JP4541884B2 - 血小板凝集の阻害のための修飾アミノ酸 - Google Patents
血小板凝集の阻害のための修飾アミノ酸 Download PDFInfo
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- JP4541884B2 JP4541884B2 JP2004520655A JP2004520655A JP4541884B2 JP 4541884 B2 JP4541884 B2 JP 4541884B2 JP 2004520655 A JP2004520655 A JP 2004520655A JP 2004520655 A JP2004520655 A JP 2004520655A JP 4541884 B2 JP4541884 B2 JP 4541884B2
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- platelet aggregation
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- A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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Landscapes
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| US39689802P | 2002-07-17 | 2002-07-17 | |
| PCT/EP2003/007739 WO2004006907A1 (en) | 2002-07-17 | 2003-07-16 | Modified amino acid for the inhibition of platelet aggregation |
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| JP2005535670A JP2005535670A (ja) | 2005-11-24 |
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| JP2007521232A (ja) | 2003-08-08 | 2007-08-02 | アブジェニックス・インコーポレーテッド | 副甲状腺ホルモン（ｐｔｈ）に対する抗体およびその使用 |
| US7318925B2 (en) | 2003-08-08 | 2008-01-15 | Amgen Fremont, Inc. | Methods of use for antibodies against parathyroid hormone |
| EP1907571B1 (en) | 2005-06-15 | 2017-04-26 | Complete Genomics Inc. | Nucleic acid analysis by random mixtures of non-overlapping fragments |
| CN101627011A (zh) * | 2005-09-19 | 2010-01-13 | 爱密斯菲尔科技公司 | N-(5-氯水杨酰基)-8-氨基辛酸的二钠盐的晶形 |
| US8895777B2 (en) | 2006-08-31 | 2014-11-25 | Emisphere Technologies Inc | Compounds and compositions for delivering active agents |
| PL2059260T3 (pl) * | 2006-08-31 | 2014-03-31 | Novartis Ag | Kompozycja farmaceutyczna obejmująca hGH do dostarczania doustnego |
| PL2215047T3 (pl) | 2007-11-02 | 2014-05-30 | Emisphere Tech Inc | Sposób leczenia niedoborów witaminy b12 |
| US20110207693A1 (en) * | 2010-02-24 | 2011-08-25 | Emisphere Technologies, Inc. | Oral B12 Therapy |
| RU2504536C1 (ru) * | 2012-08-20 | 2014-01-20 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Волгоградский государственный медицинский университет" Министерства здравоохранения и социального развития Российской Федерации | Производное амида салициловой кислоты, обладающее антибактериальной, противогрибковой и антилизоцимной активностью |
Family Cites Families (9)
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|---|---|---|---|---|
| US5260321A (en) * | 1984-11-12 | 1993-11-09 | Sandoz Ltd. | Use of 1,4-dihydropyridine derivatives and combinations thereof with calcitonins |
| US5733647A (en) * | 1992-11-05 | 1998-03-31 | Polymer Innovations, Inc. | Insole |
| US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
| US5866536A (en) * | 1995-03-31 | 1999-02-02 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| BR9604880A (pt) * | 1995-03-31 | 1998-05-19 | Emisphere Tech Inc | Composto composição forma de unidade de dosagem métodos para administração de um agente biologicamente ativo para preparar uma composição para administração de um agente ativo e para preparar um composto e composição farmacológica |
| EP0993831B1 (en) * | 1997-02-07 | 2008-01-09 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| US5773647A (en) * | 1997-02-07 | 1998-06-30 | Emisphere Technologies, Inc. | Compounds and compositions for delivering active agents |
| DE60017888T2 (de) * | 1999-04-05 | 2006-01-19 | Emisphere Technologies, Inc. | Dinatrium-salze, monohydrate und ethanol-solvate |
| US7049283B2 (en) * | 2000-12-06 | 2006-05-23 | Novartis Ag | Pharmaceutical compositions for the oral delivery of pharmacologically active agents |
-
2003
- 2003-07-15 TW TW092119264A patent/TW200403052A/zh unknown
- 2003-07-16 AU AU2003257473A patent/AU2003257473A1/en not_active Abandoned
- 2003-07-16 CA CA2492378A patent/CA2492378C/en not_active Expired - Fee Related
- 2003-07-16 ES ES03763878T patent/ES2379949T3/es not_active Expired - Lifetime
- 2003-07-16 EP EP03763878A patent/EP1556027B1/en not_active Expired - Lifetime
- 2003-07-16 PT PT03763878T patent/PT1556027E/pt unknown
- 2003-07-16 BR BR0312712-5A patent/BR0312712A/pt not_active IP Right Cessation
- 2003-07-16 CN CN038169231A patent/CN1668290B/zh not_active Expired - Fee Related
- 2003-07-16 JP JP2004520655A patent/JP4541884B2/ja not_active Expired - Fee Related
- 2003-07-16 US US10/521,492 patent/US20060106110A1/en not_active Abandoned
- 2003-07-16 WO PCT/EP2003/007739 patent/WO2004006907A1/en not_active Ceased
- 2003-07-16 AT AT03763878T patent/ATE538782T1/de active
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2008
- 2008-07-08 US US12/169,184 patent/US20080280817A1/en not_active Abandoned
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|---|---|
| AU2003257473A1 (en) | 2004-02-02 |
| ES2379949T3 (es) | 2012-05-07 |
| TW200403052A (en) | 2004-03-01 |
| BR0312712A (pt) | 2005-04-26 |
| JP2005535670A (ja) | 2005-11-24 |
| WO2004006907A1 (en) | 2004-01-22 |
| CA2492378A1 (en) | 2004-01-22 |
| US20120088833A1 (en) | 2012-04-12 |
| CN1668290B (zh) | 2010-04-28 |
| US8664211B2 (en) | 2014-03-04 |
| US20060106110A1 (en) | 2006-05-18 |
| CA2492378C (en) | 2011-06-14 |
| EP1556027A1 (en) | 2005-07-27 |
| CN1668290A (zh) | 2005-09-14 |
| PT1556027E (pt) | 2012-04-10 |
| EP1556027B1 (en) | 2011-12-28 |
| US20080280817A1 (en) | 2008-11-13 |
| ATE538782T1 (de) | 2012-01-15 |
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