-04-27 Xenoport, Inc. Screening of compounds for BGT1 transporter activity
US7670782B2 (en) * 2005-07-29 2010-03-02 Xenoport, Inc. Screening of compounds for CAT1 transporter activity
DE602005017148D1 (de) * 2005-08-30 2009-11-26 Perkinelmer Cellular Technolog Verfahren zum Nachweis einer biochemischen Interaktion
CA2664172C (fr) * 2006-09-16 2016-03-29 Terence Gilhuly Detecteurs ameliores et detection destinee a surveiller le blocage neuromusculaire
US7931791B2 (en) * 2006-10-25 2011-04-26 Southern Illinois University Carbondale Method of detecting analyte-biomolecule interactions
US7867783B2 (en) 2007-02-22 2011-01-11 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7863037B1 (en) 2007-04-04 2011-01-04 Maven Technologies, Llc Ligand binding assays on microarrays in closed multiwell plates
US20090041633A1 (en) * 2007-05-14 2009-02-12 Dultz Shane C Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US7799558B1 (en) 2007-05-22 2010-09-21 Dultz Shane C Ligand binding assays on microarrays in closed multiwell plates
US7981664B1 (en) 2008-05-22 2011-07-19 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
US8039270B2 (en) * 2008-05-22 2011-10-18 Maven Technologies, Llc Apparatus and method for performing ligand binding assays on microarrays in multiwell plates
WO2010147625A2 (fr) * 2009-06-15 2010-12-23 Brandeis University Systèmes et procédés pour déterminer des conditions de traitement dans des volumes confinés
US9700650B2 (en) 2009-11-09 2017-07-11 Spotlight Technology Partners Llc Polysaccharide based hydrogels
WO2011057133A1 (fr) 2009-11-09 2011-05-12 Spotlight Technology Partners Llc Hydrogels fragmentés
EP2507618B1 (fr) * 2009-11-30 2015-05-27 GE Healthcare Bio-Sciences AB Procédé et système d'analyse d'interaction
WO2011065913A1 (fr) * 2009-11-30 2011-06-03 Ge Healthcare Bio-Sciences Ab Procédé et système pour l'analyse d'un comportement de liaison
US8355133B2 (en) * 2009-12-30 2013-01-15 Maven Technologies, Llc Biological testing with sawtooth-shaped prisms
TWI382087B (zh) * 2010-05-24 2013-01-11 Univ Taipei Medical 一種篩檢拓樸異構酶抑制劑之裝置及其方法
GB2490652A (en) * 2011-04-18 2012-11-14 Microtest Matrices Ltd Methods of quantifying antibodies, especially IgE antibodies in a sample
JP5828507B2 (ja) * 2011-09-07 2015-12-09 国立大学法人金沢大学 尿検査方法及び尿検査用キット
JP6038950B2 (ja) 2011-12-13 2016-12-07 スリーエム イノベイティブ プロパティズ カンパニー 気体媒質内の未知の有機化合物の同定及び定量測定方法
US11280782B2 (en) 2015-02-06 2022-03-22 University Of Rochester Polymer microparticle-based method for probe deposition in label-free biosensors
CN114791477B (zh) * 2021-01-25 2023-12-05 北京中医药大学 一种大蜜丸质构感官属性检测方法在质量控制中的应用
WO2022123332A1 (fr) * 2021-08-09 2022-06-16 Debasish Banerjee Biodisponibilité et bioéquivalence par l'intermédiaire de mesures de l'activité intrinsèque et de kd in vivo chez les êtres humains
CN114112980B (zh) * 2022-01-24 2022-05-10 武汉宏韧生物医药股份有限公司 一种基于数据分析的药物组分检测方法与系统

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4548066A (en) * 1984-08-07 1985-10-22 Rca Corporation Press workpiece thickness measuring system and method
US5338659A (en) 1991-04-02 1994-08-16 Terrapin Technologies, Inc. Method for determining analyte concentration by cross-reactivity profiling
SE462454B (sv) 1988-11-10 1990-06-25 Pharmacia Ab Maetyta foer anvaendning i biosensorer
SE8902043L (sv) 1988-11-10 1990-05-11 Pharmacia Ab Foerfarande foer karakterisering av makromolekyler
SE462408B (sv) * 1988-11-10 1990-06-18 Pharmacia Ab Optiskt biosensorsystem utnyttjande ytplasmonresonans foer detektering av en specific biomolekyl, saett att kalibrera sensoranordningen samt saett att korrigera foer baslinjedrift i systemet
SE8804074D0 (sv) * 1988-11-10 1988-11-10 Pharmacia Ab Sensorenhet och dess anvaendning i biosensorsystem
SE501013C2 (sv) 1990-10-01 1994-10-17 Pharmacia Biosensor Ab Förfarande för förbättring av analys med bindning till fast fas
US5395587A (en) * 1993-07-06 1995-03-07 Smithkline Beecham Corporation Surface plasmon resonance detector having collector for eluted ligate
US5485277A (en) 1994-07-26 1996-01-16 Physical Optics Corporation Surface plasmon resonance sensor and methods for the utilization thereof
US5620850A (en) 1994-09-26 1997-04-15 President And Fellows Of Harvard College Molecular recognition at surfaces derivatized with self-assembled monolayers
SE9503028D0 (sv) 1995-09-01 1995-09-01 Pharmacia Biosensor Ab Method of analysing chemical and physical interactions at a sensor surface
GB9518429D0 (en) 1995-09-08 1995-11-08 Pharmacia Biosensor A rapid method for providing kinetic and structural data in molecular interaction analysis
NZ516848A (en) * 1997-06-20 2004-03-26 Ciphergen Biosystems Inc Retentate chromatography apparatus with applications in biology and medicine
CA2299283A1 (fr) * 1997-08-08 1999-02-18 Supratek Pharma, Inc. Procedes d'identification de compositions d'agents biologiques
US6289286B1 (en) * 1998-05-29 2001-09-11 Biacore Ab Surface regeneration of biosensors and characterization of biomolecules associated therewith
US6651008B1 (en) * 1999-05-14 2003-11-18 Cytokinetics, Inc. Database system including computer code for predictive cellular bioinformatics

Also Published As

Publication number Publication date
EP1188058B1 (fr) 2005-05-11
DE60020119T2 (de) 2005-10-06
WO2000079268A2 (fr) 2000-12-28
US20020019019A1 (en) 2002-02-14
US6808938B2 (en) 2004-10-26
JP2003502668A (ja) 2003-01-21
EP1188058A2 (fr) 2002-03-20
ATE295541T1 (de) 2005-05-15
AU6034000A (en) 2001-01-09
DE60020119D1 (de) 2005-06-16
WO2000079268A3 (fr) 2001-07-19
AU775060B2 (en) 2004-07-15
US20050037418A1 (en) 2005-02-17

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