JP4528475B2 - ５−位置メチル化変性体の識別方法 - Google Patents

５−位置メチル化変性体の識別方法 Download PDF

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Publication number
JP4528475B2
JP4528475B2 JP2001529448A JP2001529448A JP4528475B2 JP 4528475 B2 JP4528475 B2 JP 4528475B2 JP 2001529448 A JP2001529448 A JP 2001529448A JP 2001529448 A JP2001529448 A JP 2001529448A JP 4528475 B2 JP4528475 B2 JP 4528475B2
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cytosine
sequence
genomic dna
detected
sample
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JP2003511056A5 (enExample
JP2003511056A (ja
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ベルリン，クルト
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エピゲノミクス アーゲー
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6827—Hybridisation assays for detection of mutation or polymorphism

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Apparatus For Radiation Diagnosis (AREA)
  • Mechanical Treatment Of Semiconductor (AREA)
  • Control And Other Processes For Unpacking Of Materials (AREA)
  • Crystals, And After-Treatments Of Crystals (AREA)
  • Nonmetallic Welding Materials (AREA)
  • Control Of Positive-Displacement Air Blowers (AREA)
  • Stereophonic System (AREA)
  • Paper (AREA)
  • Superconductors And Manufacturing Methods Therefor (AREA)
JP2001529448A 1999-10-15 2000-10-13 ５−位置メチル化変性体の識別方法 Expired - Fee Related JP4528475B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE19951189A DE19951189C2 (de) 1999-10-15 1999-10-15 Verfahren zur Unterscheidung von 5-Position-Methylierungsänderungen von Cytosin-Basen und Cytosin-zu-Thymin-Mutationen und zum Nachweis von single nucleotide polymorphisms (SNPs) oder Punktmutation in genomischer DNA
DE19951189.6 1999-10-15
PCT/DE2000/003726 WO2001027317A2 (de) 1999-10-15 2000-10-13 Verfahren zur unterscheidung von 5-position methylierungsänderungen

Publications (3)

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JP2003511056A JP2003511056A (ja) 2003-03-25
JP2003511056A5 JP2003511056A5 (enExample) 2010-06-17
JP4528475B2 true JP4528475B2 (ja) 2010-08-18

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JP2001529448A Expired - Fee Related JP4528475B2 (ja) 1999-10-15 2000-10-13 ５−位置メチル化変性体の識別方法

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US (2) US7179594B1 (enExample)
EP (1) EP1228246B1 (enExample)
JP (1) JP4528475B2 (enExample)
AT (1) ATE299950T1 (enExample)
AU (1) AU775085B2 (enExample)
CA (1) CA2387148A1 (enExample)
DE (2) DE19951189C2 (enExample)
DK (1) DK1228246T3 (enExample)
ES (1) ES2246257T3 (enExample)
IL (1) IL149067A0 (enExample)
IS (1) IS6328A (enExample)
NZ (1) NZ518318A (enExample)
WO (1) WO2001027317A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19957827C2 (de) 1999-11-25 2003-06-12 Epigenomics Ag Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche
DE10010282B4 (de) * 2000-02-25 2006-11-16 Epigenomics Ag Verfahren zur Detektion von Cytosin-Methylierung in DNA Proben
DE10151069A1 (de) * 2001-10-05 2003-04-30 Epigenomics Ag Verfahren zum Nachweis von DNA-Methylierung mittels markierten S-Adenosylmethioninanaloga
DE10151055B4 (de) 2001-10-05 2005-05-25 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierung in CpG Inseln
US6916621B2 (en) 2002-03-27 2005-07-12 Spectral Genomics, Inc. Methods for array-based comparitive binding assays
CA2442438C (en) 2002-10-04 2012-06-19 Nisshinbo Industries, Inc. Oligonucleotide-immobilized substrate for detecting methylation
DE10338308B4 (de) * 2003-08-15 2006-10-19 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungen in DNA
US20100137154A1 (en) * 2008-12-01 2010-06-03 Ach Robert A Genome analysis using a methyltransferase
DE102015009187B3 (de) 2015-07-16 2016-10-13 Dimo Dietrich Verfahren zur Bestimmung einer Mutation in genomischer DNA, Verwendung des Verfahrens und Kit zur Durchführung des Verfahrens

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4683195A (en) * 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
WO1995021271A1 (en) * 1994-02-07 1995-08-10 Molecular Tool, Inc. Ligase/polymerase-mediated genetic bit analysistm of single nucleotide polymorphisms and its use in genetic analysis
US5786146A (en) * 1996-06-03 1998-07-28 The Johns Hopkins University School Of Medicine Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
CZ204597A3 (cs) * 1997-06-26 1998-12-16 I.N.T., Prof. Ing. Dr. Radko Krčma Drsc. Způsob výroby objemné textilie s hladkým povrchem a zařízení k jeho provádění
AR017023A1 (es) * 1997-08-29 2001-08-22 Lopez Osvaldo J Tipeo genomico de adn metiltransferasa
DE19754482A1 (de) * 1997-11-27 1999-07-01 Epigenomics Gmbh Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
DE19935772C2 (de) * 1999-07-26 2002-11-07 Epigenomics Ag Verfahren zur relativen Quantifizierung der Methylierung von Cytosin Basen in DNA-Proben
MXPA03001834A (es) * 2000-09-01 2003-08-01 Epigenomics Ag Metodo para determinar el grado de metilacion de determinadas citocinas en adn genomico en el contexto de secuencia 5'-cpg-3'.
DE10112515B4 (de) * 2001-03-09 2004-02-12 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
DE10201138B4 (de) * 2002-01-08 2005-03-10 Epigenomics Ag Verfahren zum Nachweis von Cytosin-Methylierungsmustern durch exponentielle Ligation hybridisierter Sondenoligonukleotide (MLA)

Also Published As

Publication number Publication date
DE19951189C2 (de) 2003-11-06
EP1228246A2 (de) 2002-08-07
AU2345101A (en) 2001-04-23
IL149067A0 (en) 2002-11-10
EP1228246B1 (de) 2005-07-20
DE19951189A1 (de) 2001-05-03
WO2001027317A3 (de) 2002-01-17
ATE299950T1 (de) 2005-08-15
CA2387148A1 (en) 2001-04-19
AU775085B2 (en) 2004-07-15
IS6328A (is) 2002-03-27
JP2003511056A (ja) 2003-03-25
DK1228246T3 (da) 2005-10-17
ES2246257T3 (es) 2006-02-16
DE50010776D1 (de) 2005-08-25
US20070161036A1 (en) 2007-07-12
US7179594B1 (en) 2007-02-20
WO2001027317A2 (de) 2001-04-19
NZ518318A (en) 2003-11-28

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