JP4519320B2 - ベンゾチアゾールジオキセタン類 - Google Patents

ベンゾチアゾールジオキセタン類 Download PDF

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Publication number
JP4519320B2
JP4519320B2 JP2000562018A JP2000562018A JP4519320B2 JP 4519320 B2 JP4519320 B2 JP 4519320B2 JP 2000562018 A JP2000562018 A JP 2000562018A JP 2000562018 A JP2000562018 A JP 2000562018A JP 4519320 B2 JP4519320 B2 JP 4519320B2
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Japan
Prior art keywords
dioxetane
group
sample
substance
solution
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Expired - Fee Related
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JP2000562018A
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English (en)
Japanese (ja)
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JP2002521447A5 (enExample
JP2002521447A (ja
Inventor
ブロンスタイン，イレーナ
エドワーズ，ブルックス
Original Assignee
アプライド バイオシステムズ， エルエルシー
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Application filed by アプライド バイオシステムズ， エルエルシー filed Critical アプライド バイオシステムズ， エルエルシー
Publication of JP2002521447A publication Critical patent/JP2002521447A/ja
Publication of JP2002521447A5 publication Critical patent/JP2002521447A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2000562018A 1998-07-28 1999-07-28 ベンゾチアゾールジオキセタン類 Expired - Fee Related JP4519320B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US9433698P 1998-07-28 1998-07-28
US60/094,336 1998-07-28
PCT/US1999/017094 WO2000006164A1 (en) 1998-07-28 1999-07-28 Benzothiazole dioxetanes

Publications (3)

Publication Number Publication Date
JP2002521447A JP2002521447A (ja) 2002-07-16
JP2002521447A5 JP2002521447A5 (enExample) 2006-08-24
JP4519320B2 true JP4519320B2 (ja) 2010-08-04

Family

ID=22244574

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2000562018A Expired - Fee Related JP4519320B2 (ja) 1998-07-28 1999-07-28 ベンゾチアゾールジオキセタン類

Country Status (6)

Country Link
US (2) US6355441B1 (enExample)
EP (1) EP1115400A4 (enExample)
JP (1) JP4519320B2 (enExample)
AU (1) AU5237699A (enExample)
CA (1) CA2338883A1 (enExample)
WO (1) WO2000006164A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060024762A1 (en) * 1998-07-28 2006-02-02 Brooks Edwards Heteroaryl substituted benzothiazole dioxetanes
US6660529B2 (en) * 1998-07-28 2003-12-09 Pe Corporation Heteroaryl substituted benzothiazole dioxetanes
US6783948B1 (en) 1999-07-30 2004-08-31 Bayer Corporation Chemiluminescent acridinium compounds and analogues thereof as substrates of hydrolytic enzymes
US7166478B2 (en) * 2002-03-12 2007-01-23 Enzo Life Sciences, Inc., C/O Enzo Biochem, Inc. Labeling reagents and labeled targets, target labeling processes and other processes for using same in nucleic acid determinations and analyses
US7390670B2 (en) 2003-02-20 2008-06-24 Lumigen, Inc. Signalling compounds and methods for detecting hydrogen peroxide
US20050106576A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Methods of using cleavable solid phases for isolating nucleic acids
US20050106577A1 (en) * 2003-11-17 2005-05-19 Hashem Akhavan-Tafti Cleavable solid phases for isolating nucleic acids
WO2006029302A2 (en) * 2004-09-09 2006-03-16 Applera Corporation Dioxetane-nanoparticle assemblies for energy transfer detection systems, methods of making the assemblies, and methods of using the assemblies in bioassays
US8293721B2 (en) * 2007-06-20 2012-10-23 Merck Sharpe & Dohme Corp. CETP inhibitors derived from benzoxazole arylamides
CN101462316A (zh) * 2007-12-19 2009-06-24 维斯塔斯风力系统有限公司 预成型件的制备方法
WO2010101839A2 (en) 2009-03-02 2010-09-10 Life Technologies Corporation Chemiluminescent compositions, methods, assays and kits for oxidative enzymes
CN103209970B (zh) 2010-07-08 2016-08-24 生命科技公司 原位化学发光底物和测定
WO2012151142A2 (en) * 2011-05-03 2012-11-08 Life Technologies Corporation Flash and glow 1,2-dioxetanes
CN107174883A (zh) * 2017-07-24 2017-09-19 苏州宏久航空防热材料科技有限公司 一种具有表层网状分布碳化硅纳米线过滤结构

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5616729A (en) * 1986-07-17 1997-04-01 Board Of Governors Of Wayne State University Enhanced chemiluminescence from 1,2-dioxetanes through energy transfer to tethered fluorescers
US4956477A (en) 1987-12-31 1990-09-11 Tropix, Inc. Synthesis of 1,2-dioxetanes
US5220005A (en) 1986-07-24 1993-06-15 Tropix, Inc. Substituted adamantyl dioxetanes
CA1340590C (en) 1986-07-24 1999-06-08 John C. Voyta Chemiluminescence enhancement
US4978614A (en) * 1988-10-26 1990-12-18 Tropix, Inc. Method of detecting a substance using enzymatically-induced decomposition of dioxetanes
US5605795A (en) * 1986-07-24 1997-02-25 Tropix, Inc. Assays using chemiluminescent, enzymatically cleavable substituted 1,2-dioxetanes and kits therefor
US4931223A (en) * 1986-07-24 1990-06-05 Tropix, Inc. Methods of using chemiluminescent 1,2-dioxetanes
US5112960A (en) * 1989-07-17 1992-05-12 Bronstein Irena Y Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5582980A (en) * 1989-07-17 1996-12-10 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5330900A (en) * 1987-12-31 1994-07-19 Tropix, Inc. Chemiluminescent 3-(substituted adamant-2'-ylidene) 1,2-dioxetanes
US5679802A (en) * 1989-07-17 1997-10-21 Tropix, Inc. 1,2-dioxetanes useful in chemiluminescent immunoassays
JPH0731201B2 (ja) * 1987-12-31 1995-04-10 トロピックス・インコーポレーテッド 化学発光による測定法
US4868267A (en) * 1988-01-11 1989-09-19 Owens-Corning Fiberglas Corporation Aminated hydroxylated polyester polyol resin and molding compositions comprised thereof
US4952707A (en) * 1988-06-30 1990-08-28 Tropix, Inc. Enzymatically-cleavable chemiluminescent fused polycyclic ring-containing 1,2-dioxetanes
US4931569A (en) * 1988-09-14 1990-06-05 Tropix, Inc. Purification of stable water-soluble dioxetanes
US5326882A (en) * 1989-07-17 1994-07-05 Tropix, Inc. Chemiluminescent 3-(substituted Adamant-2'-Ylidene) 1,2-dioxetanes
US5225584A (en) * 1989-09-06 1993-07-06 Tropix, Inc. Synthesis of stable water-soluble chemiluminescent 1,2-dioxetanes and intermediates therefor
US5547836A (en) * 1990-08-30 1996-08-20 Tropix, Inc. Enhancement of chemiluminescent assays
US5336596A (en) 1991-12-23 1994-08-09 Tropix, Inc. Membrane for chemiluminescent blotting applications
DK0629195T3 (da) * 1992-03-05 1999-11-08 Tropix Inc Syntese af stabile, vandopløselige kemolumininescerende 1,2-dioxetaner og mellemprodukter dertil
US5320882A (en) 1992-04-22 1994-06-14 General Electric Company Laser ablative particulate composite
CA2179726A1 (en) * 1993-12-23 1995-06-29 Brooks Edwards Chemiluminescent energy transfer assays
US5591591A (en) * 1995-02-09 1997-01-07 Tropix, Inc. Dioxetane compounds for the chemiluminescent detection of proteases, methods of use and kits therefore
EP0809804A4 (en) * 1995-02-13 1999-03-31 Tropix Inc CHEMOLUMINESCENCE ENERGY TRANSFER TEST
US5679803A (en) * 1995-10-25 1997-10-21 Tropix, Inc. 1,2 chemiluminescent dioxetanes of improved performance
US5731445A (en) * 1995-12-04 1998-03-24 Fujirebio Inc. 1,2- Dioxetane derivatives
US6602657B1 (en) * 1995-12-28 2003-08-05 Tropix, Inc. Multiple reporter gene assay
US5800999A (en) 1996-12-16 1998-09-01 Tropix, Inc. Dioxetane-precursor-labeled probes and detection assays employing the same
ATE248173T1 (de) 1998-03-13 2003-09-15 Masakatsu Matsumoto 1,2-dioxetanderivate

Also Published As

Publication number Publication date
EP1115400A1 (en) 2001-07-18
WO2000006164A1 (en) 2000-02-10
AU5237699A (en) 2000-02-21
CA2338883A1 (en) 2000-02-10
US20020042085A1 (en) 2002-04-11
US6852548B2 (en) 2005-02-08
JP2002521447A (ja) 2002-07-16
EP1115400A4 (en) 2003-02-12
US6355441B1 (en) 2002-03-12

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