JP4530665B2 - 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 - Google Patents

放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 Download PDF

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JP4530665B2
JP4530665B2 JP2003565315A JP2003565315A JP4530665B2 JP 4530665 B2 JP4530665 B2 JP 4530665B2 JP 2003565315 A JP2003565315 A JP 2003565315A JP 2003565315 A JP2003565315 A JP 2003565315A JP 4530665 B2 JP4530665 B2 JP 4530665B2
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tolylphosphonium
fluorobenzyl
imaging agent
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JP2005532262A (ja
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マダール イーガル
ティー ラヴァート ハイデン
ダナルス ロバート
エイ シェッフェル アースラ
ジェイ フロスト ジェームズ
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ジョンズ ホプキンス ユニバーシティ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0476—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group complexes from monodendate ligands, e.g. sestamibi
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/507—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for determination of haemodynamic parameters, e.g. perfusion CT
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0489—Phosphates or phosphonates, e.g. bone-seeking phosphonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Medical Informatics (AREA)
  • Engineering & Computer Science (AREA)
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  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dentistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oral & Maxillofacial Surgery (AREA)
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  • Radiology & Medical Imaging (AREA)
  • Biomedical Technology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2003565315A 2002-02-06 2003-02-06 放射性標識された親油性の塩を使用することによる、ミトコンドリアのための非浸襲性の画像診断技術 Expired - Fee Related JP4530665B2 (ja)

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Application Number Priority Date Filing Date Title
US35456302P 2002-02-06 2002-02-06
PCT/US2003/003740 WO2003065882A2 (en) 2002-02-06 2003-02-06 Non-invasive diagnostic imaging technology for mitochondria using radiolabeled lipophilic salts

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JP2005532262A JP2005532262A (ja) 2005-10-27
JP2005532262A5 JP2005532262A5 (https=) 2006-01-05
JP4530665B2 true JP4530665B2 (ja) 2010-08-25

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US (2) US8524193B2 (https=)
EP (1) EP1474177A4 (https=)
JP (1) JP4530665B2 (https=)
CN (2) CN101838289A (https=)
AU (1) AU2003217349B2 (https=)
CA (1) CA2474142C (https=)
NZ (1) NZ534496A (https=)
TW (1) TWI266634B (https=)
WO (1) WO2003065882A2 (https=)

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EP1990310A1 (en) * 2007-04-23 2008-11-12 Trasis S.A. Method for the preparation of reactive 18F fluoride, and for the labeling of radiotracers, using a modified non-ionic solid support and without any evaporation step
EP2164524B1 (en) * 2007-05-30 2013-08-07 Children's Medical Center Corporation Fluorine-18 labeled rhodamine derivatives for myocardial perfusion imaging with positron emission tomography
US9717896B2 (en) 2007-12-18 2017-08-01 Gearbox, Llc Treatment indications informed by a priori implant information
US20090287120A1 (en) 2007-12-18 2009-11-19 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Circulatory monitoring systems and methods
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US8388936B2 (en) * 2008-02-22 2013-03-05 Mcw Research Foundation, Inc. In vivo mitochondrial labeling using positively-charged nitroxide enhanced and gadolinium chelate enhanced magnetic resonance imaging
AU2009220244B2 (en) 2008-02-29 2014-10-09 Lantheus Medical Imaging, Inc. Contrast agents for applications including perfusion imaging
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KR101602992B1 (ko) 2009-04-15 2016-03-11 랜티우스 메디컬 이메징, 인크. 아스코르브산을 사용한 방사성 약제 조성물의 안정화
CA2767475A1 (en) 2009-07-10 2011-01-13 Bayer Pharma Aktiengesellschaft Usage of low to medium-pressure liquid chromatography for the purification of radiotracers
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CN107233585B (zh) * 2017-06-09 2021-01-22 四川大学华西医院 黄连素或其衍生物在制备心肌灌注显像剂中的用途
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JP2005532262A (ja) 2005-10-27
WO2003065882A2 (en) 2003-08-14
CA2474142A1 (en) 2003-08-14
US8524193B2 (en) 2013-09-03
TW200307524A (en) 2003-12-16
TWI266634B (en) 2006-11-21
CN100577213C (zh) 2010-01-06
AU2003217349B2 (en) 2008-05-22
HK1077500A1 (zh) 2006-02-17
US20050182027A1 (en) 2005-08-18
NZ534496A (en) 2006-08-31
US7112318B2 (en) 2006-09-26
EP1474177A4 (en) 2010-07-21
EP1474177A2 (en) 2004-11-10
CA2474142C (en) 2013-02-05
AU2003217349A1 (en) 2003-09-02
CN101838289A (zh) 2010-09-22
WO2003065882A3 (en) 2004-02-19
US20040033197A1 (en) 2004-02-19
CN1627962A (zh) 2005-06-15

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